HRP20221074T1 - Premošteni triciklički spojevi karbamoilpiridona i njihove farmaceutske uporabe - Google Patents
Premošteni triciklički spojevi karbamoilpiridona i njihove farmaceutske uporabe Download PDFInfo
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- HRP20221074T1 HRP20221074T1 HRP20221074TT HRP20221074T HRP20221074T1 HR P20221074 T1 HRP20221074 T1 HR P20221074T1 HR P20221074T T HRP20221074T T HR P20221074TT HR P20221074 T HRP20221074 T HR P20221074T HR P20221074 T1 HRP20221074 T1 HR P20221074T1
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- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- inhibitors
- additional therapeutic
- therapeutic agents
- Prior art date
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- OHEKQGOBJIKKIF-AWEZNQCLSA-N (12as)-n-[(4-fluorophenyl)methyl]-7-hydroxy-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide Chemical class C([C@@H]1OCCCN1C(=O)C1=C(C2=O)O)N1C=C2C(=O)NCC1=CC=C(F)C=C1 OHEKQGOBJIKKIF-AWEZNQCLSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 239000003112 inhibitor Substances 0.000 claims 8
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims 4
- 239000002777 nucleoside Substances 0.000 claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 4
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 2
- 229960004748 abacavir Drugs 0.000 claims 2
- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 claims 2
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 2
- 229940124411 anti-hiv antiviral agent Drugs 0.000 claims 2
- 210000000234 capsid Anatomy 0.000 claims 2
- 229940124765 capsid inhibitor Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 229940124784 gp41 inhibitor Drugs 0.000 claims 2
- 239000004030 hiv protease inhibitor Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 230000002441 reversible effect Effects 0.000 claims 2
- LDEKQSIMHVQZJK-CAQYMETFSA-N tenofovir alafenamide Chemical compound O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 LDEKQSIMHVQZJK-CAQYMETFSA-N 0.000 claims 2
- 229960004946 tenofovir alafenamide Drugs 0.000 claims 2
- 229960001355 tenofovir disoproxil Drugs 0.000 claims 2
- JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 claims 2
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- BRYXUCLEHAUSDY-WEWMWRJBSA-N N-[(1S)-1-[3-[4-chloro-3-(methanesulfonamido)-1-(2,2,2-trifluoroethyl)indazol-7-yl]-6-(3-methyl-3-methylsulfonylbut-1-ynyl)pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]-2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetamide Chemical compound O=S(=O)(C(C)(C)C#CC1=NC(=C(C2=CC=C(Cl)C=3C(NS(=O)(=O)C)=NN(CC(F)(F)F)C2=3)C=C1)[C@@H](NC(=O)CN1N=C(C=2[C@@H]3[C@H](C(C1=2)(F)F)C3)C(F)(F)F)CC1=CC(F)=CC(F)=C1)C BRYXUCLEHAUSDY-WEWMWRJBSA-N 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (16)
1. Spoj, naznačen time, da je predstavljen formulom:
[image]
ili
[image]
ili njegova farmaceutski prihvatljiva sol.
2. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
[image]
ili njegova farmaceutski prihvatljiva sol.
3. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
4. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
5. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
6. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
7. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
8. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
9. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
10. Spoj prema patentnom zahtjevu 1, naznačen time, da je predstavljen formulom:
[image]
ili njegova farmaceutski prihvatljiva sol.
11. Farmaceutski pripravak, naznačen time, da sadrži terapijski učinkovitu količinu spoja prema bilo kojem od patentnih zahtjeva 1 do 10, ili njegove farmaceutski prihvatljive soli, te farmaceutski prihvatljivo pomoćno sredstvo.
12. Farmaceutski pripravak prema patentnom zahtjevu 11, naznačen time, da nadalje sadrži:
(i) jedan, dva, tri ili četiri dodatna terapijska sredstva;
(ii) jedan, dva, tri ili četiri dodatna terapijska sredstva, pri čemu dodatna terapijska sredstva su anti-HIV sredstva;
(iii) jedan, dva, tri ili četiri dodatna terapijska sredstva, pri čemu dodatna terapijska sredstva su inhibitori HIV proteaze, nenukleozidni ili nenukleotidni inhibitori HIV reverzne transkriptaze, nukleozidni ili nukleotidni inhibitori HIV reverzne transkriptaze, inhibitori HIV kapsida, gp41 inhibitori, CXCR4 inhibitori, gp120 inhibitori, CCR5 inhibitori, reverzibilna sredstva latencije, inhibitori kapsidne polimerizacije, HIV nNAbs, TLR7 agonisti, farmakokinetički pojačivači, ostali lijekovi za liječenje HIV-a, ili njihove kombinacije; ili
(iv) jedan, dva, tri ili četiri dodatna terapijska sredstva, pri čemu dodatna terapijska sredstva su abakavir, tenofovir alafenamid, tenofovir disoproksil, N-((S)-1-(3-(4-kloro-3-(metilsulfonamido)-1-(2,2,2-trifluoroetil)-1H-indazol-7-il)-6-(3-metil-3-(metilsulfonil)but-1-in-1-il)piridin-2-il)-2-(3,5-difluorofenil)etil)-2-((3bS,4aR)-5,5-difluoro-3-(trifluorometil)-3b,4,4a,5-tetrahidro-1H-ciklopropa[3,4]ciklopenta[1,2-c]pirazol-1-il)acetamid, ili njihova farmaceutski prihvatljiva sol.
13. Farmaceutski pripravak prema patentnom zahtjevu 11 ili 12, naznačen time, da je farmaceutski pripravak za oralnu ili parenteralnu primjenu.
