HK1044545A1 - 貝他分泌酶組合物及其方法 - Google Patents

貝他分泌酶組合物及其方法

Info

Publication number
HK1044545A1
HK1044545A1 HK02104538.9A HK02104538A HK1044545A1 HK 1044545 A1 HK1044545 A1 HK 1044545A1 HK 02104538 A HK02104538 A HK 02104538A HK 1044545 A1 HK1044545 A1 HK 1044545A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
compositions
human beta
secretase enzyme
secretase
Prior art date
Application number
HK02104538.9A
Other languages
English (en)
Inventor
P Anderson John
Basi Guriqbal
Tam Doane Minh
Frigon Normand
John Varghese
Power Michael
Sinha Sukanto
Tatsuno Gwen
Tung Jay
Wang Shuwen
Mcconlogue Lisa
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of HK1044545A1 publication Critical patent/HK1044545A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK02104538.9A 1999-02-10 2002-06-18 貝他分泌酶組合物及其方法 HK1044545A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11957199P 1999-02-10 1999-02-10
US13917299P 1999-06-15 1999-06-15
PCT/US2000/003819 WO2000047618A2 (en) 1999-02-10 2000-02-10 HUMAN β-SECRETASE ENZYME, INHIBITORS AND THEIR COMPOSITIONS AND USES

Publications (1)

Publication Number Publication Date
HK1044545A1 true HK1044545A1 (zh) 2002-10-25

Family

ID=26817477

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02104538.9A HK1044545A1 (zh) 1999-02-10 2002-06-18 貝他分泌酶組合物及其方法
HK02104530.7A HK1044543B (zh) 1999-02-10 2002-06-18 貝他分泌酶組合物及其方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK02104530.7A HK1044543B (zh) 1999-02-10 2002-06-18 貝他分泌酶組合物及其方法

Country Status (10)

