HRP20020961A2 - Factor viia inhibitory (thio)urea derivatives, their preparation and their use - Google Patents

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Publication number

HRP20020961A2

HRP20020961A2 HRP20020961A HRP20020961A2 HR P20020961 A2 HRP20020961 A2 HR P20020961A2 HR P20020961 A HRP20020961 A HR P20020961A HR P20020961 A2 HRP20020961 A2 HR P20020961A2

Authority

HR

Croatia

Prior art keywords

group

alkyl

het

aryl

formula

Prior art date

2000-06-06

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• 238000002360 preparation method Methods 0.000 title claims description 11
• 229940012414 factor viia Drugs 0.000 title description 38
• 230000002401 inhibitory effect Effects 0.000 title description 14
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• -1 hydroxy-carbonyl- Chemical group 0.000 claims description 266
• 150000001875 compounds Chemical class 0.000 claims description 219
• 125000001424 substituent group Chemical group 0.000 claims description 79
• 125000003118 aryl group Chemical group 0.000 claims description 59
• 150000003839 salts Chemical class 0.000 claims description 52
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 49
• 239000001257 hydrogen Substances 0.000 claims description 37
• 229910052739 hydrogen Inorganic materials 0.000 claims description 37
• 125000000623 heterocyclic group Chemical group 0.000 claims description 33
• 239000000203 mixture Substances 0.000 claims description 32
• 238000000034 method Methods 0.000 claims description 29
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
• 229920006395 saturated elastomer Polymers 0.000 claims description 28
• 125000000217 alkyl group Chemical group 0.000 claims description 24
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 23
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 22
• 230000015572 biosynthetic process Effects 0.000 claims description 21
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
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