GR3004499T3 - - Google Patents

Info

Publication number: GR3004499T3
Authority: GR; Greece
Prior art keywords: hydrogen atom; lower alkyl; het; disease; optionally substituted
Prior art date: 1986-08-01

Application number

GR900400209T

Other languages

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-01

Filing date

1992-05-07

Publication date

1993-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6306478&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3004499(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-05-07 Application filed filed Critical

1993-03-31 Publication of GR3004499T3 publication Critical patent/GR3004499T3/el

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
201000008482 osteoarthritis Diseases 0.000 abstract 2
206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
206010007027 Calculus urinary Diseases 0.000 abstract 1
206010027452 Metastases to bone Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000003913 calcium metabolism Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
208000008281 urolithiasis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

GR900400209T 1986-08-01 1992-05-07 GR3004499T3 (el)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19863626058 DE3626058A1 (de)	1986-08-01	1986-08-01	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number	Publication Date
GR3004499T3 true GR3004499T3 (el)	1993-03-31

Family

ID=6306478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR900400209T GR3004499T3 (el)	1986-08-01	1992-05-07

Country Status (23)

Country	Link
US (1)	US4777163A (el)
EP (1)	EP0258618B1 (el)
JP (1)	JPH0725780B2 (el)
KR (1)	KR900004043B1 (el)
AT (1)	ATE75748T1 (el)
AU (1)	AU605778B2 (el)
CA (1)	CA1338895C (el)
CS (1)	CS266345B2 (el)
DD (1)	DD264442A5 (el)
DE (3)	DE3626058A1 (el)
DK (1)	DK168820B1 (el)
ES (1)	ES2032782T3 (el)
FI (1)	FI87223C (el)
GR (1)	GR3004499T3 (el)
HK (1)	HK47096A (el)
HU (1)	HU198078B (el)
IE (1)	IE60233B1 (el)
IL (1)	IL83332A (el)
LU (1)	LU90836I2 (el)
MX (1)	MX7510A (el)
NL (1)	NL300059I2 (el)
PT (1)	PT85457B (el)
ZA (1)	ZA875489B (el)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL77243A (en) *	1984-12-21	1996-11-14	Procter & Gamble	Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
IL84497A (en) *	1986-11-21	1994-10-21	Ciba Geigy Ag	History 2-) Imidazol-1-yl (ethane-1,1-diphosphonic acid, their preparation and pharmaceutical preparations containing them
DE3640938A1 (de) *	1986-11-29	1988-06-01	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
DK126888A (da) *	1987-03-10	1988-09-11	Yamanouchi Pharma Co Ltd	Bisphosphonsyrederivater og terapeutiske praeparater indeholdende disse forbindelser
EP0317505A1 (de) *	1987-11-13	1989-05-24	Ciba-Geigy Ag	Neue Azacycloalkylalkandiphosphonsäuren
US5110807A (en) *	1988-12-01	1992-05-05	Ciba-Geigy Corporation	Araliphatylaminoalkanediphosphonic acids
US5190930A (en) *	1987-12-11	1993-03-02	Ciba-Geigy Corporation	Araliphatylaminoalkanediphosphonic acids
DE3822650A1 (de) *	1988-07-05	1990-02-01	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) *	1988-08-12	1991-02-05	Yamanouchi Pharmaceutical Co., Ltd.	Heterocyclic bisphosphonic acid derivatives
US4898606A (en) *	1988-10-14	1990-02-06	Fmc Corporation	Phosphorylaminophenyltriazolinone herbicides
US4954159A (en) *	1988-10-18	1990-09-04	Fmc Corporation	Phosphorylaminophenyltetrahydrophthalimide herbicides
US4902338A (en) *	1988-11-04	1990-02-20	Fmc Corporation	Phosphorylaminophenylhydantoin herbicides
US4932996A (en) *	1988-10-18	1990-06-12	Fmc Corporation	Phosphorylaminophenyltetrazolinone herbicides
US4983592A (en) *	1988-12-19	1991-01-08	American Cyanamid Co.	Bis-arylphosphate ester antagonists of platelet activating factor
US5231091A (en) *	1988-12-19	1993-07-27	American Cyanamid Company	Bis-arylphosphate ester antagonists of platelet activating factor
US5147864A (en) *	1988-12-19	1992-09-15	American Cyanamid Company	Bis-arylphosphate ester antagonists of platelet activating factor
DE3917153A1 (de) *	1989-05-26	1990-11-29	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
MX21452A (es) *	1989-07-07	1994-01-31	Ciba Geigy Ag	Preparaciones farmaceuticas que se administran en forma topica.
US5139786A (en) *	1989-07-07	1992-08-18	Ciba-Geigy Corporation	Topical formulations
US5204334A (en) *	1990-10-18	1993-04-20	Ciba-Geigy Corporation	Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders
US5202111A (en) *	1991-05-09	1993-04-13	Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.	Phosphorylated polyhydroxy compounds for tartar control
EP0521622B1 (en) *	1991-07-03	1997-08-13	PHARMACIA & UPJOHN COMPANY	Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
AU4859493A (en) *	1992-10-09	1994-05-09	Upjohn Company, The	Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
