HRP20140967T1 - SPOJEVI, PRIPRAVCI I POSTUPCI ZA LIJEÄŚENJE beta-AMILOIDNIH BOLESTI I SINUKLEINOPATIJA - Google Patents
SPOJEVI, PRIPRAVCI I POSTUPCI ZA LIJEÄŚENJE beta-AMILOIDNIH BOLESTI I SINUKLEINOPATIJA Download PDFInfo
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- HRP20140967T1 HRP20140967T1 HRP20140967AT HRP20140967T HRP20140967T1 HR P20140967 T1 HRP20140967 T1 HR P20140967T1 HR P20140967A T HRP20140967A T HR P20140967AT HR P20140967 T HRP20140967 T HR P20140967T HR P20140967 T1 HRP20140967 T1 HR P20140967T1
- Authority
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- Croatia
- Prior art keywords
- disease
- synucleinopathy
- amyloid
- parkinson
- compound
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims 14
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title claims 9
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title claims 9
- 208000032859 Synucleinopathies Diseases 0.000 title claims 9
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000018737 Parkinson disease Diseases 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 206010002022 amyloidosis Diseases 0.000 claims 6
- 201000002832 Lewy body dementia Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 208000018282 ACys amyloidosis Diseases 0.000 claims 2
- 206010059245 Angiopathy Diseases 0.000 claims 2
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000007487 Familial Cerebral Amyloid Angiopathy Diseases 0.000 claims 2
- 208000032849 Hereditary cerebral hemorrhage with amyloidosis Diseases 0.000 claims 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 208000027089 Parkinsonian disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 208000035474 group of disease Diseases 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 230000035508 accumulation Effects 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000002688 persistence Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/16—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/10—Polyhydroxy benzenes; Alkylated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (17)
1. Spoj sa formulom
[image]
i njegove farmaceutski prihvatljive soli.
2. Farmaceutski pripravak naznačen time da sadrži spoj prema zahtjevu 1 i farmaceutski prihvatljivo pomoćno sredstvo.
3. Spoj prema zahtjevu 1 naznačen time da je za uporabu kod inhibicije nastanka, taloženja, akumulacije ili postojanosti Aβ amiloidnih ili α-sinukleinskih nakupina.
4. Spoj prema zahtjevu 1 naznačen time da je za uporabu kod liječenja β-amiloidne bolesti ili sinukleinopatije kod sisavaca koji od njih pati.
5. Spoj za uporabu prema zahtjevu 4 naznačen time da je β-amiloidna bolest odabrana iz skupine bolesti koja se sastoji od Alzheimerove bolesti, Downovog sindroma, nasljednog cerebralnog krvarenja s amiloidozom - nizozemski tip, te cerebralne β-amiloidne angiopatije.
6. Spoj za uporabu prema zahtjevu 4 naznačen time da β-amiloidna bolest je Alzheimerova bolest.
7. Spoj za uporabu prema zahtjevu 4 naznačen time da je sinukleinopatija odabrana iz skupine koju čine Parkinsonova bolest, nasljedna Parkinsonova bolest, bolest Lewyjevih tjelešaca, varijanta Alzheimerove bolesti s Lewyjevim tjelešcima, demencija s Lewyjevim tjelešcima, multipla sistemska atrofija, te kompleks Guam demencije s parkinsonizmom.
8. Spoj za uporabu prema zahtjevu 4 naznačen time da sinukleinopatija je Parkinsonova bolest.
9. Spoj prema zahtjevu 1 naznačen time da je za uporabu kod poboljšanja motoričkih osobina kod sisavca koji pati od sinukleinopatije.
10. Spoj prema zahtjevu 1 naznačen time da je za uporabu kod zaustavljanja napredovanja motoričkih deficita kod sisavca koji pati od Parkinsonove bolesti.
11. Uporaba spoja prema zahtjevu 1 naznačena time da je za proizvodnju medikamenta za liječenje β-amiloidne bolesti ili sinukleinopatije kod sisavaca koji od njih pati.
12. Uporaba prema zahtjevu 11 naznačena time da je β-amiloidna bolest odabrana iz skupine bolesti koja se sastoji od Alzheimerove bolesti, Downovog sindroma, nasljednog cerebralnog krvarenja s amiloidozom - nizozemski tip, te cerebralne β-amiloidne angiopatije.
13. Uporaba prema zahtjevu 11 naznačena time da β-amiloidna bolest je Alzheimerova bolest.
14. Uporaba prema zahtjevu 11 naznačena time da je sinukleinopatija odabrana iz skupine koju čine Parkinsonova bolest, nasljedna Parkinsonova bolest, bolest Lewyjevih tjelešaca, varijanta Alzheimerove bolesti s Lewyjevim tjelešcima, demencija s Lewyjevim tjelešcima, multipla sistemska atrofija, te kompleks Guam demencije s parkinsonizmom.