14. Spoj ili njegova farmaceutski prihvatljiva sol prema bilo kojem od patentnih zahtjeva 1 do 10, naznačen time, da je za uporabu u postupku liječenja HIV infekcije kod čovjeka koji ima infekciju ili je pod rizikom da dobije infekciju, pri čemu postupak obuhvaća davanje čovjeku terapijski učinkovite količine spoja ili njegove farmaceutski prihvatljive soli.
15. Spoj ili njegova farmaceutski prihvatljiva sol za uporabu prema patentnom zahtjevu 14, naznačen time, da nadalje sadrži:
(i) davanje čovjeku terapijski učinkovite količine jednog, dva, tri ili četiri dodatna terapijska sredstva;
(ii) davanje čovjeku terapijski učinkovite količine jednog, dva, tri ili četiri dodatna terapijska sredstva, pri čemu dodatna terapijska sredstva su anti-HIV sredstva;
(iii) davanje čovjeku terapijski učinkovite količine jednog, dva, tri ili četiri dodatna terapijska sredstva, pri čemu dodatna terapijska sredstva su inhibitori HIV proteaze, nenukleozidni ili nenukleotidni inhibitori HIV reverzne transkriptaze, nukleozidni ili nukleotidni inhibitori HIV reverzne transkriptaze, inhibitori HIV kapsida, gp41 inhibitori, CXCR4 inhibitori, gp120 inhibitori, CCR5 inhibitori, reverzibilna sredstva latencije, inhibitori kapsidne polimerizacije, HIV nNAbs, TLR7 agonisti, farmakokinetički pojačivači, ostali lijekovi za liječenje HIV-a, ili njihove kombinacije; ili
(iv) davanje čovjeku terapijski učinkovite količine jednog, dva, tri ili četiri dodatna terapijska sredstva, pri čemu dodatna terapijska sredstva su abakavir, tenofovir alafenamid, tenofovir disoproksil, N-((S)-1-(3-(4-kloro-3-(metilsulfonamido)-1-(2,2,2-trifluoroetil)-1H-indazol-7-il)-6-(3-metil-3-(metilsulfonil)but-1-in-1-il)piridin-2-il)-2-(3,5-difluorofenil)etil)-2-((3bS,4aR)-5,5-difluoro-3-(trifluorometil)-3b,4,4a,5-tetrahidro-1H-ciklopropa[3,4]ciklopenta[1,2-c]pirazol-1-il)acetamid, ili njihova farmaceutski prihvatljiva sol.
16. Spoj ili njegova farmaceutski prihvatljiva sol za uporabu prema patentnom zahtjevu 14 ili 15, naznačen time, da je primjena oralna, intravenozna, supkutana ili intramuskularna.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962822703P | 2019-03-22 | 2019-03-22 | |
| US201962948697P | 2019-12-16 | 2019-12-16 | |
| PCT/US2020/023819 WO2020197991A1 (en) | 2019-03-22 | 2020-03-20 | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| EP20719849.0A EP3938047B1 (en) | 2019-03-22 | 2020-03-20 | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20221074T1 true HRP20221074T1 (hr) | 2022-11-11 |
Family
ID=70293100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20221074TT HRP20221074T1 (hr) | 2019-03-22 | 2020-03-20 | Premošteni triciklički spojevi karbamoilpiridona i njihove farmaceutske uporabe |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US11084832B2 (hr) |
| EP (2) | EP4122537A1 (hr) |
| JP (2) | JP7265647B2 (hr) |
| KR (1) | KR20210142711A (hr) |
| CN (1) | CN113874079A (hr) |
| AU (2) | AU2020245350B2 (hr) |
| BR (1) | BR112021018827A2 (hr) |
| CA (1) | CA3128961A1 (hr) |
| CL (2) | CL2021002444A1 (hr) |
| CO (1) | CO2021012319A2 (hr) |
| CR (1) | CR20210486A (hr) |
| DK (1) | DK3938047T3 (hr) |
| DO (2) | DOP2021000195A (hr) |
| ES (1) | ES2927041T3 (hr) |
| HR (1) | HRP20221074T1 (hr) |
| HU (1) | HUE059677T2 (hr) |
| IL (1) | IL286328A (hr) |
| LT (1) | LT3938047T (hr) |
| MX (1) | MX2021011394A (hr) |
| PE (1) | PE20212074A1 (hr) |
| PL (1) | PL3938047T3 (hr) |
| PT (1) | PT3938047T (hr) |
| SG (1) | SG11202109650XA (hr) |
| SI (1) | SI3938047T1 (hr) |
| TW (2) | TWI745900B (hr) |
| UA (1) | UA127822C2 (hr) |
| WO (1) | WO2020197991A1 (hr) |
| ZA (1) | ZA202107015B (hr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019230858A1 (ja) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | 多環性カルバモイルピリドン誘導体 |
| BR112020024098A2 (pt) | 2018-05-31 | 2021-02-17 | Shionogi & Co., Ltd. | derivado de piridona policíclica |
| KR20210033492A (ko) * | 2018-07-16 | 2021-03-26 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 캡시드 억제제 |
| KR20210142711A (ko) | 2019-03-22 | 2021-11-25 | 길리애드 사이언시즈, 인코포레이티드 | 가교된 트리시클릭 카르바모일피리돈 화합물 및 그의 제약 용도 |
| US11697652B2 (en) | 2020-02-24 | 2023-07-11 | Gilead Sciences, Inc. | Tetracyclic compounds and uses thereof |
| JP2023543059A (ja) * | 2020-09-30 | 2023-10-12 | ギリアード サイエンシーズ， インコーポレイテッド | 架橋三環式カルバモイルピリドン化合物及びその使用 |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
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