HK66090A - Hexahydronaphth(1,2-b)-1,4-oxazines,process for their preparation and pharmaceutical formulation containing them - Google Patents

Hexahydronaphth(1,2-b)-1,4-oxazines,process for their preparation and pharmaceutical formulation containing them

Info

Publication number
HK66090A
HK66090A HK660/90A HK66090A HK66090A HK 66090 A HK66090 A HK 66090A HK 660/90 A HK660/90 A HK 660/90A HK 66090 A HK66090 A HK 66090A HK 66090 A HK66090 A HK 66090A
Authority
HK
Hong Kong
Prior art keywords
hexahydronaphth
oxazines
preparation
pharmaceutical formulation
formulation containing
Prior art date
Application number
HK660/90A
Other languages
English (en)
Inventor
James H Jones
David E Mcclure
Victor J Grenda
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK66090A publication Critical patent/HK66090A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Luminescent Compositions (AREA)
HK660/90A 1981-11-20 1990-08-23 Hexahydronaphth(1,2-b)-1,4-oxazines,process for their preparation and pharmaceutical formulation containing them HK66090A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32334981A 1981-11-20 1981-11-20

Publications (1)

Publication Number Publication Date
HK66090A true HK66090A (en) 1990-08-31

Family

ID=23258834

Family Applications (1)

Application Number Title Priority Date Filing Date
HK660/90A HK66090A (en) 1981-11-20 1990-08-23 Hexahydronaphth(1,2-b)-1,4-oxazines,process for their preparation and pharmaceutical formulation containing them

Country Status (12)

Country Link
EP (1) EP0080115B1 (fr)
JP (1) JPS5892670A (fr)
AT (1) ATE27155T1 (fr)
AU (1) AU556908B2 (fr)
CA (1) CA1204745A (fr)
DE (1) DE3276312D1 (fr)
DK (1) DK515982A (fr)
ES (1) ES8401048A1 (fr)
GR (1) GR77041B (fr)
HK (1) HK66090A (fr)
IE (1) IE54157B1 (fr)
PT (1) PT75859B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540691A (en) * 1984-04-13 1985-09-10 Nelson Research & Development Co. Dopamine agonists and use thereof
HU193979B (en) * 1984-06-12 1987-12-28 Sandoz Ag Process for producing naphtoxazine derivatives and pharmaceutical compositions containing them
US4774243A (en) * 1985-12-24 1988-09-27 Merck & Co., Inc. Dopamine agonists for treating elevated intraocular pressure
US4758661A (en) * 1986-06-24 1988-07-19 Merck & Co., Inc. Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions
US4743601A (en) * 1987-07-13 1988-05-10 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-1,4-oxazino(2,3-C)quinolines
US4942037A (en) * 1988-06-02 1990-07-17 Merck & Co., Inc. Transdermal delivery systems
FR2721027B1 (fr) * 1994-06-08 1996-07-19 Adir Nouveaux dérivés tétracycliques de la 1,4-oxazine, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2767825A1 (fr) * 1997-09-01 1999-02-26 Adir Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1853572A4 (fr) * 2005-02-14 2009-11-11 Clera Inc Phno fluorée et analogues de ladite substance
FR2906249B1 (fr) * 2006-09-26 2008-12-19 Servier Lab Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2098511A1 (fr) 2008-03-07 2009-09-09 Solvias AG Procédé pour la préparation de composés contenant une structure d'hydronaphtalène avec un cycle benzène à substitution asymétrique
GB0821432D0 (en) * 2008-11-24 2008-12-31 Gen Electric Imaging ligands
CN102898397B (zh) * 2012-09-26 2014-12-10 江苏华益科技有限公司 (4aR,10bR)-3,4,4a,5,6,10b-六氢-2H-萘并[1,2-b][1,4]噁嗪-9-醇类物质及其盐酸盐合成方法
WO2017109095A1 (fr) * 2015-12-22 2017-06-29 AbbVie Deutschland GmbH & Co. KG Composés (hétéro)cycliques fusionnés en tant que modulateurs de s1p

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642789A (en) * 1970-02-13 1972-02-15 Dow Chemical Co Indeno(1 2-b)-1 4-oxazines
US4238486A (en) * 1979-11-23 1980-12-09 Merck & Co., Inc. Indolobenzoxazines

