HRP20180178T1 - Pripravci ketorolaka, namijenjeni zacjeljivanju rane na rožnici - Google Patents
Pripravci ketorolaka, namijenjeni zacjeljivanju rane na rožnici Download PDFInfo
- Publication number
- HRP20180178T1 HRP20180178T1 HRP20180178TT HRP20180178T HRP20180178T1 HR P20180178 T1 HRP20180178 T1 HR P20180178T1 HR P20180178T T HRP20180178T T HR P20180178TT HR P20180178 T HRP20180178 T HR P20180178T HR P20180178 T1 HRP20180178 T1 HR P20180178T1
- Authority
- HR
- Croatia
- Prior art keywords
- vol
- ketorolac
- wound healing
- corneal wound
- preparation
- Prior art date
Links
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 title 1
- 229960004752 ketorolac Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000029663 wound healing Effects 0.000 title 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 claims 2
- 229960004384 ketorolac tromethamine Drugs 0.000 claims 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1. Pripravak namijenjen upotrebi u postupku poticanja zacjeljivanja rane na rožnici kod pacijenta, naznačen time što pripravak sadrži:
vodenu otopinu 0,45% tež./vol. ketorolak-trometamina; i
karboksimetilcelulozu;
gdje pripravak ne sadrži konzervans.
2. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što pripravak sadrži:
0,45% tež./vol. ketorolak-trometamina;
0,325% tež./vol. natrij-karboksimetilceluloze srednje viskoznosti;
0,175% tež./vol. natrij-karboksimetilceluloze visoke viskoznosti;
0,7% tež./vol. NaCl; i
0,2% tež./vol. natrijevog citrata dihidrata.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32262810P | 2010-04-09 | 2010-04-09 | |
| US32999210P | 2010-04-30 | 2010-04-30 | |
| US35372310P | 2010-06-11 | 2010-06-11 | |
| PCT/US2011/031453 WO2011127196A1 (en) | 2010-04-09 | 2011-04-06 | Ketorolac compositions for corneal wound healing |
| EP11715353.6A EP2555770B1 (en) | 2010-04-09 | 2011-04-06 | Ketorolac compositions for corneal wound healing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180178T1 true HRP20180178T1 (hr) | 2018-03-09 |
Family
ID=44010010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180178TT HRP20180178T1 (hr) | 2010-04-09 | 2018-01-30 | Pripravci ketorolaka, namijenjeni zacjeljivanju rane na rožnici |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20130245088A1 (hr) |
| EP (1) | EP2555770B1 (hr) |
| JP (1) | JP6114182B2 (hr) |
| AU (1) | AU2011237646A1 (hr) |
| CA (1) | CA2796071C (hr) |
| ES (1) | ES2657845T3 (hr) |
| HR (1) | HRP20180178T1 (hr) |
| PL (1) | PL2555770T3 (hr) |
| SI (1) | SI2555770T1 (hr) |
| WO (1) | WO2011127196A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2765988A1 (en) * | 2011-10-12 | 2014-08-20 | Bausch & Lomb Incorporated | Ocular composition containing bromfenac with increased bioavailability |
| WO2013085769A1 (en) * | 2011-12-06 | 2013-06-13 | Alcon Research, Ltd. | Cellulosic gel composition with improved viscosity stability |
| WO2014120293A1 (en) * | 2013-01-31 | 2014-08-07 | Sentiss Pharma Pvt.Ltd. | Ophthalmic formulations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009202969B1 (en) * | 2009-07-23 | 2009-11-19 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
| US7842714B2 (en) * | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
-
2011
- 2011-04-06 US US13/640,033 patent/US20130245088A1/en not_active Abandoned
- 2011-04-06 ES ES11715353.6T patent/ES2657845T3/es active Active
- 2011-04-06 EP EP11715353.6A patent/EP2555770B1/en active Active
- 2011-04-06 AU AU2011237646A patent/AU2011237646A1/en not_active Abandoned
