HRPK20140564B3 - 3d pla bioprinter - Google Patents
3d pla bioprinterInfo
- Publication number
- HRPK20140564B3 HRPK20140564B3 HRP20140564AA HRP20140564A HRPK20140564B3 HR PK20140564 B3 HRPK20140564 B3 HR PK20140564B3 HR P20140564A A HRP20140564A A HR P20140564AA HR P20140564 A HRP20140564 A HR P20140564A HR PK20140564 B3 HRPK20140564 B3 HR PK20140564B3
- Authority
- HR
- Croatia
- Prior art keywords
- pla
- bioprinter
- printing
- syringe
- solid
- Prior art date
Links
- 238000007639 printing Methods 0.000 claims abstract description 13
- 239000002105 nanoparticle Substances 0.000 claims abstract description 9
- 229910052729 chemical element Inorganic materials 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 8
- 238000011109 contamination Methods 0.000 claims abstract description 3
- 239000000758 substrate Substances 0.000 claims description 3
- -1 Control assembly Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 35
- 239000012620 biological material Substances 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 3
- 241000700605 Viruses Species 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000007651 thermal printing Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
3D PLA BIOPRINTER omogućuje printanje PLA nosivih struktura i i živih stanica ili njihovih dijelova ili drugih kemijskih elemenata (lijekovi, nano-čestice) u ili na PLA nosive strukture. Uređaj se sastoji od: Z-osi, X-Y plohe, Podloge za printanje, Sklopa za upravljanje, PLA termo glave, Glave sa špricom i Sterilne komore. Sterilna komora se nalazi oko plohe za printanje i onemogućuje kontaminaciju čvrstog PLA elementa za tijekom printanja.3D PLA BIOPRINTER enables the printing of PLA load-bearing structures and both living cells or their parts or other chemical elements (drugs, nano-particles) into or on PLA-bearing structures. The unit consists of: Z-axis, X-Y surface, Print pads, Control assembly, PLA thermal heads, Syringe heads and Sterile chambers. The sterile chamber is located around the print surface and prevents contamination of the solid PLA element during printing.
Description
Područje na koje se izum odnosi The field to which the invention relates
Ovaj izum prvenstveno se odnosi na uređaje za rad s tkivom, ljudskim, životinjskim ili biljnim stanicama ili kulturama virusa, a prema međunarodnoj klasifikaciji (MKP) klasificiran je kao C12M 3/00. This invention primarily relates to devices for working with tissue, human, animal or plant cells or virus cultures, and according to the international classification (ICD) is classified as C12M 3/00.
Tehnički problem Technical problem
Potrebno je pomoću jednog jednostavnog uređaja u tri-dimenzionalnom (3D) prostoru precizno napraviti noseću čvrstu biokompatibilnu ili biorazgradivu strukturu ispunjenu živim stanicama ili njihovim dijelovima (biomaterijal) It is necessary to use one simple device in a three-dimensional (3D) space to precisely create a supporting solid biocompatible or biodegradable structure filled with living cells or their parts (biomaterial).
Stanje tehnike State of the art
Postoje 3D printeri koji termički printaju bio kompatibilne ili bio razgradive PLA (polilaktid) elemente i postoje 3D bio printeri koji mogu printati žive stanice ili njihove dijelove ili druge kemijske elemente (lijekovi, nano-čestice). Za sada ne postoje uređaji koji mogu termički printati istovremeno i čvrstu PLA strukturu u sterilnoj okolini i žive stanice ili njihove dijelove ili druge kemijske elemente (lijekovi, nano-čestice)na tu istu PLA strukturu u istom uređaju. There are 3D printers that thermally print bio-compatible or biodegradable PLA (polylactide) elements and there are 3D bio printers that can print living cells or their parts or other chemical elements (drugs, nanoparticles). For now, there are no devices that can thermally print simultaneously a solid PLA structure in a sterile environment and living cells or their parts or other chemical elements (medicines, nanoparticles) on the same PLA structure in the same device.
