HK1252836A1 - 水凝膠藥物遞送 - Google Patents

水凝膠藥物遞送

Info

Publication number
HK1252836A1
HK1252836A1 HK18112166.3A HK18112166A HK1252836A1 HK 1252836 A1 HK1252836 A1 HK 1252836A1 HK 18112166 A HK18112166 A HK 18112166A HK 1252836 A1 HK1252836 A1 HK 1252836A1
Authority
HK
Hong Kong
Prior art keywords
hydrogels
drug delivery
drug
delivery
Prior art date
Application number
HK18112166.3A
Other languages
English (en)
Inventor
P‧賈勒特
R‧艾爾哈耶克
T‧S‧賈勒特
C‧D‧布利澤德
A‧S‧索內
Original Assignee
因賽普特股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 因賽普特股份有限公司 filed Critical 因賽普特股份有限公司
Publication of HK1252836A1 publication Critical patent/HK1252836A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18112166.3A 2015-05-12 2018-09-20 水凝膠藥物遞送 HK1252836A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562160394P 2015-05-12 2015-05-12

Publications (1)

Publication Number Publication Date
HK1252836A1 true HK1252836A1 (zh) 2019-06-06

Family

ID=57249111

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18112166.3A HK1252836A1 (zh) 2015-05-12 2018-09-20 水凝膠藥物遞送

Country Status (7)

Country Link
US (2) US11369591B2 (zh)
EP (2) EP3294212B1 (zh)
JP (3) JP2018515529A (zh)
AU (3) AU2016261925B2 (zh)
CA (1) CA2985656A1 (zh)
HK (1) HK1252836A1 (zh)
WO (1) WO2016183296A1 (zh)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
CN106214321B (zh) 2010-10-15 2018-08-28 科尼尔赛德生物医学公司 用于进入眼睛的装置
CA3121759C (en) 2013-05-03 2024-01-02 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
WO2016100392A1 (en) 2014-12-15 2016-06-23 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of ocular disorders
US9855317B2 (en) 2015-04-27 2018-01-02 Reflex Medical, Inc. Systems and methods for sympathetic cardiopulmonary neuromodulation
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
CA3004886A1 (en) 2015-11-12 2017-05-18 Graybug Vision, Inc. Aggregating microparticles for medical therapy
WO2017091749A1 (en) 2015-11-25 2017-06-01 Incept, Llc Shape changing drug delivery devices and methods
US11246879B2 (en) 2016-02-09 2022-02-15 Tulai Therapeutics, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
WO2017192565A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经***的局部神经调节治疗败血症及相关炎性病况
IL264764B2 (en) 2016-08-12 2024-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a drug administration needle
US20200061357A1 (en) * 2017-05-02 2020-02-27 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
EP3621594A1 (en) * 2017-05-08 2020-03-18 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
US11160870B2 (en) 2017-05-10 2021-11-02 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
US20200345637A1 (en) * 2018-01-19 2020-11-05 Aiviva Biopharma, Inc. Suspension compositions of multi-target inhibitors
WO2019173361A2 (en) 2018-03-05 2019-09-12 The Schepens Eye Research Institute, Inc. A therapy for glaucoma and optic neuropathy by targeting colony stimulating factors
EP3810082A1 (en) * 2018-06-19 2021-04-28 Cella Therapeutics, LLC Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension
CN112638437B (zh) 2018-07-02 2023-12-08 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
CN110664771A (zh) * 2018-07-03 2020-01-10 江苏海悦康医药科技有限公司 一种含盐酸培唑帕尼的药物组合物及其制备方法
KR20210031721A (ko) * 2018-07-09 2021-03-22 리제너론 파마슈티칼스 인코포레이티드 하이드로겔에서의 방출 동력학의 조정
US20200337990A1 (en) * 2019-04-25 2020-10-29 Ocular Therapeutix, Inc. Hydrogel implants for lowering intraocular pressure
US20200337989A1 (en) * 2019-04-25 2020-10-29 Ocular Therapeutix, Inc. Ocular hydrogel tyrosine kinase inhibitor implants
EP4009857A4 (en) * 2019-08-06 2023-08-02 DOSE Medical Corporation CROSS-LINKED HYDROGEL BIOERODABLE IMPLANTS AND ASSOCIATED METHODS OF USE
CN110787127A (zh) * 2019-12-11 2020-02-14 龚雁 眼用温敏凝胶及其制备方法
ES2952213T3 (es) * 2020-02-06 2023-10-30 Ocular Therapeutix Inc Composiciones y métodos para tratar enfermedades oculares
CN115697333A (zh) * 2020-02-19 2023-02-03 科尼尔赛德生物医学公司 包含阿西替尼的组合物和治疗眼部疾病的方法
MX2022010333A (es) 2020-03-25 2022-12-08 Ocular Therapeutix Inc Implante ocular que contiene un inhibidor de la tirosina cinasa.
KR20230041708A (ko) 2020-07-16 2023-03-24 오큘라 테라퓨틱스, 인코포레이티드 글루코코르티코이드를 함유하는 안구 삽입물
US11331267B2 (en) 2020-09-24 2022-05-17 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine
KR20230097020A (ko) * 2020-10-27 2023-06-30 오큘라 테라퓨틱스, 인코포레이티드 활성제를 함유하는 안구 임플란트
WO2022217017A1 (en) * 2021-04-09 2022-10-13 The Regents Of The University Of California Fluidic infiltrative assemblies of three-dimensional hydrogels
CN115227639A (zh) * 2021-04-22 2022-10-25 武汉大学 一种温敏改性甲壳素水凝胶载局部麻药缓释镇痛体系、制备方法及应用
TW202327656A (zh) * 2021-09-15 2023-07-16 美商蓋爾密迪斯公司 包含皮質類固醇之gelma聚合物組合物
CN114191381B (zh) * 2021-11-29 2023-10-24 华南农业大学 一种温敏型模拟塑性脂肪、口腔质构及消化行为可控的双凝胶及其制备和应用
WO2023150580A2 (en) * 2022-02-01 2023-08-10 Ocular Therapeutix, Inc. A controlled release implant for biologics and corresponding methods of treatment
KR20230119448A (ko) * 2022-02-07 2023-08-16 아주대학교산학협력단 가교된 하이드로젤을 이용한 체내 주입형 하이드로젤 로드, 이의 제조방법 및 이의 생의학적 용도
WO2023220717A2 (en) * 2022-05-12 2023-11-16 The General Hospital Corporation Nanoparticle doped polyethylene glycol based gels and medical devices for drug delivery
CN115487169B (zh) * 2022-09-02 2023-09-29 金陵科技学院 一种载药铈纳米颗粒水凝胶及其制备方法与应用
CN115671036A (zh) * 2022-11-15 2023-02-03 上海交通大学医学院附属第九人民医院 用于治疗眼底和眼内疾病的凝胶药物

