GR3007789T3 - - Google Patents
Info
- Publication number
- GR3007789T3 GR3007789T3 GR920403167T GR920403167T GR3007789T3 GR 3007789 T3 GR3007789 T3 GR 3007789T3 GR 920403167 T GR920403167 T GR 920403167T GR 920403167 T GR920403167 T GR 920403167T GR 3007789 T3 GR3007789 T3 GR 3007789T3
- Authority
- GR
- Greece
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61022756A JPH0696563B2 (en) | 1986-02-04 | 1986-02-04 | Acyl amino acid derivative, production method and use thereof |
| JP61043821A JPH0730020B2 (en) | 1986-02-28 | 1986-02-28 | N-substituted amino acid imide derivative, production method and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3007789T3 true GR3007789T3 (en) | 1993-08-31 |
Family
ID=26360023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR920403167T GR3007789T3 (en) | 1986-02-04 | 1993-05-06 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4826870A (en) |
| EP (1) | EP0232849B1 (en) |
| AU (1) | AU588968B2 (en) |
| CA (1) | CA1320734C (en) |
| DE (1) | DE3785684T2 (en) |
| ES (1) | ES2056791T3 (en) |
| GR (1) | GR3007789T3 (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU598750B2 (en) * | 1985-09-27 | 1990-07-05 | Mitsubishi Chemical Corporation | Phenylalanine derivative and proteinase inhibitor |
| US5198458A (en) * | 1986-02-04 | 1993-03-30 | Suntory Limited | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same |
| DE3742431A1 (en) * | 1987-12-15 | 1989-07-13 | Hoechst Ag | NEW DERIVATIVES OF CYCLIC AMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING THEM AND THEIR USE |
| JPH01250370A (en) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | Novel amino acid imide derivative, its production and use thereof |
| CA2004028C (en) * | 1988-12-08 | 1998-09-22 | Motoki Torizuka | Condensed benzene derivative |
| WO1991005555A2 (en) * | 1989-10-13 | 1991-05-02 | The Salk Institute Biotechnology/Industrial Associates, Inc. | N-acyl peptide metalloendopeptidase inhibitors and methods of using same |
| US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
| US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
| JP3810097B2 (en) * | 1993-01-15 | 2006-08-16 | 明治製菓株式会社 | Pyrrolidin-2-ylcarbonyl heterocyclic compound derivative |
| FR2703050B1 (en) * | 1993-03-24 | 1995-04-28 | Adir | New nitrogenous bicyclic derivatives, process for their preparation and the pharmaceutical compositions containing them. |
| US5767242A (en) * | 1994-04-20 | 1998-06-16 | Boehringer Ingelheim Int'l Gmbh | Isolated dimeric fibroblast activation protein alpha, and uses thereof |
| HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| DE19720011A1 (en) * | 1997-05-14 | 1998-11-19 | Boehringer Ingelheim Pharma | New modified aminoacid derivatives |
| CA2262818A1 (en) | 1996-09-10 | 1998-03-19 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Modified amino acids, pharmaceuticals containing these compounds and methods for their production |
| HUP9700442A1 (en) * | 1997-02-14 | 1999-09-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| US6313097B1 (en) | 1999-03-02 | 2001-11-06 | Boehringer Ingelheim Pharma Kg | Antagonists of calcitonin gene-related peptide |
| US6121311A (en) * | 1999-04-28 | 2000-09-19 | Japan Tobacco Inc. | Method for treating ***ism |
| FI20030014A0 (en) * | 2003-01-03 | 2003-01-03 | Orion Corp | Compositions with the inhibitory action of prolyl oligopeptidase |
| DE602004026289D1 (en) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminyl INHIBITORS |
| WO2005049027A2 (en) | 2003-11-03 | 2005-06-02 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| EP1760076A1 (en) * | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP5930573B2 (en) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| ES2548913T3 (en) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Heterocyclic derivatives such as glutaminyl cyclase inhibitors |
| EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| EA022420B1 (en) | 2010-03-10 | 2015-12-30 | Пробиодруг Аг | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1062206B (en) * | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | THYROSIN DERIVATIVES ACTIVE ON SMOOTH MUSCLE |
| GB1492640A (en) * | 1975-07-08 | 1977-11-23 | Ucb Sa | L-pyroglutamyl-l-prolinamide |
| FR2489319A1 (en) * | 1980-08-27 | 1982-03-05 | Clin Midy | DERIVATIVES OF AMINO-4 BUTYRIC ACID AND MEDICAMENTS, PARTICULARLY ACTIVE ON THE CENTRAL NERVOUS SYSTEM, CONTAINING |
| JPS60172929A (en) * | 1984-02-17 | 1985-09-06 | Yakult Honsha Co Ltd | Agent for alleviating amnesia |
| JPS60188317A (en) * | 1984-03-09 | 1985-09-25 | Yakult Honsha Co Ltd | Antiamnestic agent |
| JPS6137764A (en) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | Novel physiologically active compound having anti-prolyl-endopeptidase activity |
| JPH0651677B2 (en) * | 1985-12-23 | 1994-07-06 | サントリー株式会社 | Dipeptide derivative, production method and use thereof |
| EP0201743B1 (en) * | 1985-04-16 | 1992-04-01 | Suntory Limited | Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use |
| JPH0623190B2 (en) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | N-acylpyrrolidine derivative having inhibitor activity, process for producing the same and use thereof |
| JPH0764834B2 (en) * | 1985-11-29 | 1995-07-12 | サントリー株式会社 | Novel pyrrolidine amide derivative having prolyl endopeptidase inhibitory activity, its production and use |
| GB8618188D0 (en) * | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
| US4873253A (en) * | 1987-03-30 | 1989-10-10 | Shosuke Okamoto | Phenylalanine derivative and proteinase inhibitor |
-
1987
- 1987-01-30 CA CA000528630A patent/CA1320734C/en not_active Expired - Fee Related
- 1987-02-03 AU AU68228/87A patent/AU588968B2/en not_active Ceased
- 1987-02-03 US US07/010,490 patent/US4826870A/en not_active Expired - Lifetime
- 1987-02-04 ES ES87101504T patent/ES2056791T3/en not_active Expired - Lifetime
- 1987-02-04 EP EP87101504A patent/EP0232849B1/en not_active Expired - Lifetime
- 1987-02-04 DE DE87101504T patent/DE3785684T2/en not_active Expired - Fee Related
-
1993
- 1993-05-06 GR GR920403167T patent/GR3007789T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3785684T2 (en) | 1993-10-21 |
| AU588968B2 (en) | 1989-09-28 |
| EP0232849B1 (en) | 1993-05-05 |
| US4826870A (en) | 1989-05-02 |
| EP0232849A3 (en) | 1989-01-18 |
| CA1320734C (en) | 1993-07-27 |
| EP0232849A2 (en) | 1987-08-19 |
| DE3785684D1 (en) | 1993-06-09 |
| AU6822887A (en) | 1987-08-06 |
| ES2056791T3 (en) | 1994-10-16 |