HU193029B - Process for preparing carboxy-alkanoyl-peptide-alkylamide derivatives - Google Patents

Process for preparing carboxy-alkanoyl-peptide-alkylamide derivatives Download PDF

Info

Publication number
HU193029B
HU193029B HU822541A HU254182A HU193029B HU 193029 B HU193029 B HU 193029B HU 822541 A HU822541 A HU 822541A HU 254182 A HU254182 A HU 254182A HU 193029 B HU193029 B HU 193029B
Authority
HU
Hungary
Prior art keywords
alanyl
amide
alanine
preparation
ethyl
Prior art date
Application number
HU822541A
Other languages
English (en)
Hungarian (hu)
Inventor
Evzen Kasafirek
Premysl Fric
Jan Slaby
Alena Roubalova
Original Assignee
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Vereinigte Pharma Werke filed Critical Spofa Vereinigte Pharma Werke
Publication of HU193029B publication Critical patent/HU193029B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU822541A 1981-08-07 1982-08-06 Process for preparing carboxy-alkanoyl-peptide-alkylamide derivatives HU193029B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS815977A CS226907B1 (en) 1981-08-07 1981-08-07 Alkylamides of carboxyalkanoylpeptides

Publications (1)

Publication Number Publication Date
HU193029B true HU193029B (en) 1987-08-28

Family

ID=5405786

Family Applications (1)

Application Number Title Priority Date Filing Date
HU822541A HU193029B (en) 1981-08-07 1982-08-06 Process for preparing carboxy-alkanoyl-peptide-alkylamide derivatives

Country Status (11)

Country Link
US (1) US4554100A (it)
JP (1) JPS5849351A (it)
BE (1) BE894065A (it)
CA (1) CA1238902A (it)
CH (1) CH653038A5 (it)
CS (1) CS226907B1 (it)
DE (1) DE3229632A1 (it)
FR (1) FR2510990B1 (it)
GB (1) GB2104082B (it)
HU (1) HU193029B (it)
IT (1) IT1156108B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231228B1 (en) * 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
EP0124317B1 (en) * 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
NZ214543A (en) * 1984-12-14 1990-03-27 Australian Commercial Research Amino acid and peptide derivatives that inhibit human leucocytic elastase enzyme (hle)
FR2733995B1 (fr) * 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
JP6480025B2 (ja) 2015-06-24 2019-03-06 日東電工株式会社 イオン性化合物及び組成物並びにその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029772A (en) * 1975-12-23 1977-06-14 Merck & Co., Inc. Peptide carbazates
US4064236A (en) * 1975-12-23 1977-12-20 Merck & Co., Inc. Peptide carbazates and pharmaceutical composition
CH626872A5 (it) * 1976-06-21 1981-12-15 Hoffmann La Roche
PH14141A (en) * 1976-06-25 1981-03-05 Hoffmann La Roche Pharmaceutical composition containing dipeptide derivatives
FR2381023A1 (fr) * 1977-02-18 1978-09-15 Delalande Sa Nouveaux oligopeptides trifluoromethyles derives de la l-alanine, leur procede de preparation et leur application en therapeutique
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US4554100A (en) 1985-11-19
FR2510990A1 (fr) 1983-02-11
IT8222506A0 (it) 1982-07-21
CA1238902A (en) 1988-07-05
JPH0349918B2 (it) 1991-07-31
DE3229632A1 (de) 1983-02-24
IT8222506A1 (it) 1984-01-21
IT1156108B (it) 1987-01-28
CS226907B1 (en) 1984-04-16
JPS5849351A (ja) 1983-03-23
FR2510990B1 (fr) 1986-05-09
GB2104082B (en) 1984-09-12
CH653038A5 (de) 1985-12-13
DE3229632C2 (it) 1988-06-23
GB2104082A (en) 1983-03-02
BE894065A (fr) 1982-12-01

Similar Documents

Publication Publication Date Title
US5066643A (en) Fluorine and chlorine statine or statone containing peptides and method of use
JPH0437070B2 (it)
EP0000063B1 (en) Dipeptide derivatives of 7-(n-alpha-substituted or non-substituted x-arginyl)-amino-4-methyl-coumarin
JPH089634B2 (ja) アミジノフェニルアラニン誘導体およびそれらの製法
CZ118393A3 (en) Hydroxamic acid derivatives, process of their preparation and medicaments based thereon
GB2171103A (en) Fluorinated/chlorinated peptides
US5206343A (en) Oligopetides with cyclic proline-analogous amino acids
CA1092097A (en) Dipeptide derivatives
CA1095027A (en) Dipeptide derivatives
CA2065585A1 (en) Amidinophenylalanine derivatives, process for their preparation, their use and compositions containing them
IE883321L (en) Novel derivatives of l-proline, their preparation and their biological uses
US4528133A (en) Biologically active tripeptide and tetrapeptide alkylamides, and method for the preparation thereof
HU193029B (en) Process for preparing carboxy-alkanoyl-peptide-alkylamide derivatives
HU180925B (en) Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem
US4797471A (en) Peptide derivatives having an inhibitory action on hydroxylating enzymes, a process for their preparation, agents containing them, and their use
HU200985B (en) Process for production of active esthers of carbonic acid
EP0058567A1 (en) Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids and esters
CA2158643A1 (en) New glucocorticoids
HU206371B (en) Process for producing renin-inhibiting depeptide derivatives
SU1316556A3 (ru) Способ получени производных пролина или их фармацевтически приемлемых солей
US3362947A (en) Acylated peptides containing up to four amino acid residues, at least one of which is a basic amino acid
US4350628A (en) Preparation of dehydropeptides
US5091510A (en) Retro-inverso analogues of thymopentin, and their use in the preparation of pharmaceutical compositions
US3304296A (en) Para-arylazophenylmethyloxycarbonyl groups as amino protecting groups in peptide synthesis
KASAFÍREK et al. Anionic inhibitors of pancreatic and leukocyte elastase. Alkylamides of 3-carboxypropionyl-and 4-carboxybutyrylalanine peptides

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee