HK1045986B - 含羥基二十碳四烯酸衍生物的合成劑及其用於治療乾眼病症的方法 - Google Patents

含羥基二十碳四烯酸衍生物的合成劑及其用於治療乾眼病症的方法

Info

Publication number
HK1045986B
HK1045986B HK02107323.1A HK02107323A HK1045986B HK 1045986 B HK1045986 B HK 1045986B HK 02107323 A HK02107323 A HK 02107323A HK 1045986 B HK1045986 B HK 1045986B
Authority
HK
Hong Kong
Prior art keywords
methods
compositions containing
acid derivatives
dry eye
eye disorders
Prior art date
Application number
HK02107323.1A
Other languages
English (en)
Other versions
HK1045986A1 (en
Inventor
Wayne Schneider L
A Gamache Daniel
K Weimer Lori
L Kessler Timothy
Wei Zhongyou
Pasquine Terri
M Yanni John
G Bhagat Haresh
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of HK1045986A1 publication Critical patent/HK1045986A1/xx
Publication of HK1045986B publication Critical patent/HK1045986B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
HK02107323.1A 1999-11-09 2002-10-05 含羥基二十碳四烯酸衍生物的合成劑及其用於治療乾眼病症的方法 HK1045986B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16438599P 1999-11-09 1999-11-09
US16438499P 1999-11-09 1999-11-09
US16437099P 1999-11-09 1999-11-09
PCT/US2000/029225 WO2001034554A1 (en) 1999-11-09 2000-10-23 Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Publications (2)

Publication Number Publication Date
HK1045986A1 HK1045986A1 (en) 2002-12-20
HK1045986B true HK1045986B (zh) 2004-12-24

Family

ID=27389013

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107323.1A HK1045986B (zh) 1999-11-09 2002-10-05 含羥基二十碳四烯酸衍生物的合成劑及其用於治療乾眼病症的方法

Country Status (20)

Country Link
US (1) US6353022B1 (zh)
EP (1) EP1228032B1 (zh)
JP (1) JP2003513951A (zh)
KR (1) KR20020050239A (zh)
CN (1) CN1387505A (zh)
AR (1) AR029190A1 (zh)
AT (1) ATE272603T1 (zh)
AU (1) AU775189B2 (zh)
BR (1) BR0015416A (zh)
CA (1) CA2386619A1 (zh)
DE (1) DE60012774T2 (zh)
DK (1) DK1228032T3 (zh)
ES (1) ES2220561T3 (zh)
HK (1) HK1045986B (zh)
MX (1) MXPA02004703A (zh)
PL (1) PL355998A1 (zh)
PT (1) PT1228032E (zh)
TR (1) TR200201246T2 (zh)
TW (1) TWI267375B (zh)
WO (1) WO2001034554A1 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USH1511H (en) * 1992-09-10 1995-12-05 Chappell; Charles W. Absorbent articles having improved longitudinal fluid movement
WO2002034258A1 (en) * 2000-10-23 2002-05-02 Alcon, Inc. Use of hydroxyeicosatetraenoic acid derivatives in intraocular surgery
US20020077358A1 (en) * 2000-10-23 2002-06-20 Alcon Universal Ltd. Use of hydroperoxyeicosatetraenoic acid derivatives following refractive surgery
US20020183233A1 (en) * 2000-12-14 2002-12-05 The Clorox Company, Delaware Corporation Bactericidal cleaning wipe
US7799751B2 (en) * 2000-12-14 2010-09-21 The Clorox Company Cleaning composition
US20030100465A1 (en) * 2000-12-14 2003-05-29 The Clorox Company, A Delaware Corporation Cleaning composition
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
FR2833268B1 (fr) * 2001-12-12 2005-07-08 Fabre Pierre Dermo Cosmetique Nouvelle association contenant un poloxamer et de l'acide chondroitine sulfurique et/ou une glycoproteine et son utilisation
JP4836401B2 (ja) * 2002-04-01 2011-12-14 ロート製薬株式会社 眼科用組成物
JP2005289814A (ja) * 2002-04-12 2005-10-20 Mei Co Ltd 近視矯正手術のための医薬
EP1583527A1 (en) * 2002-06-14 2005-10-12 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
AU2003221707A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
FR2843026B1 (fr) * 2002-08-02 2006-01-06 Goemar Lab Sa Nouveau medicament
PL374700A1 (en) * 2002-09-20 2005-10-31 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
GB0411165D0 (en) * 2004-05-19 2004-06-23 Bionovate Ltd Hyaluronic acid containing pharmaceutical or veterinary compounds
TWI393567B (zh) * 2005-03-31 2013-04-21 Bausch & Lomb 治療乾眼之組合物及相關之製造方法及使用方法
US9381183B2 (en) 2012-07-18 2016-07-05 Physicians Recommended Nutriceuticals, Llc Methods for improving the quality of the meibum composition of meibomian glands
US10709680B2 (en) 2011-07-18 2020-07-14 Physicians Recommended Nutriceuticals, Llc Methods for treating dry eye
US20210121430A1 (en) 2011-07-18 2021-04-29 Prn Physician Recommended Nutriceuticals, Llc Omega-3 fatty acid supplementation for use in treating dry eye
US9115078B2 (en) 2011-07-18 2015-08-25 Physicians Recommended Nutriceuticals, Llc Compositions for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands
CN104661682B (zh) * 2012-09-27 2018-05-11 千寿制药株式会社 水性液剂
US9320709B2 (en) * 2013-08-28 2016-04-26 Presbyopia Therapies Llc Storage stable compositions and methods for the treatment of refractive errors of the eye
AU2016280616B2 (en) * 2015-06-18 2020-10-22 Lenz Therapeutics, Inc. Compositions for the improvement of distance vision and the treatment of refractive errors of the eye
US11648247B1 (en) 2021-12-16 2023-05-16 Lenz Therapeutics, Inc. Compositions and methods for the treatment of presbyopia

