GR880100578A - Ophthalmological cyclosporine composition and preparation method - Google Patents

Ophthalmological cyclosporine composition and preparation method

Info

Publication number
GR880100578A
GR880100578A GR88100578A GR880100578A GR880100578A GR 880100578 A GR880100578 A GR 880100578A GR 88100578 A GR88100578 A GR 88100578A GR 880100578 A GR880100578 A GR 880100578A GR 880100578 A GR880100578 A GR 880100578A
Authority
GR
Greece
Prior art keywords
cyclosporine
composition
enhance
corn oil
ophthalmological
Prior art date
Application number
GR88100578A
Other languages
English (en)
Other versions
GR1000558B (el
Inventor
Renee Kawsan
Original Assignee
Univ Georgia Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/092,466 external-priority patent/US4839342A/en
Application filed by Univ Georgia Research Inc filed Critical Univ Georgia Research Inc
Publication of GR880100578A publication Critical patent/GR880100578A/el
Publication of GR1000558B publication Critical patent/GR1000558B/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
GR880100578A 1987-09-03 1988-09-05 Μεθοδος παρασκευης οφθαλμικης συνθεσεως κυκλοσπορινης. GR1000558B (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/092,466 US4839342A (en) 1987-09-03 1987-09-03 Method of increasing tear production by topical administration of cyclosporin
US11721887A 1987-11-04 1987-11-04
US18782388A 1988-04-29 1988-04-29

Publications (2)

Publication Number Publication Date
GR880100578A true GR880100578A (en) 1989-06-22
GR1000558B GR1000558B (el) 1992-08-26

Family

ID=27377210

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100578A GR1000558B (el) 1987-09-03 1988-09-05 Μεθοδος παρασκευης οφθαλμικης συνθεσεως κυκλοσπορινης.

Country Status (12)

Country Link
US (1) US5411952A (el)
EP (1) EP0391909B1 (el)
JP (1) JPH0667850B2 (el)
KR (1) KR920003601B1 (el)
AT (1) ATE109970T1 (el)
DE (1) DE3851152T2 (el)
DK (1) DK54390A (el)
ES (1) ES2012116A6 (el)
GR (1) GR1000558B (el)
IE (1) IE65582B1 (el)
PH (1) PH24814A (el)
WO (1) WO1989001772A1 (el)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
JP3631490B2 (ja) 1992-05-13 2005-03-23 ノバルティス ファーマ株式会社 シクロスポリン含有眼科用組成物
US5830508A (en) 1992-08-06 1998-11-03 Deo Corporation Composition for treating dry eye
US5366739A (en) * 1992-08-06 1994-11-22 Deo Corporation Method of ophthalmic drug delivery
US5686436A (en) 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
DK0880363T3 (da) * 1996-02-13 2003-01-20 Searle & Co Kombinationer der omfatter en cyclooxygenase-2 hæmmer samt en leukotrien A4 hydrolasehæmmer, som har immunsuppressive virkninger
DE69709069T2 (de) 1996-02-13 2002-07-04 Searle & Co Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten
AU2213197A (en) * 1996-03-05 1997-09-22 Medinox, Inc. Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
NZ502362A (en) 1997-10-08 2001-05-25 Isotechnika Inc Deuterated cyclosporine A derivatives and their use as immunomodulating agents
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
GB9818278D0 (en) * 1998-08-22 1998-10-14 Smith & Nephew Compositions
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US6255280B1 (en) 1999-04-08 2001-07-03 University Of Kentucky Research Foundation Protection against traumatic brain injury
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
EP1220849B1 (en) * 1999-10-15 2004-05-19 Sucampo AG Bicyclic compounds composition and method for stabilizing the same
TR200302105T4 (tr) 2000-04-07 2004-02-23 Laboratoire Medidom S. A. Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
CA2449671A1 (en) * 2001-06-06 2002-12-12 The Regents Of The University Of Michigan Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enyzmes
WO2003033526A2 (en) * 2001-10-19 2003-04-24 Isotechnika Inc. Synthesis of cyclosporin analogs
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6930127B2 (en) * 2002-08-15 2005-08-16 Eaton Veterinary Laboratories, Inc. Veterinary treatment of ophthalmic disease in animals using topical tacrolimus
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
AU2004222306A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
EP1608347B1 (en) * 2003-03-28 2014-08-13 Sigmoid Pharma Limited Solid oral dosage form containing seamless microcapsules
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
BRPI0506983A (pt) 2004-01-20 2007-07-03 Allergan Inc composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
US20050277584A1 (en) * 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US20080113031A1 (en) * 2004-09-27 2008-05-15 Joey Moodley Minicapsule Formulations
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008515886A (ja) * 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
WO2006073786A2 (en) * 2004-12-30 2006-07-13 Bausch & Lomb Incorporated Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
US8637070B2 (en) 2005-02-09 2014-01-28 Santen Pharmaceutical Co., Ltd. Rapamycin formulations and methods of their use
WO2007011880A2 (en) 2005-07-18 2007-01-25 Minu, L.L.C. Enhanced ocular neuroprotection/neurostimulation
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
EP1937290A1 (en) * 2005-10-14 2008-07-02 Allergan, Inc. Prevention and treatment of drug-associated ocular side effects with a cyclosporin
CN101355876B (zh) * 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
CA2635797C (en) 2006-02-09 2015-03-31 Macusight, Inc. Stable formulations, and methods of their preparation and use
WO2007095486A1 (en) * 2006-02-13 2007-08-23 Allergan, Inc. Methods of treating blepharospasm using cyclosporine components
US7557082B2 (en) 2006-03-03 2009-07-07 Allergan, Inc. Treatment with cyclosporin A
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
US8222271B2 (en) 2006-03-23 2012-07-17 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20080146497A1 (en) * 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
CN103120653B (zh) 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
WO2008137617A1 (en) * 2007-05-04 2008-11-13 Allergan, Inc. Use of cyclosporines in the treatment of patients with intraocular lenses
US20090081277A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Pharmaceutical formulations and methods for treating ocular conditions
EP2197461B1 (en) 2007-10-08 2018-02-21 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
ITMI20080003A1 (it) * 2008-01-02 2009-07-03 Alfredo Pulpito Composizioni per uso oftalmico
CN102099029A (zh) * 2008-07-09 2011-06-15 阿斯普瑞瓦国际公司 治疗眼部病症的霉酚酸钠的pH值特定溶液
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
CN102271700A (zh) 2009-01-08 2011-12-07 阿勒根公司 用于促进甲生长的环孢菌素组合物
US20110009339A1 (en) * 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
EP3300723A1 (en) 2009-05-18 2018-04-04 Sigmoid Pharma Limited Composition comprising oil drops
AU2010256652B2 (en) 2009-06-05 2015-11-26 Allergan, Inc. Artificial tears and therapeutic uses
US9017725B2 (en) * 2009-06-09 2015-04-28 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
JP5911799B2 (ja) 2009-08-12 2016-04-27 シグモイド・ファーマ・リミテッドSigmoid Pharma Limited ポリマーマトリックスおよび油相を含んで成る免疫調節組成物
EP2335735A1 (en) 2009-12-14 2011-06-22 Novaliq GmbH Pharmaceutical composition for treatment of dry eye syndrome
JP2013515741A (ja) * 2009-12-23 2013-05-09 サイヴィーダ ユーエス,インコーポレイテッド 持続放出性送達デバイス
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
BR112014011770B1 (pt) * 2011-11-15 2022-11-08 Allergan, Inc Suspensões da forma 2 de ciclosporina a
BR112014011744A2 (pt) 2011-11-15 2017-05-02 Allergan Inc formulação de ação sustentável da forma 2 de ciclosporina
US8796221B2 (en) 2011-11-15 2014-08-05 Allergan, Inc. Cyclosporin A form 2 and method of making same
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130266615A1 (en) * 2012-04-10 2013-10-10 Bin Wu Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
CA2871070C (en) * 2012-04-20 2024-01-02 Howard University Method of treating an ocular disease and compositions effective for treating an ocular disease
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP3215127B1 (en) 2014-11-07 2020-10-28 Sublimity Therapeutics Limited Compositions comprising cyclosporin
US10279005B2 (en) 2014-11-25 2019-05-07 Allergan, Inc. Stabilized omega-3 ophthalmic compositions
US9820954B2 (en) 2015-08-19 2017-11-21 Jenivision Inc. Quantitative peri-orbital application of ophthalmology drugs
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388307A (en) * 1978-03-07 1983-06-14 Sandoz Ltd. Galenical compositions
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
WO1987002219A1 (en) * 1985-10-15 1987-04-23 The Liposome Company, Inc. Alpha tocopherol-based vesicles

