HRP20240218T1 - Modulatori integriranog puta stresa - Google Patents
Modulatori integriranog puta stresa Download PDFInfo
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- HRP20240218T1 HRP20240218T1 HRP20240218TT HRP20240218T HRP20240218T1 HR P20240218 T1 HRP20240218 T1 HR P20240218T1 HR P20240218T T HRP20240218T T HR P20240218TT HR P20240218 T HRP20240218 T HR P20240218T HR P20240218 T1 HRP20240218 T1 HR P20240218T1
- Authority
- HR
- Croatia
- Prior art keywords
- modulators
- integrated stress
- stress pathway
- compound
- pathway
- Prior art date
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- 230000009211 stress pathway Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
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- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/90—Ring systems containing bridged rings containing more than four rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (3)
1. Spoj, naznačen time što spoj je
[image]
ili njegova farmaceutski prihvatljiva sol.
2. Spoj prema patentnom zahtjevu 1, naznačen time što spoj je
[image]
3. Spoj prema patentnom zahtjevu 1, naznačen time što spoj je farmaceutski prihvatljiva sol od
[image]
Applications Claiming Priority (3)
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US201662332278P | 2016-05-05 | 2016-05-05 | |
PCT/US2017/031360 WO2017193034A1 (en) | 2016-05-05 | 2017-05-05 | Modulators of the integrated stress pathway |
EP17723899.5A EP3452448B1 (en) | 2016-05-05 | 2017-05-05 | Modulators of the integrated stress pathway |
Publications (1)
Publication Number | Publication Date |
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HRP20240218T1 true HRP20240218T1 (hr) | 2024-04-26 |
Family
ID=58709639
Family Applications (1)
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HRP20240218TT HRP20240218T1 (hr) | 2016-05-05 | 2017-05-05 | Modulatori integriranog puta stresa |
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US (2) | US20190144440A1 (hr) |
EP (2) | EP4356971A3 (hr) |
JP (3) | JP6997766B2 (hr) |
KR (2) | KR20230042146A (hr) |
CN (2) | CN115947681A (hr) |
AR (1) | AR110599A1 (hr) |
AU (2) | AU2017260367B2 (hr) |
BR (1) | BR112018072663A2 (hr) |
CA (1) | CA3023162A1 (hr) |
CL (1) | CL2018003142A1 (hr) |
CO (1) | CO2018012946A2 (hr) |
CR (2) | CR20210372A (hr) |
DK (1) | DK3452448T3 (hr) |
DO (1) | DOP2018000242A (hr) |
EC (1) | ECSP18089579A (hr) |
ES (1) | ES2973442T3 (hr) |
FI (1) | FI3452448T3 (hr) |
HR (1) | HRP20240218T1 (hr) |
HU (1) | HUE065713T2 (hr) |
IL (2) | IL262722B (hr) |
LT (1) | LT3452448T (hr) |
MA (1) | MA44861B1 (hr) |
MD (1) | MD3452448T2 (hr) |
MX (2) | MX2021007146A (hr) |
PE (2) | PE20231935A1 (hr) |
PH (1) | PH12018502329A1 (hr) |
PL (1) | PL3452448T3 (hr) |
PT (1) | PT3452448T (hr) |
RS (1) | RS65214B1 (hr) |
RU (2) | RU2769327C2 (hr) |
SG (1) | SG11201809695TA (hr) |
SI (1) | SI3452448T1 (hr) |
TW (1) | TWI763668B (hr) |
UA (1) | UA125513C2 (hr) |
UY (1) | UY37228A (hr) |
WO (1) | WO2017193034A1 (hr) |
Families Citing this family (24)
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EP3634952A1 (en) * | 2017-06-07 | 2020-04-15 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
JP2020525513A (ja) * | 2017-07-03 | 2020-08-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 癌および他の疾患を治療するためのatf4阻害剤としてのn−(3−(2−(4−クロロフェノキシ)アセトアミドビシクロ[1.1.1]ペンタン−1−イル)−2−シクロブタン−1−カルボキサミド誘導体および関連化合物 |