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
JPS585320A (ja) 1981-07-01 1983-01-12 Toray Ind Inc グラフト共重合体
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
BR9306038A (pt) 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
EP0696185B1 (en) 1993-04-28 1998-08-12 Focal, Inc. Apparatus, product and use related to intraluminal photothermoforming
WO1995005161A1 (en) 1993-08-13 1995-02-23 Vitaphore Corporation Hydrogel-based microsphere drug delivery systems
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
US6413539B1 (en) 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
DE69636626T2 (de) 1995-07-28 2007-08-30 Genzyme Corp., Cambridge Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
DK2111876T3 (da) 1995-12-18 2011-12-12 Angiodevice Internat Gmbh Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
AU743819B2 (en) 1997-10-27 2002-02-07 California Institute Of Technology Methods and pharmaceutical compositions for the closure of retinal breaks
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
DE10145910A1 (de) 2000-09-18 2002-06-20 Registrar University Of Delhi Ophtalmologische Formulierung mit verlangsamter Freisetzung und langer Verweildauer sowie Herstellungsverfahren hierfür
EP1370249A4 (en) 2001-02-26 2006-05-03 Univ Duke NEW DENDRITIC POLYMERS AND ITS BIOMEDICAL APPLICATIONS
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US6747090B2 (en) 2001-07-16 2004-06-08 Pharmacia Groningen Bv Compositions capable of forming hydrogels in the eye
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US20050256065A1 (en) 2004-01-26 2005-11-17 Permasight Method for stabilizing changes in corneal curvature in an eye by administering compositions containing stabilizing ophthalmic agents
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US7857849B2 (en) 2004-10-05 2010-12-28 The Board Of Trustees Of The Leland Stanford Junior Iniversity Artificial corneal implant
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US20100104654A1 (en) 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents
WO2010093873A2 (en) 2009-02-12 2010-08-19 Incept, Llc Drug delivery through hydrogel plugs
US20110189291A1 (en) * 2009-08-04 2011-08-04 Hu Yang Dendrimer hydrogels
CN102844054B (zh) 2009-12-15 2016-04-20 因赛普特有限责任公司 植入物和能生物降解的基准标记物
WO2011140519A2 (en) * 2010-05-07 2011-11-10 Medicus Biosciences, Llc In vivo gelling pharmaceutical pre-formulation
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US9194162B2 (en) 2011-07-14 2015-11-24 Inteva Products, Llc Vehicle door latch
US10226417B2 (en) * 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
KR102039468B1 (ko) 2011-12-05 2019-11-01 인셉트, 엘엘씨 의료용 유기젤 방법 및 조성물
ES2930433T3 (es) * 2013-03-05 2022-12-12 Univ Pittsburgh Commonwealth Sys Higher Education Hidrogel termosensible que contiene micropartículas de polímero para la administración ocular no invasiva de fármaco
US20160106587A1 (en) * 2014-10-16 2016-04-21 Incept, Llc Ocular gels or hydrogels and microinjectors
WO2016094646A1 (en) * 2014-12-10 2016-06-16 Incept, Llc Hydrogel drug delivery implants

