HK1039116A1 - 用作細胞增殖抑制劑的氰基胍化合物 - Google Patents

用作細胞增殖抑制劑的氰基胍化合物

Info

Publication number
HK1039116A1
HK1039116A1 HK02100324.5A HK02100324A HK1039116A1 HK 1039116 A1 HK1039116 A1 HK 1039116A1 HK 02100324 A HK02100324 A HK 02100324A HK 1039116 A1 HK1039116 A1 HK 1039116A1
Authority
HK
Hong Kong
Prior art keywords
cyanoguanidines
cell proliferation
proliferation inhibitors
inhibitors
cell
Prior art date
Application number
HK02100324.5A
Other languages
English (en)
Inventor
E‧R‧奧托森
Original Assignee
裏奧藥物制品有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 裏奧藥物制品有限公司 filed Critical 裏奧藥物制品有限公司
Publication of HK1039116A1 publication Critical patent/HK1039116A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02100324.5A 1997-05-29 2002-01-16 用作細胞增殖抑制劑的氰基胍化合物 HK1039116A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9711119.9A GB9711119D0 (en) 1997-05-29 1997-05-29 Novel cyanoguanidines
PCT/DK1998/000195 WO1998054143A1 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
HK1039116A1 true HK1039116A1 (zh) 2002-04-12

Family

ID=10813249

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02100324.5A HK1039116A1 (zh) 1997-05-29 2002-01-16 用作細胞增殖抑制劑的氰基胍化合物

Country Status (19)

Country Link
US (1) US6121297A (zh)
EP (1) EP0984937A1 (zh)
JP (1) JP2001526693A (zh)
KR (1) KR20010013158A (zh)
CN (1) CN1314890A (zh)
AU (1) AU733093B2 (zh)
BG (1) BG103867A (zh)
BR (1) BR9809496A (zh)
CA (1) CA2291489A1 (zh)
EA (1) EA002037B1 (zh)
EE (1) EE03871B1 (zh)
GB (1) GB9711119D0 (zh)
HK (1) HK1039116A1 (zh)
HU (1) HUP0003150A3 (zh)
IS (1) IS5229A (zh)
NZ (1) NZ500702A (zh)
PL (1) PL337091A1 (zh)
SK (1) SK161199A3 (zh)
WO (1) WO1998054143A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061561A1 (en) 1999-04-09 2000-10-19 Shionogi Bioresearch Corp. Cyanoguanidine compounds
AU1494702A (en) 2000-11-21 2002-06-03 Leo Pharma As Cyanoguanidine prodrugs
US20030045515A1 (en) * 2001-05-24 2003-03-06 Lise Binderup Combination medicament for treatment of neoplastic diseases
WO2002094265A1 (en) * 2001-05-24 2002-11-28 Leo Pharma A/S A method of modulating nf-$g(k)b activity
US6642215B2 (en) * 2001-05-24 2003-11-04 Leo Pharma A/S Method of modulating NF-kB activity
PL366459A1 (en) 2001-05-24 2005-02-07 Leo Pharma A/S Novel pyridyl cyanoguanidine compounds
US7253193B2 (en) 2002-05-17 2007-08-07 Leo Pharma A/S Cyanoguanidine prodrugs
WO2006066584A1 (en) 2004-12-22 2006-06-29 Leo Pharma A/S Novel cyanoguanidine compounds
US8211912B2 (en) 2007-09-26 2012-07-03 Gemin X Pharmaceuticals Canada Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl tranferase inhibitor
US8173677B2 (en) 2007-09-26 2012-05-08 Gemin X Pharmaceuticals Canada Inc. Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor
CA2751495C (en) 2009-02-06 2013-08-20 Tianjin Hemay Bio-Tech Co., Ltd. Pharmaceutical compositions comprising a pyridyl cyanoguanidine and cyclodextrin and/or derivatives thereof
KR20140020823A (ko) 2010-09-03 2014-02-19 포르마 티엠, 엘엘씨. Ｎａｍｐｔ의 억제를 위한 구아니딘 화합물 및 조성물
JP2013540781A (ja) 2010-10-26 2013-11-07 ティエンジン ホーメイ バイオ−テック カンパニー， リミテッド Ｎ−（６−（４−クロロフェノキシ）ヘキシル）−ｎ’−シアノ−ｎ’’−（４−ピリジル）グアニジンの結晶多形とその製造及び使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9219472D0 (en) * 1992-09-15 1992-10-28 Leo Pharm Prod Ltd Chemical compounds

Also Published As

Publication number Publication date
HUP0003150A3 (en) 2002-10-28
IS5229A (is) 1999-10-26
JP2001526693A (ja) 2001-12-18
GB9711119D0 (en) 1997-07-23
AU7638598A (en) 1998-12-30
PL337091A1 (en) 2000-07-31
BR9809496A (pt) 2000-06-20
US6121297A (en) 2000-09-19
SK161199A3 (en) 2000-06-12
EE9900551A (et) 2000-06-15
EA199901096A1 (ru) 2000-08-28
BG103867A (en) 2001-05-31
HUP0003150A2 (en) 2001-03-28
EA002037B1 (ru) 2001-12-24
EE03871B1 (et) 2002-10-15
CN1314890A (zh) 2001-09-26
NZ500702A (en) 2001-07-27
CA2291489A1 (en) 1998-12-03
KR20010013158A (ko) 2001-02-26
AU733093B2 (en) 2001-05-03
WO1998054143A1 (en) 1998-12-03
EP0984937A1 (en) 2000-03-15

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