Also Published As

Publication number Publication date
JPH0347270B2 (fr) 1991-07-18
EP0080115B1 (fr) 1987-05-13
EP0080115A3 (en) 1984-07-18
DK515982A (da) 1983-05-21
IE822755L (en) 1983-05-20
ES517233A0 (es) 1983-12-01
AU556908B2 (en) 1986-11-27
ATE27155T1 (de) 1987-05-15
GR77041B (fr) 1984-09-04
ES8401048A1 (es) 1983-12-01
IE54157B1 (en) 1989-07-05
DE3276312D1 (en) 1987-06-19
JPS5892670A (ja) 1983-06-02
EP0080115A2 (fr) 1983-06-01
PT75859B (en) 1986-01-21
AU1444883A (en) 1984-11-15
PT75859A (en) 1982-12-01
CA1204745A (fr) 1986-05-20

Similar Documents

Publication Publication Date Title
DE3276312D1 (en) Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them
MY108496A (en) Hypoglycemic thiazolidine diones.
DE69017596D1 (de) Verwendung eines Opiatantagonisten zur Herstellung eines transdermal zu verabreichenden Arzneimittels sowie eine Vorrichtung zur transdermalen Verabreichung.
ATE126433T1 (de) Verwendung von gamma-hydroxy-buttersäuresalzen zur herstellung von pharmazeutischen zusammensetzungen zur verwendung bei der behandlung von alkoholismus und die hergestellten zusammensetzungen.
BG101947A (en) Aryl glycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
PT85071A (en) Process for the preparation of derivatives of fused cyclic azepin-2-ones and of pharmaceutical compositions containing the same
HUT51269A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
DE3886986D1 (de) Glykoprotein, Verfahren zu dessen Herstellung und dieses als aktiven Bestandteil enthaltendes immunsuppressives Agens.
DE68904364D1 (de) (aza)naphtalensultam-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.
PT75384B (en) Process for the preparation of cyclic peptidic ergot alkaloids and of pharmaceutical composition containing them
ATE56956T1 (de) (s)-(-)-1-propyl-2',6'-pipecoloxylididhydrochloridmonohydrat, verfahren zu seiner herstellung und es enthaltendes pharmazeutisches praeparat.
ATE100095T1 (de) 2,2-dimethylchromenderivate, verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
HU902098D0 (en) Process for producing substituted 1,8-naphthyridine derivatives and pharmaceutical preparatives containing such compounds
DE3868309D1 (de) Imidazol-derivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammenstellungen und deren anwendung als arzneimittel.
IL83814A (en) 10-(cyclic)amino-9-halo-7-oxo-2,3-dihydro-7h-pyrido(3,2,1-ij)-1,3,4-benzoxadiazine-6-carboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them and some intermediates therefor
ATE32898T1 (de) 8-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-1phenyl-1,3,8-triazaspiro(4.5)decan-4-one, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
ATE65408T1 (de) Arzneimittel enthaltend in kombination interferon und 1-desoxy-piperidinosen, verfahren zu deren herstellung und deren verwendung.
ATE85218T1 (de) Oral anzuwendende arzneiform zur einmal taeglichen behandlung der hypertonie mit diltiazemhydrochlorid.
DE3274641D1 (en) Octahydrobenzo(6,7)cyclohept(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them
DE3277770D1 (en) The (r,r)-enantiomer of trans-indeno(1,2-b)-1,4-oxazines, process for its preparation and pharmaceutical formulation containing it
IL69525A0 (en) Spiro(2h-1,4-benzodioxepin-3(5h)4'piperidine and 3'-pyrrolidino)compounds,a process for preparing the same and their use as medicaments
PT70545A (de) Verfahren zur herstellung und verwendung von 7,8,9,10-tetrahydrothieno/3,2-e/pyrido/4,3-b/ indole als arzneimittel
HUT47903A (en) Process for producing cyclic amino-acid derivatives and pharmaceutical compositions containing them
PL277260A1 (en) Method of obtaining novel derivatives of tetrahydropyridine
HU907361D0 (en) Process for the production of /n-(gamma-glutamyl)-glycyl/-alanine derivatives and medical preparations containing them