GR3022730T3 - 27-hydroxyrapamycin and derivatives thereof. - Google Patents

27-hydroxyrapamycin and derivatives thereof.

Info

Publication number
GR3022730T3
GR3022730T3 GR970400422T GR970400422T GR3022730T3 GR 3022730 T3 GR3022730 T3 GR 3022730T3 GR 970400422 T GR970400422 T GR 970400422T GR 970400422 T GR970400422 T GR 970400422T GR 3022730 T3 GR3022730 T3 GR 3022730T3
Authority
GR
Greece
Prior art keywords
hydroxyrapamycin
derivatives
formula
compound
deoxo
Prior art date
Application number
GR970400422T
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of GR3022730T3 publication Critical patent/GR3022730T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GR970400422T 1992-08-13 1997-03-03 27-hydroxyrapamycin and derivatives thereof. GR3022730T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof
PCT/US1993/007581 WO1994004540A1 (en) 1992-08-13 1993-08-12 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
GR3022730T3 true GR3022730T3 (en) 1997-06-30

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970400422T GR3022730T3 (en) 1992-08-13 1997-03-03 27-hydroxyrapamycin and derivatives thereof.

Country Status (12)

Country Link
EP (1) EP0655065B1 (el)
JP (1) JPH08501084A (el)
AT (1) ATE146179T1 (el)
AU (1) AU5007193A (el)
CA (1) CA2142288A1 (el)
DE (1) DE69306585T2 (el)
DK (1) DK0655065T3 (el)
ES (1) ES2096941T3 (el)
GR (1) GR3022730T3 (el)
HU (1) HU221499B (el)
MX (1) MX9304868A (el)
WO (1) WO1994004540A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014023A1 (en) * 1993-11-19 1995-05-26 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
CA2219659C (en) * 1995-06-09 2008-03-18 Novartis Ag Rapamycin derivatives
ES2219388T3 (es) 1999-08-24 2004-12-01 Ariad Gene Therapeutics, Inc. 28-epi-rapalogos.
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
CN100522967C (zh) * 2002-02-01 2009-08-05 阿里亚德基因治疗公司 含磷化合物及其应用
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP2583678A3 (en) 2004-06-24 2013-11-13 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
EP2094241A4 (en) 2006-11-14 2013-04-17 Ariad Pharma Inc ORAL FORMULATIONS
WO2009089549A1 (en) 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
JP6525971B2 (ja) 2013-06-11 2019-06-05 タカラ バイオ ユーエスエー， インコーポレイテッド タンパク質富化微細小胞、タンパク質富化微細小胞の作製方法及び使用方法
IL278335B1 (en) 2018-05-01 2024-05-01 Revolution Medicines Inc C26-linked rapamycin analogs as MTOR inhibitors
KR20240006537A (ko) * 2021-04-09 2024-01-15 레볼루션 메디슨즈, 인크. 라파마이신 유사체 화합물의 합성

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
JPH08501084A (ja) 1996-02-06
EP0655065A1 (en) 1995-05-31
DE69306585D1 (de) 1997-01-23
DK0655065T3 (el) 1997-02-24
HU221499B (en) 2002-10-28
WO1994004540A1 (en) 1994-03-03
AU5007193A (en) 1994-03-15
CA2142288A1 (en) 1994-03-03
EP0655065B1 (en) 1996-12-11
HU9500432D0 (en) 1995-04-28
ES2096941T3 (es) 1997-03-16
HUT71614A (en) 1996-01-29
ATE146179T1 (de) 1996-12-15
DE69306585T2 (de) 1997-04-17
MX9304868A (es) 1994-05-31

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