GT200300034A - NICOTINAMIDE DERIVATIVES AND A COMBINATION TIOTROPIO SALT FOR THE TREATMENT OF DISEASES - Google Patents

NICOTINAMIDE DERIVATIVES AND A COMBINATION TIOTROPIO SALT FOR THE TREATMENT OF DISEASES

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Publication number
GT200300034A
GT200300034A GT200300034A GT200300034A GT200300034A GT 200300034 A GT200300034 A GT 200300034A GT 200300034 A GT200300034 A GT 200300034A GT 200300034 A GT200300034 A GT 200300034A GT 200300034 A GT200300034 A GT 200300034A
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GT
Guatemala
Prior art keywords
tiotropio
diseases
salt
treatment
combination
Prior art date
Application number
GT200300034A
Other languages
Spanish (es)
Inventor
Thomas Victor Magee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300034A publication Critical patent/GT200300034A/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE FORMULA GENERAL I EN DONDE R1,R2,R3,R4,X,Y,M,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES DE PDE4 DE LA FAMILIA DE LA NICOTINAMIDA POR LO QUE SON DE UTILIDAD EN NUMEROSAS PATOLOGIAS, TRASTORNOS Y AFECCIONES INFLAMATORIAS, ALERGICAS Y RESPIRATORIAS.THE PRESENT INVENTION REFERS TO A COMPOSITE OF GENERAL FORMULA I WHERE R1, R2, R3, R4, X, Y, M, N, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. THESE COMPOUNDS ARE PDE4 INHIBITORS OF THE NICOTINAMIDE FAMILY FOR WHICH THEY ARE USEFUL IN NUMEROUS PATHOLOGIES, DISORDERS AND INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS.

GT200300034A 2002-02-11 2003-02-10 NICOTINAMIDE DERIVATIVES AND A COMBINATION TIOTROPIO SALT FOR THE TREATMENT OF DISEASES GT200300034A (en)

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US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
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US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
JPWO2005026132A1 (en) * 2003-09-17 2007-11-08 日本新薬株式会社 CAMP substrate-specific inhibitors of phosphodiesterase
ATE460414T1 (en) 2003-11-03 2010-03-15 Boehringer Ingelheim Int METHOD FOR PRODUCING TIOTROPIUM SALTS
WO2005067929A1 (en) * 2004-01-09 2005-07-28 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on a scopineester and nicotinamide derivatives
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AR038404A1 (en) 2005-01-12
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