HK1158312A1 - 基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制 - Google Patents
基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制Info
- Publication number
- HK1158312A1 HK1158312A1 HK11112579.1A HK11112579A HK1158312A1 HK 1158312 A1 HK1158312 A1 HK 1158312A1 HK 11112579 A HK11112579 A HK 11112579A HK 1158312 A1 HK1158312 A1 HK 1158312A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nucleic acid
- sample preparation
- acid sample
- highly simplified
- based nucleic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12664508P | 2008-05-05 | 2008-05-05 | |
| PCT/US2009/002809 WO2009137059A1 (en) | 2008-05-05 | 2009-05-05 | Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1158312A1 true HK1158312A1 (zh) | 2012-07-13 |
Family
ID=41264882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK11112579.1A HK1158312A1 (zh) | 2008-05-05 | 2011-11-21 | 基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9207236B2 (zh) |
| EP (2) | EP3067694A1 (zh) |
| JP (2) | JP2011522521A (zh) |
| CN (1) | CN102084238B (zh) |
| CA (1) | CA2723536C (zh) |
| HK (1) | HK1158312A1 (zh) |
| WO (1) | WO2009137059A1 (zh) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| JP2011522521A (ja) | 2008-05-05 | 2011-08-04 | ロスアラモス ナショナル セキュリティ，エルエルシー | 高度に単純化された側方流動ベースの核酸サンプル調製および受動的流体流動制御 |
| US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
| US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
| US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
| US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
| US9500645B2 (en) * | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
| US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
| WO2013134739A1 (en) | 2012-03-08 | 2013-09-12 | Cyvek, Inc. | Microfluidic assay operating system and methods of use |
| US20120288961A1 (en) * | 2009-12-22 | 2012-11-15 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| US9423398B2 (en) * | 2011-02-08 | 2016-08-23 | The Board Of Regents For Oklahoma State University | Apparatus and method for biologic sample rapid collection and recovery device, and convenient storage |
| JP5978287B2 (ja) | 2011-03-22 | 2016-08-24 | サイヴェク・インコーポレイテッド | マイクロ流体装置並びに製造及び使用の方法 |
| EP2699700B8 (en) * | 2011-04-20 | 2016-08-24 | Mesa Biotech, Inc. | Integrated device for nucleic acid detection and identification |
| US9528987B2 (en) | 2011-06-23 | 2016-12-27 | University Of Washington | Reagent patterning in capillarity-based analyzers and associated systems and methods |
| WO2013067272A1 (en) * | 2011-11-04 | 2013-05-10 | Diagnostics For All, Inc. | Low cost, disposable molecular diagnostic devices |
| US9874556B2 (en) * | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| US9724689B2 (en) * | 2012-11-20 | 2017-08-08 | Detectachem Llc | Colorimetric test system designed to control flow of simultaneously released chemicals to a target area |
| CN105050720A (zh) | 2013-01-22 | 2015-11-11 | 华盛顿大学商业化中心 | 顺序递送流体体积和相关的设备、***和方法 |
| US10031100B2 (en) * | 2013-03-13 | 2018-07-24 | Robert Bosch Gmbh | Generation of pH/temperature/ionic gradients on a lateral flow platform with multiple parallel lanes for modulating protein interactions |
| US20150167065A1 (en) * | 2013-12-13 | 2015-06-18 | General Electric Company | Isothermal amplification of nucleic acids within a porous matrix |
| CN110850081B (zh) | 2014-03-07 | 2024-02-06 | 加利福尼亚大学董事会 | 用于整合分析物提取、浓缩和检测的装置 |
