HK50288A - Alphacarbamoyl-pyrrolpropionitriles,process for their preparation and pharmaceutical preparations containing them - Google Patents
Alphacarbamoyl-pyrrolpropionitriles,process for their preparation and pharmaceutical preparations containing themInfo
- Publication number
- HK50288A HK50288A HK502/88A HK50288A HK50288A HK 50288 A HK50288 A HK 50288A HK 502/88 A HK502/88 A HK 502/88A HK 50288 A HK50288 A HK 50288A HK 50288 A HK50288 A HK 50288A
- Authority
- HK
- Hong Kong
- Prior art keywords
- lower alkyl
- substituted
- compounds
- denotes
- enol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Antiinflammatory and antiarthritic compounds of the formula I <IMAGE> in which Pl denotes a 2- or 3-pyrrolyl radical, which is substituted in the 1-position by lower alkyl or Ph-lower alkyl and is unsubstituted in the three remaining positions or substituted by lower alkyl and/or a carboxyl or carboxy-lower alkoxy group; R represents lower alkyl and Ph denotes phenyl which is unsubstituted or substituted by one to three identical or different substituents from the group comprising lower alkyl, lower alkoxy, lower alkylthio, hydroxyl, halogen, trifluoromethyl, nitro, amino or lower alkanoylamino; these compounds in their enol form, their enol lower alkyl ethers or enol lower alkanoyl esters, or their salts with bases can be obtained, for example, by condensation of compounds of the formulae <IMAGE> in which X denotes lower alkoxy, lower alkanoyloxy or halogen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4606379A | 1979-06-11 | 1979-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK50288A true HK50288A (en) | 1988-07-15 |
Family
ID=21941390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK502/88A HK50288A (en) | 1979-06-11 | 1988-07-07 | Alphacarbamoyl-pyrrolpropionitriles,process for their preparation and pharmaceutical preparations containing them |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0143142A3 (en) |
| JP (1) | JPS562961A (en) |
| KR (4) | KR840001131B1 (en) |
| AT (1) | ATE14724T1 (en) |
| AU (1) | AU539967B2 (en) |
| CA (1) | CA1133917A (en) |
| CY (1) | CY1426A (en) |
| DD (1) | DD151307A5 (en) |
| DE (1) | DE3070951D1 (en) |
| DK (1) | DK155996C (en) |
| ES (1) | ES8104223A1 (en) |
| FI (1) | FI71129C (en) |
| GR (1) | GR69239B (en) |
| HK (1) | HK50288A (en) |
| HU (1) | HU182670B (en) |
| IE (1) | IE50288B1 (en) |
| IL (1) | IL60269A (en) |
| KE (1) | KE3795A (en) |
| NO (1) | NO155197C (en) |
| NZ (1) | NZ193995A (en) |
| PT (1) | PT71367A (en) |
| ZA (1) | ZA803461B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2127809B (en) * | 1982-09-28 | 1986-03-12 | Ciba Geigy Ag | Certain b-oxo-a-carbamoyl-pyrrolepropionitriles |
| DE3247454A1 (en) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituted 3-phenyl-5-methylisoxazole-4-carboxanilides, process for their preparation and pharmaceutical compositions containing these compounds |
| DE3525623A1 (en) * | 1985-07-18 | 1987-01-22 | Celamerck Gmbh & Co Kg | Fungicidally effective acrylic acid amides |
| GB8619433D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| WO1989005798A1 (en) * | 1987-12-18 | 1989-06-29 | Ciba-Geigy Ag | TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE |
| IL92508A0 (en) * | 1988-12-08 | 1990-08-31 | Ciba Geigy Ag | Novel alpha-cyano-beta-oxopropionamides |
| GR880100839A (en) * | 1988-12-15 | 1994-03-31 | Ciba Geigy | Tromethamine salt of 1-methyl-b-oxo-a-(phenylcarbamoyl)-2-pyrrolepropionitrile |
| ZA90555B (en) * | 1989-01-31 | 1990-10-31 | Merrell Pharma Inc | Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions |
| GB9720899D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
| US20050142489A1 (en) * | 2002-03-19 | 2005-06-30 | Horst Berneth | Squarylium dyes as light-absorbing compound in the information layer of optical data carriers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE861500C (en) * | 1942-07-05 | 1953-01-05 | Beth Ag Maschf | Purge air filter |
| GB1201061A (en) * | 1966-08-26 | 1970-08-05 | Endo Lab | Oxo pyrroles and process for preparing same |
| ES448386A1 (en) * | 1975-06-05 | 1978-04-16 | Hoechst Ag | 5-Methyl-isoxazole-4-carboxylic acid anilides |
| NL186239B (en) * | 1975-06-05 | Hoechst Ag | PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTIFLOGISTICAL AND / OR ANALGETICAL ACTION AND PROCEDURE FOR THE PREPARATION OF A 2-HYDROXYETHYLIDE ENCYANAACETIC ANILIDE SUITABLE FOR USE IN THIS PROCESS. | |
| DE2654797A1 (en) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | PROCESS FOR THE PREPARATION OF ISOXAZOLE DERIVATIVES |
-
1980
- 1980-06-09 FI FI801840A patent/FI71129C/en not_active IP Right Cessation
- 1980-06-09 IL IL60269A patent/IL60269A/en unknown
- 1980-06-09 AT AT80103180T patent/ATE14724T1/en not_active IP Right Cessation
- 1980-06-09 DE DE8080103180T patent/DE3070951D1/en not_active Expired
- 1980-06-09 PT PT71367A patent/PT71367A/en unknown
- 1980-06-09 EP EP84102678A patent/EP0143142A3/en not_active Withdrawn
- 1980-06-09 CA CA353,624A patent/CA1133917A/en not_active Expired
- 1980-06-09 GR GR62165A patent/GR69239B/el unknown
- 1980-06-09 EP EP80103180A patent/EP0021207B1/en not_active Expired
- 1980-06-09 DD DD80221679A patent/DD151307A5/en not_active IP Right Cessation
- 1980-06-10 DK DK250180A patent/DK155996C/en not_active IP Right Cessation
- 1980-06-10 NZ NZ193995A patent/NZ193995A/en unknown
- 1980-06-10 KR KR1019800002269A patent/KR840001131B1/en active
- 1980-06-10 AU AU59173/80A patent/AU539967B2/en not_active Ceased
- 1980-06-10 ES ES492278A patent/ES8104223A1/en not_active Expired
- 1980-06-10 IE IE1185/80A patent/IE50288B1/en not_active IP Right Cessation
- 1980-06-10 NO NO801733A patent/NO155197C/en unknown
- 1980-06-10 ZA ZA00803461A patent/ZA803461B/en unknown
- 1980-06-10 HU HU801461A patent/HU182670B/en not_active IP Right Cessation
- 1980-06-11 JP JP7790080A patent/JPS562961A/en active Granted
-
1984
- 1984-05-29 KR KR1019840002950A patent/KR840001134B1/en not_active IP Right Cessation
- 1984-05-29 KR KR1019840002949A patent/KR840001133B1/en not_active IP Right Cessation
- 1984-05-29 KR KR1019840002948A patent/KR840001132B1/en not_active IP Right Cessation
-
1988
- 1988-01-25 KE KE3795A patent/KE3795A/en unknown
- 1988-07-07 HK HK502/88A patent/HK50288A/en unknown
- 1988-09-02 CY CY1426A patent/CY1426A/en unknown
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