HRP20190494T1 - Pro-koagulantski spojevi i postupci njihove uporabe - Google Patents
Pro-koagulantski spojevi i postupci njihove uporabe Download PDFInfo
- Publication number
- HRP20190494T1 HRP20190494T1 HRP20190494TT HRP20190494T HRP20190494T1 HR P20190494 T1 HRP20190494 T1 HR P20190494T1 HR P20190494T T HRP20190494T T HR P20190494TT HR P20190494 T HRP20190494 T HR P20190494T HR P20190494 T1 HRP20190494 T1 HR P20190494T1
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- nucleic acid
- compound according
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- conjugate
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- 150000001875 compounds Chemical class 0.000 title claims 14
- 238000000034 method Methods 0.000 title claims 4
- 239000003805 procoagulant Substances 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 5
- 239000003114 blood coagulation factor Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 206010067787 Coagulation factor deficiency Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-Tyrosine Natural products OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- 125000003798 L-tyrosyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 208000014763 coagulation protein disease Diseases 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000031169 hemorrhagic disease Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000010647 peptide synthesis reaction Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Claims (13)
1. Spoj koji sadrži:
(a) sekvencu aminokiseline koja sadrži formulu (I):
naznačen time što
L je L-leucin;
A je L-alanin;
S je L-serin;
Y je L-tirozin;
C1 i C2 su cistein;
pri čemu sekvenca aminokiseline sadrži barem jednu od:
SEQ ID NO: 4, 9-22, 24-38, 43-54, 61-64, 66-91, 93-97, 99, 104-146, 148-183, 200-202, 204-208, 214-216, 219-222, 226-233, 239-242, 244-246, 260, 265-267, 269-272, 282-293, 296, 307, 315, 337, 339, 346-348, 360, 362, 364, 367-375, 380, 383-386, 389, 392, 400-402, 406, 409-415, 419-421, 424-463, 471-487, 492-495, 526-529, 531, 533, 536-537, 543, 545, 547, 550-555, te PRIRTVGPGSRSASGKLTCLASYCWLFWTGIA; ili
(b) retro-, inverzo- ili retro-inverzo varijantu sekvence aminokiseline pod a); ili njezinu farmaceutski prihvatljivu sol ili solvat.
2. Spoj prema zahtjevu 1, naznačen time što sekvenca aminokiseline sadrži barem jednu od: SEQ ID NO: 29, 48-54, 61-64, 66-86, 91, 93-97, 104-146, 148-183, 200-202, 204, 205, 214-216, 219-222, 226-233, 239-242, 244, 270-272, 282-293, 296, 307, 346, 360, 367, 369-370, 374-375, 383, 385, 389, 400-402, 406, 409-414, 419, 420, 424-440, 450-460, 462, 471-487, 492, 494, 526-529, 531, 533, 536-537, 543, 545, 547, 550-555 te PRIRTVGPGSRSASGKLTCLASYCWLFWTGIA.
3. Spoj prema zahtjevu 1 ili zahtjevu 2, naznačen time što je spoj kovalentno vezan dijelom koji produžuje poluživot, izborno pri čemu
je dio koji produžuje poluživot odabran od Fc, FcRn vezujućeg liganda, albumina, albumin-vezujućeg liganda, transferina, PEG dijela, PPG dijela, PAS dijela te HES dijela.
4. In vitro postupak povećanja katalitičke aktivnosti (kcat) faktora zgrušavanja krvi, sadrži dovođenje u kontakt faktora zgrušavanja krvi sa spojem prema bilo kojem od zahtjeva 1 do 3.
5. Postupak proizvodnje spoja prema bilo kojem od zahtjeva 1 do 3, postupak sadrži formiranje peptida koji ima sekvencu aminokiseline ili retro-, inverzo- ili retro-inverzo varijantu iste, koristeći sintezu peptida čvrste faze.
6. Konjugat koji sadrži spoj prema bilo kojem od zahtjeva 1 do 3 i prvi heterologni dio, naznačen time što su spoj i prvi heterologni dio vezani jedan na drugi preko prvog izbornog veznika.
7. Konjugat prema zahtjevu 6, koji sadrži strukturu prema Formuli (A1) ili (A2):
naznačen time što
je Het1 prvi heterologni dio;
je m cijeli broj odabran od 0 i 1;
je L1 ili odsutan (m=0) ili prisutan (m=1), te kada je prisutan je veznik;
je Pep spoj prema bilo kojem od zahtjeva 1 do 3; i
je (-) kovalentna veza.
8. Molekula nukleinske kiseline ili set molekula nukleinske kiseline koji šifrira spoj prema bilo kojem od zahtjeva 1 do 3 ili konjugat prema zahtjevu 6 ili 7 ili njihov komplement.
9. Vektor ili set vektora koji sadrži molekulu nukleinske kiseline ili set molekula nukleinske kiseline prema zahtjevu 8 ili njihov komplement.