| US10195610B2 (en) | 2014-03-10 | 2019-02-05 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
| SG11201609008PA (en) * | 2014-04-29 | 2016-11-29 | Accudx Corp | A novel affinity matrix and devices for isolation and purification of rna and dna for point of care molecular devices |
| US10472620B2 (en) | 2014-07-01 | 2019-11-12 | General Electric Company | Method, substrate and device for separating nucleic acids |
| US10870845B2 (en) | 2014-07-01 | 2020-12-22 | Global Life Sciences Solutions Operations UK Ltd | Methods for capturing nucleic acids |
| US9593368B2 (en) | 2014-07-01 | 2017-03-14 | General Electric Company | Methods for amplifying nucleic acids on substrates |
| EP3204770A1 (en) * | 2014-10-07 | 2017-08-16 | 3M Innovative Properties Company | Method of detecting an analyte using chromatographic enrichment |
| EP3204769A1 (en) | 2014-10-07 | 2017-08-16 | 3M Innovative Properties Company | Method of detecting a microorganism using chromatographic enrichment |
| EP3230477B1 (en) * | 2014-12-11 | 2024-01-17 | Global Life Sciences Solutions Operations UK Ltd | Methods for capturing nucleic acids |
| WO2016106111A1 (en) * | 2014-12-23 | 2016-06-30 | Ge Healthcare Uk Limited | Methods and reagents for reverse-transcription polymerase chain reaction |
| CN114958990A (zh) | 2014-12-31 | 2022-08-30 | 维斯比医学公司 | 使用分子诊断测试装置检测靶核酸的方法 |
| US20160310948A1 (en) | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic Test Cassette |
| WO2016187160A1 (en) * | 2015-05-16 | 2016-11-24 | Godx, Inc. | Point of need testing device and methods of use thereof |
| WO2017041030A1 (en) | 2015-09-04 | 2017-03-09 | The Regents Of The University Of California | Methods and devices for analyte collection, extraction, concentration, and detection for clinical applications |
| US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
| US10656151B2 (en) * | 2016-01-29 | 2020-05-19 | Ortho-Clinical Diagnostics, Inc. | Air capillary vent for a lateral flow assay device |
| US10596566B2 (en) * | 2016-04-15 | 2020-03-24 | Mauk et al. | Capillary-action microfluidic device for point-of-care diagnostics |
| US10987674B2 (en) | 2016-04-22 | 2021-04-27 | Visby Medical, Inc. | Printed circuit board heater for an amplification module |
| WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| KR102592388B1 (ko) * | 2016-06-09 | 2023-10-20 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 종이-기반 면역검정법에서 사용하기 위한 바이오마커 농축 및 신호 증폭, 그리고 dna의 추출, 농축 및 증폭을 위한 단일 플랫폼 |
| WO2018005710A1 (en) | 2016-06-29 | 2018-01-04 | Click Diagnostics, Inc. | Devices and methods for the detection of molecules using a flow cell |
| WO2018039139A1 (en) | 2016-08-22 | 2018-03-01 | The Regents Of The University Of California | Hydrogel platform for aqueous two-phase concentration of a target to enhance its detection |
| DE102017200183A1 (de) * | 2017-01-09 | 2018-07-12 | Robert Bosch Gmbh | Nucleinsäurebasierter Lateral Flow-Assay für schnelle Fleischspeziesbestimmung |
| WO2018183211A1 (en) | 2017-03-27 | 2018-10-04 | The Regents Of The University Of California | Semi-quantitative lateral-flow immunoassay for the detection of csf leaks |
| WO2019094784A1 (en) | 2017-11-09 | 2019-05-16 | Click Diagnostics, Inc. | Portable molecular diagnostic device and methods for the detection of target viruses |