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) * 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (el) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
EP0098457B1 (en) * 1980-02-14 1987-08-05 Sandoz Ag (1s,2r,3r)- and (1r,2s,3s)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0056782B1 (en) * 1981-01-09 1984-08-01 Sandoz Ag Novel cyclosporins
EP0090798A1 (en) * 1981-10-09 1983-10-12 Ferring AB A drug based on a substance p antagonist
EP0145714A1 (en) * 1983-05-25 1985-06-26 Alcon Laboratories, Inc. Ophthalmic gel
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
EP0365044A3 (en) * 1984-08-02 1990-08-22 Sandoz Ag Novel pharmaceutical use of (nva)2-cyclosporine
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
US4745100A (en) * 1985-05-14 1988-05-17 Eye Research Institute Of Retina Foundation Stimulation of tear secretion
GB8528032D0 (en) * 1985-11-13 1985-12-18 Ici Plc Ocular treatment
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388307A (en) * 1978-03-07 1983-06-14 Sandoz Ltd. Galenical compositions
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
WO1987002219A1 (en) * 1985-10-15 1987-04-23 The Liposome Company, Inc. Alpha tocopherol-based vesicles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAIMS NOT SEARCHED: 1-10 *
CLAIMS SEARCHED: 11-24 *

Also Published As

Publication number Publication date
DE3851152D1 (de) 1994-09-22
EP0391909A1 (en) 1990-10-17
JPH0667850B2 (ja) 1994-08-31
EP0391909B1 (en) 1994-08-17
DK54390D0 (da) 1990-03-01
PH24814A (en) 1990-10-30
WO1989001772A1 (en) 1989-03-09
KR890701084A (ko) 1989-12-19
ES2012116A6 (es) 1990-03-01
ATE109970T1 (de) 1994-09-15
DE3851152T2 (de) 1995-01-26
IE65582B1 (en) 1995-11-01
DK54390A (da) 1990-05-03
KR920003601B1 (ko) 1992-05-04
JPH03503159A (ja) 1991-07-18
GR1000558B (el) 1992-08-26
US5411952A (en) 1995-05-02
IE882663L (en) 1989-03-03

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