HRP970245A2 - Biaryl acetilenes as matrix metalloprotease inhibitors - Google Patents

Biaryl acetilenes as matrix metalloprotease inhibitors

Info

Publication number: HRP970245A2
Authority: HR; Croatia
Prior art keywords: acetilenes; biaryl; matrix metalloprotease; metalloprotease inhibitors; inhibitors
Prior art date: 1996-05-15

Application number

HR08/645,028A

Inventor

Brian R Dixon

Jinshan Chenn

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-15

Filing date

1997-05-09

Publication date

1998-04-30

1997-05-09 Application filed by Bayer Ag filed Critical Bayer Ag

1998-04-30 Publication of HRP970245A2 publication Critical patent/HRP970245A2/en

2002-06-30 Publication of HRP970245B1 publication Critical patent/HRP970245B1/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Steroid Compounds (AREA)

HR970245A 1996-05-15 1997-05-09 Biaryl acetilenes as matrix metalloprotease inhibitors HRP970245B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US64502896A	1996-05-15	1996-05-15

Publications (2)

Publication Number	Publication Date
HRP970245A2 true HRP970245A2 (en)	1998-04-30
HRP970245B1 HRP970245B1 (en)	2002-06-30

Family

ID=24587368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR970245A HRP970245B1 (en)	1996-05-15	1997-05-09	Biaryl acetilenes as matrix metalloprotease inhibitors

Country Status (18)

Country	Link
EP (1)	EP0912496A1 (en)
JP (1)	JP3090957B2 (en)
CN (1)	CN1139570C (en)
AR (1)	AR007097A1 (en)
AU (1)	AU710759B2 (en)
BR (1)	BR9709077A (en)
CA (1)	CA2253796C (en)
CO (1)	CO5080759A1 (en)
HN (1)	HN1997000088A (en)
HR (1)	HRP970245B1 (en)
ID (1)	ID16910A (en)
PA (1)	PA8429301A1 (en)
SV (1)	SV1997000035A (en)
TN (1)	TNSN97084A1 (en)
TW (1)	TW381079B (en)
WO (1)	WO1997043245A1 (en)
YU (1)	YU18697A (en)
ZA (1)	ZA974031B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288063B1 (en)	1998-05-27	2001-09-11	Bayer Corporation	Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
US6326516B1 (en)	1999-01-27	2001-12-04	American Cyanamid Company	Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
AR035478A1 (en) *	1999-01-27	2004-06-02	Wyeth Corp	AMIDA-HYDROXAMIC ACID, ACETYLLENE, BETA-SULPHONAMIDE AND PHOSPHINIC ACID AS INHIBITORS OF TACE, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
EP1031349A1 (en) *	1999-02-25	2000-08-30	Bayer Aktiengesellschaft	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en)	2000-03-10	2006-11-28	Insite Vision Incorporated	Methods and compositions for treating and inhibiting retinal neovascularization
US8765814B2 (en) *	2010-07-08	2014-07-01	Kaken Pharmaceutical Co., Ltd.	N-hydroxyformamide derivative and medicament containing same
CN106458938A (en)	2014-04-03	2017-02-22	拜耳制药股份公司	Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
CN106661008A (en)	2014-04-03	2017-05-10	拜耳制药股份公司	2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases
WO2015150363A1 (en)	2014-04-03	2015-10-08	Bayer Pharma Aktiengesellschaft	2,5-disubstituted cyclopentane carboxylic acids and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3784701A (en) *	1970-09-21	1974-01-08	American Cyanamid Co	Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2112716A1 (en) *	1971-03-17	1972-10-05	Thomae Gmbh Dr K	Biphenylyl-butyric acid derivs. - anti phlogistics
US5789434A (en) *	1994-11-15	1998-08-04	Bayer Corporation	Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

