HUE042239T2 - Tamoxifen deriváltok neoplasztikus betegségek gyógyításához, fõként magasabb HER2 proteinszinttel - Google Patents

Tamoxifen deriváltok neoplasztikus betegségek gyógyításához, fõként magasabb HER2 proteinszinttel

Info

Publication number: HUE042239T2
Authority: HU; Hungary
Prior art keywords: treatment; protein level; neoplastic diseases; her2 protein; high her2
Prior art date: 2013-04-24

Application number

HUE14721738A

Other languages

English (en)

Inventor

Jiri Neuzil

Jan Stursa

Lukas Werner

Original Assignee

Smart Brain Sro

Biotechnologicky Ustav Av Cr V V I

Kkcg Ag

Jiri Neuzil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-04-24

Filing date

2014-04-07

Publication date

2019-06-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50677895&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE042239(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-04-24 Priority claimed from CZ2013-308A external-priority patent/CZ2013308A3/cs

2014-01-29 Priority claimed from CZ2014-66A external-priority patent/CZ305571B6/cs

2014-04-07 Application filed by Smart Brain Sro, Biotechnologicky Ustav Av Cr V V I, Kkcg Ag, Jiri Neuzil filed Critical Smart Brain Sro

2019-06-28 Publication of HUE042239T2 publication Critical patent/HUE042239T2/hu

Links

101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical class C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000001613 neoplastic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5449—Polyphosphonium compounds
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/008—Dyes containing a substituent, which contains a silicium atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epidemiology (AREA)

HUE14721738A 2013-04-24 2014-04-07 Tamoxifen deriváltok neoplasztikus betegségek gyógyításához, fõként magasabb HER2 proteinszinttel HUE042239T2 (hu)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CZ2013-308A CZ2013308A3 (cs)	2013-04-24	2013-04-24	Deriváty tamoxifenu účinné proti nádorům, zejména s vyšší hladinou proteinu HER2
CZ2014-66A CZ305571B6 (cs)	2014-01-29	2014-01-29	Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2

Publications (1)

Publication Number	Publication Date
HUE042239T2 true HUE042239T2 (hu)	2019-06-28

Family

ID=50677895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE14721738A HUE042239T2 (hu)	2013-04-24	2014-04-07	Tamoxifen deriváltok neoplasztikus betegségek gyógyításához, fõként magasabb HER2 proteinszinttel

Country Status (22)

Country	Link
US (1)	US9896466B2 (hu)
EP (1)	EP2989110B1 (hu)
JP (1)	JP6375091B2 (hu)
KR (1)	KR101764991B1 (hu)
CN (1)	CN105452265B (hu)
AU (1)	AU2014256546B2 (hu)
CA (1)	CA2909994C (hu)
CY (1)	CY1120821T1 (hu)
DK (1)	DK2989110T3 (hu)
EA (1)	EA029881B1 (hu)
ES (1)	ES2699099T3 (hu)
GE (1)	GEP20186868B (hu)
HK (1)	HK1216317A1 (hu)
HR (1)	HRP20181872T1 (hu)
HU (1)	HUE042239T2 (hu)
MD (1)	MD4626C1 (hu)
NZ (1)	NZ713589A (hu)
PL (1)	PL2989110T3 (hu)
PT (1)	PT2989110T (hu)
SI (1)	SI2989110T1 (hu)
UA (1)	UA116469C2 (hu)
WO (1)	WO2014173374A1 (hu)

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US10548318B2 (en) *	2015-07-03	2020-02-04	Bayer Cropscience Aktiengesellschaft	N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamide derivatives with herbicidal action
BR112018000088B1 (pt) *	2015-07-03	2022-07-12	Bayer Cropscience Aktiengesellschaft	Derivados de n-(1,3,4-oxadiazol-2-il)aril carboxamida com ação herbicida, seu uso, composição herbicida, e método para controle de plantas indesejadas
CA3030411A1 (en) *	2016-07-12	2018-01-18	Accutar Biotechnology Inc.	Novel compounds and uses thereof
US11040019B2 (en)	2016-08-19	2021-06-22	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration
EP3330274A1 (en) *	2016-12-01	2018-06-06	Springtide Ventures s.r.o.	Compounds for treatment of senescence-related disorders
WO2018195434A1 (en)	2017-04-21	2018-10-25	Lisanti Michael P	Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
US11229657B2 (en)	2017-04-21	2022-01-25	Lunella Biotech, Inc.	Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
RU2019142102A (ru)	2017-05-19	2021-06-21	Лунелла Байотек, Инк.	Антимитосцины: направленные ингибиторы митохондриального биогенеза для эрадикации злокачественных стволовых клеток
BR112020008022A2 (pt)	2017-10-24	2020-10-27	Lunella Biotech, Inc.	mitoflavoscinas: o direcionamento de enzimas contendo flavina elimina as células-tronco de câncer (cscs) por meio da inibição da respiração mitocondrial
JP7066847B2 (ja)	2017-11-24	2022-05-13	ルネラ・バイオテック・インコーポレーテッド	がん幹細胞を根絶するトリフェニルホスホニウム誘導体化合物
US11497759B2 (en)	2017-12-01	2022-11-15	Lunella Biotech, Inc.	Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2019113210A1 (en)	2017-12-05	2019-06-13	Anthos Partners, Lp	Phosphonium-based ionic drug conjugates
US11559527B2 (en)	2017-12-20	2023-01-24	Lunella Biotech, Inc.	Targeting mitochondrial fission through mDIVI-1 derivatives
KR20210152500A (ko) *	2019-04-16	2021-12-15	루넬라 바이오테크 인코포레이티드	미토콘드리아 표적화용 알킬-tpp 화합물 및 항암 치료
EP3753944A1 (en)	2019-06-17	2020-12-23	Institute Of Biotechnology Cas, V.V.I.	3,5-bis(phenyl)-1h-heteroaryl derivatives as medicaments

