GR920100526A - Φαρμακα και καθαρα σκευασματα διυχλωρικης μελαρσονινης, μεθοδος δια την παρασκευη αυτων και ενδιαμεσα λαμβανομενα προιοντα. - Google Patents

Φαρμακα και καθαρα σκευασματα διυχλωρικης μελαρσονινης, μεθοδος δια την παρασκευη αυτων και ενδιαμεσα λαμβανομενα προιοντα.

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Publication number
GR920100526A
GR920100526A GR920100526A GR920100526A GR920100526A GR 920100526 A GR920100526 A GR 920100526A GR 920100526 A GR920100526 A GR 920100526A GR 920100526 A GR920100526 A GR 920100526A GR 920100526 A GR920100526 A GR 920100526A
Authority
GR
Greece
Prior art keywords
melarsomine
stage
preparation
pure
dihydrochloride
Prior art date
Application number
GR920100526A
Other languages
English (en)
Inventor
Jean-Pierre Etchegaray
H Robert Floc
Patrick Lubert
Regine Jackie Mazars
Gerard Wolf
Original Assignee
Rhone Merieux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Merieux filed Critical Rhone Merieux
Publication of GR920100526A publication Critical patent/GR920100526A/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/80—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/74—Aromatic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Φάρμακα με βάση καθαρά σκευάσματα διυδροχλωρικήςμελαρσομίνης, μέθοδος δια την παρασκευή αυτών, καθαράσκευάσματα διϋδροχλωρικής μελαρσομίνης και ενδιάμεσα προϊόνταπου λαμβάνονται εις τη μέθοδο αυτή.Το φάρμακο περιλαμβάνει ως δραστική ουσία ένα σκεύασμαδιϋδροχλωρικής μελαρσομίνης που έχει καθαρότηταπεριλαμβανομένη μεταξύ 98.5 και 100%. Η μέθοδος παρασκευήςτου σκευάσματος αυτού είναι ουσιαστικά η ακόλουθος:- εις το στάδιο 1, μετατρέπομε την τριχλωριοτριαζίνη (TCT)εις διαμινοχλωριοτριαζίνη (DTC) εις αμμωνιακό μέσο- εις το στάδιο 3, ανάγομε την CMA εις διϋδρίτημελαρσενοξειδίου και- εις το στάδιο 4, μετατρέπομε τον διϋδρίτη μελαρσενοξειδίουεις διϋδροχλωρική μελαρσομίνη παρουσία υδροχλωρικήςκυστεαμίνης. Εις κάθε στάδιο παίρνομε ένα καθαρισμένοπαρασκεύασμα του αντίστοιχου ενδιάμεσου προϊόντος εις τοστάδιο 4.ω
GR920100526A 1991-12-02 1992-11-26 Φαρμακα και καθαρα σκευασματα διυχλωρικης μελαρσονινης, μεθοδος δια την παρασκευη αυτων και ενδιαμεσα λαμβανομενα προιοντα. GR920100526A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919114904A FR2684382B1 (fr) 1991-12-02 1991-12-02 Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.

Publications (1)

Publication Number Publication Date
GR920100526A true GR920100526A (el) 1993-08-31

Family

ID=9419573

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920100526A GR920100526A (el) 1991-12-02 1992-11-26 Φαρμακα και καθαρα σκευασματα διυχλωρικης μελαρσονινης, μεθοδος δια την παρασκευη αυτων και ενδιαμεσα λαμβανομενα προιοντα.

Country Status (15)

Country Link
US (3) US5459263A (el)
JP (1) JP3578277B2 (el)
AU (1) AU667329B2 (el)
BR (1) BR9204643A (el)
CA (1) CA2083766C (el)
ES (1) ES2039311B1 (el)
FR (1) FR2684382B1 (el)
GR (1) GR920100526A (el)
IT (1) IT1256117B (el)
MA (1) MA22723A1 (el)
MX (1) MX9206890A (el)
MY (1) MY111175A (el)
PH (1) PH31115A (el)
PT (1) PT101105B (el)
TW (1) TW358099B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684382B1 (fr) * 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.
US6191123B1 (en) * 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
ATE437239T1 (de) * 2002-11-07 2009-08-15 Newsouth Innovations Pty Ltd Induktion der mitochondrialen permeabilitätstransition
US6686344B1 (en) 2003-01-30 2004-02-03 Paker Hughes Institute Organic-arsonic compounds
CN101595115B (zh) 2006-11-01 2012-07-18 新南部创新有限公司 有机-氧化砷化合物及其用途
US8373412B2 (en) * 2009-01-23 2013-02-12 Baker Hughes Incorporated NMR-LWD imaging tool
US8324895B2 (en) * 2009-01-23 2012-12-04 Baker Hughes Incorporated MWD/LWD NMR imaging with long echo trains
CN102558235B (zh) * 2011-04-08 2015-01-07 浙江工商大学 一种通过三甲氧苄氨嘧啶重氮化制备阿散酸制剂的方法
CN102558234B (zh) * 2011-04-08 2015-01-07 浙江工商大学 一种通过对氨基苯胂酸重氮化制备阿散酸制剂的方法
US9593052B2 (en) 2012-08-17 2017-03-14 The Curators Of The University Of Missouri Arsenic complexes for potential diagnostic applications
US20140051840A1 (en) * 2012-08-17 2014-02-20 The Curators Of The University Of Missouri Arsenic complexes for potential diagnostic applications

