HK1222664A1 - 硫酸乙酰肝素 - Google Patents

硫酸乙酰肝素

Info

Publication number
HK1222664A1
HK1222664A1 HK16110783.2A HK16110783A HK1222664A1 HK 1222664 A1 HK1222664 A1 HK 1222664A1 HK 16110783 A HK16110783 A HK 16110783A HK 1222664 A1 HK1222664 A1 HK 1222664A1
Authority
HK
Hong Kong
Prior art keywords
heparan sulphates
heparan
sulphates
Prior art date
Application number
HK16110783.2A
Other languages
English (en)
Inventor
‧納康比
‧酷爾
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of HK1222664A1 publication Critical patent/HK1222664A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
HK16110783.2A 2013-05-16 2016-09-12 硫酸乙酰肝素 HK1222664A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2013/000201 WO2014185858A1 (en) 2013-05-16 2013-05-16 Heparan sulphates

Publications (1)

Publication Number Publication Date
HK1222664A1 true HK1222664A1 (zh) 2017-07-07

Family

ID=51898698

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16110783.2A HK1222664A1 (zh) 2013-05-16 2016-09-12 硫酸乙酰肝素

Country Status (14)

Country Link
US (1) US10266612B2 (zh)
EP (1) EP2997047B1 (zh)
JP (1) JP6321786B2 (zh)
KR (1) KR102081267B1 (zh)
CN (1) CN105408361B (zh)
AU (1) AU2013389346B2 (zh)
BR (1) BR112015028710A2 (zh)
CA (1) CA2912710C (zh)
HK (1) HK1222664A1 (zh)
MX (1) MX2015015814A (zh)
NZ (1) NZ715203A (zh)
RU (1) RU2700877C2 (zh)
SG (1) SG11201509430WA (zh)
WO (1) WO2014185858A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9498494B2 (en) 2008-09-11 2016-11-22 Agency For Science, Technology And Research Glycosaminoglycans
GB0818255D0 (en) 2008-10-06 2008-11-12 Agency Science Tech & Res Isolation and identification of glycosaminoglycans
SG11201509430WA (en) 2013-05-16 2015-12-30 Agency Science Tech & Res Heparan sulphates
JP6709217B2 (ja) * 2014-11-19 2020-06-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 皮膚の修復および／または再生において使用するためのヘパラン硫酸
SG11201704086WA (en) 2014-11-19 2017-06-29 Agency Science Tech & Res Cosmetic use of heparan sulphate
US10723813B2 (en) * 2015-01-09 2020-07-28 Agency For Science, Technology And Research PDGF-B /PDGF-BB binding variants of heparan sulfates
BR112017023660A2 (pt) * 2015-05-05 2018-07-17 Mesoblast Int Sarl ensaio de potência
CA3008848A1 (en) * 2015-12-18 2017-06-22 Tega Therapeutics, Inc. Cellular glycosaminoglycan compositions and methods of making and using
EP3487989B1 (en) 2016-07-21 2022-05-18 SanBio, Inc. Msc growth predictor assays
US20200038430A1 (en) * 2016-12-16 2020-02-06 Tega Therapeutics, Inc. In vitro heparin and heparan sulfate compositions and methods of making and using
CN111721872B (zh) * 2020-06-24 2021-06-25 山东大学 一种肝素与硫酸乙酰肝素的鉴别方法及应用
KR102380735B1 (ko) * 2020-07-16 2022-04-01 (주)케어젠 제2형 중증급성호흡기증후군 코로나바이러스에 중화 활성을 갖는 펩타이드
MX2023000267A (es) * 2020-07-16 2023-02-13 Caregen Co Ltd Peptido con actividad neutralizante contra el coronavirus 2 del sindrome respiratorio agudo grave.

