HUP0001297A2 - Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof - Google Patents
Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereofInfo
- Publication number
- HUP0001297A2 HUP0001297A2 HUP0001297A HUP0001297A2 HU P0001297 A2 HUP0001297 A2 HU P0001297A2 HU P0001297 A HUP0001297 A HU P0001297A HU P0001297 A2 HUP0001297 A2 HU P0001297A2
- Authority
- HU
- Hungary
- Prior art keywords
- aryl
- alkyl
- carboxyalkyl
- aminoalkyl
- alkoxyalkyl
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 title 1
- 229940042396 direct acting antivirals thiosemicarbazones Drugs 0.000 title 1
- 150000007659 semicarbazones Chemical class 0.000 title 1
- 150000003584 thiosemicarbazones Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- -1 R23 = H Chemical group 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Treating a disorder responsive to the blockade of sodium channels in a mammal comprises the administration of a compound of formula (I), or its salt or prodrug: Y = O or S; R1 = H, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R21, R22, R23 = H, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; or R22 + R23 together with the N to which they are attached form piperidine, piperazine or morpholine ring; A1, A2 = aryl, heteroaryl or saturated or partially unsaturated carbocycle or heterocycle, any of which are optionally substituted; X = O, S, NR24, CR25R26, C(O), NR24C(O), C(O)NR24, SO, SO2 or a covalent bond; R24, R25, R26 = H, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; provided that when both A1 and A2 are phenyl and X is O or S, then the disorder is other than convulsions. Also new are compounds (I), provided that when X is O or S, and R21, R22 and R23 are H or alkyl, then A1 and A2 are not both phenyl optionally substituted by one or two non-hydrogen substituents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6264997P | 1997-10-22 | 1997-10-22 | |
| PCT/US1998/008004 WO1998047869A1 (en) | 1997-04-22 | 1998-04-22 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001297A2 true HUP0001297A2 (en) | 2000-09-28 |
| HUP0001297A3 HUP0001297A3 (en) | 2001-11-28 |
Family
ID=22043905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001297A HUP0001297A3 (en) | 1997-10-22 | 1998-04-22 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP0001297A3 (en) |
-
1998
- 1998-04-22 HU HU0001297A patent/HUP0001297A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001297A3 (en) | 2001-11-28 |
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