| US11746372B2 (en) | 2017-12-01 | 2023-09-05 | Godx, Inc. | Rapid nucleic acids separation and sample preparation via hollow-centered silica microsphere |
| KR102037411B1 (ko) * | 2018-02-09 | 2019-10-28 | 광주과학기술원 | 측방 유동 분리 기반의 dna 추출 디바이스 |
| CN111801579A (zh) * | 2018-03-02 | 2020-10-20 | 赢创运营有限公司 | 用于检测动物中的肠屏障衰竭的体外方法 |
| CN109187448B (zh) * | 2018-07-25 | 2021-08-13 | 西安交通大学 | 一种多目标物碟式侧流试纸芯片及其激光切割制备方法、使用方法、应用和检测装置 |
| GB201819417D0 (en) * | 2018-11-29 | 2019-01-16 | Quantumdx Group Ltd | Vacuum-assisted drying of filters in microfluidic systems |
| WO2020264210A1 (en) * | 2019-06-25 | 2020-12-30 | The Board Of Trustees Of The University Of Illinois | Methods and devices for identifying pathogens and antibodies and treatment device therefore |
| EP4085149A4 (en) | 2020-01-03 | 2024-03-06 | Visby Medical, Inc. | ANTIBIOTIC SUSCEPTIBILITY TESTING DEVICES AND METHODS |
| AU2021261343A1 (en) | 2020-04-22 | 2022-11-03 | President And Fellows Of Harvard College | Isothermal methods, compositions, kits, and systems for detecting nucleic acids |
| US20230227888A1 (en) * | 2020-05-12 | 2023-07-20 | Godx, Inc. | Point of need diagnostic device and methods of use thereof |
| WO2022075981A1 (en) * | 2020-10-07 | 2022-04-14 | Hewlett-Packard Development Company, L.P. | Fluid-wicking membranes |
Family Cites Families (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3667607A (en) * | 1970-11-27 | 1972-06-06 | Baker Chem Co J T | Chromatographic material |
| US4235601A (en) * | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4960691A (en) * | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| IE69047B1 (en) * | 1989-03-23 | 1996-08-07 | Gary Harold Gregory Hen Thorpe | Liquid transfer devices |
| US5541099A (en) * | 1989-08-10 | 1996-07-30 | Life Technologies, Inc. | Cloning and expression of T5 DNA polymerase reduced in 3'-to-5' exonuclease activity |
| US5225163A (en) | 1989-08-18 | 1993-07-06 | Angenics, Inc. | Reaction apparatus employing gravitational flow |
| DE69032425T2 (de) | 1990-05-11 | 1998-11-26 | Microprobe Corp., Bothell, Wash. | Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden |
| US6007999A (en) * | 1991-07-31 | 1999-12-28 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| GB9123922D0 (en) | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer devices |
| JP2832117B2 (ja) * | 1991-11-29 | 1998-12-02 | キヤノン株式会社 | サンプル測定デバイス及びサンプル測定システム |
| WO1993014217A1 (en) * | 1992-01-10 | 1993-07-22 | Life Technologies, Inc. | Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules |
| US6555349B1 (en) * | 1993-01-22 | 2003-04-29 | Cornell Research Foundation, Inc. | Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase |
| US5432065A (en) | 1993-03-30 | 1995-07-11 | United States Biochemical Corporation | Cycle sequencing with non-thermostable DNA polymerases |
| GB9307319D0 (en) * | 1993-04-07 | 1993-06-02 | British Tech Group | Liquid transfer devices |
| JPH0775600A (ja) * | 1993-09-08 | 1995-03-20 | Toyobo Co Ltd | 標的核酸の検出法 |
| KR100230718B1 (ko) | 1994-03-16 | 1999-11-15 | 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 | 등온 가닥 변위 핵산 증폭법 |
| US6037127A (en) * | 1994-03-31 | 2000-03-14 | E. I. Du Pont De Nemours And Company | Method for detection of non-denatured nucleic acid fragments |
| GB9416002D0 (en) * | 1994-08-08 | 1994-09-28 | Univ Cranfield | Fluid transport device |
| GB9502112D0 (en) * | 1995-02-03 | 1995-03-22 | British Biocell Int | Assay device and method |
