HK1208445A1 - 脂質合成的雜環調節劑 - Google Patents
脂質合成的雜環調節劑Info
- Publication number
- HK1208445A1 HK1208445A1 HK15109016.4A HK15109016A HK1208445A1 HK 1208445 A1 HK1208445 A1 HK 1208445A1 HK 15109016 A HK15109016 A HK 15109016A HK 1208445 A1 HK1208445 A1 HK 1208445A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lipid synthesis
- heterocyclic modulators
- modulators
- heterocyclic
- lipid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261667894P | 2012-07-03 | 2012-07-03 | |
US201261698511P | 2012-09-07 | 2012-09-07 | |
US201261699819P | 2012-09-11 | 2012-09-11 | |
US201361785933P | 2013-03-14 | 2013-03-14 | |
PCT/US2013/048950 WO2014008197A1 (en) | 2012-07-03 | 2013-07-01 | Heterocyclic modulators of lipid synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1208445A1 true HK1208445A1 (zh) | 2016-03-04 |
Family
ID=48790663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109016.4A HK1208445A1 (zh) | 2012-07-03 | 2015-09-15 | 脂質合成的雜環調節劑 |
Country Status (18)
Country | Link |
---|---|
US (3) | US9428502B2 (zh) |
EP (1) | EP2870150B1 (zh) |
JP (1) | JP6109934B2 (zh) |
KR (1) | KR102071095B1 (zh) |
CN (1) | CN104507928B (zh) |
AU (2) | AU2013286894B2 (zh) |
BR (1) | BR112015000106B1 (zh) |
CA (1) | CA2877999C (zh) |
ES (1) | ES2738823T3 (zh) |
HK (1) | HK1208445A1 (zh) |
IL (1) | IL236407A (zh) |
IN (1) | IN2015DN00137A (zh) |
MX (1) | MX364815B (zh) |
NZ (2) | NZ729443A (zh) |
PL (1) | PL2870150T3 (zh) |
SG (1) | SG11201500024YA (zh) |
WO (1) | WO2014008197A1 (zh) |
ZA (1) | ZA201409477B (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI522348B (zh) * | 2011-03-08 | 2016-02-21 | 3 V生物科技公司 | 脂質合成之雜環調節劑 |
WO2015105860A1 (en) * | 2014-01-07 | 2015-07-16 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
US9624173B2 (en) * | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
AU2013286894B2 (en) | 2012-07-03 | 2017-12-07 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
JP6820097B2 (ja) * | 2013-12-20 | 2021-01-27 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレータ及びその組み合わせ |
ES2833454T3 (es) * | 2014-08-15 | 2021-06-15 | Sagimet Biosciences Inc | Inhibidor de la ácido graso sintasa para su uso en el tratamiento de un cáncer farmacorresistente |
ES2838573T3 (es) * | 2014-08-21 | 2021-07-02 | Bristol Myers Squibb Co | Derivados de benzamida ligados como inhibidores potentes de ROCK |
EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
CA2979696A1 (en) * | 2015-03-19 | 2016-09-22 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
JP2018083758A (ja) * | 2015-03-25 | 2018-05-31 | 旭硝子株式会社 | ピラゾール誘導体の製造方法 |
MX2017016370A (es) | 2015-06-18 | 2018-04-11 | Cephalon Inc | Derivados de 4-bencil y 4-benzoil piperidina sustituidos. |
AU2016280255A1 (en) | 2015-06-18 | 2018-02-08 | Cephalon, Inc. | 1, 4-substituted piperidine derivatives |
JP6929285B2 (ja) | 2015-12-18 | 2021-09-01 | ヤンセン ファーマシューティカ エヌ.ベー. | 放射性標識mGluR2/3PETリガンド |
EP3389727B1 (en) | 2015-12-18 | 2020-08-12 | Janssen Pharmaceutica NV | Radiolabelled mglur2/3 pet ligands |
JP2019501222A (ja) | 2016-01-07 | 2019-01-17 | シーエス ファーマテック リミテッド | Egfrチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
WO2017119732A1 (en) | 2016-01-08 | 2017-07-13 | Samsung Electronics Co., Ltd. | Electronic device and operating method thereof |
EP3426772A4 (en) | 2016-03-09 | 2019-08-28 | Beijing Percans Oncology Co. Ltd. | TUMOR CELL SUSPENSION CULTURES AND ASSOCIATED METHODS |