US5591730A (en) *	1993-10-12	1997-01-07	The Regents Of The University Of California	Inhibition of urinary calculi growth
US5854227A (en) *	1994-03-04	1998-12-29	Hartmann; John F.	Therapeutic derivatives of diphosphonates
US7205404B1 (en) *	1999-03-05	2007-04-17	Metabasis Therapeutics, Inc.	Phosphorus-containing prodrugs
US6677320B2 (en)	2000-01-20	2004-01-13	Hoffmann-La Roches Inc.	Parenteral bisphosphonate composition with improved local tolerance
PE20011065A1 (es)	2000-02-01	2001-11-21	Procter & Gamble	Proceso para fabricar bisfosfonatos geminales
US6410520B2 (en)	2000-02-01	2002-06-25	The Procter & Gamble Company	Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
MXPA02010740A (es)	2000-05-05	2003-03-10	Hoffmann La Roche	Composicion farmaceutica similar al gel para la administracion subcutanea que comprende acidos bisfosfonicos o sus sales.
JP2005514400A (ja) *	2001-12-21	2005-05-19	ザプロクターアンドギャンブルカンパニー	骨疾患の治療方法
KR20060058151A (ko) *	2002-05-10	2006-05-29	에프. 호프만-라 로슈 아게	골다공증 치료 및 예방용 비스포스폰산
AU2003250190A1 (en) *	2002-07-30	2004-02-23	Novartis Ag	Combination of an aromatase inhibitor with a bisphosphonate
SI1596870T2 (sl) *	2002-12-20	2011-07-29	Hoffmann La Roche	Formulacija z visokim odmerkom ibandronata
US20040230076A1 (en) *	2003-02-27	2004-11-18	Revital Lifshitz-Liron	Process for purification of zoledronic acid
EP1567533B1 (en) *	2003-07-03	2009-03-11	Teva Pharmaceutical Industries Ltd.	Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation
US20050049693A1 (en) *	2003-08-25	2005-03-03	Medtronic Vascular Inc.	Medical devices and compositions for delivering biophosphonates to anatomical sites at risk for vascular disease
US20050119230A1 (en) *	2003-09-18	2005-06-02	Alexandra Glausch	Pharmaceutical products comprising bisphosphonated
US7214671B2 (en) *	2004-02-19	2007-05-08	Wisconsin Alumni Research Foundation	Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
US8012949B2 (en) *	2004-10-08	2011-09-06	The Board Of Trustees Of The University Of Illinois	Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
WO2006039721A2 (en) *	2004-10-08	2006-04-13	The Board Of Trustees Of The University Of Illinois	Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
AR054673A1 (es)	2005-07-28	2007-07-11	Gador Sa	Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
JP2009530414A (ja) *	2006-03-17	2009-08-27	ザボードオブトラスティーズオブザユニヴァーシティーオブイリノイ	ビスホスホネート化合物及び方法
US20100120723A1 (en) *	2006-12-20	2010-05-13	Mostafa Akbarieh	Pharmaceutical composition comprising a hot-melt granulated lubricant
US20100179110A1 (en) *	2006-12-20	2010-07-15	Mostafa Akbarieh	Composition Containing a Bisphosphonic Acid in Combination with Vitamin D
US20090023683A1 (en) *	2007-07-16	2009-01-22	Chandrasekhar Kocherlakota	Complexes comprising zoledronic acid and cyclodextrins
JP2011517313A (ja)	2007-12-11	2011-06-02	ビアメトファーマシューティカルズ，インク．	金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤
CN102046152A (zh) *	2008-04-04	2011-05-04	诺瓦提斯公司	含有双膦酸盐的药物组合物
CA2746612A1 (en) *	2008-12-23	2010-07-08	Novartis Ag	Phenylalkyl-imidazole-bisphosphonate compounds
FR2954320B1 (fr)	2009-12-17	2012-06-15	Cll Pharma	Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
US8882740B2 (en) *	2009-12-23	2014-11-11	Stryker Trauma Gmbh	Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
US8748097B1 (en)	2011-12-02	2014-06-10	President And Fellows Of Harvard College	Identification of agents for treating calcium disorders and uses thereof
US10449210B2 (en)	2014-02-13	2019-10-22	Ligand Pharmaceuticals Inc.	Prodrug compounds and their uses
PL407922A1 (pl)	2014-04-16	2015-10-26	Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością	Nowe bisfosfoniany i ich zastosowanie
EP3164136A4 (en)	2014-07-02	2018-04-04	Ligand Pharmaceuticals, Inc.	Prodrug compounds and uses therof
EP3698797A1 (en)	2017-10-16	2020-08-26	Tsinghua University	Mevalonic acid pathway inhibitor and pharmaceutical composition thereof
WO2019097041A1 (en) *	2017-11-20	2019-05-23	Basf Se	Aqueous acrylic polymer latexes and their use as binders
RU2020126177A (ru)	2018-01-09	2022-02-10	Лиганд Фармасьютикалз, Инк.	Ацетальные соединения и их терапевтическое применение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0084822B1 (de) *	1982-01-27	1986-01-08	Schering Aktiengesellschaft	Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
DE3203307A1 (de) *	1982-01-27	1983-07-28	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Phosphonate, und diese enthaltende pharmazeutische verbindungen
DE3203308A1 (de) *	1982-01-27	1983-07-28	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3428524A1 (de) *	1984-08-02	1986-02-13	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL84497A (en) *	1986-11-21	1994-10-21	Ciba Geigy Ag	History 2-) Imidazol-1-yl (ethane-1,1-diphosphonic acid, their preparation and pharmaceutical preparations containing them

