HUE030164T2 - Eljárás emlõrák kiújulásának elõrejelzésére endokrin kezelés alatt - Google Patents
Eljárás emlõrák kiújulásának elõrejelzésére endokrin kezelés alatt Download PDFInfo
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- HUE030164T2 HUE030164T2 HUE14188791A HUE14188791A HUE030164T2 HU E030164 T2 HUE030164 T2 HU E030164T2 HU E14188791 A HUE14188791 A HU E14188791A HU E14188791 A HUE14188791 A HU E14188791A HU E030164 T2 HUE030164 T2 HU E030164T2
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Claims (7)
- leprás émlimklláfölMásak előrejelzésére endokrin kezelés alatt SZABA DALMI )G ÉN YPONTOK. h iptás amlíA egy etalőíétM beieg: ösztrogén itm pozitív és mm segativ timiórá esetébe!, Iteal jellemezve, bogy bit eljárás a kivetkező lipse|et tartalmazza: faj egy, a szóban forgó befégbll származó tmornűmaban mcghataroz/uk a/ alábbi 8 §$n RNS-rnpmMzmmáiMiiét'. GBF2C, RACOAPI, DHCR7, STC2, A2GPI, RBBP8.1L6ST, és MGP (b) á lite forgó csoport gépjeinek egy ttmtormintában meghatározott eapresszlós szintjeinek énekeit matematikailag kombináljuk. hog> eg> konÄÄjfcmtsÄot k||§ulÉ% ahol a sióban forgó kombinált pontszáfo a szóban forgó beteg prognözMta jellemző.
- 2,- Az 1. igénypont szerimi eljárás, azzal jellemezve, bogy az I1BE2C helyettesíthető BlRC5-fol vagy TOP2A-val vagy ÂlJEKA-vaî sag> NER2-vel vagy E2Fk"Cal vagy PCNA-val vagy CYBRDl-gyei vagy ABRA2A-vai vagy BOAMiei vagy SQLE-vel yagy CCNDBgyel vagy ASPH-val vagy (iXélLH-vef vagy BIF-pel vagy PlSSléAsi vagy EGIIG •rel vagy I>HCR7-tei vagy EPHX2-vel vág} !'RIM29~eélés a DHCR7 helyettesühetó AURXA-vai, BIRCS-tei, UöB2€«vel vagy bármilyen más génnél, amely képes helyettesíteni BLRCShh vagy UBE2C.Fi és m$ m S1C2 helyettesíthető lN?P4B'vel vagy ILÖBT-vel vagy SEC!4L2-vd vágy MAFBvel Vágy CiiFfl-'gyel vagy ABAT-tal vagy S€UBE2-vel vagy ESRl-gyel vagy RB BPS-eaí vagy FÜR-rel vagy Pl'PRT-vd vagy B$PA2-vd vagy PTOER3-mal. és az AZGPI helyettesíthető PIP-pel vagy EPHX2-vel vagy RLÁTRal vagy SECi4L2*vel vagy m'I Bf 2'xel\ag> ftdbrdés az RBBP8 helyettesíthető €ELSR2-vel vagy FíJR-rel vagy STC2-vd vagy ABAT-tal vagy IL6ST-vei: és: az 1L6ST helyettesithetó ÍNPP4B-vel vagy STC2-vel vagy MAPT-vd vagy SCUBE2-veí vagy ABAT~ial vagy POR-re! vagy SEC14L2~vd vagy LSR 1 -gyei vagy OsAUgyel vagy MGF-vel vagy EFHN2~vel vagy RBRPS-cai vagy FTPRT-vel vagy PLAT-tul és az MGP helyettesíthető APÖD-dal vagy B.6ST-vef vagy FuFR-rel a. Az; I, vagy 2. igénypont szerinti eljárás, azzal ieHemezve, begy 0; szóban forgó: beteg endokrin terápiát kapott, vagy tervezik, hogy endokrin kezelést kap. 4 4 1 igénypont szerinti eljárás, azzal jellemezve, hogy a szobaa Jtaigő endokrin tef|pta: vagy egy aromataz inhibitort tartalmaz, I, Az 1-4. igénypontok bármelyike szerinti eljárás, azzal jellemezve,, hogy m esniftik kiüjulásának vagy a iákhoz köthető halálnak a kockázatát előre jelezzük. 4 Az 1, Igénypont szerinti eljárás* azzal jellemem* hogy a szóban forgó expresszios szintét sz alábbi eljárások közöl legalább egynek a használatával határozzuk meg egy FCR-alapu eljárás egy mikrofomb alapú eljárás, és egy hibridizáción alapuló eljárás,