Country Link
US (3) US7109017B1 (zh)
EP (1) EP1165609A2 (zh)
JP (1) JP4653318B2 (zh)
CN (1) CN1390232A (zh)
AU (1) AU4000900A (zh)
CA (1) CA2359785A1 (zh)
GB (1) GB2364059B (zh)
HK (2) HK1044545A1 (zh)
NZ (1) NZ534876A (zh)
WO (1) WO2000047618A2 (zh)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9701684D0 (en) * 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
CN1502692A (zh) * 1998-09-24 2004-06-09 �������Ŷ���Լ��������˾ 阿尔茨海默氏疾病分泌酶
US20040234976A1 (en) * 1998-09-24 2004-11-25 Gurney Mark E. Alzheimer's disease secretase, app substrates therefor, and uses therefor
US6699671B1 (en) 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
EP1939297A1 (en) * 1998-09-24 2008-07-02 Pharmacia & Upjohn Company LLC Alzheimer's disease secretase
US7115410B1 (en) * 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
EP1165609A2 (en) 1999-02-10 2002-01-02 Elan Pharmaceuticals, Inc. Human beta-secretase enzyme, inhibitors and their compositions and uses
WO2000058479A1 (en) * 1999-03-26 2000-10-05 Amgen Inc. Beta secretase genes and polypeptides
US7087399B1 (en) * 1999-05-13 2006-08-08 Scios, Inc. β-secretase and modulation of β-secretase activity
US7169759B1 (en) * 1999-06-15 2007-01-30 Elan Pharmaceuticals, Inc. Tetrapeptide inhibitors of β-secretase
EP1496124A1 (en) * 1999-06-28 2005-01-12 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
CN1379819A (zh) 1999-06-28 2002-11-13 俄克拉荷马州医学研究基金会 具有催化活性的重组memapsin蛋白酶及其应用方法
US20090162883A1 (en) * 1999-09-23 2009-06-25 Pharmacia & Upjohn Company Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
AU2001261728A1 (en) * 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
KR100436924B1 (ko) * 2000-06-28 2004-06-23 (주) 디지탈바이오텍 베타 시크리테아제의 제조 방법
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
JP2004504018A (ja) 2000-07-19 2004-02-12 ファルマシア・アンド・アップジョン・カンパニー β−セレクターゼ活性の基質およびアッセイ
US7806980B2 (en) * 2000-12-23 2010-10-05 Elan Pharmaceuticals, Inc. Method for crystallizing human beta secretase in complex with an inhibitor
EP1404718A2 (en) * 2000-12-28 2004-04-07 Oklahoma Medical Research Foundation Inhibitors of memapsin 2 and use thereof
WO2002068955A1 (en) 2001-02-23 2002-09-06 Elan Pharmaceuticals, Inc. Transgenic knockouts of bace-1
US7384773B1 (en) * 2001-05-10 2008-06-10 Pfizer Inc Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
US7524668B1 (en) * 2001-05-10 2009-04-28 Elan Pharmaceuticals, Inc. Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
EP1390497A2 (en) 2001-05-25 2004-02-25 Genset Human cdnas and proteins and uses thereof
EP1395551B1 (en) 2001-06-01 2008-05-21 Elan Pharmaceuticals, Inc. Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases
JP2004532894A (ja) 2001-06-13 2004-10-28 イーラン　ファーマスーティカルズ、インコーポレイテッド アルツハイマー病を治療するためのアミンジオール
BR0211118A (pt) 2001-07-10 2004-10-26 Elan Pharm Inc Composto, métodos para o tratamento ou prevenção de doenças e para fabricar um composto, intermediário, e, uso de um composto ou sal
US7053109B2 (en) 2001-07-10 2006-05-30 Pharmacia & Upjohn Company Aminediols for the treatment of Alzheimer's disease
ES2295283T3 (es) * 2001-08-21 2008-04-16 Smithkline Beecham Plc Modelos animales transgenicos para la enfermedad de alzheimer.
US7186539B1 (en) 2001-08-31 2007-03-06 Pharmacia & Upjohn Company Method for refolding enzymes
