HK1212988A1 - 作為 抑制劑的苯基乙基吡啶衍生物 - Google Patents

作為 抑制劑的苯基乙基吡啶衍生物

Info

Publication number
HK1212988A1
HK1212988A1 HK16101056.1A HK16101056A HK1212988A1 HK 1212988 A1 HK1212988 A1 HK 1212988A1 HK 16101056 A HK16101056 A HK 16101056A HK 1212988 A1 HK1212988 A1 HK 1212988A1
Authority
HK
Hong Kong
Prior art keywords
phenylethylpyridine
pde4
derivatives
pde
inhibitors
Prior art date
Application number
HK16101056.1A
Other languages
English (en)
Inventor
．阿瑪利
．阿曼尼
．瑞希卡波尼
．貝克-格倫
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of HK1212988A1 publication Critical patent/HK1212988A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
HK16101056.1A 2012-12-05 2016-01-29 作為 抑制劑的苯基乙基吡啶衍生物 HK1212988A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12195728 2012-12-05
PCT/EP2013/075520 WO2014086849A1 (en) 2012-12-05 2013-12-04 Phenylethylpyridine derivatives as pde4-inhibitors

Publications (1)

Publication Number Publication Date
HK1212988A1 true HK1212988A1 (zh) 2016-07-22

Family

ID=47323966

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101056.1A HK1212988A1 (zh) 2012-12-05 2016-01-29 作為 抑制劑的苯基乙基吡啶衍生物

Country Status (12)

Country Link
US (1) US9090606B2 (zh)
EP (1) EP2928879B1 (zh)
KR (1) KR20150090253A (zh)
CN (1) CN104822669A (zh)
AR (1) AR093797A1 (zh)
BR (1) BR112015012716A2 (zh)
CA (1) CA2893649A1 (zh)
HK (1) HK1212988A1 (zh)
RU (1) RU2015121044A (zh)
TR (1) TR201807181T4 (zh)
TW (1) TW201434817A (zh)
WO (1) WO2014086849A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR098622A1 (es) 2013-12-05 2016-06-01 Chiesi Farm Spa Derivados de benzhidrilo
US9133185B2 (en) 2013-12-05 2015-09-15 Chiesi Farmaceutici S.P.A Heteroaryl derivatives
WO2015185128A1 (en) * 2014-06-04 2015-12-10 Chiesi Farmaceutici S.P.A. 3,5-dichloro,4-(3,4-(cyclo-)alkoxyphenyl)- 2-carbonyloxy)ethyl)pyridine derivatives as pde-4 inhibitors
US9326976B2 (en) 2014-06-05 2016-05-03 Chiesi Farmaceutici S.P.A. Carbamate derivatives
US9763924B2 (en) * 2014-06-05 2017-09-19 Chiesi Farmaceutici S.P.A. Aminoester derivatives
MA42048A (fr) * 2015-05-07 2018-03-14 Chiesi Farm Spa Dérivés d'aminoesters
AR104822A1 (es) 2015-06-01 2017-08-16 Chiesi Farm Spa Derivado de aminoésteres
TW201710254A (zh) * 2015-06-01 2017-03-16 吉斯藥品公司 胺基酯衍生物
CN106699559B (zh) * 2015-11-12 2021-04-06 浙江九洲药业股份有限公司 一种洛索洛芬钠的制备工艺
CN107353195B (zh) * 2017-06-13 2020-10-13 迪嘉药业集团有限公司 一种洛索洛芬钠开环杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
EP2022783A1 (en) 2007-08-08 2009-02-11 CHIESI FARMACEUTICI S.p.A. "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors"
EP2070913A1 (en) 2007-12-14 2009-06-17 CHIESI FARMACEUTICI S.p.A. Ester derivatives as phosphodiesterase inhibitors
EP2110375A1 (en) 2008-04-14 2009-10-21 CHIESI FARMACEUTICI S.p.A. Phosphodiesterase-4 inhibitors belonging to the tertiary amine class
EP2216327A1 (en) 2009-02-06 2010-08-11 CHIESI FARMACEUTICI S.p.A. Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors
KR20130141534A (ko) * 2010-11-26 2013-12-26 키에시 파르마슈티시 엣스. 피. 에이. 글리신 유도체 및 무스카린 수용체 길항제로서의 이들의 용도
WO2012168226A1 (en) 2011-06-06 2012-12-13 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
WO2013045280A1 (en) 2011-09-26 2013-04-04 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
RU2637945C2 (ru) 2012-06-04 2017-12-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы

Also Published As

Publication number Publication date
CN104822669A (zh) 2015-08-05
TR201807181T4 (tr) 2018-06-21
US20140155428A1 (en) 2014-06-05
KR20150090253A (ko) 2015-08-05
CA2893649A1 (en) 2014-06-12
EP2928879A1 (en) 2015-10-14
BR112015012716A2 (pt) 2017-07-11
WO2014086849A1 (en) 2014-06-12
EP2928879B1 (en) 2018-02-28
RU2015121044A (ru) 2017-01-12
US9090606B2 (en) 2015-07-28
TW201434817A (zh) 2014-09-16
AR093797A1 (es) 2015-06-24

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