JP2019533714A (ja) | 2016-11-11 | 2019-11-21 | 3−ブイ・バイオサイエンシーズ・インコーポレイテッド3−V Biosciences,Inc. | 脂質合成の複素環式モジュレーター |
CN107954852A (zh) * | 2017-11-30 | 2018-04-24 | 贝利化学(张家港)有限公司 | 2,5-二卤代苯甲酸的制备方法 |
CN111592495A (zh) * | 2020-07-06 | 2020-08-28 | 上海启讯医药科技有限公司 | 一种2-正丁基-4-氯-5甲酰基咪唑的制备方法 |
CN114988975A (zh) * | 2022-06-28 | 2022-09-02 | 江苏科技大学 | 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法 |
CN116482278B (zh) * | 2023-05-06 | 2024-02-09 | 广州清瑞生物科技有限责任公司 | 一种用于检测阿昔洛韦的对照品的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101321525B (zh) | 2005-12-01 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 作为l-cpt1抑制剂的杂芳基取代的哌啶衍生物 |
US7994222B2 (en) | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
WO2008075077A1 (en) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
HUE032459T2 (en) | 2011-03-08 | 2017-09-28 | 3-V Biosciences Inc | Heterocyclic modulators of lipid synthesis |
WO2015105860A1 (en) * | 2014-01-07 | 2015-07-16 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
TWI522348B (zh) * | 2011-03-08 | 2016-02-21 | 3 V生物科技公司 | 脂質合成之雜環調節劑 |
US20170119786A1 (en) * | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
US9624173B2 (en) * | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
AU2013286894B2 (en) * | 2012-07-03 | 2017-12-07 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
JP6820097B2 (ja) * | 2013-12-20 | 2021-01-27 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレータ及びその組み合わせ |
ES2833454T3 (es) * | 2014-08-15 | 2021-06-15 | Sagimet Biosciences Inc | Inhibidor de la ácido graso sintasa para su uso en el tratamiento de un cáncer farmacorresistente |
CA2979696A1 (en) * | 2015-03-19 | 2016-09-22 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
-
2013
- 2013-07-01 AU AU2013286894A patent/AU2013286894B2/en active Active
- 2013-07-01 PL PL13737098T patent/PL2870150T3/pl unknown
- 2013-07-01 JP JP2015520627A patent/JP6109934B2/ja active Active
- 2013-07-01 CA CA2877999A patent/CA2877999C/en active Active
- 2013-07-01 EP EP13737098.7A patent/EP2870150B1/en active Active
- 2013-07-01 NZ NZ729443A patent/NZ729443A/en unknown
- 2013-07-01 CN CN201380035602.4A patent/CN104507928B/zh active Active
- 2013-07-01 KR KR1020157002727A patent/KR102071095B1/ko active IP Right Grant
- 2013-07-01 SG SG11201500024YA patent/SG11201500024YA/en unknown
- 2013-07-01 BR BR112015000106-8A patent/BR112015000106B1/pt active IP Right Grant
- 2013-07-01 WO PCT/US2013/048950 patent/WO2014008197A1/en active Application Filing
- 2013-07-01 ES ES13737098T patent/ES2738823T3/es active Active
- 2013-07-01 MX MX2015000151A patent/MX364815B/es active IP Right Grant
- 2013-07-01 IN IN137DEN2015 patent/IN2015DN00137A/en unknown
- 2013-07-01 NZ NZ703162A patent/NZ703162A/en active IP Right Revival
-
2014
- 2014-12-22 ZA ZA2014/09477A patent/ZA201409477B/en unknown
- 2014-12-23 IL IL236407A patent/IL236407A/en active IP Right Grant
- 2014-12-31 US US14/587,908 patent/US9428502B2/en active Active
-
2015
- 2015-09-15 HK HK15109016.4A patent/HK1208445A1/zh unknown
-
2016
- 2016-07-05 US US15/201,824 patent/US10053450B2/en active Active
-
2017
- 2017-11-21 AU AU2017265027A patent/AU2017265027A1/en not_active Abandoned
-
2018
- 2018-03-30 US US15/941,387 patent/US10118913B2/en active Active
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