HK1245267A1 - 用於製備噻吩並-吲哚衍生物的不對稱方法 - Google Patents

用於製備噻吩並-吲哚衍生物的不對稱方法

Info

Publication number
HK1245267A1
HK1245267A1 HK18104697.8A HK18104697A HK1245267A1 HK 1245267 A1 HK1245267 A1 HK 1245267A1 HK 18104697 A HK18104697 A HK 18104697A HK 1245267 A1 HK1245267 A1 HK 1245267A1
Authority
HK
Hong Kong
Prior art keywords
thieno
preparation
asymmetric process
indoles derivatives
indoles
Prior art date
Application number
HK18104697.8A
Other languages
English (en)
Inventor
I‧貝里亞
M‧卡魯索
D‧多納蒂
P‧奧西尼
Original Assignee
內爾維阿諾醫學科學有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 內爾維阿諾醫學科學有限公司 filed Critical 內爾維阿諾醫學科學有限公司
Publication of HK1245267A1 publication Critical patent/HK1245267A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK18104697.8A 2015-07-21 2018-04-10 用於製備噻吩並-吲哚衍生物的不對稱方法 HK1245267A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15177734 2015-07-21
PCT/EP2016/066533 WO2017012924A1 (en) 2015-07-21 2016-07-12 Asymmetric process for the preparation of thieno-indoles derivatives

Publications (1)

Publication Number Publication Date
HK1245267A1 true HK1245267A1 (zh) 2018-08-24

Family

ID=53758045

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104697.8A HK1245267A1 (zh) 2015-07-21 2018-04-10 用於製備噻吩並-吲哚衍生物的不對稱方法

Country Status (9)

Country Link
US (2) US10174048B2 (zh)
EP (1) EP3325489B1 (zh)
JP (1) JP6898300B2 (zh)
CN (1) CN107849058B (zh)
DK (1) DK3325489T3 (zh)
ES (1) ES2770694T3 (zh)
HK (1) HK1245267A1 (zh)
RU (1) RU2726638C2 (zh)
WO (1) WO2017012924A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3325489T3 (da) 2015-07-21 2020-02-17 Nerviano Medical Sciences Srl Asymmetrisk fremgangsmåde til fremstilling af thien-indolderivater

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2344818A (en) 1998-12-16 2000-06-21 Pharmacia & Upjohn Spa Anti-tumour thieno-indole derivatives
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
JP2006507322A (ja) 2002-11-14 2006-03-02 シンタルガ・ビーブイ 多重自己脱離放出スペーサーとして構築されたプロドラッグ
RU2402548C2 (ru) * 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
CN104220442B (zh) * 2012-04-05 2016-11-23 内尔维阿诺医学科学有限公司 烷化剂
US9561290B2 (en) 2012-04-05 2017-02-07 Nerviano Medical Sciences S.R.L. Functionalized thieno-indole derivatives for the treatment of cancer
WO2015038426A1 (en) * 2013-09-13 2015-03-19 Asana Biosciences, Llc Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
DK3325489T3 (da) 2015-07-21 2020-02-17 Nerviano Medical Sciences Srl Asymmetrisk fremgangsmåde til fremstilling af thien-indolderivater

Also Published As

Publication number Publication date
EP3325489B1 (en) 2019-11-13
RU2018106096A (ru) 2019-08-22
CN107849058B (zh) 2020-10-02
ES2770694T3 (es) 2020-07-02
CN107849058A (zh) 2018-03-27
US10556913B2 (en) 2020-02-11
RU2018106096A3 (zh) 2019-11-27
US10174048B2 (en) 2019-01-08
EP3325489A1 (en) 2018-05-30
US20190071451A1 (en) 2019-03-07
US20180215768A1 (en) 2018-08-02
RU2726638C2 (ru) 2020-07-15
DK3325489T3 (da) 2020-02-17
WO2017012924A1 (en) 2017-01-26
JP6898300B2 (ja) 2021-07-07
JP2018520196A (ja) 2018-07-26

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