HRP20170328T1 - Cjepivo pcsk9 - Google Patents
Cjepivo pcsk9 Download PDFInfo
- Publication number
- HRP20170328T1 HRP20170328T1 HRP20170328TT HRP20170328T HRP20170328T1 HR P20170328 T1 HRP20170328 T1 HR P20170328T1 HR P20170328T T HRP20170328T T HR P20170328TT HR P20170328 T HRP20170328 T HR P20170328T HR P20170328 T1 HRP20170328 T1 HR P20170328T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- pcsk9
- fragments
- vaccine according
- sipwnleritpr
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims 13
- 101150094724 PCSK9 gene Proteins 0.000 title 1
- 101710180553 Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 10
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0012—Lipids; Lipoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21061—Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Claims (10)
1. Cjepivo, naznačeno time, da obuhvaća najmanje dva fragmenta proproteinske konvertaze subtilizin/keksin tipa 9 (PCSK9), pri čemu barem jedan od navedena najmanje dva fragmenta sadrže najmanje devet uzastopnih aminokiselinskih ostataka od aminokiselinskih ostataka 153 do 165 od PCSK9 u skladu sa SEQ ID NO:9, i gdje barem jedan od navedena najmanje dva fragmenta sadrži najmanje devet uzastopnih aminokiselinskih ostataka od aminokiselinskih ostataka 209 do 222 od PCSK9 u skladu sa SEQ ID NO:9.
2. Cjepivo prema zahtjevu 1, naznačeno time, da su najmanje dva fragmenta odabrana iz skupine sastavljene od peptida koji imaju aminokiselinsku sekvencu SIPWNLERITPPR (SEQ ID NO:2), PEEDGTRFHRQASK (SEQ ID NO:3), PEEDGTRFHRQA (SEQ ID NO:4), EEDGTRFHRQASK (SEQ ID NO:5), EEDGTRFHRQAS (SEQ ID NO:6), SIPWNLERITP (SEQ ID NO:7) i SIPWNLERIT (SEQ ID NO:8).
3. Cjepivo prema zahtjevu 1 ili 2, naznačeno time, da najmanje jedan fragment od PCSK9 ima aminokiselinsku sekvencu odabranu iz skupine koju čine SIPWNLERITPPR (SEQ ID NO:2), SIPWNLERITP (SEQ ID NO:7) i SIPWNLERIT (SEQ ID NO:8), i najmanje jedan fragment od PCSK9 ima aminokiselinsku sekvencu odabranu iz skupine koju čine PEEDGTRFHRQASK (SEQ ID NO:3), PEEDGTRFHRQA (SEQ ID NO:4), EEDGTRFHRQASK (SEQ ID NO:5) i EEDGTRFHRQAS (SEQ ID NO:6).
4. Cjepivo prema bilo kojem od zahtjeva 1 do 3, naznačeno time, da cjepivo obuhvaća SIPWNLERITPPR (SEQ ID NO:2) i PEEDGTRFHRQASK (SEQ ID NO:3), SIPWNLERITPPR (SEQ ID NO:2) i PEEDGTRFHRQA (SEQ ID NO:4), SIPWNLERITPPR (SEQ ID NO:2) i EEDGTRFHRQASK (SEQ ID NO:5), SIPWNLERITPPR (SEQ ID NO:2) i EEDGTRFHRQAS (SEQ ID NO:6), PEEDGTRFHRQASK (SEQ ID NO:3) i SIPWNLERITP (SEQ ID NO:7), PEEDGTRFHRQASK (SEQ ID NO:3) i SIPWNLERIT (SEQ ID NO:8), PEEDGTRFHRQA (SEQ ID NO:4) i SIPWNLERITP (SEQ ID NO:7), PEEDGTRFHRQA (SEQ ID NO:4) i SIPWNLERIT (SEQ ID NO:8), EEDGTRFHRQASK (SEQ ID NO:5) i SIPWNLERITP (SEQ ID NO:7), EEDGTRFHRQASK (SEQ ID NO:5) i SIPWNLERIT (SEQ ID NO:8), EEDGTRFHRQAS (SEQ ID NO:6) i SIPWNLERITP (SEQ ID NO:7), ili EEDGTRFHRQAS (SEQ ID NO:6) i SIPWNLERIT (SEQ ID NO:8).
5. Cjepivo prema bilo kojem od zahtjeva 1 do 4, naznačeno time, da najmanje dva fragmenta od PCSK9 sadrže cisteinski ostatak na C-završnom kraju i/ili na N-završnom kraju.