JP2020530446A (ja) | 2017-08-09 | 2020-10-22 | デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. | 化合物、組成物、及び、方法 |
UY37958A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
UY37956A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
JP2021501785A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
JP2021508336A (ja) | 2017-12-13 | 2021-03-04 | プラクシス バイオテック エルエルシー | 統合的ストレス応答経路の阻害剤 |
US20210130308A1 (en) * | 2018-03-23 | 2021-05-06 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
BR112020023115A2 (pt) | 2018-06-05 | 2021-02-02 | Praxis Biotech LLC | inibidores da via integrada de resposta a tensão |
WO2020012339A1 (en) * | 2018-07-09 | 2020-01-16 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
TWI771621B (zh) * | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
TW202045164A (zh) | 2019-02-13 | 2020-12-16 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
AU2020229748A1 (en) * | 2019-02-25 | 2021-08-19 | Altos Labs, Inc. | Inhibitors of Integrated Stress Response pathway |
US20220227747A1 (en) | 2019-04-23 | 2022-07-21 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
AU2020262153A1 (en) | 2019-04-23 | 2021-11-11 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
CN114466654A (zh) | 2019-06-12 | 2022-05-10 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路调节剂 |
CR20220316A (es) * | 2019-12-06 | 2022-10-07 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
JP2023511616A (ja) | 2020-01-28 | 2023-03-20 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合的ストレス応答経路の調節因子 |
CA3165813A1 (en) | 2020-03-11 | 2021-09-16 | Holly Victoria Atton | Modulators of the integrated stress response pathway |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
JP2023546226A (ja) | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合ストレス応答経路のモジュレーター |
EP4232153A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
KR20230110509A (ko) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
CN116685319A (zh) * | 2020-12-10 | 2023-09-01 | 阿德格罗生物制药控股有限公司 | 用于治疗皮肤转移性癌的方法 |
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US162A (en) | 1837-04-17 | Island | ||
US5212A (en) | 1847-07-31 | Richard m | ||
US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
GB0400196D0 (en) * | 2004-01-07 | 2004-02-11 | Astrazeneca Ab | Therapeutic agents |
JP2007517868A (ja) | 2004-01-07 | 2007-07-05 | アストラゼネカ アクチボラグ | 治療薬i |
AU2005267093B2 (en) | 2004-07-23 | 2009-10-01 | Nuada Llc | Peptidase inhibitors |
GB0516314D0 (en) * | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Compound |
NZ566068A (en) * | 2005-08-08 | 2011-03-31 | Argenta Discovery Ltd | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
MY152283A (en) * | 2007-09-25 | 2014-09-15 | Takeda Pharmaceutical | Polo-like kinase inhibitirs |
UA108390C2 (uk) | 2010-08-10 | 2015-04-27 | Астеллас Фарма Інк. | Похідні бензімідазолу та їх застосування |
TWI538905B (zh) * | 2010-12-22 | 2016-06-21 | H 朗德貝克公司 | 雙環[3.2.1]辛基醯胺衍生物及其用途 |
CA2904794C (en) * | 2013-03-15 | 2021-11-23 | Peter Walter | Modulators of the eif2alpha pathway |
WO2015038778A1 (en) * | 2013-09-11 | 2015-03-19 | The Brigham And Women's Hospital, Inc. | SUBSTITUTED UREA EIF2α KINASE ACTIVATORS |
-
2017
- 2017-05-04 TW TW106114859A patent/TWI763668B/zh active
- 2017-05-05 DK DK17723899.5T patent/DK3452448T3/da active