15. Uporaba prema zahtjevu 11 naznačena time da sinukleinopatija je Parkinsonova bolest.
16. Uporaba spoja prema zahtjevu 1 naznačena time da je za proizvodnju lijeka za uporabu kod poboljšanja motoričkih osobina kod sisavca koji pati od sinukleinopatije.
17. Uporaba spoja prema zahtjevu 1 naznačena time da je za proizvodnju lijeka za uporabu kod zaustavljanja napredovanja motornih deficita kod sisavca koji pati od Parkinsonove bolesti.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/244,968 US8829198B2 (en) | 2007-10-31 | 2008-10-03 | Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies |
| PCT/US2009/048855 WO2010039308A1 (en) | 2008-10-03 | 2009-06-26 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF β-AMYLOID DISEASES AND SYNUCLEINOPATHIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140967T1 true HRP20140967T1 (hr) | 2014-12-05 |
Family
ID=40583657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140967AT HRP20140967T1 (hr) | 2008-10-03 | 2014-10-08 | SPOJEVI, PRIPRAVCI I POSTUPCI ZA LIJEÄŚENJE beta-AMILOIDNIH BOLESTI I SINUKLEINOPATIJA |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8829198B2 (hr) |
| EP (1) | EP2328417B1 (hr) |
| JP (1) | JP5431485B2 (hr) |
| KR (1) | KR20110086549A (hr) |
| CN (1) | CN102170787B (hr) |
| AU (2) | AU2009300298A1 (hr) |
| BR (1) | BRPI0920687A2 (hr) |
| CA (1) | CA2735120C (hr) |
| CL (1) | CL2011000739A1 (hr) |
| CO (1) | CO6382089A2 (hr) |
| CY (1) | CY1115725T1 (hr) |
| DK (1) | DK2328417T3 (hr) |
| ES (1) | ES2519140T3 (hr) |
| HR (1) | HRP20140967T1 (hr) |
| IL (1) | IL211313A (hr) |
| MA (1) | MA32686B1 (hr) |
| ME (1) | ME02017B (hr) |
| MX (1) | MX2011002830A (hr) |
| MY (1) | MY156302A (hr) |
| NZ (1) | NZ591504A (hr) |
| PE (1) | PE20110930A1 (hr) |
| PL (1) | PL2328417T3 (hr) |
| PT (1) | PT2328417E (hr) |
| RS (1) | RS53613B1 (hr) |
| RU (1) | RU2501792C2 (hr) |
| SI (1) | SI2328417T1 (hr) |
| UA (1) | UA101393C2 (hr) |
| WO (1) | WO2010039308A1 (hr) |
| ZA (1) | ZA201101278B (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009111611A2 (en) * | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes |
| DK2684873T3 (en) | 2008-06-09 | 2019-04-01 | Univ Muenchen Ludwig Maximilians | PHARMACEUTICALS FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES CONNECTED WITH PROTEIN AGGREGATION AND / OR NEURODEGENERATIVE DISEASE |
| EP2509590B1 (en) * | 2009-12-10 | 2019-10-30 | The Trustees of Columbia University in the City of New York | Histone acetyltransferase activators and uses thereof |
| US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| RU2614697C1 (ru) * | 2016-04-12 | 2017-03-28 | Общество с ограниченной ответственностью "Нормофарм" | Нейропротекторное средство |
| WO2018091444A1 (en) | 2016-11-15 | 2018-05-24 | H. Lundbeck A/S | Agents, uses and methods for the treatment of synucleinopathy |
| WO2018109058A1 (en) | 2016-12-16 | 2018-06-21 | H. Lundbeck A/S | Agents, uses and methods |
| CN113573708A (zh) * | 2019-02-07 | 2021-10-29 | 阿尔萨泰克公司 | 艾莫西平多价衍生物 |
| JP2023502794A (ja) * | 2019-11-19 | 2023-01-25 | モダグ ゲーエムベーハー | α－シヌクレインの凝集に関連する疾患の診断、治療および予防のための新規な化合物 |
| CN114573570B (zh) * | 2022-02-21 | 2023-05-30 | 中山大学 | 一类α-突触核蛋白靶向化合物及其制备方法和应用 |
| CN115650957B (zh) * | 2022-09-16 | 2023-12-15 | 中山大学 | 一类靶向α-突触核蛋白的蛋白水解嵌合体及其应用 |
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| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
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| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
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| IT1229203B (it) * | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
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