HK1217688A1 - -氯- 苯基- -茚- -酮及其用途 - Google Patents
-氯- 苯基- -茚- -酮及其用途Info
- Publication number
- HK1217688A1 HK1217688A1 HK16105696.8A HK16105696A HK1217688A1 HK 1217688 A1 HK1217688 A1 HK 1217688A1 HK 16105696 A HK16105696 A HK 16105696A HK 1217688 A1 HK1217688 A1 HK 1217688A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inden
- chloro
- phenyl
- Prior art date
Links
- VBFPHOYPKVNWMJ-RALIUCGRSA-N 6-chloro-3-(2,3,4,5,6-pentadeuteriophenyl)inden-1-one Chemical compound [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1C1=CC(=O)C2=CC(Cl)=CC=C12 VBFPHOYPKVNWMJ-RALIUCGRSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261739095P | 2012-12-19 | 2012-12-19 | |
DKPA201200811 | 2012-12-19 | ||
PCT/EP2013/077314 WO2014096151A2 (en) | 2012-12-19 | 2013-12-19 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1217688A1 true HK1217688A1 (zh) | 2017-01-20 |
Family
ID=59295365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16105696.8A HK1217688A1 (zh) | 2012-12-19 | 2016-05-18 | -氯- 苯基- -茚- -酮及其用途 |
Country Status (25)
Country | Link |
---|---|
US (1) | US9309165B2 (zh) |
EP (1) | EP2943460B1 (zh) |
JP (1) | JP6290921B2 (zh) |
KR (1) | KR102212096B1 (zh) |
CN (1) | CN104955796B (zh) |
AR (1) | AR094054A1 (zh) |
AU (1) | AU2013366693B2 (zh) |
BR (1) | BR112015014384A2 (zh) |
CA (1) | CA2893224C (zh) |
CL (1) | CL2015001720A1 (zh) |
CY (1) | CY1122715T1 (zh) |
DK (1) | DK2943460T3 (zh) |
HK (1) | HK1217688A1 (zh) |
HR (1) | HRP20200385T1 (zh) |
IL (1) | IL239097A (zh) |
LT (1) | LT2943460T (zh) |
MX (1) | MX365707B (zh) |
PL (1) | PL2943460T3 (zh) |
PT (1) | PT2943460T (zh) |
RS (1) | RS59982B1 (zh) |
RU (1) | RU2681221C2 (zh) |
SG (1) | SG11201504437SA (zh) |
SI (1) | SI2943460T1 (zh) |
WO (1) | WO2014096151A2 (zh) |
ZA (1) | ZA201504405B (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104628630B (zh) * | 2015-03-16 | 2017-01-18 | 哈尔滨工业大学 | 一种茚衍生物1‑吡啶基‑2‑溴茚及其合成方法 |
CN104892492A (zh) * | 2015-06-18 | 2015-09-09 | 哈尔滨工业大学 | 一种茚衍生物1-吡啶基-6-甲基茚及其合成方法 |
EP3774742A1 (en) * | 2018-04-06 | 2021-02-17 | H. Lundbeck A/S | Process for the preparation of 2,2-dimethylpiperazine |
EP3873885A1 (en) * | 2018-10-29 | 2021-09-08 | H. Lundbeck A/S | Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts |
US11535600B2 (en) | 2018-12-03 | 2022-12-27 | H. Lundbeck A/S | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine |
KR102051783B1 (ko) * | 2019-09-02 | 2019-12-03 | 부산대학교 산학협력단 | 3,10-이치환 벤조풀벤 유도체의 신규 합성방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE60571T1 (de) * | 1984-12-04 | 1991-02-15 | Sandoz Ag | Inden-analoga von mevalonolakton und ihre derivate. |
DE19538218A1 (de) * | 1995-10-13 | 1997-04-17 | Bayer Ag | Cyclopentan-1,3-dion-Derivate |
WO1999015524A1 (en) * | 1997-09-23 | 1999-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives |
SE9904850D0 (sv) * | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
BRPI0413555A (pt) | 2003-08-18 | 2006-10-17 | Lundbeck & Co As H | composto ou sal do mesmo, composição farmacêutica, uso de um composto ou sal, e, método para o tratamento de uma doença, para a fabricação de um composto e para a preparação de composto |
