GT200300075AA - COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075) - Google Patents

COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075)

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Publication number
GT200300075AA
GT200300075AA GT200300075AK GT200300075K GT200300075AA GT 200300075A A GT200300075A A GT 200300075AA GT 200300075A K GT200300075A K GT 200300075AK GT 200300075 K GT200300075 K GT 200300075K GT 200300075A A GT200300075A A GT 200300075AA
Authority
GT
Guatemala
Prior art keywords
compounds
procedures
therapy
preparation
fractionary
Prior art date
Application number
GT200300075AK
Other languages
Spanish (es)
Inventor
Gary Frederick Filzen
Bharat Kalidas Trivedi
Andrew George Geyer
Paul Charles Unangst
Larry Don Bratton
Bruce Jeffrey Auerbach
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GT200300075AA publication Critical patent/GT200300075AA/en

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    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCIÓN SE REFIERE A COMPUESTOS QUE ALTERAN LA ACTIVIDAD DE PPAR. LA INVENCIÓN TAMBIÉN SE REFIERE A LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS COMPUESTOS, LAS COMPOSICIONES FARMACÉUTICAMENTE ACEPTABLES QUE COMPRENDEN LOS COMPUESTOS O SUS SALES, Y LOS PROCEDIMIENTOS DE UTILIZACIÓN DE ÉSTOS COMO AGENTES TERAPÉUTICOS PARA TRATAR O PREVENIR LA HIPERLIPIDEMIA, LA HIPERCOLESTEREMIA , LA OBESIDAD, LOS TRASTORNOS ALIMENTARIOS, LA HIPERGLUCEMIA, LA ATEROSCLEROSIS, LA HIPERTRIGLICERIDEMIA, LA HIPERINSULINEMIA Y LA DIABETES EN UN MAMÍFERO, ASÍ COM PROCEDIMIENTOS PARA SUPRIMIR EL APETITO Y MODULAR LOS NIVELES DE LEPTINA EN UN MAMÍFERO. LA PRESENTE INVENCIÓN SE REFIERE TAMBIÉN A PROCEDIMIENTOS PARA LA ELABORACIÓN DE LOS COMPUESTOS DESCRITOS.THE INVENTION REFERS TO COMPOUNDS THAT ALTER THE ACTIVITY OF PPAR. THE INVENTION ALSO REFERS TO THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE COMPOUNDS, THE PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS THAT UNDERSTAND THE COMPOUNDS OR THEIR SALTS, AND THE PROCEDURES FOR USE OF THESE AS AGENTS THERAPY THREE-THREE-THREE-DAY HOPE, THERAPY THERAPY THERAPY THERAPY THERAPY THERAPY THERAPY THREE-DUTY, THE THREE-THREE-PIECES FOOD DISORDERS, HYPERGLUCEMIA, ATEROSCLEROSIS, HYPERTRIGLICERIDEMIA, HYPERINSULINEMIA AND DIABETES IN A MAMMERE, AS WELL AS PROCEDURES TO SUPPRESS THE APPETIZE AND MODULATE A LAMPHIN LEVEL. THIS INVENTION REFERS TO PROCEDURES FOR THE PREPARATION OF THE DESCRIBED COMPOUNDS.

GT200300075AK 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075) GT200300075AA (en)

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