- 2017-05-05 MD MDE20190301T patent/MD3452448T2/ro unknown
- 2017-05-05 KR KR1020237009107A patent/KR20230042146A/ko not_active Application Discontinuation
- 2017-05-05 ES ES17723899T patent/ES2973442T3/es active Active
- 2017-05-05 RU RU2018142740A patent/RU2769327C2/ru active
- 2017-05-05 SI SI201731474T patent/SI3452448T1/sl unknown
- 2017-05-05 UA UAA201812001A patent/UA125513C2/uk unknown
- 2017-05-05 HU HUE17723899A patent/HUE065713T2/hu unknown
- 2017-05-05 MX MX2021007146A patent/MX2021007146A/es unknown
- 2017-05-05 US US16/098,675 patent/US20190144440A1/en not_active Abandoned
- 2017-05-05 EP EP23213609.3A patent/EP4356971A3/en active Pending
- 2017-05-05 HR HRP20240218TT patent/HRP20240218T1/hr unknown
- 2017-05-05 PT PT177238995T patent/PT3452448T/pt unknown
- 2017-05-05 CN CN202211242583.XA patent/CN115947681A/zh active Pending
- 2017-05-05 EP EP17723899.5A patent/EP3452448B1/en active Active
- 2017-05-05 SG SG11201809695TA patent/SG11201809695TA/en unknown
- 2017-05-05 PE PE2023001939A patent/PE20231935A1/es unknown
- 2017-05-05 BR BR112018072663-0A patent/BR112018072663A2/pt not_active Application Discontinuation
- 2017-05-05 AU AU2017260367A patent/AU2017260367B2/en active Active
- 2017-05-05 AR ARP170101183A patent/AR110599A1/es unknown
- 2017-05-05 CR CR20210372A patent/CR20210372A/es unknown
- 2017-05-05 CN CN201780042069.2A patent/CN109641844B/zh active Active
- 2017-05-05 WO PCT/US2017/031360 patent/WO2017193034A1/en active Application Filing
- 2017-05-05 RU RU2022106770A patent/RU2022106770A/ru unknown
- 2017-05-05 PL PL17723899.5T patent/PL3452448T3/pl unknown
- 2017-05-05 KR KR1020187035249A patent/KR102512049B1/ko active IP Right Grant
- 2017-05-05 LT LTEPPCT/US2017/031360T patent/LT3452448T/lt unknown
- 2017-05-05 MA MA44861A patent/MA44861B1/fr unknown
- 2017-05-05 JP JP2019510575A patent/JP6997766B2/ja active Active
- 2017-05-05 MX MX2018013495A patent/MX2018013495A/es unknown
- 2017-05-05 FI FIEP17723899.5T patent/FI3452448T3/fi active
- 2017-05-05 UY UY0001037228A patent/UY37228A/es unknown
- 2017-05-05 CA CA3023162A patent/CA3023162A1/en active Pending
- 2017-05-05 PE PE2018002316A patent/PE20190348A1/es unknown
- 2017-05-05 CR CR20180574A patent/CR20180574A/es unknown
- 2017-05-05 RS RS20240199A patent/RS65214B1/sr unknown
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2018
- 2018-11-01 IL IL262722A patent/IL262722B/en unknown
- 2018-11-02 DO DO2018000242A patent/DOP2018000242A/es unknown
- 2018-11-05 CL CL2018003142A patent/CL2018003142A1/es unknown
- 2018-11-05 PH PH12018502329A patent/PH12018502329A1/en unknown
- 2018-11-29 CO CONC2018/0012946A patent/CO2018012946A2/es unknown
- 2018-11-30 EC ECSENADI201889579A patent/ECSP18089579A/es unknown
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2020
- 2020-11-24 US US17/103,003 patent/US20220363678A1/en not_active Abandoned
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2021
- 2021-09-26 IL IL286693A patent/IL286693A/en unknown
- 2021-12-17 JP JP2021204755A patent/JP7389786B2/ja active Active
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2022
- 2022-02-11 AU AU2022200946A patent/AU2022200946B2/en active Active
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2023
- 2023-11-17 JP JP2023195552A patent/JP2024023324A/ja active Pending
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