| US5989813A (en) | 1995-07-13 | 1999-11-23 | Molecular Innovations, Inc. | Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles |
| US20040110167A1 (en) | 1995-07-13 | 2004-06-10 | Gerdes John C. | Lateral flow system for nucleic acid detection |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| US6750031B1 (en) | 1996-01-11 | 2004-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Displacement assay on a porous membrane |
| EP0880598A4 (en) * | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5741647A (en) | 1996-02-16 | 1998-04-21 | Tam; Joseph Wing On | Flow through nucleic acid hybridisation uses thereof and a device thereof |
| US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
| CA2276251A1 (en) | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
| US5922617A (en) * | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
| US6190612B1 (en) | 1998-01-21 | 2001-02-20 | Bayer Corporation | Oxygen sensing membranes and methods of making same |
| JP4623536B2 (ja) | 1998-03-30 | 2011-02-02 | オラシュア テクノロジーズ，インコーポレイティド | 口腔液の検定用採集装置 |
| US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
| US6207379B1 (en) | 1998-09-11 | 2001-03-27 | One Lambda | Method for amplification of DNA |
| GB9821526D0 (en) * | 1998-10-02 | 1998-11-25 | Genosis Inc | Capture assay |
| US6261779B1 (en) * | 1998-11-10 | 2001-07-17 | Bio-Pixels Ltd. | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
| AU1821700A (en) | 1998-11-18 | 2000-06-05 | Orchid Biosciences, Inc. | One-step nucleic acid dipstick device with movable membrane |
| WO2000031538A1 (en) * | 1998-11-23 | 2000-06-02 | Praxsys Biosystems, Inc. | Improved lateral flow assays |
| US6416642B1 (en) * | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US6300069B1 (en) | 1999-05-03 | 2001-10-09 | Qiagen Gmbh | Generation and amplification of nucleic acids from ribonucleic acids |
| WO2001026813A2 (en) | 1999-10-08 | 2001-04-19 | Micronics, Inc. | Microfluidics without electrically of mechanically operated pumps |
| US6471916B1 (en) * | 1999-11-09 | 2002-10-29 | Packard Instrument Company | Apparatus and method for calibration of a microarray scanning system |
| US6875619B2 (en) * | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| US6468749B1 (en) * | 2000-03-30 | 2002-10-22 | Quark Biotech, Inc. | Sequence-dependent gene sorting techniques |
| GB0016814D0 (en) * | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (3) |
| GB0016813D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (4) |
| EP1362122A2 (en) * | 2000-09-12 | 2003-11-19 | TransGenetics Incorporated | Microarrayed organization of transcription factor target genes |
| AU2001297014A1 (en) * | 2000-10-10 | 2002-04-22 | Aviva Biosciences Corporation | An integrated biochip system for sample preparation and analysis |
| CN1182394C (zh) | 2000-12-26 | 2004-12-29 | 松下电器产业株式会社 | 特异结合分析方法及用于其的特异结合分析装置 |
| IL153504A0 (en) * | 2001-03-09 | 2003-07-06 | Nugen Technologies Inc | Methods and compositions for amplification of rna sequences |
| WO2002072773A2 (en) * | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| WO2002081729A2 (en) * | 2001-04-06 | 2002-10-17 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| WO2002090961A2 (en) | 2001-05-03 | 2002-11-14 | Immunetics, Inc. | Systems and methods for detection of analytes in biological fluids |
