HK1128699A1 - Compositions and methods for modulating hemostasis - Google Patents

Compositions and methods for modulating hemostasis

Info

Publication number
HK1128699A1
HK1128699A1 HK09106536.9A HK09106536A HK1128699A1 HK 1128699 A1 HK1128699 A1 HK 1128699A1 HK 09106536 A HK09106536 A HK 09106536A HK 1128699 A1 HK1128699 A1 HK 1128699A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
modulating hemostasis
hemostasis
modulating
Prior art date
Application number
HK09106536.9A
Other languages
English (en)
Inventor
Rodney M Camire
Original Assignee
Philadelphia Children Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philadelphia Children Hospital filed Critical Philadelphia Children Hospital
Publication of HK1128699A1 publication Critical patent/HK1128699A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
HK09106536.9A 2005-11-15 2009-07-17 Compositions and methods for modulating hemostasis HK1128699A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73668005P 2005-11-15 2005-11-15
PCT/US2006/060927 WO2007059513A2 (en) 2005-11-15 2006-11-15 Compositions and methods for modulating hemostasis

Publications (1)

Publication Number Publication Date
HK1128699A1 true HK1128699A1 (en) 2009-11-06

Family

ID=38049397

Family Applications (2)

Application Number Title Priority Date Filing Date
HK09106536.9A HK1128699A1 (en) 2005-11-15 2009-07-17 Compositions and methods for modulating hemostasis
HK12106113.5A HK1165444A1 (zh) 2005-11-15 2012-06-21 用於調整止血的組合物及方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK12106113.5A HK1165444A1 (zh) 2005-11-15 2012-06-21 用於調整止血的組合物及方法

Country Status (26)

Country Link
US (4) US8383386B2 (pt)
EP (4) EP1948690B1 (pt)
JP (4) JP5823088B2 (pt)
KR (4) KR101827569B1 (pt)
CN (1) CN101356192B (pt)
AU (1) AU2006315175B2 (pt)
BR (1) BRPI0618654B1 (pt)
CA (2) CA2629491C (pt)
CR (1) CR9956A (pt)
DK (1) DK1948690T3 (pt)
EC (1) ECSP088452A (pt)
ES (2) ES2549929T3 (pt)
GT (1) GT200800065A (pt)
HK (2) HK1128699A1 (pt)
IL (1) IL191310A (pt)
MX (3) MX336958B (pt)
MY (1) MY162181A (pt)
NO (3) NO345177B1 (pt)
NZ (1) NZ568108A (pt)
PL (1) PL1948690T3 (pt)
PT (1) PT1948690E (pt)
RU (2) RU2008123398A (pt)
SI (1) SI1948690T1 (pt)
SV (1) SV2008002906A (pt)
WO (1) WO2007059513A2 (pt)
ZA (1) ZA200804026B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE052423T2 (hu) 2007-09-28 2021-04-28 Alexion Pharma Inc Az XA faktor inhibitorok antidótumai és ezek alkalmazási módszerei
MX2011004907A (es) 2008-11-14 2011-07-29 Portola Pharm Inc Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre.
WO2010117729A1 (en) 2009-03-30 2010-10-14 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
JP6163304B2 (ja) 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
CN103221061A (zh) 2010-10-06 2013-07-24 米迪缪尼有限公司 用于治疗止血障碍的因子ii以及纤维蛋白原
WO2013049804A1 (en) 2011-09-30 2013-04-04 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
CN104755492A (zh) 2012-07-25 2015-07-01 催化剂生物科学公司 修饰的因子x多肽及其应用
EP2950813B1 (en) 2013-01-31 2019-09-04 Pfizer Inc Compositions and methods for counteracting factor xa inhibition
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
CN105579468A (zh) 2013-09-24 2016-05-11 辉瑞大药厂 包含重组人凝血因子Xa蛋白的异质性群体的组合物
CA2928762A1 (en) * 2013-11-01 2015-05-07 The Children's Hospital Of Philadelphia Compositions and methods for increasing the half-life of factor xa
DK3096779T3 (da) * 2014-01-24 2020-02-24 Pfizer Sammensætninger og fremgangsmåder til behandling af intracerebral blødning
LT3149163T (lt) 2014-05-26 2020-09-25 Academisch Ziekenhuis Leiden Prohemostatiniai baltymai, skirti kraujavimo gydymui
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
JP7181855B2 (ja) 2016-07-27 2022-12-01 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 第ｉｘ因子の機能を調節するための組成物及び方法
WO2023118150A1 (en) 2021-12-22 2023-06-29 Royal College Of Surgeons In Ireland A conjugate for use in localising a molecule to the vascular endothelium.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
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US6093699A (en) 1987-07-09 2000-07-25 The University Of Manitoba Method for gene therapy involving suppression of an immune response
WO1994017810A1 (en) 1993-02-12 1994-08-18 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
CA2160583A1 (en) 1993-04-16 1994-10-27 Stanley A. Plotkin Recombinant cytomegalovirus vaccine
WO1995005864A1 (en) 1993-08-27 1995-03-02 Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Convection-enhanced drug delivery
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
CN1136920C (zh) 1995-02-28 2004-02-04 加利福尼亚大学董事会 基因转移介导的血管形成疗法
US6228646B1 (en) 1996-03-07 2001-05-08 The Regents Of The University Of California Helper-free, totally defective adenovirus for gene therapy
AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
US20040102388A1 (en) 2000-03-22 2004-05-27 High Katherine A. Modified blood clotting factors and methods of use
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
CN104262479A (zh) * 2008-12-19 2015-01-07 国家健康与医学研究院 丝氨酸蛋白酶衍生物及其在凝血功能障碍的预防或治疗中的用途

