HK1198586A1 - -二氟甲基- -二氫- 噁嗪- -胺衍生物 - Google Patents
-二氟甲基- -二氫- 噁嗪- -胺衍生物Info
- Publication number
- HK1198586A1 HK1198586A1 HK14112072A HK14112072A HK1198586A1 HK 1198586 A1 HK1198586 A1 HK 1198586A1 HK 14112072 A HK14112072 A HK 14112072A HK 14112072 A HK14112072 A HK 14112072A HK 1198586 A1 HK1198586 A1 HK 1198586A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- oxazin
- difluoromethyl
- dihydro
- amine derivatives
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11191997 | 2011-12-05 | ||
| PCT/EP2012/074351 WO2013083557A1 (en) | 2011-12-05 | 2012-12-04 | 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1198586A1 true HK1198586A1 (zh) | 2015-04-30 |
Family
ID=47278317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK14112072A HK1198586A1 (zh) | 2011-12-05 | 2014-12-01 | -二氟甲基- -二氫- 噁嗪- -胺衍生物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20140343048A1 (zh) |
| EP (1) | EP2788346B1 (zh) |
| JP (1) | JP6169095B2 (zh) |
| KR (1) | KR102060379B1 (zh) |
| CN (1) | CN103974951B (zh) |
| AU (1) | AU2012347397B2 (zh) |
| BR (1) | BR112014013310A2 (zh) |
| CA (1) | CA2852366C (zh) |
| EA (1) | EA023909B1 (zh) |
| ES (1) | ES2558604T3 (zh) |
| HK (1) | HK1198586A1 (zh) |
| IL (1) | IL232916A (zh) |
| MX (1) | MX357384B (zh) |
| MY (1) | MY165209A (zh) |
| PH (1) | PH12014501235A1 (zh) |
| SG (1) | SG11201402734XA (zh) |
| UA (1) | UA111749C2 (zh) |
| WO (1) | WO2013083557A1 (zh) |
| ZA (1) | ZA201404074B (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119161B (zh) | 2008-06-13 | 2015-07-08 | 盐野义制药株式会社 | 具有β分泌酶抑制作用的含硫杂环衍生物 |
| JPWO2011071135A1 (ja) | 2009-12-11 | 2013-04-22 | 塩野義製薬株式会社 | オキサジン誘導体 |
| CN102933564B (zh) | 2010-06-09 | 2015-07-22 | 詹森药业有限公司 | 用作β-分泌酶(BACE)抑制剂的5,6-二氢-2H-[1,4]噁嗪-3-基-胺衍生物 |
| EP2655376B1 (en) | 2010-12-22 | 2017-08-23 | Janssen Pharmaceutica NV | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
| KR102012675B1 (ko) | 2011-03-09 | 2019-08-21 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(BACE)의 억제제로서 유용한 3,4-디하이드로-피롤로[1,2-a]피라진-1-일아민 유도체 |
| EP2788335B1 (en) * | 2011-12-06 | 2016-04-13 | Janssen Pharmaceutica, N.V. | 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives for the treatment of disorders in which beta-secretase is involved |
| WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
| ES2697684T3 (es) | 2013-06-12 | 2019-01-25 | Janssen Pharmaceutica Nv | Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5 a]pirazina como inhibidores de beta-secretasa (BACE) |
| AU2014280122B2 (en) | 2013-06-12 | 2017-12-21 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2H)-one derivatives as inhibitors of beta-secretase (BACE) |
| CA2911693C (en) | 2013-06-12 | 2021-08-24 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
| AU2015367594C1 (en) | 2014-12-18 | 2019-10-31 | Janssen Pharmaceutica Nv | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase |
| US20230074641A1 (en) * | 2020-01-27 | 2023-03-09 | Silcotek Corp. | Biopharmaceutical manufacturing process and product |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077328A1 (es) | 2009-07-24 | 2011-08-17 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos |
| US8188079B2 (en) * | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| CN102933564B (zh) | 2010-06-09 | 2015-07-22 | 詹森药业有限公司 | 用作β-分泌酶(BACE)抑制剂的5,6-二氢-2H-[1,4]噁嗪-3-基-胺衍生物 |
| BR112013017779A2 (pt) * | 2011-01-12 | 2016-10-11 | Novartis Ag | derivados de oxazina e seu uso no tratamento de distúrbios neurológicos |
| JP2012147763A (ja) * | 2011-01-17 | 2012-08-09 | Toshitaka Kobayashi | 乾物穿孔具 |
| EP2788335B1 (en) * | 2011-12-06 | 2016-04-13 | Janssen Pharmaceutica, N.V. | 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives for the treatment of disorders in which beta-secretase is involved |
-
2012
