GT201700149A - Mezcla de ácidos carboxilicos para tratar pacientes con insuficiencia renal - Google Patents
Mezcla de ácidos carboxilicos para tratar pacientes con insuficiencia renalInfo
- Publication number
- GT201700149A GT201700149A GT201700149A GT201700149A GT201700149A GT 201700149 A GT201700149 A GT 201700149A GT 201700149 A GT201700149 A GT 201700149A GT 201700149 A GT201700149 A GT 201700149A GT 201700149 A GT201700149 A GT 201700149A
- Authority
- GT
- Guatemala
- Prior art keywords
- renal
- treatment
- acid
- patients
- substitute
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- -1 CARBOXYL ACIDS Chemical class 0.000 title 1
- 208000001647 Renal Insufficiency Diseases 0.000 title 1
- 201000006370 kidney failure Diseases 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 2
- 230000003907 kidney function Effects 0.000 abstract 2
- 238000005891 transamination reaction Methods 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 239000003797 essential amino acid Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 abstract 1
- 238000001631 haemodialysis Methods 0.000 abstract 1
- 230000000322 hemodialysis Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 229940049920 malate Drugs 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-L oxaloacetate(2-) Chemical compound [O-]C(=O)CC(=O)C([O-])=O KHPXUQMNIQBQEV-UHFFFAOYSA-L 0.000 abstract 1
- 239000000779 smoke Substances 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
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- Medicinal Preparation (AREA)
Abstract
ACTUALMENTE EL TRATAMIENTO PARA PACIENTES CON ENFERMEDAD RENAL TERMINAL (ESTADIO V) CONSISTE EN TERAPIA RENAL SUSTITUTIVA (HEMODIÁLISIS, DIÁLISIS PERITONEAL O TRANSPLANTE RENAL); EXTRAORDINARIAMENTE COSTOSA QUE CONLLEVA UN POBRE CALIDAD DE VIDA. NUESTRO INVENTO ES UNA MEZCLA DE ÁCIDOS CARBOXÍLICOS: ÁCIDO CÍTRICO, ÁCIDO SUCCÍNICO, ÁCIDO FUMÁRICO Y ÁCIDO MÁLICO, Y CUALESQUIERA DE SUS COMBINACIONES POSIBLES. DICHO PRODUCTO SE UTILIZA PREFERENTEMENTE VÍA ORAL O TAMBIÉN VÍA INTRAVENOSA, EN EL TRATAMIENTO DE PACIENTES CON INSUFICIENCIA RENAL CRÓNICA, HIPERAMONEMIA O CONDICIONES HUMANAS QUE CURSEN CON BALANCE NITROGENADO NEGATIVO. ESTE PRODUCTO ES BENÉFICO PARA DISMINUIR LOS VALORES SÉRICOS DE UREA Y DE AMONIO SÉRICO, A LA VEZ QUE POR TRANSAMINACIÓN DEL OXALACETATO FORMADO VÍA SUCCINATO, FUMARATO Y MALATO, PROMUEVE LA BIOSÍNTESIS DE AMINOÁCIDOS NO ESENCIALES; POR TRANSAMINACIÓN DEL ALFA CETO GLUTARATO FORMADO VÍA CITRATO, GENERA ÁCIDO GLUTÁMICO Y LOS AMINOÁCIDOS RELACIONADOS AL MISMO COMO GLUTAMINA. ESTE TRATAMIENTO PREVIENE, PRESERVA E INCLUSIVE MEJORA LA FUNCIÓN RENAL. EN OTROS PACIENTES RETARDA EL DETERIORO DE LA FUNCIÓN RENAL Y LA IMPERIOSA NECESIDAD DEL TRATAMIENTO RENAL SUSTITUTIVO. EN OTROS MÁS, SE UTILIZA COMO TRATAMIENTO COMPLEMENTARIO AL TRATAMIENTO RENAL SUSTITUTIVO PARA MEJORAR LA CALIDAD DE VIDA DEL PACIENTE Y MEJORAR LOS PARÁMETROS LABORATORIALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2015003641A MX357998B (es) | 2015-03-20 | 2015-03-20 | Una mezcla de acidos carboxilicos, especificamente acido citrico, acido succinico, acido fumarico y acido malico para el tratamiento de pacientes con insuficiencia renal cronica, insuficiencia renal aguda, hepatopatias agudas o cronicas que cursen con hiperamonemia, enfermedades congenitas con alteraciones enzimaticas en el ciclo de la urea, asi como condiciones clínicas que cursen con balance nitrogenado negativo. |