Izlaganje suštine izuma Presentation of the essence of the invention
Primarni cilj izuma 3D PLA BIOPRINTERA je mogućnost 3D termičkog printanja PLA struktura i živih stanica ili njihovih dijelova ili drugih kemijskih elemenata (lijekovi, nano-čestice, biomaterijal ) u istom 3D prostoru. The primary goal of the invention of the 3D PLA BIOPRINTER is the possibility of 3D thermal printing of PLA structures and living cells or their parts or other chemical elements (medicines, nano-particles, biomaterial) in the same 3D space.
Sekundarni cilj izuma 3D PLA BIOPRINTERA je printanje PLA struktura u sterilnom prostoru. The secondary goal of the 3D PLA BIOPRINTER invention is the printing of PLA structures in a sterile space.
Dalji cilj izuma je jednostavnost konstrukcije 3D PLA BIOPRINTERA. A further goal of the invention is the simplicity of the construction of the 3D PLA BIOPRINTER.
Dodatni ciljevi izuma pokazat će se u opisu i u primjeni izuma. Additional objects of the invention will become apparent from the description and application of the invention.
3D PLA BIOPRINTER se sastoji od: Z-osi, X-Y plohe, Podloge za printanje, Sklopa za upravljanje, PLA termo glave, Glave sa špricom i Sterilne komore. 3D PLA BIOPRINTER consists of: Z-axis, X-Y surface, Printing substrate, Control assembly, PLA thermal head, Head with syringe and Sterile chamber.
Na Z-osi nalazi se PLA termo glava i Glava sa špricom. Šprica se može odvojiti od glave i u nju se mogu staviti žive stanice ili njihovi dijelovi ili drugi kemijski elementi (lijekovi, nano-čestice) prethodno pripremljeni u laboratoriju. On the Z-axis there is a PLA thermal head and a Head with a syringe. The syringe can be separated from the head and living cells or their parts or other chemical elements (medicines, nanoparticles) previously prepared in the laboratory can be put into it.
Nakon što se šprica postavi u glavu, sklop za upravljanje dovodi u 3D poziciju špricu i otpušta iz šprice bio materijal. PLA termo glava se također nalazi na Z osi, ali fizički odmaknuta od šprice za duljinu D u X osi. Pomoću PLA termo glave se izrađuje čvrsti element odgovarajuće strukture (struktura može odgovarati npr. strukturi kosti) na Podlogi za printanje, koja se poslije toga ispunjava s bio materijalom iz Šprice. After the syringe is placed in the head, the control assembly brings the syringe into 3D position and releases the bio material from the syringe. The PLA thermal head is also located on the Z axis, but physically offset from the syringe by a length D in the X axis. Using a PLA thermal head, a solid element of the appropriate structure is created (the structure can correspond to, for example, the structure of a bone) on the Printing Substrate, which is then filled with bio material from the Syringe.
Sterilna komora se nalazi oko plohe za printanje i onemogućuje kontaminaciju s bakterijama ili virusima čvrstog PLA elementa. A sterile chamber is located around the printing surface and prevents contamination with bacteria or viruses of the solid PLA element.
Sklop za upravljanje na osnovu prethodno napisanog programa omogućuje ispuštanje PLA čestica ili bio materijala u specificiranom 3D prostoru (X, Y, Z) te upravlja sa sterilnom komorom. The control assembly based on a previously written program enables the release of PLA particles or biomaterials in the specified 3D space (X, Y, Z) and controls the sterile chamber.
Kratak opis crteža Brief description of the drawing
Popratni crtež ilustrira 3D PLA BIOPRINTER. The accompanying drawing illustrates the 3D PLA BIOPRINTER.
Slika 1 je blok shema 3D PLA BIOPRINTERA. Figure 1 is a block diagram of the 3D PLA BIOPRINTER.