6. Cjepivo prema bilo kojem od zahtjeva 1 do 5, naznačeno time, da su najmanje dva fragmenta od PCSK9 spojena na farmaceutski prihvatljiv nosač, poželjno na KLH (Keyhole Limpet Hemocyanin).
7. Cjepivo prema bilo kojem od zahtjeva 1 do 6, naznačeno time, da su najmanje dva fragmenta od PCSK9 formulirana za intradermalnu, subkutanu ili intramuskularnu primjenu.
8. Cjepivo prema bilo kojem od zahtjeva 1 do 7, naznačeno time, da cjepivo obuhvaća najmanje jedno pomoćno sredstvo, poželjno aluminijev hidroksid.
9. Cjepivo prema bilo kojem od zahtjeva 1 do 8, naznačeno time, da se upotrebljava u liječenju i/ili u prevenciji kardiovaskularnih bolesti, moždanog udara, okluzivnih bolesti perifernih arterija, koronarne srčane bolesti, apoplektičkog cerebralnog napada ili perifernih vaskularnih bolesti.
10. Cjepivo prema zahtjevu 9, naznačeno time, da se najmanje dva fragmenta od PCSK9 daju pojedincu po jednoj dozi, u količini od 0,1 ng do 10 mg, poželjno od 1 μg do 500 μg.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11181090.9A EP2570135B1 (en) | 2011-09-13 | 2011-09-13 | PCSK9 Vaccine |
| PCT/EP2012/067950 WO2013037889A2 (en) | 2011-09-13 | 2012-09-13 | Vaccine |
| EP12759427.3A EP2755678B1 (en) | 2011-09-13 | 2012-09-13 | Pcsk9 vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170328T1 true HRP20170328T1 (hr) | 2017-05-19 |
Family
ID=46851983
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160392TT HRP20160392T1 (hr) | 2011-09-13 | 2016-04-15 | Cjepivo pcsk9 |
| HRP20170328TT HRP20170328T1 (hr) | 2011-09-13 | 2017-02-27 | Cjepivo pcsk9 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160392TT HRP20160392T1 (hr) | 2011-09-13 | 2016-04-15 | Cjepivo pcsk9 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9220762B2 (hr) |
| EP (2) | EP2570135B1 (hr) |
| JP (1) | JP6054400B2 (hr) |
| KR (1) | KR101983685B1 (hr) |
| CN (1) | CN103874504B (hr) |
| AU (1) | AU2012307348B8 (hr) |
| BR (1) | BR112014005756A2 (hr) |
| CA (1) | CA2848487A1 (hr) |
| CY (2) | CY1117335T1 (hr) |
| DK (2) | DK2570135T3 (hr) |
| ES (2) | ES2565757T3 (hr) |
| HR (2) | HRP20160392T1 (hr) |
| HU (2) | HUE028583T2 (hr) |
| IL (1) | IL231043A (hr) |
| LT (1) | LT2755678T (hr) |
| MX (1) | MX346883B (hr) |
| PL (2) | PL2570135T3 (hr) |
| PT (1) | PT2755678T (hr) |
| RS (1) | RS54639B1 (hr) |
| RU (2) | RU2640258C2 (hr) |
| SG (1) | SG11201400086QA (hr) |
| SI (2) | SI2570135T1 (hr) |
| SM (1) | SMT201600082B (hr) |
| WO (1) | WO2013037889A2 (hr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| EP2703483A1 (en) | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
| MX2016010838A (es) * | 2014-02-28 | 2016-11-17 | Affiris Ag | Vacunas de proproteina convertasa subtilisina/kexina tipo 9 (pcsk9). |
| CN105085684B (zh) * | 2014-05-14 | 2020-04-17 | 上海亨臻实业有限公司 | Pcsk9靶向重组疫苗设计及其应用 |
| CN106822881A (zh) * | 2016-12-09 | 2017-06-13 | 四川大学 | 一种针对pcsk9的抗高血脂蛋白疫苗 |
| MX2019012083A (es) | 2017-04-13 | 2019-11-21 | Cadila Healthcare Ltd | Nueva vacuna de peptidos contra la pcsk9. |
| CN107488215A (zh) * | 2017-07-19 | 2017-12-19 | 邱志华 | 人前蛋白转化酶枯草溶菌素9免疫原性肽段及其载体疫苗 |
| JP2023511619A (ja) * | 2020-01-28 | 2023-03-20 | ユナイテッド・バイオメディカル・インコーポレーテッド | Ｐｃｓｋ９媒介性障害を予防及び治療するための、ｐｃｓｋ９を標的とするペプチド免疫原及びその製剤 |
| KR20210158693A (ko) * | 2020-06-24 | 2021-12-31 | 바이오스트림테크놀러지스(주) | 항 ｐｃｓｋ９ 항체 및 이의 용도 |