Publications (1)
Publication Number | Publication Date |
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GT201700149A true GT201700149A (es) | 2018-10-25 |
Family
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Family Applications (1)
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GT201700149A GT201700149A (es) | 2015-03-20 | 2017-06-27 | Mezcla de ácidos carboxilicos para tratar pacientes con insuficiencia renal |
Country Status (26)
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US (2) | US10688068B2 (es) |
EP (1) | EP3219315B1 (es) |
JP (1) | JP6771191B2 (es) |
KR (1) | KR102057555B1 (es) |
CN (1) | CN108024981B (es) |
AU (1) | AU2015387986B2 (es) |
BR (1) | BR112017017189A2 (es) |
CA (1) | CA2972889C (es) |
CL (1) | CL2017001262A1 (es) |
CO (1) | CO2017007046A2 (es) |
CR (1) | CR20170320A (es) |
DO (1) | DOP2017000161A (es) |
EA (1) | EA036702B1 (es) |
EC (1) | ECSP17056559A (es) |
ES (1) | ES2850998T3 (es) |
GT (1) | GT201700149A (es) |
HK (1) | HK1249426A1 (es) |
IL (1) | IL253480B (es) |
MX (1) | MX357998B (es) |
MY (1) | MY173111A (es) |
NZ (1) | NZ733186A (es) |
PE (1) | PE20180228A1 (es) |
PH (1) | PH12017501157A1 (es) |
SG (1) | SG11201705163XA (es) |
TN (1) | TN2017000257A1 (es) |
WO (1) | WO2016153331A1 (es) |
Families Citing this family (9)
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WO2018193648A1 (ja) * | 2017-04-18 | 2018-10-25 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
JP7219898B2 (ja) * | 2017-04-18 | 2023-02-09 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
IT201700087359A1 (it) * | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
IT201700087376A1 (it) | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
AU2019361520A1 (en) * | 2018-10-17 | 2021-05-20 | Nippon Chemiphar Co., Ltd. | Novel pharmaceutical composition |
CN109125310A (zh) * | 2018-11-06 | 2019-01-04 | 河北工业大学 | 琥珀酸在抑制Kv10.1离子通道活性中的应用和药物 |
EP3976559A4 (en) | 2019-05-30 | 2023-06-21 | Koch Agronomic Services, LLC | FOLIAR SOLUTIONS OF MICRONUTRIENTS |
US11666548B2 (en) * | 2020-06-05 | 2023-06-06 | Baxter International Inc. | Parenteral nutrition formulation |
CN115414383A (zh) * | 2022-10-14 | 2022-12-02 | 青岛普瑞森医药科技有限公司 | 血液透析浓缩液及其制备方法 |
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US5475031A (en) * | 1993-09-03 | 1995-12-12 | Livingston; William H. | Discovery of a valuable property for succinic acid and other intermediary metabolites |
US5500232A (en) * | 1994-10-06 | 1996-03-19 | Bristol-Myers Squibb Company | Calcium fortified beverages |
US6488961B1 (en) * | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
EP0938849A1 (en) | 1998-02-18 | 1999-09-01 | Quest International B.V. | A composition with a fresh, fruit like taste |
US6288116B1 (en) * | 1998-05-13 | 2001-09-11 | Novartis Nutrition Ag | Method of administration of a nutritional product to a person having renal failure |
WO2001026487A1 (en) * | 1999-10-12 | 2001-04-19 | Meiji Seika Kaisha, Ltd. | Low potassium juice, method for producing thereof and food containing the same |
AU2002211770A1 (en) * | 2000-10-16 | 2002-04-29 | Pepsico, Inc. | Calcium-supplemented beverages and method of making same |
