HRP20000408B1 - 5-/4-/2-(n-methyl-n-(2-pyridil)amino)ethoxy/benzyl/thiazolidine-2,4-dione, maleic acid salt, hydrate as pharmaceutical - Google Patents

5-/4-/2-(n-methyl-n-(2-pyridil)amino)ethoxy/benzyl/thiazolidine-2,4-dione, maleic acid salt, hydrate as pharmaceutical

Info

Publication number: HRP20000408B1
Authority: HR; Croatia
Prior art keywords: thiazolidine; dione; hydrate; ethoxy; benzyl
Prior art date: 1997-12-16

Application number

HR20000408A

Other languages

English (en)

Croatian (hr)

Inventor

David James Blackler Paul

C. Lee David

John Sasse Michael

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-16

Filing date

2000-06-16

Publication date

2008-04-30

2000-06-16 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2000-08-31 Publication of HRP20000408A2 publication Critical patent/HRP20000408A2/hr

2008-04-30 Publication of HRP20000408B1 publication Critical patent/HRP20000408B1/xx

Links

ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
150000002688 maleic acid derivatives Chemical class 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
238000000634 powder X-ray diffraction Methods 0.000 abstract 3
239000000126 substance Substances 0.000 abstract 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
238000001237 Raman spectrum Methods 0.000 abstract 1
YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 abstract 1
238000002329 infrared spectrum Methods 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
239000011976 maleic acid Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000000279 solid-state nuclear magnetic resonance spectrum Methods 0.000 abstract 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HR20000408A 1997-12-16 2000-06-16 5-/4-/2-(n-methyl-n-(2-pyridil)amino)ethoxy/benzyl/thiazolidine-2,4-dione, maleic acid salt, hydrate as pharmaceutical HRP20000408B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9726566.4A GB9726566D0 (en)	1997-12-16	1997-12-16	Novel pharmaceutical
PCT/EP1998/008155 WO1999031095A1 (en)	1997-12-16	1998-12-14	5-[4-[2- (n-methyl-n- (2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical

Publications (2)

Publication Number	Publication Date
HRP20000408A2 HRP20000408A2 (en)	2000-08-31
HRP20000408B1 true HRP20000408B1 (en)	2008-04-30

Family

ID=10823692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20000408A HRP20000408B1 (en)	1997-12-16	2000-06-16	5-/4-/2-(n-methyl-n-(2-pyridil)amino)ethoxy/benzyl/thiazolidine-2,4-dione, maleic acid salt, hydrate as pharmaceutical

Country Status (35)

Country	Link
EP (2)	EP1040110A1 (xx)
JP (1)	JP2002508373A (xx)
KR (1)	KR100549142B1 (xx)
CN (3)	CN101381367A (xx)
AP (1)	AP1365A (xx)
AR (1)	AR017214A1 (xx)
AU (1)	AU1967999A (xx)
BG (1)	BG64988B1 (xx)
BR (1)	BR9813600A (xx)
CA (1)	CA2314107A1 (xx)
CO (1)	CO4980880A1 (xx)
CZ (1)	CZ299965B6 (xx)
DZ (1)	DZ2681A1 (xx)
EA (1)	EA004260B1 (xx)
EG (1)	EG22337A (xx)
GB (1)	GB9726566D0 (xx)
HR (1)	HRP20000408B1 (xx)
HU (1)	HUP0100509A3 (xx)
IL (1)	IL136424A (xx)
IN (1)	IN192487B (xx)
MA (1)	MA26580A1 (xx)
MY (1)	MY135612A (xx)
NO (1)	NO317254B1 (xx)
OA (1)	OA11766A (xx)
PE (1)	PE20000058A1 (xx)
PL (1)	PL341146A1 (xx)
RS (1)	RS50126B (xx)
SA (1)	SA99191115B1 (xx)
SK (1)	SK286618B6 (xx)
TR (2)	TR200001799T2 (xx)
TW (1)	TW509690B (xx)
UA (1)	UA72198C2 (xx)
UY (2)	UY25304A1 (xx)
WO (1)	WO1999031095A1 (xx)
ZA (1)	ZA9811506B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9726568D0 (en)	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
US6664278B2 (en)	1997-12-16	2003-12-16	Smithkline Beecham P.L.C.	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9909041D0 (en) *	1999-04-20	1999-06-16	Smithkline Beecham Plc	Novel pharmaceutical
KR100744359B1 (ko) *	1999-04-23	2007-07-30	스미스클라인비이참피이엘시이	티아졸리딘디온 유도체 및 항당뇨병제로서 그의 용도
TR200103060T2 (tr) *	1999-04-23	2002-05-21	Smithkline Beecham P. L. C.	Yeni farmasötik maddeler
ATE246191T1 (de) *	1999-04-23	2003-08-15	Smithkline Beecham Plc	Polymorph von 5-(4-(2-(n-methyl-n-(2- pyrdyl)amino)äthoxy)benzyl)thiazolidin-2,4-dion maleinsäuresalz
WO2001081327A1 (fr)	2000-04-25	2001-11-01	Kyorin Pharmaceutical Co., Ltd.	Nouveau cristal stable de derive thiazolidinedione et son procede de production
GB0014005D0 (en) *	2000-06-08	2000-08-02	Smithkline Beecham Plc	Novel pharmaceutical
GB0021784D0 (en) *	2000-09-05	2000-10-18	Smithkline Beecham Plc	Novel pharmaceutical
GB0021978D0 (en) *	2000-09-07	2000-10-25	Smithkline Beecham Plc	Novel pharmaceutical
CA2426117A1 (en) *	2000-09-26	2002-04-04	Dr. Reddy's Research Foundation	Novel polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation
WO2003050112A1 (en) *	2001-12-13	2003-06-19	Smithkline Beecham Plc	Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
GB0129872D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
GB2405403A (en) *	2003-08-29	2005-03-02	Cipla Ltd	Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) *	2004-07-28	2004-10-28	Chemi Spa	Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) *	2005-05-24	2007-09-26	Zentiva, A. S.	Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
EP2184055A1 (en)	2008-11-07	2010-05-12	LEK Pharmaceuticals d.d.	Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3856378T2 (de) *	1987-09-04	2000-05-11	Beecham Group Plc	Substituierte Thiazolidindionderivate
GB8820389D0 (en) *	1988-08-26	1988-09-28	Beecham Group Plc	Novel compounds
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
SG47100A1 (en) *	1994-02-10	1998-03-20	Smithkline Beecham Plc	Use of insulin sensitisers for treating renal diseases

