HU219332B - Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények - Google Patents
Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények Download PDFInfo
- Publication number
- HU219332B HU219332B HU9301313A HU9301313A HU219332B HU 219332 B HU219332 B HU 219332B HU 9301313 A HU9301313 A HU 9301313A HU 9301313 A HU9301313 A HU 9301313A HU 219332 B HU219332 B HU 219332B
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- HU
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- Prior art keywords
- methyl
- cyclohexanol
- dimethylamino
- trans
- methoxyphenyl
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract
Description
Hatóanyag-kombináció | Dózis (mg/kg po.) | ED50 30 percnél (95%-os megbízhatósági határ) | |||
(TramadokAPAP) | Tramadol | APAP | Fájdalomcsillapítás | Tramadol | APAP |
Tramadol (egyedül) | 2 3 4 6 8 10 16 | 0 0 0 0 0 0 0 | 3/15 4/15 14/45 20/45 40/60 15/15 14/15 | 5,5 (4,8-6,4) | |
1000:1 | 3,75 | 0,00 375 | 1/13 | ||
7,5 | 0,00 75 | 8/15 | 7,0 | 0,01 | |
15 | 0,015 | 15/15 | (5,7-8,4) | (0,1-0,1) | |
100:1 | 1,875 | 0,01 875 | 0/15 | ||
3,75 | 0,03 75 | 4/15 | 6,9 | 0,1 | |
7,5 | 0,07 5 | 5/15 | (5,2-9,0) | (0,1-0,1) | |
15 | 0,15 | 15/15 | |||
20:1 | 1,875 | 0,09 375 | 0/15 | ||
3,75 | 0,18 75 | 4/15 | 6,5 | 0,3 | |
7,5 | 0,37 5 | 7/15 | (5,1-8,3) | (0,3-0,4) | |
15 | 0,75 | 15/15 | |||
3:1 | 3,75 | 1,25 | 3/30 | ||
7,5 | 2,5 | 12/30 | 7,8 | 2,6 | |
15 | 5 | 28/30 | (6,6-9,1) | (2,2-3,0) | |
1:1 | 0,94 | 0,94 | 3/15 | ||
1,87 5 | 1,87 5 | 8/30 | |||
3,75 | 3,75 | 14/30 | 3,8 | 3,8 | |
5 | 5 | 12/28 | (3,0-4,8) | (3,0-4,8) | |
7,5 | 7,5 | 24/30 | |||
15 | 15 | 15/15 | |||
1:3 | 3,75 | 11,25 | 7/30 | ||
5 | 15 | 7/15 | 4,7 | 14,2 | |
7,5 | 22,5 | 29/30 | (4,3-5,2) | (12,8-15,7) | |
1:5 | 2,5 | 12,5 | 7/30 | ||
5 | 25 | 8/30 | 4,0 | 19,8 | |
10 | 50 | 30/30 | (3,3-4,7) | (16,7-23,4) | |
1:5,7 | 0,47 0,94 1,88 3,75 7,5 15 | 2,66 5,313 10,62 5 21,25 42,5 85 | 0/15 4/15 1/15 5/15 11/15 15/15 | 4,1 (3,0-5,7) | 23,3 (16,8-32,3) |
1:19 | 0,94 1,88 3,75 5 7,5 15 | 17,81 3 36,62 5 71,25 95 142,5 285 | 4/30 10/28 21/30 22/30 29/30 15/15 | 2,5 (2,0-3,0) | 47,3 (38,9-57,5) |
Hatóanyag-kombináció | Dózis (mg/kg po.) | ED50 30 percnél (95%-os megbízhatósági határ) | |||
(Tramadol: APAP) | Tramadol | APAP | Fájdalomcsillapítás | Tramadol | APAP |
1:50 | 0,25 | 12,5 | 3/30 | ||
0,5 | 25 | 7/30 | |||
1 | 50 | 9/30 | 1,2 | 61,4 | |
2 | 100 | 19/30 | (L0-1,5) | (49,0-77,1) | |
4 | 200 | 27/30 | |||