10. Stanica domaćin koja sadrži vektor ili set vektora prema zahtjevu 9.
11. Farmaceutski pripravak koji sadrži spoj prema bilo kojem od zahtjeva 1 do 3, konjugat prema zahtjevu 6 ili 7, molekulu nukleinske kiseline ili set molekula nukleinske kiseline prema zahtjevu 8 ili vektor ili set vektora prema zahtjevu 9 i farmaceutski prihvatljiv nosač.
12. Spoj prema bilo kojem od zahtjeva 1 do 3, konjugat prema zahtjevu 6 ili 7, molekula nukleinske kiseline ili set molekula nukleinske kiseline prema zahtjevu 8, vektor ili set vektora prema zahtjevu 9, ili farmaceutski pripravak prema zahtjevu 11, za uporabu u liječenju, ublažavanju ili prevenciji bolesti ili poremećaja krvarenja kod subjekta kojemu je to potrebno.
13. Spoj prema bilo kojem od zahtjeva 1 do 3, konjugat prema zahtjevu 6 ili 7, molekula nukleinske kiseline ili set molekula nukleinske kiseline prema zahtjevu 8, vektor ili set vektora prema zahtjevu 9, ili farmaceutski pripravak prema zahtjevu 11, za uporabu u liječenju, ublažavanju ili prevenciji nedostatka faktora zgrušavanja kod sisavca, pri čemu je faktor zgrušavanja odabran iz skupine koja se sastoji od FVII, FVIIa, FVIII, FIX i FXI.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161495818P | 2011-06-10 | 2011-06-10 | |
US201161496542P | 2011-06-13 | 2011-06-13 | |
US201161496540P | 2011-06-13 | 2011-06-13 | |
US201161496541P | 2011-06-13 | 2011-06-13 | |
US201161496543P | 2011-06-13 | 2011-06-13 | |
US201261600237P | 2012-02-17 | 2012-02-17 | |
US201261605540P | 2012-03-01 | 2012-03-01 | |
PCT/US2012/041777 WO2012170969A2 (en) | 2011-06-10 | 2012-06-09 | Pro-coagulant compounds and methods of use thereof |
EP12797036.6A EP2717898B1 (en) | 2011-06-10 | 2012-06-09 | Pro-coagulant compounds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190494T1 true HRP20190494T1 (hr) | 2019-07-12 |
Family
ID=47296790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190494TT HRP20190494T1 (hr) | 2011-06-10 | 2019-03-12 | Pro-koagulantski spojevi i postupci njihove uporabe |
Country Status (14)
Country | Link |
---|---|
US (1) | US9486507B2 (hr) |
EP (2) | EP3527218A1 (hr) |
AU (1) | AU2012267484B2 (hr) |
CA (1) | CA2838833A1 (hr) |
CY (1) | CY1121509T1 (hr) |
DK (1) | DK2717898T3 (hr) |
ES (1) | ES2724778T3 (hr) |
HR (1) | HRP20190494T1 (hr) |
HU (1) | HUE043894T2 (hr) |
LT (1) | LT2717898T (hr) |
PL (1) | PL2717898T3 (hr) |
PT (1) | PT2717898T (hr) |
SI (1) | SI2717898T1 (hr) |
WO (1) | WO2012170969A2 (hr) |
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2012
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- 2012-06-09 CA CA2838833A patent/CA2838833A1/en not_active Abandoned
- 2012-06-09 DK DK12797036.6T patent/DK2717898T3/en active
- 2012-06-09 AU AU2012267484A patent/AU2012267484B2/en not_active Ceased
- 2012-06-09 SI SI201231560T patent/SI2717898T1/sl unknown
- 2012-06-09 EP EP18211167.4A patent/EP3527218A1/en not_active Withdrawn
- 2012-06-09 LT LTEP12797036.6T patent/LT2717898T/lt unknown
- 2012-06-09 PL PL12797036T patent/PL2717898T3/pl unknown
- 2012-06-09 US US14/125,040 patent/US9486507B2/en active Active
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- 2012-06-09 PT PT12797036T patent/PT2717898T/pt unknown
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2019
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LT2717898T (lt) | 2019-03-25 |
DK2717898T3 (en) | 2019-03-25 |
AU2012267484B2 (en) | 2017-03-23 |
HUE043894T2 (hu) | 2019-09-30 |
WO2012170969A3 (en) | 2013-08-15 |
EP3527218A1 (en) | 2019-08-21 |
WO2012170969A2 (en) | 2012-12-13 |
SI2717898T1 (sl) | 2019-07-31 |
AU2012267484A1 (en) | 2014-01-16 |
CY1121509T1 (el) | 2020-05-29 |
ES2724778T3 (es) | 2019-09-16 |
PT2717898T (pt) | 2019-05-20 |
CA2838833A1 (en) | 2012-12-13 |
US9486507B2 (en) | 2016-11-08 |
EP2717898B1 (en) | 2018-12-19 |
EP2717898A2 (en) | 2014-04-16 |
PL2717898T3 (pl) | 2019-06-28 |
NZ619079A (en) | 2016-11-25 |
US20140303084A1 (en) | 2014-10-09 |
EP2717898A4 (en) | 2014-11-26 |
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