GT200400020A - USEFUL TRIAZOL COMPOUNDS IN THERAPY - Google Patents
USEFUL TRIAZOL COMPOUNDS IN THERAPYInfo
- Publication number
- GT200400020A GT200400020A GT200400020A GT200400020A GT200400020A GT 200400020 A GT200400020 A GT 200400020A GT 200400020 A GT200400020 A GT 200400020A GT 200400020 A GT200400020 A GT 200400020A GT 200400020 A GT200400020 A GT 200400020A
- Authority
- GT
- Guatemala
- Prior art keywords
- useful
- therapy
- compounds
- triazol compounds
- triazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN LA QUE A,B,X,Y,Z,W,V, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. POR SUS CARACTERISTICAS ESPECIALES, ESTOS COMPUESTOS SON DE UTILIDAD EN UNA AMPLIA VARIEDAD DE PATOLOGIAS TALES COMO ANSIEDAD, ANOREXIA NERVIOSA, HIPERTENSION, EDEMA, ENTRE OTRAS MUCHAS DESCRITAS EN LA INVENCION.THE PRESENT INVENTION REFERS TO COMPOUNDS OF GENERAL FORMULA I IN WHICH A, B, X, Y, Z, W, V, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. BY THEIR SPECIAL CHARACTERISTICS, THESE COMPOUNDS ARE USEFUL IN A WIDE VARIETY OF SUCH PATHOLOGIES AS ANXIETY, NERVOUS ANOREXY, HYPERTENSION, EDEMA, BETWEEN MANY DESCRIBED IN THE INVENTION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0303852.8A GB0303852D0 (en) | 2003-02-19 | 2003-02-19 | Triazole compounds useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200400020A true GT200400020A (en) | 2004-09-21 |
Family
ID=9953327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200400020A GT200400020A (en) | 2003-02-19 | 2004-02-18 | USEFUL TRIAZOL COMPOUNDS IN THERAPY |
Country Status (11)
Country | Link |
---|---|
CN (1) | CN1751047A (en) |
AR (1) | AR043210A1 (en) |
CL (1) | CL2004000293A1 (en) |
GB (1) | GB0303852D0 (en) |
GT (1) | GT200400020A (en) |
NL (1) | NL1025527C2 (en) |
PA (1) | PA8596101A1 (en) |
PE (1) | PE20050222A1 (en) |
TW (1) | TW200500367A (en) |
UY (1) | UY28201A1 (en) |
WO (1) | WO2004074291A1 (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0325021D0 (en) * | 2003-10-27 | 2003-12-03 | Pfizer Ltd | Therapeutic combinations |
US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
DE102004001871A1 (en) * | 2004-01-14 | 2005-09-01 | Bayer Healthcare Ag | Tricyclic benzazepine derivatives and their use |
US7456170B2 (en) | 2004-08-25 | 2008-11-25 | Pfizer Inc. | Triazolobenzodiazepines and their use as vasopressin antagonists |
WO2006114706A1 (en) * | 2005-04-26 | 2006-11-02 | Pfizer Limited | Triazole derivatives as vasopressin antagonists |
KR101348499B1 (en) | 2008-11-13 | 2014-01-06 | 에프. 호프만-라 로슈 아게 | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes |
PL2358714T3 (en) | 2008-11-18 | 2012-12-31 | Hoffmann La Roche | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
UA103504C2 (en) | 2008-11-28 | 2013-10-25 | Ф. Хоффманн-Ля Рош Аг | Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists |
CA2756871A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
CA2779088A1 (en) * | 2009-11-16 | 2011-05-19 | Mellitech | [1,5]-diazocin derivatives |
US8420633B2 (en) * | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) * | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) * | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
US9006450B2 (en) * | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
AR083313A1 (en) | 2010-10-07 | 2013-02-13 | Takeda Pharmaceutical | DERIVATIVES OF 1,4-OXAZEPAN USEFUL AS INHIBITORS OF THE RECOVERY OF SUPERIOR MONOAMINE |
