HUP0000964A2 - Anti-convulsant isoquinolyl-benzamide derivatives, process for producing them and pharmaceutical compositions containing them - Google Patents
Anti-convulsant isoquinolyl-benzamide derivatives, process for producing them and pharmaceutical compositions containing themInfo
- Publication number
- HUP0000964A2 HUP0000964A2 HU0000964A HUP0000964A HUP0000964A2 HU P0000964 A2 HUP0000964 A2 HU P0000964A2 HU 0000964 A HU0000964 A HU 0000964A HU P0000964 A HUP0000964 A HU P0000964A HU P0000964 A2 HUP0000964 A2 HU P0000964A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- cycloalkyl
- isoquinolyl
- benzamide derivatives
- alkylco
- Prior art date
Links
- MWXSOBRDESEPGR-UHFFFAOYSA-N 2-isoquinolin-1-ylbenzamide Chemical class NC(=O)C1=CC=CC=C1C1=NC=CC2=CC=CC=C12 MWXSOBRDESEPGR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 229960003965 antiepileptics Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- -1 1-6C alkylCO- Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Isoquinolyl-benzamide derivatives of formula (I) are new: R1 = H, 1-6C alkyl (optionally substituted by OH or 1-4C alkoxy), 1-6C alkenyl, 1-6C alkynyl, 1-6C alkylCO-, formyl, CF3CO- or 1-6C alkyl SO2-; R2 = H; NR5R6; or 1-3 of halo, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, trifluoromethyldiazirinyl, 1-6C alkyl, 1-6C alkenyl, 16C alkynyl, 1-6C perfluoroalkyl, 3-6C cycloalkyl, 3-6C cycloalkyl(1 4C)alkyl, 1-6C alkylO-, 1-6C alkylCO-, 3-6C cycloalkylO-, 3-6C cycloalkylCO-, 3-6C cycloalkyl-(1-4C)alkylO-, 3-6C cycloalkyl-(1 4C)alkylCO-, Ph, phenoxy, benzyloxy, benzoyl, Ph-(1-4C)alkyl, 16C alkylS-, 1-6C alkylSO2-, (1-4C alkyl)2NSO2-, 1-4C alkylNHSO2-, (1-4C alkyl)2NCO-, 1-4C alkylNHCO- or CONH2; or two R2 together form an optionally unsaturated carbocyclic ring optionally substituted by OH or oxo; R5 = H or 1-4C alkyl; R6 = H, 1-4C alkyl, formyl, -CO2(1-4C)alkyl or -CO(1-4C)alkyl; two R3 and two R4 = H or 1-6C alkyl; or the 2 R3 and/or 2 R4 together form a 3-6C spiro group provided that at least 1 of R3 and R4 is not H.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726660.5A GB9726660D0 (en) | 1997-12-17 | 1997-12-17 | Novel compounds |
| PCT/GB1998/000781 WO1998041507A1 (en) | 1997-03-18 | 1998-03-16 | Anti-convulsant isoquinolyl-benzamide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000964A2 true HUP0000964A2 (en) | 2000-09-28 |
| HUP0000964A3 HUP0000964A3 (en) | 2003-01-28 |
Family
ID=10823761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000964A HUP0000964A3 (en) | 1997-12-17 | 1998-03-16 | Anti-convulsant isoquinolyl-benzamide derivatives, process for producing them and pharmaceutical compositions containing them |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB9726660D0 (en) |
| HU (1) | HUP0000964A3 (en) |
-
1997
- 1997-12-17 GB GBGB9726660.5A patent/GB9726660D0/en not_active Ceased
-
1998
- 1998-03-16 HU HU0000964A patent/HUP0000964A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9726660D0 (en) | 1998-02-18 |
| HUP0000964A3 (en) | 2003-01-28 |
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