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0240399A (ja) * 1988-07-27 1990-02-09 Takeda Chem Ind Ltd 線維芽細胞増殖因子ムテインの複合体あるいは組成物
GB9017008D0 (en) * 1990-08-02 1990-09-19 Erba Carlo Spa Process for the enzymatic preparation of basic fibroblast growth factor
JP3390836B2 (ja) * 1991-04-16 2003-03-31 生化学工業株式会社 線維芽細胞増殖因子に結合性を有するオリゴ糖及びその製造法
NO921495L (no) 1991-04-16 1992-10-19 Seikagaku Kogyo Co Ltd Oligosakkarid og fremgangsmaate for dets fremstilling
GB9206291D0 (en) 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
WO1996023003A1 (en) * 1995-01-27 1996-08-01 Amrad Operations Pty. Ltd. A therapeutic molecule
AUPN261895A0 (en) * 1995-04-28 1995-05-18 Australian National University, The Preparation and use of sulfated oligosaccharides
US6492503B1 (en) * 1998-07-31 2002-12-10 Seikagaku Corporation Glycosaminoglycan and drug compositions containing the same
EP2343077B1 (en) * 2001-09-12 2013-07-17 SIGMA-TAU Research Switzerland S.A. Derivatives of totally N-desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
ATE407709T1 (de) * 2002-04-09 2008-09-15 Numat As Medizinische prothesevorrichtungen mit verbesserer biokompatibilität
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
JP2005290383A (ja) * 2004-04-05 2005-10-20 Seikagaku Kogyo Co Ltd ６−ｏ−硫酸化ｎ−アセチルヘパロサン及び造血幹細胞増殖助剤
US20060183712A1 (en) 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
WO2006098332A1 (ja) * 2005-03-14 2006-09-21 Seikagaku Corporation 硬組織形成促進剤
WO2010011185A1 (en) * 2008-07-21 2010-01-28 Agency For Science, Technology And Research Stem cells obtained through in vitro culture with heparan sulfate
GB0818255D0 (en) * 2008-10-06 2008-11-12 Agency Science Tech & Res Isolation and identification of glycosaminoglycans
GB2463474B (en) 2008-09-11 2012-05-02 Agency Science Tech & Res Therapeutic bone growth and regeneration
LT2679278T (lt) 2008-11-20 2017-12-27 Laboratori Derivati Organici S.P.A. Dermatologinės kompozicijos, apimančios heparano sulfatą
FR2940610B1 (fr) 2008-12-30 2011-05-06 Oreal Association de monosaccharides avec des derives c-glycosides et son utilisation en cosmetique
SG188756A1 (en) 2011-09-16 2013-04-30 Agency Science Tech & Res Glycosaminoglycans
SG11201509430WA (en) 2013-05-16 2015-12-30 Agency Science Tech & Res Heparan sulphates
JP6709217B2 (ja) 2014-11-19 2020-06-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 皮膚の修復および／または再生において使用するためのヘパラン硫酸
SG11201704086WA (en) 2014-11-19 2017-06-29 Agency Science Tech & Res Cosmetic use of heparan sulphate

Also Published As

Publication number Publication date
WO2014185858A1 (en) 2014-11-20
BR112015028710A2 (pt) 2017-09-19
RU2700877C2 (ru) 2019-09-23
US20160115251A1 (en) 2016-04-28
KR20160009674A (ko) 2016-01-26
US10266612B2 (en) 2019-04-23
CN105408361B (zh) 2019-09-06
JP6321786B2 (ja) 2018-05-09
EP2997047B1 (en) 2021-04-28
EP2997047A4 (en) 2016-11-23
AU2013389346B2 (en) 2019-02-21
MX2015015814A (es) 2016-06-02
CN105408361A (zh) 2016-03-16
KR102081267B1 (ko) 2020-02-25
SG11201509430WA (en) 2015-12-30
AU2013389346A1 (en) 2016-01-21
JP2016520697A (ja) 2016-07-14
CA2912710C (en) 2020-06-30
EP2997047A1 (en) 2016-03-23
RU2015153735A (ru) 2017-06-21
CA2912710A1 (en) 2014-11-20
NZ715203A (en) 2019-07-26

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