HK1244808A1 - 苯並哌啶類衍生物、其製備方法及其在醫藥上的應用 - Google Patents

苯並哌啶類衍生物、其製備方法及其在醫藥上的應用

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Publication number
HK1244808A1
HK1244808A1 HK18104375.7A HK18104375A HK1244808A1 HK 1244808 A1 HK1244808 A1 HK 1244808A1 HK 18104375 A HK18104375 A HK 18104375A HK 1244808 A1 HK1244808 A1 HK 1244808A1
Authority
HK
Hong Kong
Prior art keywords
preparation
medical use
benzopiperidine
derivative
benzopiperidine derivative
Prior art date
Application number
HK18104375.7A
Other languages
English (en)
Inventor
楊方龍
張羚
王春飛
何明勛
胡齊悅
賀峰
陶維康
孫飄揚
Original Assignee
江蘇恒瑞醫藥股份有限公司
上海恒瑞醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江蘇恒瑞醫藥股份有限公司, 上海恒瑞醫藥有限公司 filed Critical 江蘇恒瑞醫藥股份有限公司
Publication of HK1244808A1 publication Critical patent/HK1244808A1/zh

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
HK18104375.7A 2015-12-22 2018-04-02 苯並哌啶類衍生物、其製備方法及其在醫藥上的應用 HK1244808A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510975923 2015-12-22
PCT/CN2016/108367 WO2017107754A1 (zh) 2015-12-22 2016-12-02 苯并哌啶类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
HK1244808A1 true HK1244808A1 (zh) 2018-08-17

Family

ID=59088987

Family Applications (1)

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HK18104375.7A HK1244808A1 (zh) 2015-12-22 2018-04-02 苯並哌啶類衍生物、其製備方法及其在醫藥上的應用

Country Status (13)

Country Link
US (1) US10398689B2 (zh)
EP (1) EP3395809A4 (zh)
JP (1) JP2019503346A (zh)
KR (1) KR20180095564A (zh)
CN (1) CN107428721B (zh)
AU (1) AU2016379672A1 (zh)
BR (1) BR112018011817A2 (zh)
CA (1) CA3006683A1 (zh)
HK (1) HK1244808A1 (zh)
MX (1) MX2018007844A (zh)
RU (1) RU2727705C1 (zh)
TW (1) TWI732810B (zh)
WO (1) WO2017107754A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018007844A (es) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo.
TW201803870A (zh) 2016-04-20 2018-02-01 阿斯特捷利康公司 化學化合物
US10149839B2 (en) 2016-07-25 2018-12-11 Astrazeneca Ab Chemical compounds
DK3433256T3 (da) 2016-10-24 2019-10-28 Astrazeneca 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinolinderivat, der er anvendeligt til behandling af cancer
MY196317A (en) 2017-01-30 2023-03-24 Astrazeneca Ab Estrogen Receptor Modulators
WO2018233591A1 (zh) * 2017-06-20 2018-12-27 江苏恒瑞医药股份有限公司 一种苯并哌啶类衍生物的盐、其晶型及盐、其晶型的制备方法
CN109867659A (zh) * 2017-12-04 2019-06-11 江苏恒瑞医药股份有限公司 苯并哌啶类衍生物的制备方法
CN111601797B (zh) * 2018-05-23 2022-11-22 江苏恒瑞医药股份有限公司 苯并哌啶或杂芳基并哌啶类衍生物、其制备方法及其在医药上的应用
CN111205188A (zh) * 2018-11-22 2020-05-29 上海盛迪医药有限公司 环烷烃化合物的制备方法
CN111349076B (zh) * 2018-12-20 2022-07-26 江苏恒瑞医药股份有限公司 一种苯并哌啶类衍生物的l-赖氨酸盐的晶型及其制备方法
CN112830919B (zh) * 2019-11-22 2022-05-27 江苏恒瑞医药股份有限公司 苯并哌啶衍生物可药用盐及其制备方法

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EP1102755B1 (en) * 1998-08-07 2006-01-04 Chiron Corporation Substituted isoxazole derivatives as estrogen receptor modulators
JP3581103B2 (ja) * 1999-04-01 2004-10-27 ファイザー・プロダクツ・インク ソルビトールデヒドロゲナーゼ阻害薬としてのアミノピリミジン
EP1196163B1 (en) * 1999-07-06 2009-11-11 Endorecherche Inc. Pharmaceutical compositions for the treatment of insulin resistance
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
DE602004013427T2 (de) * 2003-02-28 2009-06-04 Schering Corp. Biaryltetrahydroisochinolin-piperidine als selektive mch-rezeptor-antagonisten zur behandlung von adipositas und verwandten erkrankungen
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JP6387023B2 (ja) 2013-02-28 2018-09-05 ティウムバイオ カンパニー、リミテッドＴｉｕｍＢｉｏ Ｃｏ．， Ｌｔｄ． 三環式化合物およびその使用
WO2014141292A2 (en) 2013-03-04 2014-09-18 Intas Pharmaceuticals Limited Endoxifen citrate polymorph and process for preparing the same
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JP2016522167A (ja) 2013-04-04 2016-07-28 ジ アドミニストレーターズ オブ ザ トゥレーン エデュケーショナル ファンド ヒト間葉系幹細胞に対するダイゼイン類似体の骨形成活性の向上
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WO2015092634A1 (en) * 2013-12-16 2015-06-25 Novartis Ag 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders
MX2018007844A (es) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo.

Also Published As

Publication number Publication date
JP2019503346A (ja) 2019-02-07
US10398689B2 (en) 2019-09-03
BR112018011817A2 (pt) 2018-12-04
KR20180095564A (ko) 2018-08-27
MX2018007844A (es) 2019-01-21
CN107428721B (zh) 2020-07-28
EP3395809A1 (en) 2018-10-31
EP3395809A4 (en) 2019-06-19
CN107428721A (zh) 2017-12-01
CA3006683A1 (en) 2017-06-29
US20180318284A1 (en) 2018-11-08
TWI732810B (zh) 2021-07-11
WO2017107754A1 (zh) 2017-06-29
TW201722929A (zh) 2017-07-01
RU2727705C1 (ru) 2020-07-23
AU2016379672A1 (en) 2018-06-21

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