HK1247098A1 - 通過核酸接種增强car-工程化的t細胞的作用 - Google Patents

通過核酸接種增强car-工程化的t細胞的作用

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Publication number
HK1247098A1
HK1247098A1 HK18106629.6A HK18106629A HK1247098A1 HK 1247098 A1 HK1247098 A1 HK 1247098A1 HK 18106629 A HK18106629 A HK 18106629A HK 1247098 A1 HK1247098 A1 HK 1247098A1
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HK
Hong Kong
Prior art keywords
engineered
enhancing
car
cells
nucleic acid
Prior art date
Application number
HK18106629.6A
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English (en)
Inventor
尤格.薩因
凱薩琳.萊因哈德
皮特拉.西蒙
卡羅利娜.安娜.姆羅茲
凱思琳.霍博姆
Original Assignee
拜恩科技細胞&基因治療有限公司
Tron-美因茨約翰尼斯‧古騰堡大學附屬轉化腫瘤醫學院公益有限公司
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Application filed by 拜恩科技細胞&基因治療有限公司, Tron-美因茨約翰尼斯‧古騰堡大學附屬轉化腫瘤醫學院公益有限公司 filed Critical 拜恩科技細胞&基因治療有限公司
Publication of HK1247098A1 publication Critical patent/HK1247098A1/zh

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HK18106629.6A 2015-05-11 2018-05-22 通過核酸接種增强car-工程化的t細胞的作用 HK1247098A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/060356 WO2016180467A1 (en) 2015-05-11 2015-05-11 Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination
PCT/EP2016/060332 WO2016180778A1 (en) 2015-05-11 2016-05-09 Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination

Publications (1)

Publication Number Publication Date
HK1247098A1 true HK1247098A1 (zh) 2018-09-21

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA40921A (fr) * 2014-11-05 2017-09-12 Abbvie Stemcentrx Llc Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation
WO2016180467A1 (en) * 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination
MX2018007204A (es) 2015-12-16 2018-12-11 Gritstone Oncology Inc Identificacion, fabricacion y uso de neoantigeno.
US10188749B2 (en) 2016-04-14 2019-01-29 Fred Hutchinson Cancer Research Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
EP3565535A4 (en) * 2017-01-05 2020-12-30 Fred Hutchinson Cancer Research Center SYSTEMS AND METHODS FOR IMPROVING THE EFFECTIVENESS OF A VACCINE
WO2018166589A1 (en) * 2017-03-15 2018-09-20 Biontech Cell & Gene Therapies Gmbh Antigen receptors and uses thereof
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
US11633365B2 (en) 2017-08-04 2023-04-25 Kyowa Kirin Co., Ltd. Nucleic acid-containing lipid nanoparticle
IL301638B1 (en) 2017-09-29 2024-05-01 Daiichi Sankyo Co Ltd Conjugation of an antibody with a pyrrolobenzodiazepine derivative
WO2019075112A1 (en) 2017-10-10 2019-04-18 Gritstone Oncology, Inc. IDENTIFICATION OF NEO-ANTIGENS USING HOT POINTS
US11885815B2 (en) 2017-11-22 2024-01-30 Gritstone Bio, Inc. Reducing junction epitope presentation for neoantigens
US11555070B2 (en) * 2018-03-08 2023-01-17 Phanes Therapeutics, Inc. Anti-claudin 18.2 antibodies and uses thereof
US20220033464A1 (en) * 2018-08-24 2022-02-03 La Jolla Institute For Immunology Methods and compositons for modulations of immune response
WO2020043903A1 (en) * 2018-08-31 2020-03-05 Invectys Method to assess car functionality
KR20210080435A (ko) * 2018-10-18 2021-06-30 다케다 야쿠힌 고교 가부시키가이샤 T 세포의 활성화/증식을 위한 방법
WO2020092387A1 (en) * 2018-10-30 2020-05-07 Nantbio, Inc. Self replicating rna system
EP3920960B1 (en) * 2019-02-08 2024-04-17 Biontech Cell & Gene Therapies Gmbh Treatment involving car-engineered t cells and cytokines
SG11202108339TA (en) 2019-02-08 2021-08-30 Biontech Cell & Gene Therapies Gmbh Chimeric antigen receptor-modified cells for the treatment of cldn6-expressing cancers
CN112237628A (zh) * 2019-07-17 2021-01-19 四川大学华西医院 靶向EBV的LMP2-mRNA纳米疫苗
TW202134285A (zh) 2019-11-26 2021-09-16 瑞士商諾華公司 Cd19和cd22嵌合抗原受體及其用途
WO2021129927A1 (en) * 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor
WO2022254337A1 (en) 2021-06-01 2022-12-08 Novartis Ag Cd19 and cd22 chimeric antigen receptors and uses thereof
IL309021A (en) * 2021-06-08 2024-01-01 Biontech Cell & Gene Therapies Gmbh Agents and methods for activation and targeting of immune effector cells
CN113687085A (zh) * 2021-08-27 2021-11-23 复旦大学附属中山医院 一种评估实体肿瘤Claudin18.2蛋白表达的方法和应用
WO2023105005A1 (en) 2021-12-09 2023-06-15 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
WO2024046572A1 (en) 2022-09-01 2024-03-07 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
AU2008216669B2 (en) 2007-02-15 2013-12-12 Mannkind Corporation A method for enhancing T cell response
EP2221375A1 (en) * 2009-02-20 2010-08-25 Ganymed Pharmaceuticals AG Methods and compositions for diagnosis and treatment of cancer
JP2010265327A (ja) * 2010-08-25 2010-11-25 Hokkaido Univ 癌抗原非特異的な標的化t細胞の製造方法及び医薬
DK3214091T3 (en) * 2010-12-09 2019-01-07 Univ Pennsylvania USE OF CHEMICAL ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF CANCER
WO2013143555A1 (en) 2012-03-26 2013-10-03 Biontech Ag Rna formulation for immunotherapy
TW201414837A (zh) * 2012-10-01 2014-04-16 Univ Pennsylvania 標定基質細胞以治療癌症之組合物和方法
US9657105B2 (en) * 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
WO2015014869A1 (en) * 2013-07-30 2015-02-05 Biontech Ag Tumor antigens for determining cancer therapy
JP6558699B2 (ja) 2013-10-01 2019-08-14 国立大学法人三重大学 抗原提示を促進するエピトープ間配列を含むt細胞誘導ワクチン
EA035259B1 (ru) * 2014-02-14 2020-05-21 Иммьюн Дизайн Корп. Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции
PT3126381T (pt) * 2014-04-01 2019-04-18 Ganymed Pharmaceuticals Ag Imunorrecetores e epítopos de células t específicos da claudina-6
WO2016180467A1 (en) * 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination

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