GR920100326A - Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών. - Google Patents

Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.

Info

Publication number
GR920100326A
GR920100326A GR920100326A GR920100326A GR920100326A GR 920100326 A GR920100326 A GR 920100326A GR 920100326 A GR920100326 A GR 920100326A GR 920100326 A GR920100326 A GR 920100326A GR 920100326 A GR920100326 A GR 920100326A
Authority
GR
Greece
Prior art keywords
inhibition
compounds
related viruses
methods
hiv related
Prior art date
Application number
GR920100326A
Other languages
English (en)
Inventor
Thomas Peter Lind
Michael John Morin
Rolf Noreen
John Robert Ternansky
Original Assignee
Medivir Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ag filed Critical Medivir Ag
Publication of GR920100326A publication Critical patent/GR920100326A/el

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η αγωγή του Επίκτητου Συνδρόμου Ανοσοποιητικής Ανεπάρκειας (AIDS), αναστολή της αναπαραγωγής του HIV και σχετικών ιών και διατυπώσεις χρησιμοποιούσες παράγωγες ενώσεις θειουρίας ή άλατα αυτών περιγράφονται. Επίσης περιγράφονται νέες ενώσεις θειουρίας.ω
GR920100326A 1992-07-21 1992-07-21 Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών. GR920100326A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR92100326 1992-07-21

Publications (1)

Publication Number Publication Date
GR920100326A true GR920100326A (el) 1994-03-31

Family

ID=10941144

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920100326A GR920100326A (el) 1992-07-21 1992-07-21 Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.

Country Status (1)

Country Link
GR (1) GR920100326A (el)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2102605A1 (de) * 1970-01-21 1971-07-29 Sumitomo Chemical Co , Ltd, Osaka (Japan) Thiohydantoindenvate, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
JPS55143973A (en) * 1979-04-24 1980-11-10 Otsuka Pharmaceut Factory Inc Phenylacetic acid derivative
PL137012B1 (en) * 1982-05-27 1986-04-30 Politechnika Gdanska Process for preparing 3,5-substituted derivatives of 2-thiohydantoin
EP0196185A2 (en) * 1985-03-16 1986-10-01 The Wellcome Foundation Limited Antiviral nucleosides
EP0236951A2 (de) * 1986-03-06 1987-09-16 Pascal Zimmer Verwendung von Diphenylhydantoin und seinen Derivaten zur Herstellung eines pharmazeutischen Mittels zur Behandlung von Immunerkrankungen
EP0384522A1 (en) * 1989-02-23 1990-08-29 Janssen Pharmaceutica N.V. Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2102605A1 (de) * 1970-01-21 1971-07-29 Sumitomo Chemical Co , Ltd, Osaka (Japan) Thiohydantoindenvate, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
JPS55143973A (en) * 1979-04-24 1980-11-10 Otsuka Pharmaceut Factory Inc Phenylacetic acid derivative
PL137012B1 (en) * 1982-05-27 1986-04-30 Politechnika Gdanska Process for preparing 3,5-substituted derivatives of 2-thiohydantoin
EP0196185A2 (en) * 1985-03-16 1986-10-01 The Wellcome Foundation Limited Antiviral nucleosides
EP0236951A2 (de) * 1986-03-06 1987-09-16 Pascal Zimmer Verwendung von Diphenylhydantoin und seinen Derivaten zur Herstellung eines pharmazeutischen Mittels zur Behandlung von Immunerkrankungen
EP0384522A1 (en) * 1989-02-23 1990-08-29 Janssen Pharmaceutica N.V. Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones

Non-Patent Citations (34)