RU2366654C2 (ru) * | 2004-06-08 | 2009-09-10 | ЭнЭсЭйБи, ФИЛИАЛ АФ НЕУРОСЕРЧ СВИДЕН АБ, СВЕРИЙЕ | Новые дизамещенные фенилпиперидины/пиперазины в качестве модуляторов допаминовой нейротрансмиссии |
TWI453198B (zh) | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s)-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
EP1910322B1 (en) * | 2005-07-29 | 2012-09-05 | Concert Pharmaceuticals Inc. | Novel deuterated benzo [d][1,3]-dioxol derivatives as serotonin reuptake inhibitors |
WO2008086158A1 (en) * | 2007-01-04 | 2008-07-17 | Smithkline Beecham Corporation | Benzodihydroquinazoline as pi3 kinase inhibitors |
TW201102370A (en) | 2009-07-07 | 2011-01-16 | Lundbeck & Co As H | Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine |
KR101149529B1 (ko) * | 2009-09-11 | 2012-05-25 | 한국화학연구원 | 인덴온 유도체 및 이를 포함하는 약학적 조성물 |
EP2639216B1 (en) | 2010-11-09 | 2018-07-11 | Kaneka Corporation | Halogenated indenones and method for producing optically active indanones or optically active indanols by using same |
CN103429577A (zh) | 2011-01-07 | 2013-12-04 | H.隆德贝克有限公司 | 4-((1r,3s)-6-氯-3-苯基-茚满-1-基)-1,2,2-三甲基哌嗪和1-((1r,3s)-6-氯-3-苯基-茚满-1-基)-3,3-二甲基哌嗪的拆分方法 |
ES2719145T3 (es) * | 2011-06-20 | 2019-07-08 | H Lundbeck As | 1-Piperazino-3-fenil-indanos deuterados para el tratamiento de la esquizofrenia |
-
2013
- 2013-12-17 AR ARP130104787A patent/AR094054A1/es active IP Right Grant
- 2013-12-19 PL PL13811511T patent/PL2943460T3/pl unknown
- 2013-12-19 PT PT138115118T patent/PT2943460T/pt unknown
- 2013-12-19 US US14/653,318 patent/US9309165B2/en active Active
- 2013-12-19 LT LTEP13811511.8T patent/LT2943460T/lt unknown
- 2013-12-19 KR KR1020157015940A patent/KR102212096B1/ko active IP Right Grant
- 2013-12-19 DK DK13811511.8T patent/DK2943460T3/da active
- 2013-12-19 SI SI201331680T patent/SI2943460T1/sl unknown
- 2013-12-19 SG SG11201504437SA patent/SG11201504437SA/en unknown
- 2013-12-19 EP EP13811511.8A patent/EP2943460B1/en active Active
- 2013-12-19 MX MX2015007727A patent/MX365707B/es active IP Right Grant
- 2013-12-19 BR BR112015014384A patent/BR112015014384A2/pt not_active Application Discontinuation
- 2013-12-19 JP JP2015548555A patent/JP6290921B2/ja active Active
- 2013-12-19 AU AU2013366693A patent/AU2013366693B2/en active Active
- 2013-12-19 RU RU2015123308A patent/RU2681221C2/ru active
- 2013-12-19 CA CA2893224A patent/CA2893224C/en active Active
- 2013-12-19 CN CN201380065995.3A patent/CN104955796B/zh active Active
- 2013-12-19 WO PCT/EP2013/077314 patent/WO2014096151A2/en active Application Filing
- 2013-12-19 RS RS20200220A patent/RS59982B1/sr unknown
-
2015
- 2015-05-31 IL IL239097A patent/IL239097A/en active IP Right Grant
- 2015-06-18 CL CL2015001720A patent/CL2015001720A1/es unknown
- 2015-06-18 ZA ZA2015/04405A patent/ZA201504405B/en unknown
-
2016
- 2016-05-18 HK HK16105696.8A patent/HK1217688A1/zh unknown
-
2020
- 2020-03-05 CY CY20201100198T patent/CY1122715T1/el unknown
- 2020-03-09 HR HRP20200385TT patent/HRP20200385T1/hr unknown
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