Detaljan opis najmanje jednog od načina ostvarivanja izuma A detailed description of at least one way of realizing the invention
3D PLA BIOPRINTER prikazan je na slici 1. On omogućuje printanje PLA nosivih struktura i i živih stanica ili njihovih dijelova ili drugih kemijskih elemenata (lijekovi, nano-čestice) u ili na PLA nosive strukture. PLA termo glava pisača se fizički nalazi na polugi Z-osi pisača zajedno sa glavom šprice u koju se umeće šprica. Step motori u tri smjera X, Y i Z preko mehaničkih pretvarača određuju točke u 3D prostoru na kojima se nanosi PLA ili biomaterijali. Biomaterijali u šprici mogu biti prethodno pripremljeni u labaratoriju, a šprica se mehanički uglavljuje u glavu za špricanje. Step motorima upravlja sklop za kontrolu 3D PLA bioprintera, koji isto tako određuje i količinu PLA ili biomaterijala iz šprice koja će se otpustiti u određenoj točki printanja. 3D PLA BIOPRINTER is shown in Figure 1. It enables the printing of PLA supporting structures and living cells or their parts or other chemical elements (medicines, nano-particles) in or on PLA supporting structures. The PLA thermal printer head is physically located on the Z-axis lever of the printer together with the syringe head into which the syringe is inserted. Step motors in three directions X, Y and Z via mechanical transducers determine the points in 3D space where PLA or biomaterials are applied. The biomaterials in the syringe can be pre-prepared in the laboratory, and the syringe is mechanically wedged into the injection head. The stepper motors are controlled by the control circuit of the 3D PLA bioprinter, which also determines the amount of PLA or biomaterial from the syringe that will be released at a certain point of printing.
Sterilna komora je zatvoreni prostor 3D PLA BIOPRINTERA u kojoj se nalaze ploha za printanje i PLA termo glava, a izvedena je pomoću UVA lampi koje održavaju sterilnost printanih PLA elemenata. Jedan od primjera korištenja 3D PLA BIOPRINTERA je printanje biorazgradivog PLA vijka za ugradnju u kosti napunjenog s nano gelatiziranim česticama koje na sebi nose serum plazme koji smanjuje upale i ubrzava zarastanje kostiju. Biorazgradivi PLA vijak printa se pomoću termo PLA glave, a gelatizirane nanočestice sa serumom plazme prethodno pripremljene u labaratoriju se sa špricom nanose u strukturu PLA vijka. The sterile chamber is a closed space of the 3D PLA BIOPRINTER, which contains the printing surface and the PLA thermal head, and is made using UVA lamps that maintain the sterility of the printed PLA elements. One of the examples of using the 3D PLA BIOPRINTER is the printing of a biodegradable PLA screw for embedding in bones filled with nano-gelatized particles that carry plasma serum that reduces inflammation and accelerates bone healing. Biodegradable PLA screw is printed using a thermal PLA head, and gelatinized nanoparticles with plasma serum previously prepared in the laboratory are applied with a syringe to the structure of the PLA screw.