| ES2344078T3 (es) * | 2001-06-05 | 2010-08-17 | Curevac Gmbh | Arnm estabilizado con un contenido de g/c aumentado para la terapia genetica. |
| US20030044862A1 (en) | 2001-06-22 | 2003-03-06 | The Board Of Trustees Of The Leland Stanford Jr. University | Diagnostic marker for tumor hypoxia and prognosis |
| US7790439B2 (en) | 2001-08-09 | 2010-09-07 | Panasonic Corporation | Biosensor and measurement method |
| US6916541B2 (en) | 2001-09-07 | 2005-07-12 | Penn State Research Foundation | Modified substrates for the attachment of biomolecules |
| KR100488281B1 (ko) | 2001-09-15 | 2005-05-10 | 아람 바이오시스템 주식회사 | 열 대류를 이용한 염기서열 증폭 방법 및 장치 |
| WO2003046508A2 (en) * | 2001-11-09 | 2003-06-05 | Biomicroarrays, Inc. | High surface area substrates for microarrays and methods to make same |
| CA2469464A1 (en) * | 2001-12-07 | 2003-06-19 | Dyax Corporation | Method and apparatus for washing magnetically responsive particles |
| US8110351B2 (en) * | 2002-01-16 | 2012-02-07 | Invitrogen Dynal As | Method for isolating nucleic acids and protein from a single sample |
| US7772383B2 (en) | 2002-01-25 | 2010-08-10 | The Trustees Of Princeton University | Chemical PCR: Compositions for enhancing polynucleotide amplification reactions |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| US20060160078A1 (en) * | 2002-07-12 | 2006-07-20 | Cardy Donald L N | Lateral flow assay device and method |
| DE03707568T1 (de) | 2002-07-23 | 2005-11-10 | Microban Products Co. | Antimikrobielles melaminharz und daraus hergestellte produkte |
| US20040064435A1 (en) | 2002-07-26 | 2004-04-01 | Ahmad-Maher Moubayed | Clinical assessment and diagnostic tool for use with peristaltic pump |
| US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
| WO2004027025A2 (en) * | 2002-09-20 | 2004-04-01 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| US7662594B2 (en) * | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| US20050221281A1 (en) | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| CA2513880A1 (en) * | 2003-01-21 | 2004-08-05 | Micronics Inc. | Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing |
| TWI333545B (en) * | 2003-04-02 | 2010-11-21 | Cholestech Corp | Adhered membranes retaining porosity and biological activity |
| FR2856046B1 (fr) | 2003-06-16 | 2005-07-29 | Biomerieux Sa | Microvanne fluidique a ouverture par commande electrique |
| US7722817B2 (en) | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| AU2004317007A1 (en) * | 2003-09-03 | 2005-09-15 | Life Patch International, Inc. | Personal diagnostic devices and related methods |
| US7354706B2 (en) * | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| US20070039835A1 (en) | 2003-09-15 | 2007-02-22 | Diagno Swiss S.A. | Microfluidic flow monitoring device |
| JP2005110621A (ja) | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| WO2005051295A2 (en) * | 2003-11-21 | 2005-06-09 | Anp Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
| JP4250523B2 (ja) * | 2003-12-25 | 2009-04-08 | 株式会社東芝 | マイクロリアクタ、分析システム、分析方法、反応システム、反応方法、分離システム、分離方法 |
| JP4980884B2 (ja) * | 2004-03-30 | 2012-07-18 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 側方流動方式、材料、及び方法 |
| US20050250141A1 (en) * | 2004-03-30 | 2005-11-10 | Lambert James L | Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots |
| KR101270676B1 (ko) | 2004-04-07 | 2013-06-07 | 액세스 바이오 인코포레이티드 | 핵산 탐지 키트 |