Also Published As

Publication number Publication date
EP2423224B1 (en) 2015-08-12
KR101827569B1 (ko) 2018-02-09
JP2016005464A (ja) 2016-01-14
US20140120155A1 (en) 2014-05-01
AU2006315175B2 (en) 2013-02-07
DK1948690T3 (da) 2014-09-01
NO20200670A1 (no) 2008-07-30
WO2007059513A3 (en) 2007-11-29
JP6571735B2 (ja) 2019-09-04
US9410137B2 (en) 2016-08-09
KR20160029135A (ko) 2016-03-14
MX337059B (es) 2016-02-09
ES2496567T3 (es) 2014-09-19
NO20082182L (no) 2008-07-30
BRPI0618654A2 (pt) 2011-09-06
CN101356192B (zh) 2013-09-11
KR20140005383A (ko) 2014-01-14
RU2011130932A (ru) 2013-01-27
JP6236194B2 (ja) 2017-11-22
JP2014073127A (ja) 2014-04-24
US20090175931A1 (en) 2009-07-09
WO2007059513A2 (en) 2007-05-24
EP1948690A2 (en) 2008-07-30
SI1948690T1 (sl) 2014-09-30
MX2008006313A (es) 2008-11-06
JP5823088B2 (ja) 2015-11-25
KR20140115374A (ko) 2014-09-30
US9896676B2 (en) 2018-02-20
CR9956A (es) 2008-08-21
EP2431389A1 (en) 2012-03-21
CN101356192A (zh) 2009-01-28
US8383386B2 (en) 2013-02-26
JP2009515559A (ja) 2009-04-16
AU2006315175A1 (en) 2007-05-24
EP2431390B1 (en) 2015-08-12
NO345177B1 (no) 2020-10-26
BRPI0618654A8 (pt) 2019-01-15
EP2423224A1 (en) 2012-02-29
SV2008002906A (es) 2008-10-22
EP1948690B1 (en) 2014-06-11
US20160362673A1 (en) 2016-12-15
RU2570547C2 (ru) 2015-12-10
ECSP088452A (es) 2008-07-30
KR20080078664A (ko) 2008-08-27
MX336958B (es) 2016-02-05
GT200800065A (es) 2008-11-03
JP5957167B2 (ja) 2016-07-27
MY162181A (en) 2017-05-31
NZ568108A (en) 2011-09-30
PL1948690T3 (pl) 2014-11-28
US20180251745A1 (en) 2018-09-06
KR101574042B1 (ko) 2015-12-03
IL191310A (en) 2015-06-30
ES2549929T3 (es) 2015-11-03
RU2008123398A (ru) 2009-12-27
NO20200671A1 (no) 2008-07-30
EP2431390A1 (en) 2012-03-21
HK1165444A1 (zh) 2012-10-05
CA2629491A1 (en) 2007-05-24
CA2971971A1 (en) 2007-05-24
PT1948690E (pt) 2014-09-08
EP1948690A4 (en) 2009-06-17
JP2018033459A (ja) 2018-03-08
ZA200804026B (en) 2009-10-28
BRPI0618654B1 (pt) 2021-10-19
CA2629491C (en) 2019-05-07
KR101600158B1 (ko) 2016-03-08

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