HUE029556T2 - Reduced immunoreactivity of AAV virions and their use - Google Patents

Reduced immunoreactivity of AAV virions and their use Download PDF

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Publication number
HUE029556T2
HUE029556T2 HUE04755800A HUE04755800A HUE029556T2 HU E029556 T2 HUE029556 T2 HU E029556T2 HU E04755800 A HUE04755800 A HU E04755800A HU E04755800 A HUE04755800 A HU E04755800A HU E029556 T2 HUE029556 T2 HU E029556T2
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Hungary
Prior art keywords
aav
amely amely
virion
dna
capsid
Prior art date
Application number
HUE04755800A
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English (en)
Hungarian (hu)
Inventor
Alejandra Elena Arbetman
Peter Colosi
Michael A Lochrie
Richard T Surosky
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Genzyme Corp
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Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of HUE029556T2 publication Critical patent/HUE029556T2/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
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  • Virology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
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  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
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HUE04755800A 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their use HUE029556T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48039503P 2003-06-19 2003-06-19
US56731004P 2004-04-30 2004-04-30
US57650104P 2004-06-03 2004-06-03

Publications (1)

Publication Number Publication Date
HUE029556T2 true HUE029556T2 (en) 2017-03-28

Family

ID=33545345

Family Applications (5)

Application Number Title Priority Date Filing Date
HUE13163182A HUE034597T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their applications
HUE11158742A HUE034546T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their applications
HUE17162137A HUE054046T2 (hu) 2003-06-19 2004-06-21 Csökkentett immunreaktivitású AAV virionok és alkalmazásaik
HUE04755800A HUE029556T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their use
HUE13163168A HUE034785T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their use

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HUE13163182A HUE034597T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their applications
HUE11158742A HUE034546T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their applications
HUE17162137A HUE054046T2 (hu) 2003-06-19 2004-06-21 Csökkentett immunreaktivitású AAV virionok és alkalmazásaik

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE13163168A HUE034785T2 (en) 2003-06-19 2004-06-21 Reduced immunoreactivity of AAV virions and their use

Country Status (11)

Country Link
US (6) US7259151B2 (pt)
EP (5) EP2357189B1 (pt)
JP (7) JP2007524386A (pt)
CY (5) CY1117575T1 (pt)
DK (5) DK2357189T3 (pt)
ES (5) ES2627913T3 (pt)
HU (5) HUE034597T2 (pt)
PL (5) PL3235827T3 (pt)
PT (5) PT1633772E (pt)
SI (5) SI2657248T1 (pt)
WO (1) WO2004112727A2 (pt)

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WO1999061601A2 (en) 1998-05-28 1999-12-02 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aav5 vector and uses thereof
WO2000075365A2 (en) 1999-06-08 2000-12-14 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
CN102181480B (zh) 2001-11-13 2016-01-27 宾夕法尼亚大学托管会 检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
US7419817B2 (en) 2002-05-17 2008-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
EP1608763A2 (en) 2003-03-31 2005-12-28 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
WO2005017101A2 (en) 2003-05-19 2005-02-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH Avian adenoassociated virus (aaav) and uses thereof
DK2357189T3 (en) 2003-06-19 2017-06-19 Genzyme Corp AAV virions with reduced immunoreactivity and applications thereof
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US9233131B2 (en) * 2003-06-30 2016-01-12 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
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WO2011032100A1 (en) 2009-09-11 2011-03-17 Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Inhibitors of kshv vil6 and human il6
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PL2657247T3 (pl) 2017-09-29
CY1119279T1 (el) 2018-02-14
EP2357189A2 (en) 2011-08-17
US7259151B2 (en) 2007-08-21
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US11083800B2 (en) 2021-08-10
US20060051333A1 (en) 2006-03-09
JP2018029614A (ja) 2018-03-01
JP2014057579A (ja) 2014-04-03
DK2657247T3 (en) 2017-07-10
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US20170232117A1 (en) 2017-08-17
CY1119222T1 (el) 2018-02-14
JP5551029B2 (ja) 2014-07-16
PL2357189T3 (pl) 2017-08-31
EP1633772A2 (en) 2006-03-15
DK1633772T3 (en) 2016-02-29
PT2657247T (pt) 2017-06-29
SI2657248T1 (sl) 2017-07-31
EP3235827A2 (en) 2017-10-25
JP2023106497A (ja) 2023-08-01
HUE054046T2 (hu) 2021-08-30
DK3235827T3 (da) 2021-04-19
EP2357189B1 (en) 2017-03-08
SI3235827T1 (sl) 2021-05-31
US20080008690A1 (en) 2008-01-10
PL1633772T3 (pl) 2016-10-31
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PL2657248T3 (pl) 2017-09-29

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