HRP20050712A2 - SUBSTITUTED HEXAHYDROPYRAZINO[1,2-a]PYRIMIDIN-4,7-DION DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS - Google Patents
SUBSTITUTED HEXAHYDROPYRAZINO[1,2-a]PYRIMIDIN-4,7-DION DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTSInfo
- Publication number
- HRP20050712A2 HRP20050712A2 HR20050712A HRP20050712A HRP20050712A2 HR P20050712 A2 HRP20050712 A2 HR P20050712A2 HR 20050712 A HR20050712 A HR 20050712A HR P20050712 A HRP20050712 A HR P20050712A HR P20050712 A2 HRP20050712 A2 HR P20050712A2
- Authority
- HR
- Croatia
- Prior art keywords
- production
- pyrimidin
- medicaments
- derivatives
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Izum se odnosi na supstituirane derivate heksahidro-pirazino[1,2-a]pirimidin-4,7-diona, na njihove fiziološki podnošljive soli i njihove fiziološki funkcionalne derivate. Opisani su spojevi formule (I)u kojima radikali imaju navedena značenja, kao injihove fiziološki podnošljive soli i postupci zanjihovu proizvodnju. Ovi spojevi se mogu upotrijebiti, na primjer, kao anorektici.The invention relates to substituted hexahydro-pyrazino [1,2-a] pyrimidine-4,7-dione derivatives, to their physiologically tolerable salts and to their physiologically functional derivatives. Described are compounds of formula (I) in which the radicals have the meanings indicated, such as their physiologically tolerable salts and methods for their production. These compounds can be used, for example, as anorexics.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10305885A DE10305885A1 (en) | 2003-02-13 | 2003-02-13 | New pyrazinopyrimidine or pyrazinoimidazole derivatives useful for weight reduction in mammals, for preventing or treating obesity, type II diabetes or metabolic syndrome and for treating sexual disorders |
DE10349672A DE10349672A1 (en) | 2003-10-24 | 2003-10-24 | New pyrazinopyrimidine or pyrazinoimidazole derivatives useful for weight reduction in mammals, for preventing or treating obesity, type II diabetes or metabolic syndrome and for treating sexual disorders |
PCT/EP2004/000769 WO2004072076A1 (en) | 2003-02-13 | 2004-01-29 | Substituted hexahydropyrazino(1,2-a)pyrimidin-4,7-dion derivatives, method for the production and use thereof as medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20050712A2 true HRP20050712A2 (en) | 2006-09-30 |
Family
ID=32870334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20050712A HRP20050712A2 (en) | 2003-02-13 | 2005-08-12 | SUBSTITUTED HEXAHYDROPYRAZINO[1,2-a]PYRIMIDIN-4,7-DION DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1599480B1 (en) |
JP (1) | JP2006517550A (en) |
KR (1) | KR20050111588A (en) |
AR (1) | AR043155A1 (en) |
AT (1) | ATE472548T1 (en) |
AU (1) | AU2004212042A1 (en) |
BR (1) | BRPI0407507A (en) |
CA (1) | CA2515735A1 (en) |
CO (1) | CO5690597A2 (en) |
DE (1) | DE502004011328D1 (en) |
HR (1) | HRP20050712A2 (en) |
MA (1) | MA27654A1 (en) |
MX (1) | MXPA05007516A (en) |
MY (1) | MY135902A (en) |
NO (1) | NO20054085L (en) |
PE (1) | PE20050192A1 (en) |
PL (1) | PL377227A1 (en) |
RS (1) | RS20050564A (en) |
RU (1) | RU2005128497A (en) |
TW (1) | TW200508235A (en) |
WO (1) | WO2004072076A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8080657B2 (en) | 2001-10-12 | 2011-12-20 | Choongwae Pharma Corporation | Compounds of reverse turn mimetics and the use thereof |
US7576084B2 (en) | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US7671054B1 (en) | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US7232822B2 (en) | 2001-10-12 | 2007-06-19 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US7566711B2 (en) | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US20040072831A1 (en) * | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
KR20050100686A (en) * | 2003-02-13 | 2005-10-19 | 사노피-아벤티스 도이칠란트 게엠베하 | Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, method for the production and use thereof as medicaments |