* Cited by examiner, † Cited by third party
Title
ACTA CHIM. (BUDAPEST), vol. 68, no. 1, 1971, pages 93-132; S. SOLYOM et al.: "Thiokarbamidderivate mit tuberkulostatischer Wirkung" *
AGRIC. BIOL. CHEM., vol. 55, no. 11, November 1991, pages 2751-2756; S. MORIKAWA et al.: "Chemical modification of neutral protease from Bacillus subtilis var, amylosacchariticus: assignment of tyrosyl residues iodinated" *
ANAL. BIOCHEM., vol. 192, no. 2, 1st February 1991, pages 429-433; J.H. WAITE: "Detection of peptidyl-3,4-dihydroxyphenylalanine by amino acid analysis and microsequencing techniques" *
ANAL. CHEM., vol. 29, no. 9, 23rd August 1957, pages 1283-1287: A. EPP: "Infrared spectra of 3-phenyl-2-thiohydantoins of amino acids" *
ANGEW. CHEM., vol. 82, no. 18, 1970, pages 771-772; C. BIRR et al.: "4-Isothiocyanato-benzolsulfons{ure als Reagens f}r einen eindeutigen Peptidabbau nach Edman" *
ARCH. PHARM., vol. 296, no. 10, October 1963, pages 641-650; D. MARTIN et al.: "Synthetische Senfölbildner, IV" *
AUST. J. CHEM., vol. 28, no. 10, October 1975, pages 2289-2298; C.J. BURRELL et al.: "The use of p-iodophenyl(125I) isothiocyanate for determination of N-terminal amino acids in nanomole quantities of protein" *
BANGLADESH J. BIOL. SCI., vol. 5, no. 1, 1976, pages 28-30; M.K. RAHMAN et al.: "Synthesis and biological studies of thiohydantoins" *
BIOL. CHEM. HOPPE-SEYLER, vol. 367, no. 10, October 1986, pages 1055-1059; A. LILOVA et al.: "Preparation and characterization of 5-(4-hydroxy-3-nitrobenzyl)-3-phenyl-2-thiohydantoin, the phenylthiohydantoin derivative of 3-nitrotyrosine" *
BIOMED. CHROMATOGR., vol. 2, no. 4, 1987, pages 139-144; H. MIYANO et al.: "Micro-scale sequence analysis from the N-terminus of peptides using the fluorogenic Edman reagent 4-N,N-dimethylamino-1-naphthyl isothiocyanate" *
BULL. ACAD. POL. SCI., SER. SCI. CHIM., vol. 24, no. 10, 1976, pages 781-790; I.A. ATTIA et al.: "On the stereoisomerism of 3-(o-tolyl)-and 3-(alpha-naphthyl-2-thiohydantoins" *
CHEMICAL ABSTRACTS, vol. 110, no. 9, 27th February 1989, page 653, abstract no. 75501n, Columbus, Ohio, US; & PL-B1-137 012 (POLITECHNIKA GDANSKA) 30-06-1987 *
CHEMICAL ABSTRACTS, vol. 111, no. 25, 18th December 1989, page 854, abstract no. 233511t, Columbus, Ohio, US; G. XU et al.: "Synthesis and antinociceptive activity of thiohydantoin derivatives", & ZHONGGUO YAOKE DAXUE XUEBAO 1988, 19(4), 245-8 *
CHEMICAL ABSTRACTS, vol. 112, no. 7, 12th February 1990, page 14, abstract no. 48249w, Columbus, Ohio, US; G. XU et al.: "Determination of hydrolysis rate and preliminary structure-activity relationship of thiohydantoin derivatives", & ZHONGGUO YAOKE DAXUE XUEBAO 1989, 20(4), 199-202 *
CHEMICAL ABSTRACTS, vol. 60, no. 11, 25th May 1964, page 1964, abstract no. 13546f, Columbus, Ohio, US; V.M. NEPLYUEV et al.: "Chromatographic separation of 4-dimethylamino-3,5-dinitrophenylthiohydantoins of amino acids", & BIOKHIMIYA 1964, 29(1), 51-52 *
CHEMICAL ABSTRACTS, vol. 76, no. 23, 5th June 1972, page 46, abstract no. 135847w, Columbus, Ohio, US; S. TSUTSUMI et al.: "Improvement of antileprous drugs. III. Inhibitory effect of some drugs on the growth of leprosy bacilli in the footpads of mice", & REPURA 1970, 39(1), 33-47 *
CHEMICAL ABSTRACTS, vol. 90, no. 7, 12th February 1979, page 107, abstract no. 49009g, Columbus, Ohio, US; E.G. DELEGAN et al.: "Antimicrobial activity of some 5-R-3-alkenyl-2-thiohydantoins and products of their cyclization", & FIZIOL. AKT. VESHCHESTVA 1978, 10, 65-67 *
CHEMICAL ABSTRACTS, vol. 94, no. 17, 27th April 1981, page 766, abstract no. 139811z, Columbus, Ohio, US; & JP-A-55 143 973 (OTSUKA SEIYAKU KOJO CO., LTD) 10-11-1980 *
CHEMICAL ABSTRACTS, vol. 95, no. 19, 9th November 1981, page 731, Abstract no. 169070v, Columbus, Ohio, US; V. ZUBENKO et al:: "Synthesis, transformation, spectral and analytical characterization of 2-thiohydantoin derivatives from (-)-3-(3,4-dihydroxyphenyl)-L-alanine", & FARM. ZH. (KIEV) 1981, 3, 31-5 *
CHIMIA, vol. 18, no. 1, 1964, pages 23-24; G. PATAKI: Zur D}nnschichtchromatographie von 3-Phenyl-2-thiohydantoinen" *
COLLECT. CZECH. CHEM. COMMUN., vol. 39, no. 3, 1974, pages 773-778; V. KNOPPOVA et al.: "Synthesis and physico-chemical properties of some 3,5-disubstituted 2-thiohydantoines" *
EGYPT. J. PHARM. SCI., vol. 28, nos. 1-4, 1987, pages 77-86; K.M. GHONEIM et al.: "Hydantoin and thiohydanthoin derivatives as potential antimicrobial agents: part I" *
EUR. J. BIOCHEM., vol. 20, 1971, pages 72-80; F. WEYGAND et al.: "Massenspektrometrische Identifizierung substituierter Phenylthiohydantoine aus dem Edman-Abbau von Peptiden" *
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 10, no. 8, 1988, pages 997-1010, Oxford, GB; M.E. KAMM]LLER et al.: "Structural requirements for hydantoins and 2-thiohydantoins to induce lymphoproliferative popliteal lymph node reactions in the mouse" *
J. CHEM. SOC. PERKIN 2 1979, pages 659-663; H. FUJIWARA et al.: "An X-ray study of the aromatic ring-dipole interaction in hydantoin crystals" *
J. CHEM. SOC. PERKIN TRANS 2 1980, pages 1573-1577; H. FUJIWARA et al.: "C nuclear magnetic resonance studies on the conformation of substituted hydantoins" *
J. CHROMATOGR., no. 180, 1979, pages 111-118; M.J. HORN et al.: "Methylthiohydantoin amino acids: chromatographic separation and comparison to phenylthiohydantoin amino acids" *
J. CHROMATOGR., no. 298, 1984, pages 279-288; T.J. MAHACHI et al.: "p-N,N-dimethylaminophenylisothiocyanate as an electrochemical label for high-performance liquid chromatographic determination of amino acids" *
J. MED. CHEM., vol. 13, no. 6, 1970, pages 1179-1181; J.V. MARX et al.: "Peripheral inhibition of thyroxine by thiohydantoins derived from amino acids" *
J. MED. CHEM., vol. 7, no. 1, 1964, pages 97-101; J.G. LOMBARDINO et al.: "Preparation and hypoglycemic activity of some 3,5-disubstituted hydantoins" *
J. PHARM. PHARMACOL., vol. 34, no. 11, November 1982, pages 752-754; L.A. MAMMO et al.: "Inhibition of alpha-chymotrypsin by 5-substituted-3-phenyl-2-thioxo-4-imidazolinones and derivatives" *
POL. J. PHARMACOL. PHARM., vol. 28, no. 5, 1976, pages 423-427; M.J. KOROHODA et al.: "Synthesis of 3-aryl-2-thiohydantoin- and 3-arylhydantoin-5-acetic acids and screening of some of their pharmacological properties" *
ROCZ. CHEM., vol. 47, no. 12, 1973, pages 2377-2378; K. NOWAK: "Application of allylisothiocyanate in synthesis of 3-allyl-2-thiohydantoins from amino acids and in degradation of proteins" *
SYNTHESIS, May 1983, pages 391-392; G. BLOTNY: "Reactivity of dithiocarbamic esters: methods for the preparation of 3,5-substituted 2-thiohydantoins" *