8 | 400 | 30/30 | |||
1:100 | 0,25 | 25 | 3/60 | ||
0,5 | 50 | 12/60 | |||
1 | 100 | 19/60 | 1,1 | 111,3 | |
2 | 200 | 51/60 | (1,0-1,3) | (96,4-128,6) | |
4 | 400 | 55/60 | |||
8 | 800 | 30/30 | |||
1:200 | 0,12 5 | 25 | 1/60 | ||
0,25 | 50 | 9/60 | |||
0,5 | 100 | 27/60 | 0,6 | 129,7 | |
1 | 200 | 44/60 | (0,6-0,8) | (110,4-152,4) | |
2 | 400 | 48/60 | |||
4 | 800 | 30/30 | |||
1:40 | 0,06 25 | 25 | 2/15 | ||
0,12 5 | 50 | 4/30 | |||
0,25 | 100 | 18/30 | 0,2 | 95,1 | |
0,5 | 200 | 12/15 | (0,2-0,3) | (75,4-119,8) | |
1 | 400 | 28/30 | |||
2 | 800 | 15/15 | |||
1:800 | 0,03 125 | 25 | 4/30 | ||
0,06 25 | 50 | 9/30 | |||
0,12 5 | 100 | 15/30 | 0,1 | 77,4 | |
0,25 | 200 | 27/30 | (0,1-0,1) | (62,9-95,2) | |
0,5 | 400 | 30/30 | |||
1:600 | 0,03 125 | 50 | 2/30 | ||
0,06 25 | 100 | 14/30 | |||
0,12 5 | 200 | 22/30 | 0,1 | 125,7 | |
0,25 | 400 | 27/30 | (0,1-0,1) | (102,7-153,8) | |
0,5 | 800 | 30/30 | |||
APAP (egyedül) | 0 | 30 | 2/15 | ||
0 | 40 | 12/43 | |||
0 | 50 | 1/15 | |||
0 | 60 | 8/30 | |||
0 | 80 | 23/60 | |||
0 | 100 | 13/30 | - | 164,3 | |
0 | 120 | 13/30 | (122,7-219,9) | ||
0 | 160 | 10/30 | |||
0 | 200 | 13/25 | |||
0 | 240 | 14/25 | |||
0 | 400 | 12/15 | |||
0 | 800 | 13/15 |
Claims (10)
- SZABADALMI IGÉNYPONTOK1. Szinergetikus gyógyszerkészítmény, amely transz- 55 (±)-2-[(dimetil-amino)-metil]-l-(3-metoxi-fenil)-ciklohexanolt vagy fiziológiásán elfogadható sóját és acetaminofent tartalmaz.
- 2. Az 1. igénypont szerinti gyógyszerkészítmény, amelyben a transz-(±)-2-[(dimetil-amino)-metil]-l-(3- 60 metoxi-fenil)-ciklohexanol-hatóanyag transz-(± )-2[(dimetil-amino)-metil]-1 -(3-metoxi-fenil)-ciklohexanol-hidroklorid.
- 3. A 2. igénypont szerinti gyógyszerkészítmény, amelyben a transz-(±)-2-[(dimetil-amino)-metil]-l-(3metoxi-fenil)-ciklohexanol-hidroklorid racém.
- 4. Az 1. igénypont szerinti gyógyszerkészítmény, amelyben a transz-(±)-2-[(dimetil-amino)-metil]-l-(36HU 219 332 Β metoxi-fenil)-ciklohexanol-hatóanyag és az acetaminofen tömegaránya 1:1 és 1:1600 közötti.
- 5. A 4. igénypont szerinti gyógyszerkészítmény, amelyben a tömegarány 1:1.
- 6. A 4. igénypont szerinti gyógyszerkészítmény, 5 amelyben a tömegarány 1:5 és 1:1600 közötti.
- 7. A 6. igénypont szerinti gyógyszerkészítmény, amelyben a tömegarány 1:5.
- 8. A 4. igénypont szerinti gyógyszerkészítmény, amelyben a tömegarány 1:19 és 1:800 közötti.
- 9. A 8. igénypont szerinti gyógyszerkészítmény, amelyben a tömegarány 1:19 és 1:50 közötti.
