HK1248736A1 - 通過mhc細胞文庫檢測新免疫原性t細胞表位和分離新抗原-特異性t細胞受體的方法 - Google Patents

通過mhc細胞文庫檢測新免疫原性t細胞表位和分離新抗原-特異性t細胞受體的方法

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Publication number
HK1248736A1
HK1248736A1 HK18108647.0A HK18108647A HK1248736A1 HK 1248736 A1 HK1248736 A1 HK 1248736A1 HK 18108647 A HK18108647 A HK 18108647A HK 1248736 A1 HK1248736 A1 HK 1248736A1
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Hong Kong
Prior art keywords
cell
specific
mhc
immunogenic
library
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HK18108647.0A
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English (en)
Inventor
Felix Lorenz
Wolfgang Uckert
Christian Ellinger
Dolores Schendel
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Max Delbrueck Centrum Fue R Molekulare Medizin In Der Helmholtz Gemeinschaft
Helmholtz Zentrum Muenc Hen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh
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Application filed by Max Delbrueck Centrum Fue R Molekulare Medizin In Der Helmholtz Gemeinschaft, Helmholtz Zentrum Muenc Hen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh filed Critical Max Delbrueck Centrum Fue R Molekulare Medizin In Der Helmholtz Gemeinschaft
Publication of HK1248736A1 publication Critical patent/HK1248736A1/zh

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Cell Biology (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
HK18108647.0A 2015-03-16 2018-07-04 通過mhc細胞文庫檢測新免疫原性t細胞表位和分離新抗原-特異性t細胞受體的方法 HK1248736A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15159212 2015-03-16
PCT/EP2016/055518 WO2016146618A1 (en) 2015-03-16 2016-03-15 Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library

Publications (1)

Publication Number Publication Date
HK1248736A1 true HK1248736A1 (zh) 2018-10-19

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Country Status (12)

Country Link
US (2) US11001830B2 (zh)
EP (1) EP3271382B1 (zh)
JP (1) JP6944876B2 (zh)
CN (1) CN107636152B (zh)
AU (1) AU2016232280B2 (zh)
CA (1) CA2979493A1 (zh)
DK (1) DK3271382T3 (zh)
ES (1) ES2790725T3 (zh)
HK (1) HK1248736A1 (zh)
IL (1) IL254511B (zh)
SG (1) SG11201707540QA (zh)
WO (1) WO2016146618A1 (zh)

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SG11201707540QA (en) 2017-10-30
CN107636152A (zh) 2018-01-26
DK3271382T3 (da) 2020-05-04
KR20170126500A (ko) 2017-11-17
CN107636152B (zh) 2021-09-21
IL254511B (en) 2021-12-01
WO2016146618A1 (en) 2016-09-22
IL254511A0 (en) 2017-11-30
US20180073013A1 (en) 2018-03-15
US11001830B2 (en) 2021-05-11
AU2016232280B2 (en) 2018-05-31
JP2018509911A (ja) 2018-04-12
EP3271382A1 (en) 2018-01-24
US20210261947A1 (en) 2021-08-26
ES2790725T3 (es) 2020-10-29
CA2979493A1 (en) 2016-09-22
AU2016232280A1 (en) 2017-10-12
EP3271382B1 (en) 2020-02-12
JP6944876B2 (ja) 2021-10-06

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