HK1001956A1 - Oral cyclosporin formulations. - Google Patents

Oral cyclosporin formulations.

Info

Publication number
HK1001956A1
HK1001956A1 HK98101006A HK98101006A HK1001956A1 HK 1001956 A1 HK1001956 A1 HK 1001956A1 HK 98101006 A HK98101006 A HK 98101006A HK 98101006 A HK98101006 A HK 98101006A HK 1001956 A1 HK1001956 A1 HK 1001956A1
Authority
HK
Hong Kong
Prior art keywords
oral cyclosporin
cyclosporin formulations
formulations
oral
cyclosporin
Prior art date
Application number
HK98101006A
Other languages
English (en)
Inventor
Moo J Cho
Ralph E Levy
Philippe J Pouletty
Robert Floch
Christian Merle
Original Assignee
Sangstat Medical Corp
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/519,689 external-priority patent/US5834017A/en
Priority claimed from US08/620,021 external-priority patent/US5766629A/en
Priority claimed from US08/622,516 external-priority patent/US5827822A/en
Application filed by Sangstat Medical Corp, Univ North Carolina filed Critical Sangstat Medical Corp
Publication of HK1001956A1 publication Critical patent/HK1001956A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
HK98101006A 1995-08-25 1998-02-10 Oral cyclosporin formulations. HK1001956A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/519,689 US5834017A (en) 1995-08-25 1995-08-25 Oral cyclopsporin formulations
US08/620,021 US5766629A (en) 1995-08-25 1996-03-21 Oral cyclosporin formulations
US08/622,516 US5827822A (en) 1996-03-25 1996-03-25 Cyclosporin a formulations as nanoparticles
PCT/US1996/012569 WO1997007787A1 (en) 1995-08-25 1996-07-31 Oral cyclosporin formulations

Publications (1)

Publication Number Publication Date
HK1001956A1 true HK1001956A1 (en) 1998-07-24

Family

ID=27414735

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101006A HK1001956A1 (en) 1995-08-25 1998-02-10 Oral cyclosporin formulations.

Country Status (27)

Country Link
EP (1) EP0789561B1 (es)
JP (1) JP3009742B2 (es)
KR (1) KR100294935B1 (es)
CN (1) CN1164828A (es)
AR (1) AR001985A1 (es)
AT (1) ATE263550T1 (es)
AU (1) AU709548B2 (es)
BG (1) BG62875B1 (es)
BR (1) BR9606603A (es)
CA (1) CA2202887A1 (es)
CZ (1) CZ124897A3 (es)
DE (2) DE69632125T2 (es)
ES (1) ES2129381T1 (es)
GE (1) GEP20012547B (es)
HK (1) HK1001956A1 (es)
HU (1) HUP9801052A3 (es)
IL (1) IL120673A0 (es)
IS (1) IS4460A (es)
MX (1) MX9702809A (es)
NO (1) NO971890D0 (es)
NZ (1) NZ313899A (es)
PL (1) PL319898A1 (es)
RO (1) RO119815B1 (es)
SI (1) SI9620014A (es)
SK (1) SK53697A3 (es)
TW (1) TW460287B (es)
WO (1) WO1997007787A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
SI0969856T1 (en) * 1997-03-12 2005-06-30 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
US6657104B1 (en) 1997-10-16 2003-12-02 Texas Systems, University Of The Board Of The Regents Transgenic mouse model for cardiac hypertrophy and methods of use thereof
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
KR100978836B1 (ko) * 2001-10-19 2010-08-30 이소테크니카 인코포레이티드 신규한 시클로스포린 유사체 미세유화액 예비농축물
PT2079456E (pt) * 2007-04-04 2013-03-13 Sigmoid Pharma Ltd Composições farmacêuticas de ciclosporina
WO2008132707A1 (en) 2007-04-26 2008-11-06 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
BRPI1012196B1 (pt) 2009-05-18 2021-11-30 Sublimity Therapeutics Limited Composição compreendendo gotas de óleo
GB2485327A (en) 2009-08-12 2012-05-09 Sigmoid Pharma Ltd Immunomodulatory compositions comprising a polymer matrix and an oil phase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
CN107106644B (zh) 2014-11-07 2022-04-15 卓越治疗有限公司 包含环孢菌素的组合物
CN104940132B (zh) * 2015-06-05 2018-02-27 河南牧翔动物药业有限公司 一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
EP0589843B1 (en) * 1992-09-25 2001-11-28 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
RU2158601C2 (ru) * 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения

Also Published As

Publication number Publication date
CZ124897A3 (en) 1997-09-17
IL120673A0 (en) 1997-08-14
SI9620014A (sl) 1998-04-30
BG101443A (en) 1998-03-31
SK53697A3 (en) 1997-10-08
ES2129381T1 (es) 1999-06-16
NO971890L (no) 1997-04-24
HUP9801052A2 (hu) 1998-09-28
EP0789561A4 (en) 1998-12-02
EP0789561B1 (en) 2004-04-07
DE789561T1 (de) 1999-06-10
KR100294935B1 (ko) 2001-07-12
AU709548B2 (en) 1999-09-02
DE69632125D1 (de) 2004-05-13
EP0789561A1 (en) 1997-08-20
BG62875B1 (bg) 2000-10-31
PL319898A1 (en) 1997-09-01
MX9702809A (es) 1998-02-28
CA2202887A1 (en) 1997-03-06
GEP20012547B (en) 2001-10-25
NO971890D0 (no) 1997-04-24
IS4460A (is) 1997-04-08
HUP9801052A3 (en) 1998-12-28
AU6644196A (en) 1997-03-19
JPH10509462A (ja) 1998-09-14
WO1997007787A1 (en) 1997-03-06
AR001985A1 (es) 1998-01-07
RO119815B1 (ro) 2005-04-29
JP3009742B2 (ja) 2000-02-14
TW460287B (en) 2001-10-21
CN1164828A (zh) 1997-11-12
KR970706803A (ko) 1997-12-01
ATE263550T1 (de) 2004-04-15
DE69632125T2 (de) 2004-09-16
BR9606603A (pt) 1997-09-30
NZ313899A (en) 2000-03-27

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080731