- 10. Az 1. igénypont szerinti gyógyszerkészítmény, amely gyógyászatilag elfogadható vivőanyagot is tartalmaz.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75592491A | 1991-09-06 | 1991-09-06 | |
PCT/US1992/007542 WO1993004675A1 (en) | 1991-09-06 | 1992-09-03 | Composition comprising a tramadol material and acetaminophen and its use |
CN92112594A CN1071571C (zh) | 1991-09-06 | 1992-10-24 | 含有反胺苯环醇物质和乙酰氨基苯的组合物及其应用 |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9301313D0 HU9301313D0 (en) | 1993-09-28 |
HUT64838A HUT64838A (en) | 1994-03-28 |
HU219332B true HU219332B (hu) | 2001-03-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9301313A HU219332B (hu) | 1991-09-06 | 1992-09-03 | Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények |
Country Status (17)
Country | Link |
---|---|
US (2) | US5336691A (hu) |
EP (1) | EP0566709B3 (hu) |
JP (1) | JP3381190B2 (hu) |
KR (1) | KR100243956B1 (hu) |
CN (1) | CN1071571C (hu) |
AT (1) | ATE169498T1 (hu) |
AU (1) | AU651247B2 (hu) |
CA (1) | CA2095523C (hu) |
DE (2) | DE69226624T3 (hu) |
DK (1) | DK0566709T5 (hu) |
ES (1) | ES2120451T7 (hu) |
HU (1) | HU219332B (hu) |
LU (1) | LU91079I2 (hu) |
NL (1) | NL300152I2 (hu) |
RU (1) | RU2121346C1 (hu) |
SG (1) | SG80535A1 (hu) |
WO (1) | WO1993004675A1 (hu) |
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-
1992
- 1992-09-03 ES ES92919762T patent/ES2120451T7/es active Active
- 1992-09-03 CA CA002095523A patent/CA2095523C/en not_active Expired - Lifetime
- 1992-09-03 EP EP92919762A patent/EP0566709B3/en not_active Expired - Lifetime
- 1992-09-03 RU RU93043625A patent/RU2121346C1/ru active
- 1992-09-03 HU HU9301313A patent/HU219332B/hu not_active IP Right Cessation
- 1992-09-03 AU AU25799/92A patent/AU651247B2/en not_active Expired
- 1992-09-03 AT AT92919762T patent/ATE169498T1/de active
- 1992-09-03 DE DE69226624T patent/DE69226624T3/de not_active Expired - Lifetime
- 1992-09-03 DE DE200412000032 patent/DE122004000032I2/de active Active
- 1992-09-03 DK DK92919762T patent/DK0566709T5/da active
- 1992-09-03 JP JP50544793A patent/JP3381190B2/ja not_active Expired - Lifetime
- 1992-09-03 SG SG9605733A patent/SG80535A1/en unknown
- 1992-09-03 KR KR1019930701352A patent/KR100243956B1/ko not_active IP Right Cessation
- 1992-09-03 WO PCT/US1992/007542 patent/WO1993004675A1/en active IP Right Grant
- 1992-10-24 CN CN92112594A patent/CN1071571C/zh not_active Expired - Lifetime
- 1992-11-10 US US07/974,865 patent/US5336691A/en not_active Ceased
-
2004
- 2004-01-20 US US10/761,096 patent/USRE39221E1/en not_active Expired - Lifetime
- 2004-05-26 LU LU91079C patent/LU91079I2/fr unknown
- 2004-05-27 NL NL300152C patent/NL300152I2/nl unknown
Also Published As
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---|---|
US5336691A (en) | 1994-08-09 |
SG80535A1 (en) | 2001-05-22 |
DE69226624T3 (de) | 2009-11-05 |
RU2121346C1 (ru) | 1998-11-10 |
AU651247B2 (en) | 1994-07-14 |
LU91079I2 (fr) | 2004-07-26 |
DE122004000032I1 (de) | 2005-11-24 |
JPH06502869A (ja) | 1994-03-31 |
DK0566709T5 (da) | 2009-05-18 |
EP0566709A4 (hu) | 1994-04-06 |
CN1086133A (zh) | 1994-05-04 |
CA2095523A1 (en) | 1993-03-07 |
WO1993004675A1 (en) | 1993-03-18 |
HU9301313D0 (en) | 1993-09-28 |
EP0566709B3 (en) | 2009-04-08 |
NL300152I2 (nl) | 2006-05-01 |
DK0566709T3 (da) | 1999-05-10 |
DE69226624D1 (de) | 1998-09-17 |
NL300152I1 (nl) | 2004-08-02 |
ES2120451T7 (es) | 2009-11-05 |
AU2579992A (en) | 1993-04-05 |
EP0566709A1 (en) | 1993-10-27 |
USRE39221E1 (en) | 2006-08-01 |
CN1071571C (zh) | 2001-09-26 |
CA2095523C (en) | 2004-06-22 |
ATE169498T1 (de) | 1998-08-15 |
JP3381190B2 (ja) | 2003-02-24 |
DE122004000032I2 (de) | 2006-02-09 |
DE69226624T2 (de) | 1999-03-04 |
ES2120451T3 (es) | 1998-11-01 |
EP0566709B1 (en) | 1998-08-12 |
HUT64838A (en) | 1994-03-28 |
KR100243956B1 (ko) | 2000-03-02 |
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Free format text: PRODUCT NAME: COMBINATION OF TRAMADOL OR IT'S SALTS AND PARACETAMOL; REG. NO/DATE: OGYI-T-20557/01-06 20080514; FIRST REG.: FR NL 25971 20020415 Spc suppl protection certif: S0800018 Filing date: 20081107 Expiry date: 20120903 |
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