- 2012-04-12 UA UAA201403502A patent/UA111749C2/uk unknown
- 2012-12-04 JP JP2014543939A patent/JP6169095B2/ja not_active Expired - Fee Related
- 2012-12-04 EA EA201491116A patent/EA023909B1/ru not_active IP Right Cessation
- 2012-12-04 CA CA2852366A patent/CA2852366C/en not_active Expired - Fee Related
- 2012-12-04 WO PCT/EP2012/074351 patent/WO2013083557A1/en active Application Filing
- 2012-12-04 AU AU2012347397A patent/AU2012347397B2/en not_active Ceased
- 2012-12-04 KR KR1020147013840A patent/KR102060379B1/ko active IP Right Grant
- 2012-12-04 MX MX2014006689A patent/MX357384B/es active IP Right Grant
- 2012-12-04 ES ES12794731.5T patent/ES2558604T3/es active Active
- 2012-12-04 BR BR112014013310A patent/BR112014013310A2/pt not_active Application Discontinuation
- 2012-12-04 US US14/362,523 patent/US20140343048A1/en not_active Abandoned
- 2012-12-04 EP EP12794731.5A patent/EP2788346B1/en active Active
- 2012-12-04 CN CN201280059719.1A patent/CN103974951B/zh not_active Expired - Fee Related
- 2012-12-04 MY MYPI2014700925A patent/MY165209A/en unknown
- 2012-12-04 SG SG11201402734XA patent/SG11201402734XA/en unknown
-
2014
- 2014-06-02 IL IL232916A patent/IL232916A/en active IP Right Grant
- 2014-06-02 PH PH12014501235A patent/PH12014501235A1/en unknown
- 2014-06-04 ZA ZA2014/04074A patent/ZA201404074B/en unknown
- 2014-12-01 HK HK14112072A patent/HK1198586A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL232916A (en) | 2016-07-31 |
| BR112014013310A2 (pt) | 2017-06-13 |
| PH12014501235B1 (en) | 2014-09-08 |
| ES2558604T3 (es) | 2016-02-05 |
| EP2788346B1 (en) | 2015-10-28 |
| AU2012347397B2 (en) | 2016-09-22 |
| NZ626662A (en) | 2015-05-29 |
| IL232916A0 (en) | 2014-08-03 |
| ZA201404074B (en) | 2016-10-26 |
| UA111749C2 (uk) | 2016-06-10 |
| KR20140107209A (ko) | 2014-09-04 |
| CN103974951B (zh) | 2016-04-13 |
| CN103974951A (zh) | 2014-08-06 |
| CA2852366C (en) | 2020-02-18 |
| MY165209A (en) | 2018-03-05 |
| MX2014006689A (es) | 2014-09-04 |
| JP6169095B2 (ja) | 2017-07-26 |
| US20140343048A1 (en) | 2014-11-20 |
| PH12014501235A1 (en) | 2014-09-08 |
| SG11201402734XA (en) | 2014-06-27 |
| EA023909B1 (ru) | 2016-07-29 |
| EA201491116A1 (ru) | 2014-12-30 |
| KR102060379B1 (ko) | 2019-12-30 |
| WO2013083557A1 (en) | 2013-06-13 |
| MX357384B (es) | 2018-07-06 |
| EP2788346A1 (en) | 2014-10-15 |
| JP2015500223A (ja) | 2015-01-05 |
| CA2852366A1 (en) | 2013-06-13 |
| AU2012347397A1 (en) | 2014-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2762476A4 (en) | 1,2,4-triazine-6-carboxamide derivative | |
| ZA201205788B (en) | 1,2,4-triazine-4-amine derivatives | |
| SI2694508T1 (sl) | Soli substituiranega 2,3-dihidroimidazo(1,2-C)kinazolina | |
| SG10201601802YA (en) | Dispiropyrrolidine derivatives | |
| HK1198586A1 (zh) | -二氟甲基- -二氫- 噁嗪- -胺衍生物 | |
| ZA201401884B (en) | New dihydroquinoline-2-one derivatives | |
| IL247640A0 (en) | History of heteroaryl piperidine | |
| EP2699091A4 (en) | 2 ', 6'-dioxo-3'-deutero-PIPERIDIN-3-YL-isoindoline COMPOUNDS | |
| HK1198535A1 (zh) | -氨基苯基 -烷基- -二氫- 噁嗪- -胺衍生物 | |
| IL231950B (en) | Aryl-quinoline derivatives | |
| HK1192757A1 (zh) | 取代的 -芳基- -苯基- -三嗪- -胺 | |
| EP2721029A4 (en) | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | |
| EP2671878A4 (en) | SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | |
| MY165626A (en) | 1,2,4,-triazolone derivative | |
| IL233001A0 (en) | New iso-ergoline histories | |
| SI2766342T1 (sl) | Derivati fenil-gvanidina | |
| HK1191942A1 (zh) | 新型六氫環戊二烯並吡咯酮，六氫吡咯並吡咯酮，八氫吡咯並吡啶酮和八氫吡啶酮化合物 | |
| IL232630A0 (en) | A method for the preparation of 6,2-difluoroacetophenones | |
| ZA201308049B (en) | 3-ureidoisoquinolin-8-yl derivatives | |
| ZA201209319B (en) | Cyclopropyl-indole derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20201210 |