CA2462851A1 (en) 2001-10-04 2003-04-10 Elan Pharmaceuticals, Inc. Hydroxypropylamines
JP4547152B2 (ja) 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
NZ533107A (en) 2001-11-08 2007-04-27 Upjohn Co N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
MXPA04005428A (es) 2001-12-06 2004-12-06 Elan Pharm Inc Hidroxietilaminas substituidas.
CH698246B1 (de) * 2001-12-20 2009-06-30 Hoffmann La Roche Test zur Identifizierung von Inhibitoren von Beta-Sekretasen.
CA2477243A1 (en) 2002-02-21 2003-09-04 Pharmacia & Upjohn Company Modified bace
CA2477675C (en) 2002-03-05 2013-05-21 Ramot At Tel-Aviv University Ltd. Immunizing composition and method for inducing an immune response against the .beta.-secretase cleavage site of amyloid precursor protein
AU2003303141A1 (en) 2002-04-30 2004-07-22 Elan Pharmaceuticals, Inc. Hydroxypropyl amides for the treatment of alzheimer's disease
US7442537B1 (en) 2002-05-10 2008-10-28 Elan Pharmaceuticals, Inc. Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof
BR0316629A (pt) 2002-11-27 2005-10-11 Elan Pharm Inc Uréias e carbamatos substituìdos
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
AR044044A1 (es) 2003-04-21 2005-08-24 Elan Pharm Inc 2-hidroxi-3-diaminoalcanos de benzamida
WO2004099402A1 (en) * 2003-05-02 2004-11-18 Elan Pharmaceuticals, Inc. Glycosylation variants of bace
US20050014160A1 (en) * 2003-07-18 2005-01-20 Sriram Kumaraswamy Assays for protease enzyme activity
CA2558034A1 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
CA2573138A1 (en) 2004-07-09 2006-01-26 Elan Pharmaceuticals Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
BRPI0518151A2 (pt) * 2004-10-13 2009-06-16 Ablynx Nv polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo
WO2006081171A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
NZ561029A (en) * 2005-03-14 2011-03-31 High Point Pharmaceuticals Llc Benzazole dervatives, compositions, and method of use as beta-secretase inhibitors
CA2618508A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating alzheimer's disease
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
WO2007056401A1 (en) * 2005-11-09 2007-05-18 Merck & Co., Inc. Method for identifying modulators of osbp useful for treating alzheimer's disease
JP4590638B2 (ja) * 2006-03-20 2010-12-01 国立大学法人鳥取大学 家族性筋萎縮性側索硬化症（ｆａｌｓ）発症するトランスジェニックマウス
US20070292895A1 (en) * 2006-05-19 2007-12-20 Xiao-Ping Shi Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
KR20090027877A (ko) * 2007-09-13 2009-03-18 한국생명공학연구원 Ｂｅｔａ－ｓｉｔｅ ＡＰＰ ｃｌｅａｖｉｎ ｇｅｎｚｙｍｅ（ＢＡＣＥ）를 발현하는 형질전환 식물체
CN101270359B (zh) * 2008-04-30 2012-05-23 江苏省原子医学研究所 一种重组人淀粉样蛋白Aβ42的制备方法及应用
TW201020244A (en) 2008-11-14 2010-06-01 Astrazeneca Ab New compounds
EP2281824A1 (en) 2009-08-07 2011-02-09 Noscira, S.A. Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders
TW201300417A (zh) 2010-11-10 2013-01-01 Genentech Inc 用於神經疾病免疫療法之方法及組合物
JP2013542973A (ja) 2010-11-22 2013-11-28 ノスシラ、ソシエダッド、アノニマ 神経変性疾患または神経変性状態を治療するためのビピリジンスルホンアミド誘導体
EP2766028B1 (en) 2011-10-14 2017-08-16 F. Hoffmann-La Roche AG Peptide inhibitors of bace1
EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
WO2016081639A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Antibodies against bace1 and use thereof for neural disease immunotherapy

