HK1252852A1 - 阻止HIF2α基因表達的組合物及方法 - Google Patents

阻止HIF2α基因表達的組合物及方法

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Publication number
HK1252852A1
HK1252852A1 HK18112183.2A HK18112183A HK1252852A1 HK 1252852 A1 HK1252852 A1 HK 1252852A1 HK 18112183 A HK18112183 A HK 18112183A HK 1252852 A1 HK1252852 A1 HK 1252852A1
Authority
HK
Hong Kong
Prior art keywords
hif2alpha
compositions
methods
gene expression
inhibiting gene
Prior art date
Application number
HK18112183.2A
Other languages
English (en)
Inventor
So Wong
David L Lewis
David B Rozema
Darren H Wakefield
Weijun Chen
Lauren J Almeida
Andrei V Blokhin
Jeffrey C Carlson
Anthony L Nicholas
Aaron Almeida
Steven B Kanner
Jonathan D Benson
Justin Woods
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of HK1252852A1 publication Critical patent/HK1252852A1/zh

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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HK18112183.2A 2015-05-29 2018-09-21 阻止HIF2α基因表達的組合物及方法 HK1252852A1 (zh)

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US201562168244P 2015-05-29 2015-05-29

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HK1252852A1 true HK1252852A1 (zh) 2019-06-06

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US (3) US9976141B2 (zh)
EP (1) EP3302503A4 (zh)
JP (3) JP7021076B2 (zh)
KR (1) KR20180011198A (zh)
CN (2) CN108064156B (zh)
AR (1) AR104754A1 (zh)
AU (2) AU2016270593B2 (zh)
BR (1) BR112017025698A2 (zh)
CA (1) CA2984498C (zh)
EA (1) EA201792103A1 (zh)
HK (1) HK1252852A1 (zh)
IL (1) IL255998A (zh)
MX (1) MX2017014641A (zh)
SG (1) SG10202105989WA (zh)
TW (1) TWI761305B (zh)
WO (1) WO2016196239A1 (zh)
ZA (1) ZA201707148B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3302503A4 (en) * 2015-05-29 2019-08-07 Arrowhead Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING THE GENE EXPRESSION OF HIF2ALPHA
JOP20210043A1 (ar) 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
WO2019075419A1 (en) * 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
CN111526880A (zh) * 2017-11-01 2020-08-11 箭头药业股份有限公司 整联蛋白配体及其用途
EP3784267A4 (en) 2018-04-27 2022-03-23 Arrowhead Pharmaceuticals, Inc. ANTI-INTEGRIN LIGANDS AND USES THEREOF
CN112074290A (zh) * 2018-04-27 2020-12-11 箭头药业股份有限公司 整联蛋白靶向配体和其用途
WO2020146521A2 (en) * 2019-01-09 2020-07-16 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
CN117915953A (zh) * 2021-09-07 2024-04-19 国立大学法人京都大学 衰老细胞清除药的筛选方法和衰老细胞清除药
CN114106012B (zh) * 2021-12-13 2023-05-23 宜昌博仁凯润药业有限公司 一种化合物Biotin-PEG3-SS-DBCO制备方法及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU767195B2 (en) 1999-03-10 2003-11-06 Phogen Limited Delivery of substances to cells
US20080188430A1 (en) * 2001-05-18 2008-08-07 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
ATE465255T1 (de) * 2002-11-26 2010-05-15 Univ Massachusetts Verabreichung von sirnas
WO2005089287A2 (en) 2004-03-15 2005-09-29 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna
CN101500548A (zh) 2006-08-18 2009-08-05 弗·哈夫曼-拉罗切有限公司 用于体内递送多核苷酸的多缀合物
CN101868251B (zh) * 2007-08-06 2012-10-10 千寿制药株式会社 含有HIF-1α和HIF-2α表达抑制物质的药物
PL2842575T3 (pl) * 2008-03-18 2018-02-28 Seattle Genetics, Inc. Koniugaty aurystatyny lek łącznik
BRPI0911332A2 (pt) * 2008-04-04 2019-09-24 Calando Pharmaceuticals Inc composições e uso de inibidores de epas1
WO2010080129A2 (en) 2008-12-18 2010-07-15 Dicerna Pharmaceuticals, Inc. Extended dicer substrate agents and methods for the specific inhibition of gene expression
WO2010093788A2 (en) 2009-02-11 2010-08-19 Dicerna Pharmaceuticals, Inc. Multiplex dicer substrate rna interference molecules having joining sequences
ES2562817T3 (es) 2010-02-24 2016-03-08 Arrowhead Research Corporation Composiciones para el suministro dirigido de ARNip
KR101223660B1 (ko) * 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
US8501930B2 (en) 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
JP2014504295A (ja) * 2010-12-17 2014-02-20 アローヘッド リサーチ コーポレイション ｓｉＲＮＡ用ガラクトースクラスター−薬物動態調節剤標的指向部分
CA3131967A1 (en) 2010-12-29 2012-07-05 F. Hoffman-La Roche Ag Small molecule conjugates for intracellular delivery of nucleic acids
WO2012174224A2 (en) * 2011-06-17 2012-12-20 Calando Pharmaceuticals, Inc. Methods for administering nucleic acid-based therapeutics
MX2014001971A (es) 2011-08-26 2014-03-31 Arrowhead Res Corp Polimeros de poli(vinilester) para suministro de acido nucleico in vivo.
CN103764153A (zh) 2012-04-18 2014-04-30 箭头研究公司 用于体内核酸递送的聚(丙烯酸酯)聚合物
SG10201706960TA (en) * 2013-02-28 2017-10-30 Arrowhead Res Corp Organic compositions to treat epas1-related diseases
CA2919088A1 (en) * 2013-08-07 2015-02-12 Arrowhead Research Corporation Polyconjugates for delivery of rnai triggers to tumor cells in vivo
WO2016149020A1 (en) * 2015-03-17 2016-09-22 Arrowhead Research Corporation Rna interference agents
EP3302503A4 (en) * 2015-05-29 2019-08-07 Arrowhead Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING THE GENE EXPRESSION OF HIF2ALPHA

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