1986
- 1986-08-01 DE DE19863626058 patent/DE3626058A1/de not_active Withdrawn
1987
- 1987-07-24 US US07/077,228 patent/US4777163A/en not_active Expired - Lifetime
- 1987-07-25 ES ES198787110830T patent/ES2032782T3/es not_active Expired - Lifetime
- 1987-07-25 EP EP87110830A patent/EP0258618B1/de not_active Expired - Lifetime
- 1987-07-25 DE DE2001199050 patent/DE10199050I1/de active Pending
- 1987-07-25 DE DE8787110830T patent/DE3778800D1/de not_active Expired - Lifetime
- 1987-07-25 AT AT87110830T patent/ATE75748T1/de active
- 1987-07-26 IL IL83332A patent/IL83332A/xx not_active IP Right Cessation
- 1987-07-27 ZA ZA875489A patent/ZA875489B/xx unknown
- 1987-07-27 MX MX751087A patent/MX7510A/es unknown
- 1987-07-29 AU AU76256/87A patent/AU605778B2/en not_active Expired
- 1987-07-29 CA CA000543290A patent/CA1338895C/en not_active Expired - Lifetime
- 1987-07-30 CS CS875702A patent/CS266345B2/cs not_active IP Right Cessation
- 1987-07-30 DK DK398187A patent/DK168820B1/da not_active IP Right Cessation
- 1987-07-30 DD DD87305527A patent/DD264442A5/de not_active IP Right Cessation
- 1987-07-30 PT PT85457A patent/PT85457B/pt unknown
- 1987-07-30 JP JP62189069A patent/JPH0725780B2/ja not_active Expired - Lifetime
- 1987-07-31 HU HU873542A patent/HU198078B/hu active Protection Beyond IP Right Term
- 1987-07-31 IE IE208387A patent/IE60233B1/en not_active IP Right Cessation
- 1987-07-31 FI FI873339A patent/FI87223C/fi not_active IP Right Cessation
- 1987-08-01 KR KR1019870008480A patent/KR900004043B1/ko not_active IP Right Cessation
1992
- 1992-05-07 GR GR900400209T patent/GR3004499T3/el unknown
1996
- 1996-03-14 HK HK47096A patent/HK47096A/xx not_active IP Right Cessation
2001
- 2001-09-18 NL NL300059C patent/NL300059I2/nl unknown
- 2001-09-19 LU LU90836C patent/LU90836I2/fr unknown

Also Published As

Publication number	Publication date
EP0258618B1 (de)	1992-05-06
DK398187D0 (da)	1987-07-30
JPS6341486A (ja)	1988-02-22
CA1338895C (en)	1997-02-04
ZA875489B (en)	1988-04-27
PT85457A (de)	1987-08-01
IL83332A0 (en)	1987-12-31
NL300059I2 (nl)	2002-03-01
IL83332A (en)	1992-03-29
AU605778B2 (en)	1991-01-24
HUT44262A (en)	1988-02-29
CS570287A2 (en)	1989-02-10
FI873339A (fi)	1988-02-02
KR880002885A (ko)	1988-05-12
DE10199050I1 (de)	2002-01-10
EP0258618A2 (de)	1988-03-09
LU90836I2 (fr)	2001-11-19
JPH0725780B2 (ja)	1995-03-22
NL300059I1 (nl)	2001-12-01
EP0258618A3 (en)	1988-06-15
DK398187A (da)	1988-02-02
DD264442A5 (de)	1989-02-01
DE3626058A1 (de)	1988-02-11
HK47096A (en)	1996-03-22
IE60233B1 (en)	1994-06-15
FI87223C (fi)	1992-12-10
DE3778800D1 (de)	1992-06-11
FI87223B (fi)	1992-08-31
ATE75748T1 (de)	1992-05-15
AU7625687A (en)	1988-02-04
KR900004043B1 (ko)	1990-06-09
US4777163A (en)	1988-10-11
DK168820B1 (da)	1994-06-20
HU198078B (en)	1989-07-28
FI873339A0 (fi)	1987-07-31
MX7510A (es)	1993-12-01
IE872083L (en)	1988-02-01
ES2032782T3 (es)	1993-03-01
CS266345B2 (en)	1989-12-13
PT85457B (pt)	1990-06-29

Publication	Publication Date	Title
GR3004499T3 (el)	1993-03-31
AU598569B2 (en)	1990-06-28	Diphosphonic acid derivatives and medicines containing them
DE3373302D1 (en)	1987-10-08	Derivatives of aminopyridinecarboxylic acids, methods for their preparation and pharmaceutical compositions containing them