| JPWO2022244845A1 (hr) * | 2021-05-19 | 2022-11-24 | ||
| WO2023161528A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE COMPRISING AT LEAST A ß-GLUCAN |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101036126B1 (ko) * | 2006-05-11 | 2011-05-23 | 알닐람 파마슈티칼스 인코포레이티드 | Ｐｃｓｋ9 유전자의 발현을 억제하기 위한 조성물 및 방법 |
| TW200906439A (en) * | 2007-04-13 | 2009-02-16 | Novartis Ag | Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| AR070316A1 (es) * | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| AT507604A1 (de) * | 2008-11-19 | 2010-06-15 | Affiris Forschungs & Entwicklungs Gmbh | Behandlung von atherosklerose |
| PE20121544A1 (es) | 2009-09-03 | 2012-12-02 | Pfizer Vaccines Llc | Vacuna de pcsk9 |
-
2011
- 2011-09-13 RS RS20160183A patent/RS54639B1/en unknown
- 2011-09-13 SI SI201130773A patent/SI2570135T1/sl unknown
- 2011-09-13 ES ES11181090.9T patent/ES2565757T3/es active Active
- 2011-09-13 DK DK11181090.9T patent/DK2570135T3/en active
- 2011-09-13 EP EP11181090.9A patent/EP2570135B1/en active Active
- 2011-09-13 HU HUE11181090A patent/HUE028583T2/en unknown
- 2011-09-13 PL PL11181090T patent/PL2570135T3/pl unknown
-
2012
- 2012-09-13 HU HUE12759427A patent/HUE031860T2/en unknown
- 2012-09-13 WO PCT/EP2012/067950 patent/WO2013037889A2/en active Application Filing
- 2012-09-13 RU RU2014114506A patent/RU2640258C2/ru not_active IP Right Cessation
- 2012-09-13 PT PT127594273T patent/PT2755678T/pt unknown
- 2012-09-13 PL PL12759427T patent/PL2755678T3/pl unknown
- 2012-09-13 DK DK12759427.3T patent/DK2755678T3/en active
- 2012-09-13 JP JP2014530217A patent/JP6054400B2/ja not_active Expired - Fee Related
- 2012-09-13 KR KR1020147009735A patent/KR101983685B1/ko active IP Right Grant
- 2012-09-13 AU AU2012307348A patent/AU2012307348B8/en not_active Ceased
- 2012-09-13 US US14/344,879 patent/US9220762B2/en not_active Expired - Fee Related
- 2012-09-13 BR BR112014005756A patent/BR112014005756A2/pt not_active Application Discontinuation
- 2012-09-13 ES ES12759427.3T patent/ES2618796T3/es active Active
- 2012-09-13 SG SG11201400086QA patent/SG11201400086QA/en unknown
- 2012-09-13 MX MX2014002879A patent/MX346883B/es active IP Right Grant
- 2012-09-13 LT LTEP12759427.3T patent/LT2755678T/lt unknown
- 2012-09-13 SI SI201230903A patent/SI2755678T1/sl unknown
- 2012-09-13 CA CA2848487A patent/CA2848487A1/en not_active Abandoned
- 2012-09-13 CN CN201280044571.4A patent/CN103874504B/zh not_active Expired - Fee Related
- 2012-09-13 EP EP12759427.3A patent/EP2755678B1/en active Active
- 2012-09-13 RU RU2017139094A patent/RU2017139094A/ru not_active Application Discontinuation
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2014
- 2014-02-19 IL IL231043A patent/IL231043A/en active IP Right Grant
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2015
- 2015-10-23 US US14/921,485 patent/US9669079B2/en not_active Expired - Fee Related
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2016
- 2016-03-22 SM SM201600082T patent/SMT201600082B/xx unknown
- 2016-03-31 CY CY20161100266T patent/CY1117335T1/el unknown
- 2016-04-15 HR HRP20160392TT patent/HRP20160392T1/hr unknown
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2017
- 2017-02-27 HR HRP20170328TT patent/HRP20170328T1/hr unknown
- 2017-03-16 CY CY20171100333T patent/CY1118856T1/el unknown
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