| US8173078B2 (en) | 2004-04-28 | 2012-05-08 | Industrial Technology Research Institute | Gravity-driven micropump |
| US7273590B2 (en) | 2004-04-29 | 2007-09-25 | Industrial Technology Research Institute | gravity-driven apparatus and method for control of microfluidic devices |
| US7796266B2 (en) * | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
| EP1804059A2 (en) * | 2004-05-21 | 2007-07-04 | Atonomics A/S | Surface acoustic wave sensor comprising a hydrogel |
| SE527036C2 (sv) * | 2004-06-02 | 2005-12-13 | Aamic Ab | Analysanordning med reglerat flöde och motsvarande förfarande |
| AU2004325277A1 (en) | 2004-11-30 | 2006-06-08 | Global Technologies (Nz) Ltd | Method of sample analysis and apparatus therefor |
| US20060127886A1 (en) * | 2004-12-15 | 2006-06-15 | Kaylor Rosann M | Sample-efficient lateral flow immunoassay |
| DK1843850T3 (en) | 2005-01-31 | 2015-12-07 | Realbio Technologies Ltd | LATERAL FLOW STEERING CAPILLAR DEVICE |
| US7396689B2 (en) | 2005-02-04 | 2008-07-08 | Decision Biomarkers Incorporated | Method of adjusting the working range of a multi-analyte assay |
| WO2006098804A2 (en) * | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US20060240569A1 (en) * | 2005-04-20 | 2006-10-26 | Becton, Dickinson And Company | Semi-quantitative immunochromatographic device |
| US7439079B2 (en) | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| WO2006122311A2 (en) * | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Microfluidic chip |
| KR101255400B1 (ko) * | 2005-05-23 | 2013-04-17 | 파디아 에이비 | 2 단계 횡 유동 검사 방법 및 장치 |
| US20070015166A1 (en) * | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
| JP2009506788A (ja) | 2005-09-06 | 2009-02-19 | ジェン−プローブ・インコーポレーテッド | 核酸の等温増幅のための方法、組成物及びキット |
| JP2007071711A (ja) * | 2005-09-07 | 2007-03-22 | Fujifilm Corp | 分析チップ |
| CN101400993A (zh) | 2005-11-10 | 2009-04-01 | 阿普尔拉股份有限公司 | 包括多孔聚合物电极的微流体*** |
| WO2008002462A2 (en) | 2006-06-23 | 2008-01-03 | Micronics, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
| US20090053773A1 (en) | 2006-01-20 | 2009-02-26 | Toppan Printing Co., Ltd. | Reaction Container and Dna Amplification Reaction Method |
| US7537917B2 (en) | 2006-03-31 | 2009-05-26 | Collins Michael J | Microwave assisted PCR amplification of DNA |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| JP2008148690A (ja) * | 2006-11-22 | 2008-07-03 | Fujifilm Corp | マイクロチップを用いた核酸増幅方法およびマイクロチップ、それを用いた核酸増幅システム |
| EP1972938B1 (de) * | 2007-03-19 | 2014-05-14 | Ivoclar Vivadent | Teststreifen für die Bestimmung des Kariesrisikos |
| US8105783B2 (en) * | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| JP5531367B2 (ja) | 2007-08-01 | 2014-06-25 | ダナ−ファーバー キャンサー インスチテュート | 標的配列の濃縮 |
| TW200909338A (en) | 2007-08-23 | 2009-03-01 | Ind Tech Res Inst | Autonomous microfluidic apparatus |
| US9409166B2 (en) | 2007-12-10 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| AU2009216635B2 (en) * | 2008-02-22 | 2015-08-13 | Orion Diagnostica Oy | Method and device for detection of an analyte |
| AU2009222181B2 (en) | 2008-02-29 | 2014-12-04 | Northwestern University | Barriers for facilitating biological reactions |
| WO2009137509A2 (en) | 2008-05-05 | 2009-11-12 | Great Lakes Orthodontics Ltd. | Method of designing custom articulator inserts using four-dimensional data |
| JP2011522521A (ja) | 2008-05-05 | 2011-08-04 | ロスアラモス ナショナル セキュリティ，エルエルシー | 高度に単純化された側方流動ベースの核酸サンプル調製および受動的流体流動制御 |