1997
- 1997-12-16 GB GBGB9726566.4A patent/GB9726566D0/en not_active Ceased
1998
- 1998-12-14 KR KR1020007006515A patent/KR100549142B1/ko not_active IP Right Cessation
- 1998-12-14 TR TR2000/01799T patent/TR200001799T2/xx unknown
- 1998-12-14 CA CA002314107A patent/CA2314107A1/en not_active Abandoned
- 1998-12-14 MA MA25389A patent/MA26580A1/fr unknown
- 1998-12-14 CN CNA200810087031XA patent/CN101381367A/zh active Pending
- 1998-12-14 JP JP2000539019A patent/JP2002508373A/ja not_active Withdrawn
- 1998-12-14 AU AU19679/99A patent/AU1967999A/en not_active Abandoned
- 1998-12-14 IL IL13642498A patent/IL136424A/xx unknown
- 1998-12-14 CZ CZ20002204A patent/CZ299965B6/cs not_active IP Right Cessation
- 1998-12-14 OA OA1200000178A patent/OA11766A/en unknown
- 1998-12-14 RS YUP-363/00A patent/RS50126B/sr unknown
- 1998-12-14 EP EP98964510A patent/EP1040110A1/en not_active Withdrawn
- 1998-12-14 WO PCT/EP1998/008155 patent/WO1999031095A1/en active IP Right Grant
- 1998-12-14 EP EP05077331A patent/EP1661895A1/en not_active Withdrawn
- 1998-12-14 HU HU0100509A patent/HUP0100509A3/hu unknown
- 1998-12-14 PL PL98341146A patent/PL341146A1/xx not_active Application Discontinuation
- 1998-12-14 SK SK917-2000A patent/SK286618B6/sk not_active IP Right Cessation
- 1998-12-14 CN CN98812089A patent/CN1281453A/zh active Pending
- 1998-12-14 CN CNA2008100870305A patent/CN101302215A/zh active Pending
- 1998-12-14 AP APAP/P/2000/001831A patent/AP1365A/en active
- 1998-12-14 UA UA2000063485A patent/UA72198C2/uk unknown
- 1998-12-14 EA EA200000654A patent/EA004260B1/ru not_active IP Right Cessation
- 1998-12-14 BR BR9813600-3A patent/BR9813600A/pt not_active Application Discontinuation
- 1998-12-15 UY UY25304A patent/UY25304A1/es unknown
- 1998-12-15 ZA ZA9811506A patent/ZA9811506B/xx unknown
- 1998-12-15 MY MYPI98005674A patent/MY135612A/en unknown
- 1998-12-15 EG EG155698A patent/EG22337A/xx active
- 1998-12-15 DZ DZ980291A patent/DZ2681A1/xx active
- 1998-12-15 AR ARP980106370A patent/AR017214A1/es unknown
- 1998-12-15 UY UY25308A patent/UY25308A1/es not_active IP Right Cessation
- 1998-12-16 TR TR1998/02625A patent/TR199802625A3/tr unknown
- 1998-12-16 CO CO98074834A patent/CO4980880A1/es unknown
- 1998-12-16 IN IN3772DE1998 patent/IN192487B/en unknown
- 1998-12-16 PE PE1998001233A patent/PE20000058A1/es not_active Application Discontinuation
- 1998-12-16 TW TW087121121A patent/TW509690B/zh not_active IP Right Cessation
1999
- 1999-02-27 SA SA99191115A patent/SA99191115B1/ar unknown
2000
- 2000-06-15 NO NO20003069A patent/NO317254B1/no not_active IP Right Cessation
- 2000-06-16 HR HR20000408A patent/HRP20000408B1/xx not_active IP Right Cessation
- 2000-07-13 BG BG104603A patent/BG64988B1/bg unknown