Similar Documents

Publication Publication Date Title
ES2051641A1 (es) Procedimientos para la preparacion de compuestos derivados de tiourea.
DE69232649D1 (de) Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b
CY1107626T1 (el) Παραγωγα πυραζολιου για την θεραπεια του hiv
ES554967A0 (es) Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
DK602988A (da) Nukleosidderivater med antiviral virkning og laegemiddelpraeparat indeholdende saadanne forbindelser
HU9302496D0 (en) Method for producing anti-viral nucleoside combinations and one for preparing medical preparatives containing said compounds
ATE131730T1 (de) Nukleosidanalogen enthaltende antiviren- zubereitungen
DE69019533D1 (de) Behandlung von hiv-infizierungen und nützliche verbindungen dafür.
SE8000435L (sv) N-bensylimidazoler med selektivt inhiberande verkan pa tromboxansyntetasenzymet jemte farmaceutiska beredningar innehallande sadana n-bensylimidazoler och sett for deras framstellning
ATE139531T1 (de) Arylsubstituierte rhodaninderivate
ATE182271T1 (de) Arzneimittel zur behandlung von krebs, aids und viruserkrankungen
FI921525A (fi) Amidinofenylalaninderivat, foerfarande foer deras framstaellning, deras anvaendning och dessa innehaollande aemnen
DK0387821T3 (da) 2-Alkyl-4-arylmethylchinoliner, deres anvendelse og lægemidler fremstillet hermed
ATE122562T1 (de) Derivate von penciclovir zur behandlung von hepatitis-b-infektionen.
GR920100326A (el) Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
ATE108335T1 (de) Kit oder zusammensetzung zur vorbeugung oder behandlung von hiv-1 infektionen.
UA37251C2 (uk) Лікарський засіб для лікування або профілактики вірусної інфекції гепатиту в і спосіб лікування вірусної інфекції гепатиту в
NO965591L (no) Kombinasjonsbehandling av HIV-infeksjon
YU47096B (sh) Antivirusna jedinjenja i postupak za njihovo dobijanje
NO933628L (no) Fremgangsmaate og blanding for behandling av Herpes-infeksjoner
GR930100335A (el) Ενώσεις και μέ?οδοι αναστολής του ΗΙV και των σχετικών ιών.
NO931337L (no) Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus
ES2062266T3 (es) Uso de quinolil- e isoquinoliloxazol-2-onas para la obtencion de un medicamento destinado para la prevencion de infecciones por virus envueltos por glicoproteinas.
NO931338L (no) Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus
DE69010736D1 (de) Anti-HIV Zusammensetzungen.