| US9034605B2 (en) | 2009-03-12 | 2015-05-19 | Brandeis University | Reagents and methods for PCR |
| US8084272B2 (en) * | 2009-03-25 | 2011-12-27 | Abbott Point Of Care Inc. | Amelioration of heterophile antibody immunosensor interference |
| FR2945097B1 (fr) | 2009-04-30 | 2011-06-03 | Commissariat Energie Atomique | Vanne microfluidique a usage unique. |
| US20120288961A1 (en) | 2009-12-22 | 2012-11-15 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| NZ721912A (en) | 2010-03-09 | 2018-01-26 | Netbio Inc | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
| CN103370425B (zh) | 2010-12-17 | 2019-03-19 | 生命技术公司 | 用于核酸扩增的方法、组合物、***、仪器和试剂盒 |
-
2009
- 2009-05-05 JP JP2011508502A patent/JP2011522521A/ja active Pending
- 2009-05-05 CA CA2723536A patent/CA2723536C/en active Active
- 2009-05-05 CN CN200980125614.XA patent/CN102084238B/zh active Active
- 2009-05-05 WO PCT/US2009/002809 patent/WO2009137059A1/en active Application Filing
- 2009-05-05 EP EP15196744.5A patent/EP3067694A1/en not_active Ceased
- 2009-05-05 EP EP09743046.6A patent/EP2279403B1/en active Active
-
2010
- 2010-11-05 US US12/940,973 patent/US9207236B2/en active Active
-
2011
- 2011-11-21 HK HK11112579.1A patent/HK1158312A1/zh unknown
-
2015
- 2015-02-02 JP JP2015018327A patent/JP6026570B2/ja active Active
- 2015-12-08 US US14/962,967 patent/US9944922B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9944922B2 (en) | 2018-04-17 |
| JP2015108637A (ja) | 2015-06-11 |
| WO2009137059A1 (en) | 2009-11-12 |
| EP2279403A1 (en) | 2011-02-02 |
| EP3067694A1 (en) | 2016-09-14 |
| CN102084238A (zh) | 2011-06-01 |
| US9207236B2 (en) | 2015-12-08 |
| JP2011522521A (ja) | 2011-08-04 |
| CA2723536A1 (en) | 2009-11-12 |
| EP2279403A4 (en) | 2011-11-23 |
| EP2279403B1 (en) | 2016-03-16 |
| CN102084238B (zh) | 2016-06-01 |
| CA2723536C (en) | 2017-06-13 |
| US20110117540A1 (en) | 2011-05-19 |
| JP6026570B2 (ja) | 2016-11-16 |
| US20160083716A1 (en) | 2016-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1158312A1 (zh) | 基於高度簡化的側向流動的核酸樣品製備和被動流體流動控制 | |
| EP2297470A4 (en) | SYSTEM AND METHOD FOR MICROFLUIDIC FLOW CONTROL | |
| IL188975A0 (en) | Fluid control device with stopper | |
| EP2321405A4 (en) | MICROFLUIDIC CONTINUOUS FLOW DEVICE | |
| EP2259072A4 (en) | FLOW PASSAGE CONTROL MECHANISM FOR MICROCHIP | |
| EP2259839A4 (en) | DEVICES, ASSEMBLIES AND METHODS FOR CONTROLLING A FLUID FLOW | |
| GB0908373D0 (en) | Fluid flow control device | |
| EP2350423A4 (en) | SYSTEMS AND METHODS FOR CONTROLLING WELL FLOW | |
| EP2609416A4 (en) | SIDE FLOW ANALYSIS | |
| EG26663A (en) | Fluid flow control valve | |
| EP2313527A4 (en) | Lateral flow NUCLEIC DETECTOR | |
| GB201210905D0 (en) | Fluid control and manifol assembly | |
| GB0819927D0 (en) | Control fluid flow | |
| GB2464283B (en) | Fluid flow control system and method | |
| SG10201403159RA (en) | Dual-purpose fluid control valve | |
| GB201011973D0 (en) | Fluid flow sensor | |
| GB0816767D0 (en) | Fluid flow meter | |
| ZA201102707B (en) | Fluid flow assessment | |
| GB0807147D0 (en) | Fluid flow meter | |
| GB0808138D0 (en) | Liquid flow sensing systems | |
| GB2476352B (en) | Fluid flow control device | |
| GB2459536B (en) | Liquid flow valve | |
| GB2454565B (en) | Liquid flow control | |
| GB2476540B (en) | Fluid flow control device | |
| ZA200806385B (en) | Fluid flow control regulator |