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200339A (en) 1990-08-17 1993-04-06 Abraham Carmela R Proteases causing abnormal degradation of amyloid β-protein precursor
US5292652A (en) 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
ES2236682T5 (es) 1991-01-21 2011-03-31 Elan Pharmaceuticals, Inc. Ensayo y modelo para la enfermedad de alzheimer.
JPH07504818A (ja) 1992-03-09 1995-06-01 カイロン　コーポレイション 細胞内ｐａｃｅ４およびｐａｃｅ４．１遺伝子ならびにポリペプチドに関する組成物および方法
IL105793A0 (en) 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
US5455169A (en) 1992-06-04 1995-10-03 Alzheimer's Institute Of America, Inc. Nucleic acids for diagnosing and modeling Alzheimer's disease
US5766846A (en) 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
US5837672A (en) 1992-07-10 1998-11-17 Athena Neurosciences, Inc. Methods and compositions for the detection of soluble β-amyloid peptide
EP0683234B2 (en) 1993-01-25 2007-06-06 Takeda Chemical Industries, Ltd. Antibody against beta-amyloid or their derivative and use thereof
ATE198622T1 (de) 1993-10-27 2001-01-15 Elan Pharm Inc Transgene tiere, die app allele mit der schwedischen mutation beherbergen
CA2198451A1 (en) 1994-09-01 1996-03-07 Gurparkash Singh Transgenic animal expressing a familial form of human amyloid precursor protein
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
EP0818951A4 (en) 1995-04-04 2002-10-16 Lilly Co Eli Amyloid precursor protein PROTEASE
US6329163B1 (en) 1995-06-07 2001-12-11 Elan Pharmaceuticals, Inc. Assays for detecting β-secretase inhibition
EP0871720A2 (en) 1995-06-07 1998-10-21 Athena Neurosciences, Inc. Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition
US5744346A (en) 1995-06-07 1998-04-28 Athena Neurosciences, Inc. β-secretase
US6221645B1 (en) 1995-06-07 2001-04-24 Elan Pharmaceuticals, Inc. β-secretase antibody
EP0959894B1 (en) * 1996-06-10 2004-10-13 The Scripps Research Institute Use of substrate subtraction libraries to distinguish enzyme specificities
GB9618966D0 (en) 1996-09-11 1996-10-23 Smithkline Beecham Plc Novel compounds
DE19641180A1 (de) 1996-09-24 1998-03-26 Schering Ag Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung
WO1998021589A1 (en) 1996-11-15 1998-05-22 The Trustees Of The University Of Pennsylvania Screening for modulators of amyloid processing
AU734220B2 (en) 1996-11-20 2001-06-07 Oklahoma Medical Research Foundation Cloning and characterization of napsin, an aspartic protease
JPH10155487A (ja) 1996-11-28 1998-06-16 Kagaku Gijutsu Shinko Jigyodan アミノ酸配列と、このアミノ酸配列を有する 蛋白が結合するｄｎａ配列
WO1998026059A1 (en) * 1996-12-11 1998-06-18 Athena Neurosciences, Inc. Beta-secretase isolated from human 293 cells
GB9626022D0 (en) 1996-12-14 1997-01-29 Smithkline Beecham Plc Novel compounds
EP0848062A3 (en) 1996-12-14 2000-07-05 Smithkline Beecham Corporation Aspartic protease ASP1
GB9701684D0 (en) * 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds
US6037137A (en) 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
GB9721094D0 (en) 1997-10-03 1997-12-03 Unilever Plc Autophobic hairspray compositions
AU758004B2 (en) 1997-12-17 2003-03-13 Genset S.A. Extended cDNAs for secreted proteins
WO1999033963A1 (en) 1997-12-31 1999-07-08 Chiron Corporation Metastatic cancer regulated gene
PT1490386E (pt) 1998-03-10 2008-11-24 Genentech Inc Novos polipéptidos e ácidos nucleicos que os codificam
KR20010052499A (ko) 1998-06-05 2001-06-25 아방티 파르마 소시에테 아노님 베타-시크리타제형 활성을 지닌 폴리펩타이드
CN1502692A (zh) 1998-09-24 2004-06-09 �������Ŷ���Լ��������˾ 阿尔茨海默氏疾病分泌酶
US6699671B1 (en) 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US20040234976A1 (en) 1998-09-24 2004-11-25 Gurney Mark E. Alzheimer's disease secretase, app substrates therefor, and uses therefor
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6245884B1 (en) 1998-10-16 2001-06-12 Vivian Y. H. Hook Secretases related to alzheimer's dementia
US6313268B1 (en) 1998-10-16 2001-11-06 Vivian Y. H. Hook Secretases related to Alzheimer's dementia
GB2389182B (en) 1999-02-10 2004-02-04 Elan Pharm Inc Method of purifying b-secretase
EP1445263A1 (en) 1999-02-10 2004-08-11 Elan Pharmaceuticals, Inc. Human beta-secretase enzyme, inhibitors and their compositions and uses
EP1165609A2 (en) 1999-02-10 2002-01-02 Elan Pharmaceuticals, Inc. Human beta-secretase enzyme, inhibitors and their compositions and uses
DE19910108C2 (de) 1999-03-08 2001-02-22 Falk Fahrenholz Zellen, die ein Amyloidvorläuferprotein und eine alpha-Sekretase coexprimieren, ein Testverfahren zur Identifikation alpha-Sekretase-aktiver Substanzen sowie eines zur Identifikation weiterer Sekretasen, ein Testverfahren zur Bestimmung der Anfälligkeit gegenüber Morbus Alzheimer und Verwendung von Nukleinsäuren, die für eine alpha-Sekretase codieren, für die Gentherapie
WO2000058479A1 (en) 1999-03-26 2000-10-05 Amgen Inc. Beta secretase genes and polypeptides
AU4640600A (en) 1999-05-11 2000-11-21 Eli Lilly And Company Amyloid precursor protein protease and related nucleic acid compounds
US7087399B1 (en) 1999-05-13 2006-08-08 Scios, Inc. β-secretase and modulation of β-secretase activity
CN1379819A (zh) 1999-06-28 2002-11-13 俄克拉荷马州医学研究基金会 具有催化活性的重组memapsin蛋白酶及其应用方法
ATE431419T1 (de) 1999-09-23 2009-05-15 Pharmacia & Upjohn Co Llc Alzheimer krankheit sekretase, app (amyloid vorlaüfer-protein) substrate dafür und verwendungen
GB9924957D0 (en) 1999-10-21 1999-12-22 Smithkline Beecham Plc Novel treatment
GB9925136D0 (en) 1999-10-22 1999-12-22 Smithkline Beecham Plc Novel treatment
US6361975B1 (en) 1999-11-16 2002-03-26 Smithkline Beecham Corporation Mouse aspartic secretase-2(mASP-2)
US6291223B1 (en) 1999-11-23 2001-09-18 Smithkline Beecham Corporation Mouse aspartic secretase-1 (mASP1)