- 2011-04-06 SI SI201131410T patent/SI2555770T1/en unknown
- 2011-04-06 PL PL11715353T patent/PL2555770T3/pl unknown
- 2011-04-06 JP JP2013503924A patent/JP6114182B2/ja active Active
- 2011-04-06 WO PCT/US2011/031453 patent/WO2011127196A1/en active Application Filing
- 2011-04-06 CA CA2796071A patent/CA2796071C/en active Active
-
2018
- 2018-01-30 HR HRP20180178TT patent/HRP20180178T1/hr unknown
-
2021
- 2021-02-19 US US17/179,650 patent/US20210315805A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011237646A1 (en) | 2012-11-08 |
| ES2657845T3 (es) | 2018-03-07 |
| CA2796071C (en) | 2018-06-26 |
| JP6114182B2 (ja) | 2017-04-12 |
| CA2796071A1 (en) | 2011-10-13 |
| WO2011127196A1 (en) | 2011-10-13 |
| US20130245088A1 (en) | 2013-09-19 |
| EP2555770B1 (en) | 2017-11-01 |
| EP2555770A1 (en) | 2013-02-13 |
| SI2555770T1 (en) | 2018-04-30 |
| JP2013523829A (ja) | 2013-06-17 |
| US20210315805A1 (en) | 2021-10-14 |
| PL2555770T3 (pl) | 2018-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015502539B1 (en) | Cenicriviroc compositions and methods of making and using the same | |
| EP4218759A3 (en) | Combination therapy | |
| MX366393B (es) | Sales o co-cristales de 3-(3-dimetilamino-1-etil-2-metil-propil)-f enol. | |
| BR112014029510A2 (pt) | composição esterilizada e meio aquoso compreendendo, pelo menos, um ácido hialurônico e, pelo menos, um sal hidrossolúvel de sacarose octassulfato, processo de fabricação, e de utilização da mesma, formulação cosméstica, e, kit | |
| RU2016124331A (ru) | Композиция для ухода за полостью рта | |
| JP2009519312A5 (hr) | ||
| HRP20180178T1 (hr) | Pripravci ketorolaka, namijenjeni zacjeljivanju rane na rožnici | |
| JP2012143233A5 (hr) | ||
| BR112015013774A2 (pt) | membrana de hidrogel para prevenção de adesão | |
| NZ608202A (en) | Agent for treatment of dry eye characterized by combining p2y2 receptor agonist and hyaluronic acid or salt thereof, method for treating dry eye, and use of the p2y2 receptor agonist and hyaluronic acid or salt thereof | |
| EA201591957A1 (ru) | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения | |
| TN2015000520A1 (en) | Pharmaceutical compositions comprising collagen and sodium hyaluronate | |
| EA201201239A1 (ru) | Композиция, содержащая в качестве активного ингредиента l-карнитин в комбинации с гидроксикинуренин-о-бета-dl-глюкозидом, для предотвращения и/или лечения патологий глаза, вызванных ультрафиолетовым излучением | |
| CU20130072A7 (es) | 1 h-pirazol-5-olato sódico sustituido | |
| GB201305417D0 (en) | Process for producing low endotoxin chitosan | |
| CA2922375C (en) | Alpha-tea salt forms: compositions and uses for treating disease | |
| RU2010132162A (ru) | Пленочное покрытие на основе хитозана и способ его получения | |
| JP2012217972A5 (hr) | ||
| EP2494954A3 (en) | Ophthalmic composition based on lactobionic acid useful for reducing corneal edema and inflammation | |
| MX359713B (es) | Composiciones mejoradas para la cicatrizacion de heridas que comprenden microesferas. | |
| JP2015528515A5 (hr) | ||
| BR112015027992A2 (pt) | uso de ácido petroselínico para combater desordens estéticas da figura do corpo | |
| UA100883C2 (ru) | Применение дронедарона для получения лекарственного средства для лечения пациентов с аритмией и с повышенным уровнем креатинина в результате введения дронедарона | |
| WO2014006635A3 (en) | Solid oral compositions of silodosin | |
| EP3925608A3 (en) | Use of phenoxypropylamine compounds to treat or improve at least one disorder or parameter of sleep |