RU2011122942A (en) | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | NEW KINAZ INHIBITORS |
US8828989B2 (en) * | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
RU2014117471A (en) * | 2011-10-05 | 2015-11-10 | Ф. Хоффманн-Ля Рош Аг | CYCLOGEXYL-4H, 6H-5-OXA-2,3,10B-TRIAZABENZO [e] ASULENES AS V1A RECEPTOR ANTAGONISTS |
WO2013186159A1 (en) | 2012-06-13 | 2013-12-19 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
CN102766674A (en) * | 2012-07-25 | 2012-11-07 | 辉源生物科技(上海)有限公司 | Establishment of screening platform for cynomolgus monkey antidiuretic hormone receptor V1A antagonist |
IN2015DN00960A (en) | 2012-09-25 | 2015-06-12 | Hoffmann La Roche | |
AR095079A1 (en) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO |
CN105492010B (en) * | 2013-08-19 | 2020-01-03 | 豪夫迈·罗氏有限公司 | V1a antagonists for the treatment of phase shift sleep disorders |
PL3074400T3 (en) | 2013-11-26 | 2018-03-30 | F.Hoffmann-La Roche Ag | Octahydro-cyclobuta [1,2-c;3,4-c']dipyrrole derivatives as autotaxin inhibitors |
CA3142754C (en) | 2013-12-05 | 2024-01-02 | F. Hoffmann-La Roche Ag | Synthesis of trans-8-chloro-5-methyl- 1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crystalline forms thereof |
MA50635A (en) | 2014-03-26 | 2020-08-12 | Hoffmann La Roche | NEW BICYCLIC COMPOUNDS AS INHIBITORS OF AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID PRODUCTION |
UA119347C2 (en) | 2014-03-26 | 2019-06-10 | Ф. Хоффманн-Ля Рош Аг | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
MA41898A (en) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | BICYCLIC QUINAZOLINONE DERIVATIVES |
PE20180479A1 (en) | 2015-09-04 | 2018-03-07 | Hoffmann La Roche | NEW DERIVATIVES OF PHENOXYMETHYL |
RU2724899C2 (en) | 2015-09-24 | 2020-06-26 | Ф. Хоффманн-Ля Рош Аг | New bicyclic compounds as dual inhibitors of atx/ca |
CA2983782A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
CA2991615A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
CA2984585A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
JP7090099B2 (en) | 2017-03-16 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | A novel bicyclic compound as an ATX inhibitor |
CN110392679B (en) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | Heterocyclic compounds useful as dual ATX/CA inhibitors |
EP3634963B8 (en) | 2017-06-05 | 2023-03-29 | Blackthorn Therapeutics, Inc. | 1-(2-azaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives as v1a receptor antagonists for treating neuropsychological disorders |
TW201938171A (en) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | Tricyclic compounds as vasopressin V1a receptor antagonists |
HU231206B1 (en) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepines |
CN111170983B (en) * | 2019-12-26 | 2021-07-09 | 中国农业大学 | Benzylthio acetamide compound and preparation method and application thereof |
CN114644635B (en) * | 2020-12-21 | 2023-02-03 | 上海济煜医药科技有限公司 | Triazole tricyclic derivative and preparation method and application thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823475D0 (en) * | 1988-10-06 | 1988-11-16 | Merck Sharp & Dohme | Chemical compounds |
US5438035A (en) * | 1994-06-24 | 1995-08-01 | American Cyanamid Company | Methods for controlling undesirable plant species with benzodiazepine compounds |
US5753648A (en) * | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
