HRP20220638T1 - Postupak dobivanja vodene otopine hitozana, sastav hitozana, aerosol hitozana, postupak proizvodnje hidrogel membrane hitozana i postupak proizvodnje biopolimernog materijala hitozan-protein - Google Patents
Postupak dobivanja vodene otopine hitozana, sastav hitozana, aerosol hitozana, postupak proizvodnje hidrogel membrane hitozana i postupak proizvodnje biopolimernog materijala hitozan-protein Download PDFInfo
- Publication number
- HRP20220638T1 HRP20220638T1 HRP20220638TT HRP20220638T HRP20220638T1 HR P20220638 T1 HRP20220638 T1 HR P20220638T1 HR P20220638T T HRP20220638T T HR P20220638TT HR P20220638 T HRP20220638 T HR P20220638T HR P20220638 T1 HRP20220638 T1 HR P20220638T1
- Authority
- HR
- Croatia
- Prior art keywords
- chitosan
- biologically active
- mass
- aqueous solution
- solution
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title claims 22
- 238000000034 method Methods 0.000 title claims 21
- 239000007864 aqueous solution Substances 0.000 title claims 9
- 239000000443 aerosol Substances 0.000 title claims 3
- 229920001222 biopolymer Polymers 0.000 title claims 3
- 239000000017 hydrogel Substances 0.000 title claims 3
- 239000000463 material Substances 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title claims 3
- 239000012528 membrane Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 12
- 108010010803 Gelatin Proteins 0.000 claims 8
- 239000000243 solution Substances 0.000 claims 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 7
- 239000008273 gelatin Substances 0.000 claims 7
- 229920000159 gelatin Polymers 0.000 claims 7
- 235000019322 gelatine Nutrition 0.000 claims 7
- 235000011852 gelatine desserts Nutrition 0.000 claims 7
- 102000008186 Collagen Human genes 0.000 claims 6
- 108010035532 Collagen Proteins 0.000 claims 6
- 229920001436 collagen Polymers 0.000 claims 6
- 108090000988 Lysostaphin Proteins 0.000 claims 5
- 239000004599 antimicrobial Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 241000251468 Actinopterygii Species 0.000 claims 4
- 238000004132 cross linking Methods 0.000 claims 4
- 239000004014 plasticizer Substances 0.000 claims 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 3
- 239000001569 carbon dioxide Substances 0.000 claims 3
- 230000001143 conditioned effect Effects 0.000 claims 3
- 239000006185 dispersion Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000011260 aqueous acid Substances 0.000 claims 1
- 235000011089 carbon dioxide Nutrition 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000007792 gaseous phase Substances 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Colloid Chemistry (AREA)
- Peptides Or Proteins (AREA)
Claims (14)
1. Postupak dobivanja vodene otopine hitozana s molekulskom težinom ne manjom od 10 kDa, poželjno 50-400 kDa, i stupnjem deacetilacije ne manjim od 20%, poželjno od 50 do 95%, koji obuhvaća korak pripreme otopine hitozana u vodenoj otopini kiseline koja se zatim neutralizira i odvaja, a zatim se tako dobijeni mikrokristalni hitozan poželjno ispire s vodom, naznačen time što se dobivena otopina kemijski nemodificiranog mikrokristalnog hitozana dopunjava vodom u količini u kojoj koncentracija hitozana u odnosu na njegovu suhu masu u vodenoj otopini iznosi najmanje 0.001% masenog udjela, poželjno od 0.5 do 2.0% masenog udjela, te se zatim dobivena otopina hitozana miješa na temperaturi ne nižoj od 0°C, poželjno 25°C, pod uvjetima atmosferskog tlaka, dok je tijekom procesa miješanja otopina zasićena anorganskim kiselim oksidima, poželjno ugljikovim dioksidom, dok se ne dobije bistra otopina hitozana i otapanje hitozana.
2. Postupak prema patentnom zahtjevu 1, naznačen time što se ugljikov dioksid koristi u plinovitoj fazi i/ili u obliku suhog leda.
3. Sastav hitozana naznačen time što sadrži vodenu otopinu hitozana dobivenu prema jednom od zahtjeva 1-2, u količini ne manjoj od 80% masenog udjela, i najmanje jedan biološki aktivni spoj i/ili najmanje jedan spoj za umrežavanje, i/ili jedan plastifikator u količini ne većoj od 20% masenog udjela.
4. Smjesa prema patentnom zahtjevu 3, naznačena time što kao biološki aktivni spoj sadrži antimikrobni spoj i/ili tvar, poželjno lizostafin.