1997
- 1997-05-09 TN TNTNSN97084A patent/TNSN97084A1/en unknown
- 1997-05-09 ZA ZA9704031A patent/ZA974031B/en unknown
- 1997-05-09 HR HR970245A patent/HRP970245B1/en not_active IP Right Cessation
- 1997-05-09 CO CO97025172A patent/CO5080759A1/en unknown
- 1997-05-12 WO PCT/US1997/007921 patent/WO1997043245A1/en not_active Application Discontinuation
- 1997-05-12 JP JP09540980A patent/JP3090957B2/en not_active Expired - Fee Related
- 1997-05-12 AR ARP970101977A patent/AR007097A1/en unknown
- 1997-05-12 EP EP97923622A patent/EP0912496A1/en not_active Withdrawn
- 1997-05-12 HN HN1997000088A patent/HN1997000088A/en unknown
- 1997-05-12 PA PA19978429301A patent/PA8429301A1/en unknown
- 1997-05-12 AU AU29386/97A patent/AU710759B2/en not_active Ceased
- 1997-05-12 YU YU18697A patent/YU18697A/en unknown
- 1997-05-12 BR BR9709077A patent/BR9709077A/en not_active Application Discontinuation
- 1997-05-12 CA CA002253796A patent/CA2253796C/en not_active Expired - Fee Related
- 1997-05-12 TW TW086106283A patent/TW381079B/en not_active IP Right Cessation
- 1997-05-12 CN CNB971964564A patent/CN1139570C/en not_active Expired - Fee Related
- 1997-05-12 SV SV1997000035A patent/SV1997000035A/en unknown
- 1997-05-14 ID IDP971606A patent/ID16910A/en unknown

Also Published As

Publication number	Publication date
AU2938697A (en)	1997-12-05
WO1997043245A1 (en)	1997-11-20
CN1225623A (en)	1999-08-11
EP0912496A1 (en)	1999-05-06
AR007097A1 (en)	1999-10-13
TW381079B (en)	2000-02-01
CA2253796C (en)	2003-10-28
JP3090957B2 (en)	2000-09-25
SV1997000035A (en)	1999-01-14
BR9709077A (en)	1999-08-03
TNSN97084A1 (en)	2005-03-15
CN1139570C (en)	2004-02-25
CO5080759A1 (en)	2001-09-25
ZA974031B (en)	1998-02-19
JPH11511179A (en)	1999-09-28
ID16910A (en)	1997-11-20
HRP970245B1 (en)	2002-06-30
PA8429301A1 (en)	2000-05-24
CA2253796A1 (en)	1997-11-20
HN1997000088A (en)	1997-06-18
YU18697A (en)	1999-11-22
AU710759B2 (en)	1999-09-30

Legal Events

Date	Code	Title	Description
1998-04-30	A1OB	Publication of a patent application
1998-10-30	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2002-06-30	B1PR	Patent granted
2004-04-28	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20040428 Year of fee payment: 8
2005-11-10	PBON	Lapse due to non-payment of renewal fee	Effective date: 20050510

Publication	Publication Date	Title
ZA959948B (en)	1997-05-22	Matrix metalloprotease inhibitors
ZA977700B (en)	1998-02-23	Phosphinic acid amides as matrix metalloprotease inhibitors.
IL128663A0 (en)	2000-01-31	1,4-heterocyclic metalloprotease inhibitors
IL128661A0 (en)	2000-01-31	1,3-diheterocyclic metalloprotease inhibitors
AU3102397A (en)	1998-01-07	Metalloprotease inhibitors
PL328307A1 (en)	1999-01-18	Serinic protease inhibitors
IL128665A0 (en)	2000-01-31	Bidenatate metalloprotease inhibitors
AU8858398A (en)	1999-02-08	Matrix metalloproteinase inhibitors
ZA96850B (en)	1997-11-03	Matrix metalloprotease inhibitors.
GB9613547D0 (en)	1996-08-28	Matrix metalloproteinase inhibitors
PL328875A1 (en)	1999-03-01	Serinic protease inhibitors
PL328223A1 (en)	1999-01-18	Aspartil protease inhibitors
HUP9904664A3 (en)	2001-03-28	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors
HUP0101300A3 (en)	2002-11-28	Matrix metalloprotease inhibitors
HRP970245A2 (en)	1998-04-30	Biaryl acetilenes as matrix metalloprotease inhibitors
HRP970247A2 (en)	1998-04-30	Substituted 4-arylbutric acid derivatives as matrix metalloprotease inhibitors
HRP970246B1 (en)	2002-04-30	Substituted oxobutric acids as matrix metalloprotease inhibitors
AU9747098A (en)	1999-04-23	Aporphinoid matrix metalloproteinase inhibitors
EP0975612A4 (en)	2001-06-13	Protease inhibitors
GB9702085D0 (en)	1997-03-19	Matrix metalloproteinase inhibitors
ZA9610604B (en)	1997-06-20	Matrix metalloprotease inhibitors
SI0901466T1 (en)	2002-02-28	Biphenylsulfonamide matrix metalloproteinase inhibitors
GB9714548D0 (en)	1997-09-17	Matrix metalloproteinase inhibitors
HUP9902606A3 (en)	2001-01-29	Matrix metalloproteinase inhibitors
GB9415619D0 (en)	1994-09-21	Metalloprotease inhibitors