HUE037847T2 - pH-dependens opioid receptor agonista fentanil-származékok - Google Patents

pH-dependens opioid receptor agonista fentanil-származékok

Info

Publication number
HUE037847T2
HUE037847T2 HUE12753447A HUE12753447A HUE037847T2 HU E037847 T2 HUE037847 T2 HU E037847T2 HU E12753447 A HUE12753447 A HU E12753447A HU E12753447 A HUE12753447 A HU E12753447A HU E037847 T2 HUE037847 T2 HU E037847T2
Authority
HU
Hungary
Prior art keywords
receptor agonists
opioid receptor
fentanyl derivatives
dependent opioid
dependent
Prior art date
Application number
HUE12753447A
Other languages
English (en)
Inventor
Christoph Stein
Marcus Weber
Christian Zoellner
Olga Perepelica
Original Assignee
Univ Berlin Charite
Konrad Zuse Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Berlin Charite, Konrad Zuse Inst filed Critical Univ Berlin Charite
Publication of HUE037847T2 publication Critical patent/HUE037847T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
HUE12753447A 2011-08-19 2012-08-17 pH-dependens opioid receptor agonista fentanil-származékok HUE037847T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11178122A EP2559685A1 (en) 2011-08-19 2011-08-19 Fentanyl derivatives as pH-dependent opioid receptor agonists

Publications (1)

Publication Number Publication Date
HUE037847T2 true HUE037847T2 (hu) 2018-09-28

Family

ID=46763055

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12753447A HUE037847T2 (hu) 2011-08-19 2012-08-17 pH-dependens opioid receptor agonista fentanil-származékok

Country Status (11)

Country Link
US (1) US9133120B2 (hu)
EP (2) EP2559685A1 (hu)
DK (1) DK2744781T3 (hu)
ES (1) ES2655646T3 (hu)
HR (1) HRP20180048T1 (hu)
HU (1) HUE037847T2 (hu)
NO (1) NO2744781T3 (hu)
PL (1) PL2744781T3 (hu)
PT (1) PT2744781T (hu)
RS (1) RS56734B1 (hu)
WO (1) WO2013026787A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020006563A1 (en) * 2018-06-29 2020-01-02 Marquette University Fluorinated compounds as ph-sensitive analgesics
CN113292485B (zh) * 2021-06-08 2023-10-27 河南大学 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用
CN114949220B (zh) * 2022-01-30 2023-09-22 浙江大学 一种靶向损伤节段背根神经节的pH响应镇痛药及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923992A (en) * 1974-05-23 1975-12-02 Univ Mississippi Analgetic composition and method of use
US6677332B1 (en) * 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof

Also Published As

Publication number Publication date
EP2744781B1 (en) 2017-10-11
ES2655646T3 (es) 2018-02-21
EP2744781A1 (en) 2014-06-25
US20140228406A1 (en) 2014-08-14
DK2744781T3 (en) 2018-01-15
WO2013026787A1 (en) 2013-02-28
PL2744781T3 (pl) 2018-05-30
HRP20180048T1 (hr) 2018-03-23
NO2744781T3 (hu) 2018-03-10
EP2559685A1 (en) 2013-02-20
PT2744781T (pt) 2018-01-16
RS56734B1 (sr) 2018-03-30
US9133120B2 (en) 2015-09-15

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