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4744980A (en) 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4818537A (en) 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US4921644A (en) 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
US4906467A (en) 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US4923700A (en) 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension
US5064655A (en) 1989-02-24 1991-11-12 Liposome Technology, Inc. Liposome gel composition and method
US5075104A (en) 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5174988A (en) 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
AU655919B2 (en) 1990-02-22 1995-01-19 Macnaught Pty Limited Artificial tears
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
ATE132366T1 (de) 1990-05-29 1996-01-15 Boston Ocular Res Zusammensetzung zur behandlung von dry eye erkrankungen
ZA912797B (en) 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
US5102670A (en) 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
ZA927277B (en) 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
EP0546728A3 (en) 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
AU674681B2 (en) 1992-04-21 1997-01-09 Schepens Eye Research Institute, Inc., The Ocular androgen therapy in Sjogren's syndrome
US5290572A (en) 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5358706A (en) 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5389383A (en) 1993-06-18 1995-02-14 Allergan, Inc. Method for treating hypoxia-associated ocular complications
US5696166A (en) 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
US5676166A (en) * 1996-09-11 1997-10-14 Chang; Wen-Shyong Hair clip
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol

Also Published As

Publication number Publication date
ATE272603T1 (de) 2004-08-15
EP1228032B1 (en) 2004-08-04
BR0015416A (pt) 2002-07-16
KR20020050239A (ko) 2002-06-26
CA2386619A1 (en) 2001-05-17
PT1228032E (pt) 2004-10-29
AU775189B2 (en) 2004-07-22
TWI267375B (en) 2006-12-01
HK1045986A1 (en) 2002-12-20
JP2003513951A (ja) 2003-04-15
PL355998A1 (en) 2004-05-31
DK1228032T3 (da) 2004-11-01
EP1228032A1 (en) 2002-08-07
DE60012774D1 (de) 2004-09-09
AU1340801A (en) 2001-06-06
ES2220561T3 (es) 2004-12-16
CN1387505A (zh) 2002-12-25
AR029190A1 (es) 2003-06-18
WO2001034554A1 (en) 2001-05-17
MXPA02004703A (es) 2004-09-10
TR200201246T2 (tr) 2002-09-23
DE60012774T2 (de) 2005-01-13
US6353022B1 (en) 2002-03-05

Similar Documents

Publication Publication Date Title
HK1045986B (zh) 含羥基二十碳四烯酸衍生物的合成劑及其用於治療乾眼病症的方法
HK1048247A1 (en) Stable carotene-xanthophyll beadlet compositions and methods of use
EP1227821A4 (en) THERAPEUTIC COMPOSITIONS AND METHOD FOR USE THEREOF
HK1045302B (zh) 羥基二十碳四烯酸鹽合成劑及其用於治療乾眼症的方法
EP1229930A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALLERGIC DISORDERS
PL331006A1 (en) Risk assessing method for use in cardiovascular diseases and other diseases as well as phytosterol-based compositions useful in prophylaxis and treatment of cardiovascular and other diseases
NO20030295L (no) Anvendelse av derivater av valproinsyre- og 2- valproensyreamider for behandling av manier ved bipolare lidelser
IL143594A0 (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
PL349193A1 (en) Branched chain amino acid−dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy
HK1044536A1 (en) Crystals of an oxyiminoalkanoic acid derivative and their use as antidiabetics
PL352333A1 (en) Dihydrobenzodiazepines and use of same in treatment of dislipidemia
HK1066804A1 (en) Derivatives of indole and their use as phosphodiesterase 4 inhibitors
EP1150669A4 (en) FORMULATIONS ON L-ARGININE BASE FOR DISEASE TREATMENT AND USE THEREOF
AU8031400A (en) 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
PL330797A1 (en) Derivatives of piperidinacetic acid and their application in treating thrombotic disorders
HK1045983B (zh) 羥基二十碳四烯酸類似物及其用於治療乾眼病症的方法
PL356127A1 (en) Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye
HUP0204180A3 (en) External composition and its use for treating of allergic skin diseases
EP1418167A3 (en) Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
AU2001254825A1 (en) Butenoic acids derivatives and their use in the treatment of rhinitis
AU2256801A (en) Methods and compositions for use in the treatment of filovirus mediated disease conditions
GB9828845D0 (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
AU4101900A (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
GB9922709D0 (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
GB9905310D0 (en) Therapy and use of compounds in therapy (4)

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20081023