Also Published As

Publication number	Publication date
NO317254B1 (no)	2004-09-27
BR9813600A (pt)	2000-10-10
KR100549142B1 (ko)	2006-02-03
CN101302215A (zh)	2008-11-12
SK286618B6 (sk)	2009-02-05
CN1281453A (zh)	2001-01-24
IN192487B (xx)	2004-04-24
NO20003069L (no)	2000-06-15
EA004260B1 (ru)	2004-02-26
BG64988B1 (bg)	2006-11-30
OA11766A (en)	2005-07-19
GB9726566D0 (en)	1998-02-11
HUP0100509A3 (en)	2002-06-28
TR199802625A2 (xx)	1999-10-21
CN101381367A (zh)	2009-03-11
TW509690B (en)	2002-11-11
AR017214A1 (es)	2001-08-22
TR199802625A3 (tr)	1999-10-21
PE20000058A1 (es)	2000-02-26
SK9172000A3 (en)	2001-01-18
PL341146A1 (en)	2001-03-26
IL136424A0 (en)	2001-06-14
UY25304A1 (es)	2000-12-29
MY135612A (en)	2008-05-30
WO1999031095A1 (en)	1999-06-24
BG104603A (en)	2001-03-30
RS50126B (sr)	2009-03-25
TR200001799T2 (tr)	2001-01-22
YU36300A (sh)	2004-03-12
AP1365A (en)	2005-01-26
EG22337A (en)	2002-12-31
UA72198C2 (en)	2005-02-15
JP2002508373A (ja)	2002-03-19
CZ299965B6 (cs)	2009-01-07
ZA9811506B (en)	2000-11-06
HUP0100509A2 (hu)	2002-05-29
HRP20000408A2 (en)	2000-08-31
DZ2681A1 (fr)	2004-06-20
MA26580A1 (fr)	2004-12-20
EP1040110A1 (en)	2000-10-04
AP2000001831A0 (en)	2000-06-30
IL136424A (en)	2003-12-10
EP1661895A1 (en)	2006-05-31
CO4980880A1 (es)	2000-11-27
SA99191115B1 (ar)	2006-10-11
CA2314107A1 (en)	1999-06-24
AU1967999A (en)	1999-07-05
CZ20002204A3 (cs)	2000-11-15
KR20010033141A (ko)	2001-04-25
EA200000654A1 (ru)	2000-12-25
UY25308A1 (es)	1999-07-19
NO20003069D0 (no)	2000-06-15

Legal Events

Date	Code	Title	Description
2000-08-31	A1OB	Publication of a patent application
2001-02-28	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2008-04-30	B1PR	Patent granted
2008-11-21	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20081121 Year of fee payment: 11
2010-06-15	PBON	Lapse due to non-payment of renewal fee	Effective date: 20091215

Publication	Publication Date	Title
HRP20000408B1 (en)	2008-04-30	5-/4-/2-(n-methyl-n-(2-pyridil)amino)ethoxy/benzyl/thiazolidine-2,4-dione, maleic acid salt, hydrate as pharmaceutical
EA200000656A1 (ru)	2000-12-25	Замещенное производное тиазолидиндиона, способ его получения и его фармацевтическое применение
MX9604020A (es)	1997-03-29	Arilalquildiazinonas.
RS50114B (sr)	2009-03-25	Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline
DE60314639D1 (de)	2007-08-09	Fusionierte heteroaryl-derivative zur verwendung als p38 kinase inhibitoren zur behandlung von u.a rheumatischer arthritis
HRP20010772B1 (en)	2007-05-31	Polymorph of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt
MY135770A (en)	2008-06-30	Novel pharmaceutical
DK0407024T3 (da)	1994-09-19	Middel og fremgangsmåde til inhibering af væksten af mikroorganismer
CO5170420A1 (es)	2002-06-27	Nuevos farmacos hidrocloruro
AU2838001A (en)	2001-09-03	Method for the production of protein preparations with essentially constant properties with regard to solubility and functionality within a ph range from about ph 3 to ph 10
ECSP982779A (es)	1999-05-17	Un hidrato de la sal de acido maleico, proceso para la preparacion, composicion farmaceutica y su uso en medicina
ECSP982781A (es)	1999-05-17	Hidrato de la sal de maleico de 5-[4- (-n -metil-n- (2-piridil) amino) etoxi) bensil) tiazolidina - 2,4 diona
PL346003A1 (en)	2002-01-14	N-substituted azabicycloheptane derivatives, production and use thereof