Način primjene izuma Method of application of the invention
Izum se primjenjuje na način da omogućuje jednostavnu konstrukciju i primjenu 3D PLA BIOPRINTRA u cilju izrade čvrstih PLA struktura i živih stanica ili njihovih dijelova ili drugih kemijskih elemenata (lijekovi, nano-čestice. The invention is applied in a way that enables the simple construction and application of 3D PLA BIOPRINTRA in order to create solid PLA structures and living cells or their parts or other chemical elements (medicines, nano-particles.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP20140564AA HRPK20140564B3 (en) | 2014-06-13 | 2014-06-13 | 3d pla bioprinter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP20140564AA HRPK20140564B3 (en) | 2014-06-13 | 2014-06-13 | 3d pla bioprinter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20140564A2 HRP20140564A2 (en) | 2015-12-18 |
| HRPK20140564B3 true HRPK20140564B3 (en) | 2017-05-19 |
Family
ID=54837431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140564AA HRPK20140564B3 (en) | 2014-06-13 | 2014-06-13 | 3d pla bioprinter |
Country Status (1)
| Country | Link |
|---|---|
| HR (1) | HRPK20140564B3 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10675379B2 (en) | 2014-12-18 | 2020-06-09 | Cellink Ab | Cellulose nanofibrillar bioink for 3D bioprinting for cell culturing, tissue engineering and regenerative medicine applications |
| US11186736B2 (en) | 2018-10-10 | 2021-11-30 | Cellink Ab | Double network bioinks |
-
2014
- 2014-06-13 HR HRP20140564AA patent/HRPK20140564B3/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10675379B2 (en) | 2014-12-18 | 2020-06-09 | Cellink Ab | Cellulose nanofibrillar bioink for 3D bioprinting for cell culturing, tissue engineering and regenerative medicine applications |
| US11186736B2 (en) | 2018-10-10 | 2021-11-30 | Cellink Ab | Double network bioinks |
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20140564A2 (en) | 2015-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Xue et al. | Bone tissue engineering in the treatment of bone defects | |
| Johnson et al. | 3D printed anatomical nerve regeneration pathways | |
| Kjar et al. | Application of micro-scale 3D printing in pharmaceutics | |
| Jeong et al. | Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics | |
| Katakam et al. | Top-down and bottom-up approaches in 3D printing technologies for drug delivery challenges | |
| WO2016036275A1 (en) | Device and methods for printing biological tissues and organs | |
| JP2017136437A (en) | Tip-loaded microneedle arrays for transdermal insertion | |
| BR112018004105A2 (en) | cartridge for use with an apparatus configured to heat smokable material, apparatus and system | |
| CN108697882A (en) | Utilize the preparation method of the micropin of biocompatibility macromolecule | |
| BR112013002640A2 (en) | handling unit with forced implant sequence and independent drive mechanism | |
| BR112015022694A2 (en) | randomly uniform three-dimensional fabric framework of absorbable and non-absorbable material | |
| CL2007002490A1 (en) | METHODS FOR THE TREATMENT OF A LIVING GUEST WHO HAS AN INFECTION BY HEPATITIS C VIRUS; COMPOSITION FOR THE TREATMENT OF INFECTION BY HEPATITIS C; AND AN ELABORATION PRODUCT FOR THE ADMINISTRATION OF COMBINED THERAPY FOR TRAT | |
| BRMU8600225U (en) | sterile sterile silicone disposable kit | |
| HRPK20140564B3 (en) | 3d pla bioprinter | |
| Pazhouhnia et al. | Portable hand‐held bioprinters promote in situ tissue regeneration | |
| Montero et al. | Main 3D manufacturing techniques for customized bone substitutes. A systematic review | |
| AR046282A1 (en) | COMPOSITE BIOMATERIALS FOR BONE IMPLANTS | |
| EP4241730A3 (en) | Medical device for releasing an implant and improved osseodisintegratable implant | |
| Calin et al. | A review on stimuli-actuated 3D micro/nanostructures for tissue engineering and the potential of laser-direct writing via two-photon polymerization for structure fabrication | |
| Tabury et al. | Bioprinting of cardiac tissue in space: Where are we? | |
| BR112018000018A2 (en) | safety-related single-use release device and system | |
| AR069639A1 (en) | COMPOSITION OF NANOPARTICLES WITH MODIFIED SURFACE | |
| Oliveira et al. | Effect of low-intensity pulsed ultrasound therapy on a fibroblasts cell culture | |
| EA201790382A1 (en) | METHODS OF TREATMENT OF PERIIMPLANTITA | |
| Mian et al. | Three‐dimensional printing in oral and maxillofacial surgery: Current landscape and future directions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AKOB | Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent) | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20161024 Year of fee payment: 3 |
|
| PKB1 | Consensual patent granted | ||
| PBKO | Lapse due to non-payment of renewal fee for consensual patent |
Effective date: 20170613 |