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CA1289570C (en) *	1986-06-16	1991-09-24	Tetsuji Asao	1,1,2-triaryl-1-alkene derivatives
CA2092996A1 (en) *	1990-10-01	1992-04-02	David Yang	High affinity tamoxifen derivatives and uses thereof
JP3635708B2 (ja) *	1995-03-06	2005-04-06	出光興産株式会社	有機エレクトロルミネッセンス素子
TWI309571B (en) *	2002-12-31	2009-05-11	Ind Tech Res Inst	Delivery carrier for targeting cells haring over-expressed estrogen
JP4648319B2 (ja) *	2003-08-22	2011-03-09	アンティポディーンファーマシューティカルズインコーポレイティド	ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体
SG156613A1 (en) *	2004-07-13	2009-11-26	Oridis Biomed Forschungs Und E	Use of mitochondrially targeted antioxidant in the treatment of liver diseases and epithelial cancers
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MX2011010956A (es) *	2009-04-17	2012-01-27	Colby Pharmaceutical Company	Composiciones farmaceuticamente activas que comprenden moduladores de estres oxidativo (osm por sus siglas en inglés), nuevas entidades quimicas, composiciones y usos.
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2014
- 2014-04-07 NZ NZ713589A patent/NZ713589A/en unknown
- 2014-04-07 CA CA2909994A patent/CA2909994C/en active Active
- 2014-04-07 MD MD20150117A patent/MD4626C1/ro active IP Right Grant
- 2014-04-07 UA UAA201510642A patent/UA116469C2/uk unknown
- 2014-04-07 SI SI201430928T patent/SI2989110T1/sl unknown
- 2014-04-07 WO PCT/CZ2014/000035 patent/WO2014173374A1/en active Application Filing
- 2014-04-07 AU AU2014256546A patent/AU2014256546B2/en active Active
- 2014-04-07 PL PL14721738T patent/PL2989110T3/pl unknown
- 2014-04-07 US US14/786,710 patent/US9896466B2/en active Active
- 2014-04-07 JP JP2016509298A patent/JP6375091B2/ja active Active
- 2014-04-07 PT PT14721738T patent/PT2989110T/pt unknown
- 2014-04-07 KR KR1020157030376A patent/KR101764991B1/ko active IP Right Grant
- 2014-04-07 DK DK14721738.4T patent/DK2989110T3/en active
- 2014-04-07 ES ES14721738T patent/ES2699099T3/es active Active
- 2014-04-07 HU HUE14721738A patent/HUE042239T2/hu unknown
- 2014-04-07 EP EP14721738.4A patent/EP2989110B1/en active Active
- 2014-04-07 EA EA201591918A patent/EA029881B1/ru unknown
- 2014-04-07 CN CN201480033316.9A patent/CN105452265B/zh active Active
2015
- 2015-04-07 GE GEAP201513996A patent/GEP20186868B/en unknown
2016
- 2016-04-14 HK HK16104277.8A patent/HK1216317A1/zh unknown
2018
- 2018-11-06 CY CY181101155T patent/CY1120821T1/el unknown
- 2018-11-08 HR HRP20181872TT patent/HRP20181872T1/hr unknown

Also Published As

Publication number	Publication date
WO2014173374A1 (en)	2014-10-30
EA201591918A1 (ru)	2016-02-29
CA2909994A1 (en)	2014-10-30
CN105452265B (zh)	2017-05-10
ES2699099T3 (es)	2019-02-07
CA2909994C (en)	2018-06-26
EA029881B1 (ru)	2018-05-31
MD4626B1 (ro)	2019-04-30
US9896466B2 (en)	2018-02-20
HRP20181872T1 (hr)	2019-02-08
HK1216317A1 (zh)	2016-11-04
JP6375091B2 (ja)	2018-08-15
KR20150144756A (ko)	2015-12-28
SI2989110T1 (sl)	2019-01-31
MD4626C1 (ro)	2019-11-30
CY1120821T1 (el)	2019-12-11
AU2014256546B2 (en)	2017-03-30
DK2989110T3 (en)	2018-12-03
CN105452265A (zh)	2016-03-30
NZ713589A (en)	2017-12-22
EP2989110A1 (en)	2016-03-02
JP2016522179A (ja)	2016-07-28
MD20150117A2 (ro)	2016-08-31
AU2014256546A1 (en)	2015-11-12
PT2989110T (pt)	2018-11-15
UA116469C2 (uk)	2018-03-26
KR101764991B1 (ko)	2017-08-10
US20160075726A1 (en)	2016-03-17
PL2989110T3 (pl)	2019-03-29
GEP20186868B (en)	2018-06-25
EP2989110B1 (en)	2018-08-08

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