- 7. Az előző Igénypontok bármelyike szerinti eljárás, azzal jellemem, hogy az expressziós szintek szóban forgó meghtórozását egy formaiinnal rögzített, beágyazott tumormintából, vagy egy frissen lefagyasztott tumormmtábói hajtjuk végre, ,4 \z előző igénypontok hnmoKiU vetett' e ntrás, txzm uile-nez^e, hogy legalahh egy markergén expressziós szintjét meghatározzuk egy expawiős mintázatként, legalább egy referencia génhez, \agy egy számított átlag*>s expresszié* epékhez v Iszony tt\ a,
- 9, Az előző Igénypontok hirnteiyíke szerinti eljárás:, azzal jellemezve, hogy a matematikai kombinálás szóban forgó lépése tartalmaz egy lépést, amelyben egy algoritmust alkalmazunk az adott gének expresszié* szintjeit reprezentáló értékekre. 10, A 9. Igénypont szerinti eljárás, azzal jellemezve, hogy a szóban forgó algoritmus az adott gének expresszié* szintjét reprezentáló szóban forgó értékek lineáris komhlhápfgm 11. A 10. igénypont szerimi eljárás, azzal jellemezve, hogy egy adott gén expresszié*; szintje reprezentációs értékének az értékéi egy koefficienssel szorozzuk.
- 12. Az előző igénypontok bármelyike szerinti eljárás, azzal jellemezte, bogi égy. kettő, vagy több küszöbértéket határozunk meg a szóban forgó kombinált pontszámúi, amely magas és alacsony kockázatú, magas, közepes és alacsony kockázatú, vagy több kockázati csoportot különböztet meg a küszöbértéket alkalmazva a kombinált pontszámút, különösen, ha egy magas kombinált pont-szám a cifotoxtkus kemoterápiából származó jótékony hatást jelzi. Í3i Az előző igénypontok bármelyike szerimi eljárás, azzal jellemezve., hogy I bftég nyirokcsomó státuszára vonatkozó Információt abban a lépésben resszlős szintjeit matematikailag kombináljuk, hogy kombinált pontszámot kapjunk.
- 14. A tt vagy 13. igénypont szerint! eljárás, ázzál jellemezve, hogy a nyirokcsomó siátm Sllra vonatkozó információ egy numerikus ettek, ha a * \ * un tót go ny mfoesomo státusz negatív, és a sgőhan forgó információ egy eltérő számérték, ha a szóban forgó nyirokcsomó stlfpsZ pozitfA #; 114 iőnböző vagy azonos szám, ha a szóban forgó nyirokcsomó státusz ismeretien.
- 15, Egy készlet alkalmazása az. l~14. igénypontok bármelyike szerinti eljárás végrehajtására, a szóban forgó készlet oltgööukleotiáök egy csoportját tartalmazza, amelyek képesek specifikusan megkötni szekvebctákab vágy a gének fmgmeőseinek a szekvenciáit gének kombinációiban, alto; a szóban forgó kombináció a következő 8 gént tartalmazza: UBE2C. RAC'OAPI, DBCR", STCÔ, AZOF!, RBBPS, IL5ST, és MGP,
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| EP10158561 | 2010-03-31 |
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| WO (1) | WO2011120984A1 (hu) |
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