HK1207379A1 - 6-aminoindole derivatives as trp channel antagonists trp 6- - Google Patents

6-aminoindole derivatives as trp channel antagonists trp 6-

Info

Publication number
HK1207379A1
HK1207379A1 HK15108052.1A HK15108052A HK1207379A1 HK 1207379 A1 HK1207379 A1 HK 1207379A1 HK 15108052 A HK15108052 A HK 15108052A HK 1207379 A1 HK1207379 A1 HK 1207379A1
Authority
HK
Hong Kong
Prior art keywords
trp
channel antagonists
aminoindole derivatives
aminoindole
derivatives
Prior art date
Application number
HK15108052.1A
Other languages
English (en)
Chinese (zh)
Inventor
陳智
肖恩．戴維．埃里克森
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1207379A1 publication Critical patent/HK1207379A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
HK15108052.1A 2012-10-17 2015-08-19 6-aminoindole derivatives as trp channel antagonists trp 6- HK1207379A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261714957P 2012-10-17 2012-10-17
PCT/EP2013/071377 WO2014060328A1 (fr) 2012-10-17 2013-10-14 Dérivés 6-aminoindole à utiliser en tant qu'antagonistes du canal trp

Publications (1)

Publication Number Publication Date
HK1207379A1 true HK1207379A1 (en) 2016-01-29

Family

ID=49385243

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15108052.1A HK1207379A1 (en) 2012-10-17 2015-08-19 6-aminoindole derivatives as trp channel antagonists trp 6-

Country Status (11)

Country Link
US (1) US9388166B2 (fr)
EP (1) EP2909172A1 (fr)
JP (1) JP2015534957A (fr)
KR (1) KR20150070290A (fr)
CN (1) CN104755461A (fr)
BR (1) BR112015008564A2 (fr)
CA (1) CA2888369A1 (fr)
HK (1) HK1207379A1 (fr)
MX (1) MX2015004500A (fr)
RU (1) RU2015115677A (fr)
WO (1) WO2014060328A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物
TWI752155B (zh) 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
TWI674260B (zh) 2017-02-01 2019-10-11 德商菲尼克斯製藥股份有限公司 芳基烴受體(AhR)調節劑化合物
TW201835070A (zh) * 2017-02-21 2018-10-01 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270426A1 (en) * 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
SI1986633T1 (sl) * 2006-02-10 2015-03-31 Summit Corporation Plc Zdravljenje Duchennove mišične distrofije
JP2010535708A (ja) * 2007-08-03 2010-11-25 ビオマリン アイジーエー リミテッド デュシェンヌ型筋ジストロフィーの治療のための薬物併用
ME02418B (fr) * 2009-03-27 2016-09-20 Merck Sharp & Dohme Inhibiteurs de la réplication du virus de l'hépatite c
MX2012003539A (es) * 2009-09-24 2012-04-30 Hoffmann La Roche Derivados de indol como moduladores de los canales de calcio activados por la liberacion de calcio (crac).
WO2011091407A1 (fr) * 2010-01-25 2011-07-28 Glaxosmithkline Llp Antagonistes de trpv4
CN103201262B (zh) * 2010-08-20 2016-06-01 艾米拉医药股份有限公司 自分泌运动因子抑制剂及其用途

Also Published As

Publication number Publication date
RU2015115677A (ru) 2016-12-10
MX2015004500A (es) 2015-07-06
US9388166B2 (en) 2016-07-12
CA2888369A1 (fr) 2014-04-24
JP2015534957A (ja) 2015-12-07
BR112015008564A2 (pt) 2017-07-04
US20150218133A1 (en) 2015-08-06
WO2014060328A1 (fr) 2014-04-24
CN104755461A (zh) 2015-07-01
KR20150070290A (ko) 2015-06-24
EP2909172A1 (fr) 2015-08-26

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