5. Aerosol hitozana naznačen time što sadrži disperzijsku fazu u obliku vodene otopine hitozana dobivenu prema postupku definiranom u jednom od zahtjeva 1-2, u količini od 90 do 98% masenog udjela, kontinuiranu fazu u obliku propelanta, poželjno ugljikovog dioksida, u količini od 2 do 10% masenog udjela, te najmanje jedan biološki aktivan spoj u količini ne većoj od 5% masenog udjela.
6. Aerosol prema patentnom zahtjevu 5, naznačen time što kao biološki aktivni spoj sadrži antimikrobni spoj i/ili tvar, poželjno lizostafin.
7. Postupak za proizvodnju hidrogel membrane hitozana naznačen time što je vodena otopina hitozana dobivena prema postupku definiranom u jednom od zahtjeva 1-2 u kojem se u kalup izlijeva koncentracija hitozana u odnosu na njegovu suhu masu u vodenoj otopini koja iznosi ne manje od 1.0% masenog udjela, poželjno od 1 do 2.0% masenog udjela, te se zatim kondicionira na temperaturi ne nižoj od 1°C, poželjno na sobnoj temperaturi, pod uvjetima atmosferskog tlaka, u vremenu ne kraćem od 12 sati, poželjno 24 sata, ali prije izlijevanja u kalup i kondicioniranja poželjno je dodati u vodenu otopinu hitozana najmanje jedan biološki aktivni spoj i/ili najmanje jedan spoj za umrežavanje, i/ili najmanje jedan plastifikator, u količini ne većoj od 20% masenog udjela i otopina se miješa dok ne postane homogena.
8. Postupak prema patentnom zahtjevu 7, naznačen time što kao biološki aktivni spoj sadrži antimikrobni spoj i/ili tvar, poželjno lizostafin.
9. Postupak za proizvodnju biopolimernog materijala hitozan-protein naznačen time što se vodena otopina hitozana dobivena prema postupku definiranom u jednom od zahtjeva 1-2, miješa s modifikacijskim aditivima kao što su spojevi za umrežavanje, plastifikatori, biološki aktivne tvari, sredstva za konzerviranje, i zatim se miješa s disperzijom kolagena i/ili želatine, oblikuje, inkubira i kondicionira prema poznatom postupku.
10. Postupak prema patentnom zahtjevu 9 naznačen time što se koristi riblja želatina i/ili želatina sisavca i/ili rekombinantna želatina, i/ili riblji i/ili kolagen sisavca i/ili rekombinantni kolagen.
11. Postupak prema patentnom zahtjevu 9, naznačen time što kao biološki aktivni spoj sadrži antimikrobni spoj i/ili tvar, poželjno lizostafin.
12. Postupak za proizvodnju biopolimernog materijala hitozan-protein, naznačen time što se vodena otopina hitozana dobivena prema postupku definiranom u jednom od zahtjeva 1-2 miješa s modifikacijskim aditivima kao što su spojevi za umrežavanje, plastifikatori, biološki aktivne tvari, sredstva za konzerviranje, te zatim miješa s disperzijom kolagena i/ili proteina želatine, pijeni, oblikuje, te inkubira prema poznatom postupku, a zatim se dobiveni hidrogel suši pod uvjetima atmosferskog tlaka ili liofilizacijom, te se kondicionira prema poznatom postupku.
13. Postupak prema patentnom zahtjevu 12 naznačen time što koristi riblja želatina i/ili želatina sisavca i/ili rekombinantna želatina, i/ili riblji i/ili kolagen sisavca i/ili rekombinantni kolagen.