DE102004042441A1 (en) * | 2004-08-31 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Amino acid substituted hexahydro-pyrazino (1,2-a) pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments |
WO2007003962A2 (en) | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
EP1957516B1 (en) | 2005-11-08 | 2016-03-09 | Choongwae Pharma Corporation | Alfa-helix mimetics and method relating to the treatment of cancer stem cells |
WO2007056513A1 (en) * | 2005-11-08 | 2007-05-18 | Institute For Chemical Genomics | α-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS |
AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
EA016507B1 (en) | 2007-01-04 | 2012-05-30 | Прозидион Лимитед | Piperidine gpcr agonists |
AR064736A1 (en) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | GPCR AGONISTS |
CL2008000018A1 (en) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | COMPOUNDS DERIVED FROM NITROGEN AND OXYGEN HETEROCICLES, GPCR AGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF OBESITY, DIABETES, METABOLIC SYNDROME, HYPERLIPIDEMIA, TOLERANCE |
GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
CA2674348A1 (en) | 2007-01-04 | 2008-07-10 | Prosidion Limited | Piperidine gpcr agonists |
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
AR072707A1 (en) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | HETEROCICLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, DRUGS THAT UNDERSTAND THESE COMPOUNDS AND THE USE OF THEM |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
ES2443016T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi | New crystalline hydrates of heteroaromatic fluoroglycosides, pharmaceutical products comprising these compounds, and their use |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
EP2683701B1 (en) | 2011-03-08 | 2014-12-24 | Sanofi | Oxathiazine derivatives substituted with benzyl or heteromethylene groups, method for their preparation, their usage as medicament, medicament containing same and its use |
EP2683702B1 (en) | 2011-03-08 | 2014-12-24 | Sanofi | New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
EP2683699B1 (en) | 2011-03-08 | 2015-06-24 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120051A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184223B1 (en) * | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
JP3514774B2 (en) * | 1997-06-25 | 2004-03-31 | ファイザー・インク | Dipeptide derivatives as growth hormone secretagogues |
US6294525B1 (en) * | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
KR20050100686A (en) * | 2003-02-13 | 2005-10-19 | 사노피-아벤티스 도이칠란트 게엠베하 | Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, method for the production and use thereof as medicaments |
-
2004
- 2004-01-29 AU AU2004212042A patent/AU2004212042A1/en not_active Abandoned
- 2004-01-29 KR KR1020057014859A patent/KR20050111588A/en not_active Application Discontinuation
- 2004-01-29 WO PCT/EP2004/000769 patent/WO2004072076A1/en active Application Filing
- 2004-01-29 RU RU2005128497/04A patent/RU2005128497A/en not_active Application Discontinuation
- 2004-01-29 PL PL377227A patent/PL377227A1/en not_active Application Discontinuation
- 2004-01-29 MX MXPA05007516A patent/MXPA05007516A/en not_active Application Discontinuation
- 2004-01-29 DE DE502004011328T patent/DE502004011328D1/en not_active Expired - Lifetime
- 2004-01-29 CA CA002515735A patent/CA2515735A1/en not_active Abandoned
- 2004-01-29 EP EP04706170A patent/EP1599480B1/en not_active Expired - Lifetime
- 2004-01-29 BR BRPI0407507-2A patent/BRPI0407507A/en not_active IP Right Cessation
- 2004-01-29 AT AT04706170T patent/ATE472548T1/en not_active IP Right Cessation
- 2004-01-29 RS YUP-2005/0564A patent/RS20050564A/en unknown
- 2004-01-29 JP JP2006501649A patent/JP2006517550A/en active Pending
- 2004-02-09 PE PE2004000147A patent/PE20050192A1/en not_active Application Discontinuation
- 2004-02-11 TW TW093103121A patent/TW200508235A/en unknown
- 2004-02-11 AR ARP040100427A patent/AR043155A1/en unknown