Also Published As

Publication number Publication date
AU4000900A (en) 2000-08-29
US7067271B1 (en) 2006-06-27
GB2364059B (en) 2004-01-14
JP2003524393A (ja) 2003-08-19
WO2000047618A3 (en) 2001-09-07
GB2364059A (en) 2002-01-16
GB0121314D0 (en) 2001-10-24
HK1044543B (zh) 2004-12-03
CA2359785A1 (en) 2000-08-17
US6627739B1 (en) 2003-09-30
EP1165609A2 (en) 2002-01-02
WO2000047618A9 (en) 2001-10-25
HK1044543A1 (en) 2002-10-25
CN1390232A (zh) 2003-01-08
WO2000047618A2 (en) 2000-08-17
NZ534876A (en) 2006-02-24
JP4653318B2 (ja) 2011-03-16
US7109017B1 (en) 2006-09-19

Similar Documents

Publication Publication Date Title
HK1044545A1 (zh) 貝他分泌酶組合物及其方法
HUP0201214A2 (en) Inhibitors of impdh enzyme, pharmaceutical compositions containing them and their use
IL144214A0 (en) Benzoheterocycles and their use as mek inhibitors
HUP0200347A2 (en) N-cyanomethylamides as protease inhibitors, pharmaceutical compositions containing them and their use
ZA200203316B (en) New use and novel n-azabicyclo-amide derivatives.
AU2208401A (en) Inhibitors of complement activation, their preparation and use
PT1499729E (pt) Derivados da enzima de indução de nf-kappab, sua preparação e utilização
AU5213300A (en) 2-nh-pyridones and pyrimidones as mrs inhibitors
PL353214A1 (en) Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-ones and their use as lipase inhibitors
GB9924522D0 (en) Enzyme inhibitors
AU1152601A (en) Compositions and their use
AU3883800A (en) Hob-bp2h compositions, methods and uses thereof
EP1218393A4 (en) CELL TARGETING COMPOSITIONS AND METHODS OF USE THEREOF
AU5179800A (en) Mycolactone and related compounds, compositions and methods of use
GB9922135D0 (en) Compositions and uses
GB0318112D0 (en) ›-Secretase enzyme compositions and methods
HK1049329A1 (en) Benzoxa-and benzothiazolyl sulfamates and their use as steroid sulfatase inhibitors.
PL339493A1 (en) Bis-ethers of 1-oxa, aza and thinaphtalen-2-ones as phospholamane inhibitors
AU6976400A (en) 1,2,3-thiadiazoles and their use as cox-2 inhibitors
HUP0201308A3 (en) Imidazo-containing heterocyclic compounds, their compositions and uses
SI1214302T1 (en) Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-ones and their use as lipase inhibitors
GB9911606D0 (en) Composition and use
IL149749A0 (en) N-(1-phenylethyl)-5-phenylimidazole-2-amine compounds, their compositions and uses
IL142251A0 (en) Use of s-ydcb and b-ydcb, essential bacterial genes
ZA200105277B (en) New amidinobenzylamine derivatives and their use as thrombin inhibitors.