Also Published As

Publication number Publication date
AU2023200212A1 (en) 2023-02-16
CA2985656A1 (en) 2016-11-17
US20160331738A1 (en) 2016-11-17
EP4279064A3 (en) 2024-02-28
WO2016183296A1 (en) 2016-11-17
EP3294212A4 (en) 2019-02-27
AU2016261925B2 (en) 2020-10-01
JP2018515529A (ja) 2018-06-14
US20220370419A1 (en) 2022-11-24
JP2021120395A (ja) 2021-08-19
AU2016261925A1 (en) 2017-11-30
JP7256226B2 (ja) 2023-04-11
AU2020294200B2 (en) 2023-02-02
AU2020294200A1 (en) 2021-01-28
JP2023055829A (ja) 2023-04-18
EP4279064A2 (en) 2023-11-22
EP3294212B1 (en) 2023-10-25
US11369591B2 (en) 2022-06-28
EP3294212A1 (en) 2018-03-21

Similar Documents

Publication Publication Date Title
HK1252836A1 (zh) 水凝膠藥物遞送
HK1245071A1 (zh) 用於回腸-空腸給藥的組合物
HK1247878A1 (zh) 藥物輸送裝置
HK1247875A1 (zh) 藥物輸送裝置
HK1248626A1 (zh) 藥物輸送裝置
IL257077B (en) A multi-ligand agent for drug delivery
EP3265064A4 (en) Drug delivery device
HK1246707A1 (zh) 藥物輸送裝置
HK1249034A1 (zh) 遞送媒介物
GB201515650D0 (en) Medicament delivery devices
HK1250370A1 (zh) 基於硼替佐米的遞送系統
PL3142740T3 (pl) Urządzenia do dostarczania leku
EP3185940A4 (en) Drug delivery apparatus
HUE057487T2 (hu) Gyógyszeradagoló rendszer
GB201715590D0 (en) Delivery system
IL246874A0 (en) drug delivery system
IL247106A0 (en) Material delivery system
EP3217947A4 (en) Kidney-targeted drug delivery systems
HK1247871A1 (zh) 藥物輸送裝置
HK1247870A1 (zh) 藥物輸送裝置
IL275664A (en) drug delivery system
GB2559449B (en) Hypoallergic drug delivery system
GB201615989D0 (en) Drug Delivery
GB201711779D0 (en) Delivery
GB201712561D0 (en) Delivery system