14. Postupak prema patentnom zahtjevu 12, naznačen time što kao biološki aktivni spoj sadrži antimikrobni spoj i/ili tvar, poželjno lizostafin.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400078A PL223280B1 (pl) | 2012-07-20 | 2012-07-20 | Sposób wytwarzania chitozanowo-białkowego materiału biopolimerowego |
| PL403697A PL222739B1 (pl) | 2013-04-26 | 2013-04-26 | Kompozycja chitozanowa i sposób wytwarzania hydrożelowej membrany chitozanowej |
| EP13820587.7A EP2920240B1 (en) | 2012-07-20 | 2013-06-26 | The method of obtaining the aqueous solution of chitosan, chitosan composition, chitosan aerosol, the method of producing the chitosan hydrogel membrane and the method of producing chitosan-protein biopolymer material |
| PCT/PL2013/000085 WO2014014370A2 (en) | 2012-07-20 | 2013-06-26 | The method of obtaining the aqueous solution of chitosan, chitosan composition, chitosan aerosol, the method of producing the chitosan hydrogel membrane and the method of producing chitosan-protein biopolymer material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220638T1 true HRP20220638T1 (hr) | 2022-06-24 |
Family
ID=49949329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220638TT HRP20220638T1 (hr) | 2012-07-20 | 2013-06-26 | Postupak dobivanja vodene otopine hitozana, sastav hitozana, aerosol hitozana, postupak proizvodnje hidrogel membrane hitozana i postupak proizvodnje biopolimernog materijala hitozan-protein |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2920240B1 (hr) |
| DK (1) | DK2920240T3 (hr) |
| ES (1) | ES2913107T3 (hr) |
| HR (1) | HRP20220638T1 (hr) |
| LT (1) | LT2920240T (hr) |
| PT (1) | PT2920240T (hr) |
| WO (1) | WO2014014370A2 (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150258200A1 (en) * | 2014-03-14 | 2015-09-17 | Taiwan Biomaterial Company Ltd. | Pressure-sensitive hydrogel and method of use |
| WO2017223462A1 (en) * | 2016-06-24 | 2017-12-28 | President And Fellows Of Harvard College | Composition and method for adhering biomaterials to a target surface |
| RU2629819C1 (ru) * | 2016-08-23 | 2017-09-04 | Федеральное бюджетное учреждение науки "Казанский научно-исследовательский институт эпидемиологии и микробиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Антибактериальная композиция на основе хитозана и лизостафина |
| US9862780B1 (en) | 2017-01-24 | 2018-01-09 | Jordan University Of Science And Technology | Process of producing and method of using soluble high molecular-weight chitosan |
| US10517988B1 (en) | 2018-11-19 | 2019-12-31 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
| CN111518284B (zh) * | 2020-05-06 | 2022-10-18 | 盐城工学院 | 一种甲壳素多层水凝胶材料的制备方法 |
| CN112972489A (zh) * | 2021-03-19 | 2021-06-18 | 季华实验室 | 具有减肥降脂功能的壳聚糖基组合物及制备方法、应用 |
| CN114558167A (zh) * | 2022-03-09 | 2022-05-31 | 上海长征医院 | 一种快速止血喷雾及其制备方法 |
| EP4285737A1 (en) * | 2022-06-05 | 2023-12-06 | Chitone sp. z o.o. | Chitosan composition using as a stabilising and preserving agent for food products, method for obtaining the composition, use of the composition asa preserving and stabilising agent for the protection of food products |
| PL443403A1 (pl) * | 2023-01-03 | 2024-07-08 | Politechnika Gdańska | Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych |
| CN117530999B (zh) * | 2023-11-13 | 2024-07-16 | 深圳市中兴恒熙环保有限公司 | 基于黑水虻的多肽组合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4570629A (en) * | 1982-03-17 | 1986-02-18 | University Of Illinois Foundation | Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same |
| EP1243688A1 (de) * | 2001-03-22 | 2002-09-25 | Cognis Iberia, S.L. | Verwendung von Chitosan-Nanopartikeln |
| JP2010053080A (ja) * | 2008-08-28 | 2010-03-11 | Fujifilm Corp | キトサンとコラーゲンを含む構造体 |
-
2013
- 2013-06-26 ES ES13820587T patent/ES2913107T3/es active Active
- 2013-06-26 HR HRP20220638TT patent/HRP20220638T1/hr unknown
- 2013-06-26 LT LTEPPCT/PL2013/000085T patent/LT2920240T/lt unknown
- 2013-06-26 DK DK13820587.7T patent/DK2920240T3/da active
- 2013-06-26 PT PT138205877T patent/PT2920240T/pt unknown
- 2013-06-26 WO PCT/PL2013/000085 patent/WO2014014370A2/en active Application Filing
- 2013-06-26 EP EP13820587.7A patent/EP2920240B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT2920240T (pt) | 2022-05-23 |
| EP2920240B1 (en) | 2022-03-09 |
| WO2014014370A2 (en) | 2014-01-23 |
| WO2014014370A3 (en) | 2015-04-09 |
| ES2913107T3 (es) | 2022-05-31 |
| EP2920240A2 (en) | 2015-09-23 |
| LT2920240T (lt) | 2022-06-27 |
| DK2920240T3 (da) | 2022-05-30 |
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