- 2004-02-12 MY MYPI20040456A patent/MY135902A/en unknown
-
2005
- 2005-08-11 MA MA28428A patent/MA27654A1/en unknown
- 2005-08-11 CO CO05079789A patent/CO5690597A2/en not_active Application Discontinuation
- 2005-08-12 HR HR20050712A patent/HRP20050712A2/en not_active Application Discontinuation
- 2005-09-02 NO NO20054085A patent/NO20054085L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200508235A (en) | 2005-03-01 |
RU2005128497A (en) | 2006-01-27 |
CA2515735A1 (en) | 2004-08-26 |
RS20050564A (en) | 2007-09-21 |
EP1599480B1 (en) | 2010-06-30 |
BRPI0407507A (en) | 2006-02-14 |
PL377227A1 (en) | 2006-01-23 |
KR20050111588A (en) | 2005-11-25 |
DE502004011328D1 (en) | 2010-08-12 |
PE20050192A1 (en) | 2005-04-01 |
EP1599480A1 (en) | 2005-11-30 |
MY135902A (en) | 2008-07-31 |
JP2006517550A (en) | 2006-07-27 |
ATE472548T1 (en) | 2010-07-15 |
MA27654A1 (en) | 2005-12-01 |
WO2004072076A1 (en) | 2004-08-26 |
NO20054085L (en) | 2005-09-02 |
AR043155A1 (en) | 2005-07-20 |
CO5690597A2 (en) | 2006-10-31 |
AU2004212042A1 (en) | 2004-08-26 |
MXPA05007516A (en) | 2006-01-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20050712A2 (en) | SUBSTITUTED HEXAHYDROPYRAZINO[1,2-a]PYRIMIDIN-4,7-DION DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | |
HRP20050711A2 (en) | NITROGEN-SUBSTITUTED HEXAHYDROPYRAZINO[1,2-a]PYRIMIDINE-4,7-DIONE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | |
HRP20050532A2 (en) | Novel fluoroglycoside heterocyclic derivatives, pharmaceutical products containing said compounds and the use thereof | |
HRP20050531B1 (en) | Novel aromatic fluoroglycoside derivatives, pharmaceutical products containing said compounds and the use thereof | |
GB0305929D0 (en) | Organic compounds | |
ZA201100526B (en) | Triazolo [4,5-d]pyramidine derivatives and their use as purine receptor antagonists | |
MX337817B (en) | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES. | |
HRP20050710A2 (en) | Substituted n-arylheterocycles, method for production and use thereof as medicaments | |
MX2010006748A (en) | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS. | |
EA201000552A1 (en) | PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS PROTEINKINASE INHIBITORS IN | |
BRPI0513287A (en) | pyrido pyrimidine derivatives, their preparation, their application in therapeutic | |
DK1869049T3 (en) | Imidazopyridazine compounds | |
GEP20135780B (en) | Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents | |
IL195033A0 (en) | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases | |
GEP20084551B (en) | 4-phenylamino-quinazolin-6-yl-amides | |
TW200504062A (en) | Novel pyridopyrazines and the use thereof as kinase inhibitors | |
MY150747A (en) | Pyrido[2,3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer | |
TW200505917A (en) | Novel pyridopyrazines and the use thereof as kinase inhibitors | |
NO20080418L (en) | Pyrido [2,3-D] pyrimidiride derivatives, process for their preparation and therapeutic use of the same | |
PT1869038E (en) | Substituted 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-ylamine compounds and their use for producing drugs | |
ATE512968T1 (en) | 1,2,3,4-TETRAHYDROPYRROLO(1,2-A)PYRAZINE-6-CARBOXAMIDE AND 2,3,4,5-TETRAHYDROPYRROLO(1,2-A)-DIAZEPINE-7-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | |
HRP20050741A2 (en) | 1,3-substituted cycloalkyl containing acidic, mainly heterocyclic groups, corresponding production method and use of said derivatives as medicaments | |
RS88704A (en) | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof | |
HRP20050739A2 (en) | Cycloalkyl-substituted alkanoic acid derivatives, methods for the production thereof, and use thereof as a medicament | |
UA100138C2 (en) | SUBSTITUTED CYCLOALCANO[e AND d] PYRAZOLO [1,5-a]PYRIMIDINES/ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS AND METHODS FOR THE PRODUCTION AND USE THEREOF |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080116 Year of fee payment: 5 |
|
OBST | Application withdrawn |