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH242529A (de) * 1940-12-10 1946-05-15 Friedheim Ernst Albert Hermann Verfahren zur Darstellung von m-(2,4-Diamino-1,3,5-triazinyl-(6))-amino-phenylarsinoxyd.
CH245837A (de) * 1946-11-16 1946-11-30 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-2,4-Diamino-1,3,5-triazinyl-(6)-amino-phenyl-arsenoxyd.
CH254164A (de) * 1946-11-16 1948-04-15 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-(2,4-Diamino-1,3,5-triazinyl-(6)-aminophenyl-arsenoxyd.
FR2150705A1 (el) * 1971-07-20 1973-04-13 Friedheim Ernst Ah
WO1983003606A1 (en) * 1982-04-12 1983-10-27 Univ Rockefeller Improved melaminylthioarsenites
FR2572730A1 (fr) * 1984-11-02 1986-05-09 Centre Nat Rech Scient Nouveaux derives de l'arsenic, leur preparation et leur application, notamment comme medicaments antiparasitaires
FR2640269A1 (fr) * 1988-12-13 1990-06-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE437342A (el) * 1938-12-23 1900-01-01
NL60802C (el) * 1940-12-10
US2422724A (en) * 1944-01-20 1947-06-24 Ernst A H Friedheim Substituted 1,3,5-triazinyl-(6)-aminophenyl-arsenic compounds
US2400547A (en) * 1944-01-20 1946-05-21 Ernst A H Friedheim Substituted 1, 3, 5-triazinyl-(6)-aminophenyl-arsenic compounds
US2390091A (en) * 1944-06-03 1945-11-27 Ernst A H Friedheim Substituted 1,3,5-triazinyl-(6)-aminophenyl-arsenic compounds
US2659723A (en) * 1947-01-28 1953-11-17 Ernst A H Friedheim Triazine organometallic compounds and process for preparing same
US2593434A (en) * 1947-02-19 1952-04-22 Ernst A H Friedheim Propylene glycol solution of arsenic medicaments
US3482171A (en) * 1966-07-15 1969-12-02 Itt Bidirectional electronic phase shifter
US3856971A (en) * 1971-07-20 1974-12-24 E Friedheim Method of combating filariasis in dogs
GB2024008B (en) * 1978-06-28 1983-02-16 Merck & Co Inc Compositions for treating trypanosomiasis infections
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
FR2684382B1 (fr) * 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH242529A (de) * 1940-12-10 1946-05-15 Friedheim Ernst Albert Hermann Verfahren zur Darstellung von m-(2,4-Diamino-1,3,5-triazinyl-(6))-amino-phenylarsinoxyd.
CH245837A (de) * 1946-11-16 1946-11-30 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-2,4-Diamino-1,3,5-triazinyl-(6)-amino-phenyl-arsenoxyd.
CH254164A (de) * 1946-11-16 1948-04-15 Dr Friedheim Ernst A H Verfahren zur Darstellung von p-(2,4-Diamino-1,3,5-triazinyl-(6)-aminophenyl-arsenoxyd.
FR2150705A1 (el) * 1971-07-20 1973-04-13 Friedheim Ernst Ah
WO1983003606A1 (en) * 1982-04-12 1983-10-27 Univ Rockefeller Improved melaminylthioarsenites
FR2572730A1 (fr) * 1984-11-02 1986-05-09 Centre Nat Rech Scient Nouveaux derives de l'arsenic, leur preparation et leur application, notamment comme medicaments antiparasitaires
FR2640269A1 (fr) * 1988-12-13 1990-06-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
US5635499A (en) 1997-06-03
BR9204643A (pt) 1993-06-08
ITMI922692A1 (it) 1994-05-25
JP3578277B2 (ja) 2004-10-20
ES2039311A1 (es) 1993-09-16
MA22723A1 (fr) 1993-07-01
JPH0624960A (ja) 1994-02-01
AU2972092A (en) 1993-06-03
CA2083766A1 (en) 1993-06-03
ITMI922692A0 (it) 1992-11-25
US5770733A (en) 1998-06-23
US5459263A (en) 1995-10-17
PT101105A (pt) 1994-03-31
ES2039311B1 (es) 1997-08-16
IT1256117B (it) 1995-11-28
FR2684382A1 (fr) 1993-06-04
MY111175A (en) 1999-09-30
MX9206890A (es) 1993-08-01
FR2684382B1 (fr) 1994-10-21
PH31115A (en) 1998-02-23
PT101105B (pt) 1999-10-29
AU667329B2 (en) 1996-03-21
CA2083766C (en) 2002-09-10
TW358099B (en) 1999-05-11

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