CA2268327C (en) * | 1996-11-01 | 2002-05-21 | American Home Products Corporation | 3-carboxamide derivatives of 5h-pyrrolo[2,1-c][1,4]-benzodiazepines |
HU229074B1 (en) * | 1999-01-19 | 2013-07-29 | Ortho Mcneil Pharm Inc | Tricyclic benzodiazepines as vasopressin receptor antagonists |
US7109193B2 (en) * | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
-
2003
- 2003-02-19 GB GBGB0303852.8A patent/GB0303852D0/en not_active Ceased
-
2004
- 2004-02-09 WO PCT/IB2004/000432 patent/WO2004074291A1/en active IP Right Grant
- 2004-02-09 CN CNA2004800047089A patent/CN1751047A/en active Pending
- 2004-02-17 PE PE2004000165A patent/PE20050222A1/en not_active Application Discontinuation
- 2004-02-18 PA PA20048596101A patent/PA8596101A1/en unknown
- 2004-02-18 CL CL200400293A patent/CL2004000293A1/en unknown
- 2004-02-18 AR ARP040100495A patent/AR043210A1/en not_active Application Discontinuation
- 2004-02-18 TW TW093103978A patent/TW200500367A/en unknown
- 2004-02-18 GT GT200400020A patent/GT200400020A/en unknown
- 2004-02-19 NL NL1025527A patent/NL1025527C2/en not_active IP Right Cessation
- 2004-02-19 UY UY28201A patent/UY28201A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1751047A (en) | 2006-03-22 |
PE20050222A1 (en) | 2005-04-13 |
GB0303852D0 (en) | 2003-03-26 |
AR043210A1 (en) | 2005-07-20 |
PA8596101A1 (en) | 2005-08-04 |
UY28201A1 (en) | 2004-09-30 |
TW200500367A (en) | 2005-01-01 |
NL1025527C2 (en) | 2005-03-14 |
WO2004074291A1 (en) | 2004-09-02 |
CL2004000293A1 (en) | 2005-01-07 |
NL1025527A1 (en) | 2004-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GT200400020A (en) | USEFUL TRIAZOL COMPOUNDS IN THERAPY | |
GT200500208A (en) | USEFUL INDAZOLS TO TREAT CARDIOVASCULAR DISEASES | |
GT200300028A (en) | DERIVATIVES III OF DIHYDROBENZODIACEPINA-2-ONA | |
GT200500112A (en) | TETRAHYDRONAFTIRIDINE DERIVATIVES | |
GT200500157A (en) | DIFENYLIMIDAZOPIRIMIDINE AND IMIDAZOL AMINAS AS BETA-SECRETASA INHIBITORS | |
GT200400268A (en) | PIRIDO [2,3-D] PIRIMIDINA-2,4-DIAMINAS AS PDE 2 INHIBITORS | |
GT200200220AA (en) | NEW PIRROLIDINE DERIVATIVES | |
GT200600181A (en) | DERIVATIVES OF REPLACED AMIDA AND METHODS OF USE | |
GT200300226A (en) | 4-PIPERAZINILBENCENOSULFONILINDOLES AND USES OF THE SAME | |
GT200400032A (en) | NEW CONDENSED HETEROAROMATIC COMPOUNDS THAT ARE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) | |
GT200300219A (en) | TIAZOL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | |
RS52117B (en) | Exo-and diastereo-selective syntheses of himbacine analogs | |
GT200500103A (en) | 4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDAS | |
GT200300171A (en) | HETEROBIARILO DERIVATIVES AS METALOPROTEINASE IN MATRIX INHIBITORS | |
GT200300098A (en) | ARIL-HETEROARILOXI-ARILOXI-PYRIMIDINA-2,4,6-TRIONA METALOPROTEINASE INHIBITORS | |
GT200300296A (en) | PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH | |
GT200400161A (en) | REPLACED PYRIDINONES | |
GT200200122A (en) | IMIDAZOTRIAZINAS | |
GT200300087A (en) | 2- (2,6-DICLOROPHENYL) -DIARYLIMIDAZOLS | |
GT200200280A (en) | LACTAMAS AS TAQUIQUININE ANTAGONISTS | |
GT200300093A (en) | HETEROARILOXI-ARIL-ESPIRO-PYRIMIDINE-2,4,6-TRIONA N-SUBSTITUTED METALOPROTEINASE INHIBITORS | |
GT200600430A (en) | CARBOXYAMINE COMPOUNDS AND SAME USE METHODS | |
HN2003000416A (en) | PIRROLOPIRIMIDINE DERIVATIVES | |
GT200200253A (en) | HETEROARIL NITRILOS | |
GT200600072A (en) | PHARMACEUTICAL COMPOSITIONS |