US20030211204A1 (en) * | 2002-05-10 | 2003-11-13 | Fields Christine C. | Method of preparing beverages and beverage concentrates nutritionally supplemented with minerals |
US20090186127A1 (en) * | 2004-12-15 | 2009-07-23 | Krumhar Kim C | Energy drink compositions |
BRPI0602825A2 (pt) * | 2006-06-23 | 2012-04-24 | Rhodia Br Ltda | formulação de pó efervescente auto-refrigerante para bebidas e uso de formulação em pó efervescente |
US20080058421A1 (en) | 2006-09-05 | 2008-03-06 | John Alex Lopes | Compositions for cleaning and disinfecting nasal tract and sinus cavity |
CN105380936A (zh) * | 2006-12-12 | 2016-03-09 | 味之素株式会社 | 铁代谢改善剂 |
CN101568334A (zh) * | 2006-12-12 | 2009-10-28 | 味之素株式会社 | 铁代谢改善剂 |
US20080226799A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Diet Cola Beverages |
WO2009032538A1 (en) * | 2007-08-31 | 2009-03-12 | C.B. Fleet Company, Inc. | Method of preventing nephrocalcinosis |
JP5740393B2 (ja) * | 2009-05-15 | 2015-06-24 | バイオセプタ コーポレイションbioCEPTA Corporation | 皮膚および爪の真菌感染症の局所治療に適した組成物 |
NL2009407C2 (en) * | 2012-09-03 | 2014-03-04 | Dutch Renewable Energy B V | Antimicrobial composition. |
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2015
- 2015-03-20 MX MX2015003641A patent/MX357998B/es active IP Right Grant
- 2015-11-04 CR CR20170320A patent/CR20170320A/es unknown
- 2015-11-04 MY MYPI2017702409A patent/MY173111A/en unknown
- 2015-11-04 AU AU2015387986A patent/AU2015387986B2/en not_active Ceased
- 2015-11-04 JP JP2017541850A patent/JP6771191B2/ja active Active
- 2015-11-04 PE PE2017001076A patent/PE20180228A1/es not_active Application Discontinuation
- 2015-11-04 TN TN2017000257A patent/TN2017000257A1/en unknown
- 2015-11-04 KR KR1020177022643A patent/KR102057555B1/ko active IP Right Grant
- 2015-11-04 EA EA201700339A patent/EA036702B1/ru unknown
- 2015-11-04 SG SG11201705163XA patent/SG11201705163XA/en unknown
- 2015-11-04 EP EP15886606.1A patent/EP3219315B1/en active Active
- 2015-11-04 BR BR112017017189-9A patent/BR112017017189A2/pt not_active Application Discontinuation
- 2015-11-04 CA CA2972889A patent/CA2972889C/en active Active
- 2015-11-04 ES ES15886606T patent/ES2850998T3/es active Active
- 2015-11-04 US US15/547,620 patent/US10688068B2/en active Active
- 2015-11-04 NZ NZ733186A patent/NZ733186A/en unknown
- 2015-11-04 WO PCT/MX2015/000144 patent/WO2016153331A1/es active Application Filing
- 2015-11-04 CN CN201580072466.5A patent/CN108024981B/zh active Active
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2017
- 2017-05-17 CL CL2017001262A patent/CL2017001262A1/es unknown
- 2017-06-20 PH PH12017501157A patent/PH12017501157A1/en unknown
- 2017-06-27 GT GT201700149A patent/GT201700149A/es unknown
- 2017-07-06 DO DO2017000161A patent/DOP2017000161A/es unknown
- 2017-07-13 CO CONC2017/0007046A patent/CO2017007046A2/es unknown
- 2017-07-13 IL IL253480A patent/IL253480B/en active IP Right Grant
- 2017-08-28 EC ECIEPI201756559A patent/ECSP17056559A/es unknown
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2018
- 2018-07-12 HK HK18109048.3A patent/HK1249426A1/zh unknown
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2019
- 2019-11-29 US US16/699,207 patent/US20200138755A1/en not_active Abandoned
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